
High-Grade Glioma - Pipeline Insight, 2024
Description
High-Grade Glioma - Pipeline Insight, 2024
DelveInsight’s, “High-grade Glioma – Pipeline Insight, 2024,” report provides comprehensive insights about 150+ companies and 150+ pipeline drugs in High-grade Glioma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
High-grade Glioma: Overview
A glioma is a name for tumours of the glial cells. These are the supporting cells of the nervous system. Gliomas can arise in any part of the brain and may also be found in the spinal cord. More than half of all brain tumours in children are gliomas. There are different types of gliomas. Physicians use the terms “glioma” and “astrocytoma” interchangeably.
High grade means that the glioma is growing rapidly. High grade gliomas are either World Health Organization (WHO) grade 3 tumours or grade 4. Grade 3 and 4 tumours tend to grow rapidly and spread faster than tumours of a lower grade.
The most common grade 3 tumour is anaplastic astrocytoma and the most common grade 4 tumour is glioblastoma multiforme. Other more complex high grade gliomas include: oligoastrocytoma, pleiomorphic xanthoastrocytoma, and gliosarcoma.
Symptoms
Children with supratentorial high grade gliomas show signs and symptoms that depend on which area of the brain is involved. There may be neurological deficits, seizures, accompanied by signs and symptoms of increased intracranial pressure:
- Headaches, mostly in the morning
- Nausea and vomiting, mostly in the morning
- Blurred or decreased vision
- Sluggishness or drowsiness
- Changes in behaviour
- Seizures
Typical imaging techniques such as MRI or CT may be used to determine that there is a tumour present, but the actual diagnosis of a supratentorial high grade glioma depends on histological testing. Histological testing is when a biopsy is done to remove a small sample of the tumour from the brain, and the sample is studied under the microscope for the presence or absence of certain characteristics. Complete staging, using MRI of the spine and examination of the cerebrospinal fluid, is not usually a part of the initial diagnostic testing. However, high grade gliomas can spread, and if there are any concerns, complete staging will be considered.
Treatment
Treatment of high grade gliomas include:
- Surgery is the main form of treatment and is combined with radiation and chemotherapy in children older than three years old.
- Chemotherapy has not yet been shown to have a proven benefit in the treatment of this tumour type.
This segment of the High-grade Glioma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
High-grade Glioma Emerging Drugs
- OT101: Mateon Therapeutics
- BMX-001: BioMimetix
- A clean safety profile
- Clear evidence for bone marrow protection
- Early indications for protection of cognitive function
- Survival data consistent with a positive trend
- The dose and regimen for Ph2 and clinical practice
- OKN-007: Oblato, Inc.
- PTC596: PTC Therapeutics
Further product details are provided in the report……..
High-grade Glioma: Therapeutic Assessment
This segment of the report provides insights about the different High-grade Glioma drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in High-grade Glioma
- Phases
- Late-stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage products (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Infusion
- Intradermal
- Intramuscular
- Intranasal
- Intravenous
- Oral
- Parenteral
- Subcutaneous
- Molecule Type
- Gene therapies
- Small molecule
- Vaccines
- Polymers
- Peptides
- Monoclonal antibodies
- Product Type
High-grade Glioma: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses High-grade Glioma therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging High-grade Glioma drugs.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence High-grade Glioma R&D. The therapies under development are focused on novel approaches to treat/improve High-grade Glioma.
- In October 2018, Oblato acquired all rights from OMRF to OKN-007, an investigational drug for the treatment of glioblastoma, a deadly form of brain cancer.
- In September 2019, Mateon Therapeutics announced that the US Food and Drug Administration (FDA) granted Rare Pediatric Disease Designation for OT101/Trabedersen for the treatment of diffuse intrinsic pontine glioma (DIPG) as a drug for a “rare pediatric disease.”
- High-grade Glioma Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing High-grade Glioma drugs?
- How many High-grade Glioma drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of High-grade Glioma?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the High-grade Glioma therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for High-grade Glioma and their status?
- What are the key designations that have been granted to the emerging drugs?
- Mateon Therapeutics
- BioMimetix
- Oblato, Inc
- PTC Therapeutics
- Lee's Pharmaceutical Limited
- Nuvation Bio, Inc.
- Laminar Pharmaceuticals
- Basilea Pharmaceutica
- Aadi, LLC
- Erimos Pharmaceuticals
- OT101
- BMX-001
- OKN-007
- PTC596
- TG02
- NUV-422
- 2-OHOA
- BAL101553
- ABI-009
- Terameprocol
Table of Contents
200 Pages
- Introduction
- Executive Summary
- High-grade Glioma: Overview
- Causes
- Mechanism of Action
- Signs and Symptoms
- Diagnosis
- Disease Management
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- High-grade Glioma – DelveInsight’s Analytical Perspective
- In-depth Commercial Assessment
- High-grade Glioma companies’ collaborations, Licensing, Acquisition -Deal Value Trends
- High-grade Glioma Collaboration Deals
- Company-Company Collaborations (Licensing / Partnering) Analysis
- Company-University Collaborations (Licensing / Partnering) Analysis
- Late Stage Products (Phase III)
- Comparative Analysis
- OT101: Mateon Therapeutics
- Product Description
- Research and Development
- Product Development Activities
- Mid Stage Products (Phase II and Phase I/II)
- Comparative Analysis
- BMX-001: BioMimetix
- Product Description
- Research and Development
- Product Development Activities
- OKN-007: Oblato, Inc.
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- PTC596: PTC Therapeutics
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Pre-clinical and Discovery Stage Products
- Comparative Analysis
- Drug Name: Company Name
- Product Description
- Research and Development
- Product Development Activities
- Inactive Products
- Comparative Analysis
- High-grade Glioma Key Companies
- High-grade Glioma Key Products
- High-grade Glioma- Unmet Needs
- High-grade Glioma- Market Drivers and Barriers
- High-grade Glioma- Future Perspectives and Conclusion
- High-grade Glioma Analyst Views
- High-grade Glioma Key Companies
- Appendix
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