
Ewing Sarcoma - Pipeline Insight, 2024
Description
Ewing Sarcoma - Pipeline Insight, 2024
DelveInsight’s, “Ewing Sarcoma - Pipeline Insight, 2024,” report provides comprehensive insights about 25+ companies and 25+ pipeline drugs in Ewing Sarcoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Ewing Sarcoma: Overview
Ewing sarcoma is the second most common primary malignant bone tumor, mostly affecting adolescents in the second decade of their life, and it is a highly metastatic class of sarcoma. Despite the use of radiotherapy or surgery, historically, an estimated 85% to 90% of patients died within a few months from a metastasis. Due to the considerable progress in the treatment of disease with both local therapy and multi-agent adjuvant chemotherapy, 5–year survival rate improved from less than 20% to greater than 70%, but the recurrence rate remains high. It must be promptly recognized and treated to avoid high morbidity and mortality. Ewing sarcoma family tumors (ESFT) are characterized by the presence of non-random chromosomal translocations producing fusion genes that encode aberrant transcription factors. The t(11;22)(q24;q12) translocation is associated with 85% of tumors and leads to EWS-FLI-1 formation, whereas t(21;12)(22;12) and other less common translocations induced EWS-ERG fusion comprises the remaining 10% to 15% of cases. Ewing sarcoma is composed of small round cells with an increased nuclear-cytoplasmic ratio that represents a family of small round blue cell tumors of childhood (e.g., retinoblastoma, neuroblastoma, rhabdomyosarcoma, and nephroblastoma). Ewing cells have scant eosinophilic cytoplasm containing abundant glycogen that is often detected by staining with periodic-acid-Schiff. The standard of care for patients with or without metastasis includes interprofessional treatment with chemotherapy and local therapy, including surgery and radiotherapy (RT).
""Ewing Sarcoma - Pipeline Insight, 2024"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Ewing Sarcoma pipeline landscape is provided which includes the disease overview and Ewing Sarcoma treatment guidelines. The assessment part of the report embraces, in depth Ewing Sarcoma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Ewing Sarcoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- In April 2022, AI Therapeutics announced the acquisition of EntreChem’s, investigational drug candidate EC-8042 (redesignated AIT-102), a novel targeted cancer therapy in development for rare pediatric and other cancers. AIT-102 specifically targets the mutations responsible for the formation and progression of two notable pediatric tumors, rhabdoid tumors and Ewing sarcoma, and holds the potential to treat a broader family of tumors that share a common mechanism of mutated or dysregulated SWI/SNF activity.
- In December 2021, Rakovina Therapeutics announced that it has been selected to join a three year US$975,000 (CDN$1,297,000) research program funded by the St. Baldrick’s Foundation Martha’s BEST Grant for All, which is aimed at developing new treatments for Ewing sarcoma.
This segment of the Ewing Sarcoma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Ewing Sarcoma Emerging Drugs
- Vigil: Gradalis
- ONCT216: Oncternal Therapeutics
- SP-2577: Salarius Pharmaceuticals
Further product details are provided in the report……..
Ewing Sarcoma: Therapeutic Assessment
This segment of the report provides insights about the different Ewing Sarcoma drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Ewing Sarcoma
- Phases
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Inhalation
- Inhalation/Intravenous/Oral
- Intranasal
- Intravenous
- Intravenous/ Subcutaneous
- NA
- Oral
- Oral/intranasal/subcutaneous
- Parenteral
- Subcutaneous
- Molecule Type
- Antibody
- Antisense oligonucleotides
- Immunotherapy
- Monoclonal antibody
- Peptides
- Protein
- Recombinant protein
- Small molecule
- Stem Cell
- Vaccine
- Product Type
Ewing Sarcoma: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Ewing Sarcoma therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Ewing Sarcoma drugs.
Ewing Sarcoma Report Insights
- Ewing Sarcoma Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Ewing Sarcoma drugs?
- How many Ewing Sarcoma drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Ewing Sarcoma?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Ewing Sarcoma therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Ewing Sarcoma and their status?
- What are the key designations that have been granted to the emerging drugs?
- Gradalis, Inc.
- Shanghai Pharmaceuticals Holding Co., Ltd
- Tyme, Inc
- Pfizer
- Hutchison Medipharma Limited
- Bristol-Myers Squibb
- Salarius Pharmaceuticals
- BioAtla, Inc.
- Cellectar Biosciences
- Valent Technologies
- Inhibrx, Inc.
- Eisai Co Ltd
- Amgen
- Y-mAbs Therapeutics
- NanoValent Pharmaceuticals.
- Oncternal Therapeutics
- Aptadel Therapeutics
- Gibson Oncology
- Edison Oncology
- Oncoheroes Biosciences
- CotheraBio
- Rakovina Therapeutics
- Vigil
- TK216
- SM-88
- Pembrolizumab
- Palbociclib
- Surufatinib
- Nivolumab
- Seclidemstat
- CAB-AXL-ADC
- CLR 131
- VAL-413
- Eribulin mesylate
- INBRX-109
- AMG 479
- Naxitamab
- NV101
- NV103
- ADEL101
- LMP400
- Orotecan
- PC002
Table of Contents
115 Pages
- Introduction
- Executive Summary
- Ewing Sarcoma: Overview
- Causes
- Mechanism of Action
- Signs and Symptoms
- Diagnosis
- Disease Management
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Ewing Sarcoma – DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- Vigil: Gradalis
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- ONCT216: Oncternal Therapeutics
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I/II)
- Comparative Analysis
- SP-2577: Salarius Pharmaceuticals
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- CLR 131: Cellectar Biosciences
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Ewing Sarcoma Key Companies
- Ewing Sarcoma Key Products
- Ewing Sarcoma- Unmet Needs
- Ewing Sarcoma- Market Drivers and Barriers
- Ewing Sarcoma- Future Perspectives and Conclusion
- Ewing Sarcoma Analyst Views
- Ewing Sarcoma Key Companies
- Appendix
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