Dyskinesia- Pipeline Insight, 2025
Description
DelveInsight’s, “Dyskinesia- Pipeline Insight, 2025” report provides comprehensive insights about 20+ companies and 22+ pipeline drugs in Dyskinesia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Dyskinesia: Overview
Dyskinesia’s are involuntary, erratic, writhing movements of the face, arms, legs or trunk. They are often fluid and dance-like, but they may also cause rapid jerking or slow and extended muscle spasms. They are not a symptom of Parkinson's itself. Rather, they are a complication from some Parkinson's medications. They may be caused by systemic, metabolic, endocrinologic, structural, vascular, infectious or inherited degenerative conditions, or be toxin- or drug-induced. Dyskinesia’s usually begin after a few years of treatment with levodopa and can often be alleviated by adjusting dopaminergic medications. Younger people with PD are thought to develop earlier motor fluctuations and dyskinesia’s in response to levodopa.
Dyskinesias may be mild and non-bothersome, or they can be severe. Most people with Parkinson’s prefer to be “on” with some dyskinesias rather than “off” and unable to move well. However, for some people, dyskinesias can be severe enough that they interfere with normal functioning. Dyskinesia is a complication of long-term levodopa use in people who have had Parkinson's for several years. Other risk factors include being younger at diagnosis and using higher amounts of levodopa for longer periods of time. Involuntary movement is the chief symptom of dyskinesia. This can present in only one part of the body, such as a person’s arm or leg, or it can affect the whole body. Common symptoms include writhing or wriggling, head bobbing, fidgeting, rocking, swaying some other symptoms also relates to rapid blinking, waving of the arms or hands, sticking out the tongue, a random movement of the lips, tongue, or jaw, some movements in the limbs, fingers, and toes, swaying movements of the hips or torso in severe cases, difficulty breathing, also in severe cases.
The treatment options used to treat the disease includes changing the dose and/or timing of levodopa so get enough in each dose to control the symptoms but not too much that it causes dyskinesia. Switching to a different formulation of levodopa, such as extended-release (Rytary) or the gel infusion (Duopa). These drugs aim to keep dopamine levels steady to control symptoms and limit dyskinesia.
Adding amantadine. Gocovri (amantadine extended release) works on the glutamate brain chemical system to lessen dyskinesia. Prior to Gocovri's 2017 FDA approval, amantadine immediate-release often was (and still may be) used in some cases. Undergoing deep brain stimulation (DBS), a surgical procedure. This is not an option for everyone. But DBS may be considered for those who've had Parkinson's for at least four years, benefit from levodopa, and have dyskinesia or significant ""off"" time — periods when medication isn't working well and symptoms return.
""Dyskinesia- Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Dyskinesia pipeline landscape is provided which includes the disease overview and Dyskinesia treatment guidelines. The assessment part of the report embraces, in depth Dyskinesia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Dyskinesia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
This segment of the Dyskinesia report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Dyskinesia Emerging Drugs
Further product details are provided in the report……..
Dyskinesia: Therapeutic Assessment
This segment of the report provides insights about the different Dyskinesia drugs segregated based on following parameters that define the scope of the report, such as:
Dyskinesia: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Dyskinesia therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Dyskinesia drugs.
Dyskinesia Report Insights
Current Treatment Scenario and Emerging Therapies:
Geography Covered
- Global coverage
Dyskinesia: Overview
Dyskinesia’s are involuntary, erratic, writhing movements of the face, arms, legs or trunk. They are often fluid and dance-like, but they may also cause rapid jerking or slow and extended muscle spasms. They are not a symptom of Parkinson's itself. Rather, they are a complication from some Parkinson's medications. They may be caused by systemic, metabolic, endocrinologic, structural, vascular, infectious or inherited degenerative conditions, or be toxin- or drug-induced. Dyskinesia’s usually begin after a few years of treatment with levodopa and can often be alleviated by adjusting dopaminergic medications. Younger people with PD are thought to develop earlier motor fluctuations and dyskinesia’s in response to levodopa.
Dyskinesias may be mild and non-bothersome, or they can be severe. Most people with Parkinson’s prefer to be “on” with some dyskinesias rather than “off” and unable to move well. However, for some people, dyskinesias can be severe enough that they interfere with normal functioning. Dyskinesia is a complication of long-term levodopa use in people who have had Parkinson's for several years. Other risk factors include being younger at diagnosis and using higher amounts of levodopa for longer periods of time. Involuntary movement is the chief symptom of dyskinesia. This can present in only one part of the body, such as a person’s arm or leg, or it can affect the whole body. Common symptoms include writhing or wriggling, head bobbing, fidgeting, rocking, swaying some other symptoms also relates to rapid blinking, waving of the arms or hands, sticking out the tongue, a random movement of the lips, tongue, or jaw, some movements in the limbs, fingers, and toes, swaying movements of the hips or torso in severe cases, difficulty breathing, also in severe cases.
The treatment options used to treat the disease includes changing the dose and/or timing of levodopa so get enough in each dose to control the symptoms but not too much that it causes dyskinesia. Switching to a different formulation of levodopa, such as extended-release (Rytary) or the gel infusion (Duopa). These drugs aim to keep dopamine levels steady to control symptoms and limit dyskinesia.
Adding amantadine. Gocovri (amantadine extended release) works on the glutamate brain chemical system to lessen dyskinesia. Prior to Gocovri's 2017 FDA approval, amantadine immediate-release often was (and still may be) used in some cases. Undergoing deep brain stimulation (DBS), a surgical procedure. This is not an option for everyone. But DBS may be considered for those who've had Parkinson's for at least four years, benefit from levodopa, and have dyskinesia or significant ""off"" time — periods when medication isn't working well and symptoms return.
""Dyskinesia- Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Dyskinesia pipeline landscape is provided which includes the disease overview and Dyskinesia treatment guidelines. The assessment part of the report embraces, in depth Dyskinesia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Dyskinesia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Dyskinesia R&D. The therapies under development are focused on novel approaches to treat/improve Dyskinesia.
This segment of the Dyskinesia report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Dyskinesia Emerging Drugs
- P-1037 IS : Parion Sciences
- NLX 112 : Neurolixis
- DSP-9632P : Sumitomo Dainippon Pharma
- JM-010 : Contera Pharma
Further product details are provided in the report……..
Dyskinesia: Therapeutic Assessment
This segment of the report provides insights about the different Dyskinesia drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Dyskinesia
- There are approx. 20+ key companies which are developing the therapies for Dyskinesia. The companies which have their Dyskinesia drug candidates in the most advanced stage, i.e. phase III include, Parion Sciences
- Phases
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Oral
- Intravenous
- Subcutaneous
- Parenteral
- Topical
- Molecule Type
- Recombinant fusion proteins
- Small molecule
- Monoclonal antibody
- Peptide
- Polymer
- Gene therapy
- Product Type
Dyskinesia: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Dyskinesia therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Dyskinesia drugs.
Dyskinesia Report Insights
- Dyskinesia Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Dyskinesia drugs?
- How many Dyskinesia drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Dyskinesia?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Dyskinesia therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Dyskinesia and their status?
- What are the key designations that have been granted to the emerging drugs?
- Parion Sciences
- Neurolixis
- Sumitomo Dainippon Pharma
- Contera Pharma
- ReCode Therapeutics
- Integrative Research Laboratories
- Luye Pharma Group
- Celon Pharma
- VistaGen Therapeutics, Inc.
- Novartis
- MapLight Therapeutics
- Ethris
- Contera Pharma
- Teva Pharmaceutical
- Sinopia Biosciences
- SOM Biotech
- Cycle Pharmaceuticals
- Medicure Inc.
- P-1037 IS
- NLX 112
- DSP-9632P
- JM-010
- RCT1100
- Mesdopetam (IRL790)
- LPM3770164
- CPL500036
- AV-101
- AQW051
- ML-007C-MA
- ETH 42
- ETH 43
- ETH 44
- CP 011
- Deutetrabenazine
- SB-0107
- SOM 3366
- Research Programme: Cycle Pharmaceuticals
- TARDOXAL
Table of Contents
80 Pages
- Introduction
- Executive Summary
- Dyskinesia: Overview
- Causes
- Pathophysiology
- Signs and Symptoms
- Diagnosis
- Disease Management
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Dyskinesia– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- P-1037 IS: Parion Sciences
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- DSP-9632P : Sumitomo Dainippon Pharma
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Comparative Analysis
- Drug Name: Company Name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Dyskinesia Key Companies
- Dyskinesia Key Products
- Dyskinesia- Unmet Needs
- Dyskinesia- Market Drivers and Barriers
- Dyskinesia- Future Perspectives and Conclusion
- Dyskinesia Analyst Views
- Dyskinesia Key Companies
- Appendix
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