Advanced Non-Squamous & Squamous NSCLC - Pipeline Insight, 2025
Description
DelveInsight’s, “Advanced Non-Squamous & Squamous NSCLC - Pipeline Insight, 2025” report provides comprehensive insights about 9+ companies and 11+ pipeline drugs in Advanced Non-Squamous & Squamous NSCLC pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Advanced Non-Squamous & Squamous NSCLC: Overview
Lung cancer, particularly non-small-cell lung cancer (NSCLC), is a significant global health concern, with adenocarcinoma (LUAD) and squamous cell carcinoma (LSCC) being the most common subtypes. For advanced NSCLC patients, personalized treatment plans involving chemotherapy, immune checkpoint inhibitors, and targeted therapies are crucial. Targeted therapies, which interfere with specific tumor molecules, are recommended for patients with actionable mutations identified through tumor genetic profiling, often using next-generation sequencing (NGS). FDA-approved targeted agents target genetic driver alterations like EGFR mutations, ALK/ROS1/RET rearrangements, NTRK fusions, MET exon 14 skipping mutation, KRAS G12C mutation, BRAF V600E mutation, and ERBB2 (HER2) mutation. Ongoing research aims to develop new agents for these targets, overcome treatment resistance, and explore novel driver mutations for therapeutic targeting, including traditionally not druggable mutations.
The etiology of non-small-cell lung cancer (NSCLC) involves avoidable and unavoidable risk factors. Inhaled tobacco use is the most prominent avoidable risk factor, while other causes include alcohol use, exposure to secondhand smoke, asbestos, radon, arsenic, chromium, nickel, ionizing radiation, and polycyclic aromatic hydrocarbons. Additionally, radiation therapy for other cancers like breast cancer can lead to primary lung cancer. Patients with pulmonary fibrosis face a significantly higher risk of developing lung cancer, independent of tobacco use. Moreover, individuals with HIV have an increased incidence of lung cancer, irrespective of smoking habits or antiretroviral therapy, highlighting the multifactorial nature of NSCLC development.
Advanced non-squamous and squamous non-small cell lung cancer (NSCLC) present with distinct signs and symptoms. In advanced non-squamous NSCLC, common indicators include more breathing difficulties, bone pain, abdominal or back pain, headaches, weakness, seizures, speech difficulties, and hormonal imbalances due to tumor-secreted hormones. On the other hand, squamous NSCLC patients may experience symptoms like chronic cough, sputum with blood, hoarseness, and fever. These symptoms often correlate with the stage and pathological diagnosis of NSCLC, with more advanced stages showing a higher likelihood of symptom development, emphasizing the importance of early detection and tailored treatment approaches.
Treatment for advanced non-squamous and squamous non-small cell lung cancer (NSCLC) involves a multidisciplinary approach. For non-squamous NSCLC, treatment options include targeted therapies such as EGFR tyrosine kinase inhibitors like osimertinib, immunotherapy with atezolizumab, and chemotherapy with doublets containing platinum compounds. For squamous NSCLC, treatment often involves platinum-based chemotherapy regimens, such as docetaxel and pemetrexed, and targeted therapies like erlotinib. Additionally, immunotherapy with pembrolizumab and nivolumab have shown efficacy in both non-squamous and squamous NSCLC.
""Advanced Non-Squamous & Squamous NSCLC - Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Advanced Non-Squamous & Squamous NSCLC pipeline landscape is provided which includes the disease overview and Advanced Non-Squamous & Squamous NSCLC treatment guidelines. The assessment part of the report embraces, in depth Advanced Non-Squamous & Squamous NSCLC commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Advanced Non-Squamous & Squamous NSCLC collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
This segment of the Advanced Non-Squamous & Squamous NSCLC report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II/III, II, I, preclinical and discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Advanced Non-Squamous & Squamous NSCLC Emerging Drugs
Further product details are provided in the report……..
Advanced Non-Squamous & Squamous NSCLC: Therapeutic Assessment
This segment of the report provides insights about the different Advanced Non-Squamous & Squamous NSCLC drugs segregated based on following parameters that define the scope of the report, such as:
Advanced Non-Squamous & Squamous NSCLC: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Advanced Non-Squamous & Squamous NSCLC therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Advanced Non-Squamous & Squamous NSCLC drugs.
Advanced Non-Squamous & Squamous NSCLC Report Insights
Current Treatment Scenario and Emerging Therapies:
Geography Covered
- Global coverage
Advanced Non-Squamous & Squamous NSCLC: Overview
Lung cancer, particularly non-small-cell lung cancer (NSCLC), is a significant global health concern, with adenocarcinoma (LUAD) and squamous cell carcinoma (LSCC) being the most common subtypes. For advanced NSCLC patients, personalized treatment plans involving chemotherapy, immune checkpoint inhibitors, and targeted therapies are crucial. Targeted therapies, which interfere with specific tumor molecules, are recommended for patients with actionable mutations identified through tumor genetic profiling, often using next-generation sequencing (NGS). FDA-approved targeted agents target genetic driver alterations like EGFR mutations, ALK/ROS1/RET rearrangements, NTRK fusions, MET exon 14 skipping mutation, KRAS G12C mutation, BRAF V600E mutation, and ERBB2 (HER2) mutation. Ongoing research aims to develop new agents for these targets, overcome treatment resistance, and explore novel driver mutations for therapeutic targeting, including traditionally not druggable mutations.
The etiology of non-small-cell lung cancer (NSCLC) involves avoidable and unavoidable risk factors. Inhaled tobacco use is the most prominent avoidable risk factor, while other causes include alcohol use, exposure to secondhand smoke, asbestos, radon, arsenic, chromium, nickel, ionizing radiation, and polycyclic aromatic hydrocarbons. Additionally, radiation therapy for other cancers like breast cancer can lead to primary lung cancer. Patients with pulmonary fibrosis face a significantly higher risk of developing lung cancer, independent of tobacco use. Moreover, individuals with HIV have an increased incidence of lung cancer, irrespective of smoking habits or antiretroviral therapy, highlighting the multifactorial nature of NSCLC development.
Advanced non-squamous and squamous non-small cell lung cancer (NSCLC) present with distinct signs and symptoms. In advanced non-squamous NSCLC, common indicators include more breathing difficulties, bone pain, abdominal or back pain, headaches, weakness, seizures, speech difficulties, and hormonal imbalances due to tumor-secreted hormones. On the other hand, squamous NSCLC patients may experience symptoms like chronic cough, sputum with blood, hoarseness, and fever. These symptoms often correlate with the stage and pathological diagnosis of NSCLC, with more advanced stages showing a higher likelihood of symptom development, emphasizing the importance of early detection and tailored treatment approaches.
Treatment for advanced non-squamous and squamous non-small cell lung cancer (NSCLC) involves a multidisciplinary approach. For non-squamous NSCLC, treatment options include targeted therapies such as EGFR tyrosine kinase inhibitors like osimertinib, immunotherapy with atezolizumab, and chemotherapy with doublets containing platinum compounds. For squamous NSCLC, treatment often involves platinum-based chemotherapy regimens, such as docetaxel and pemetrexed, and targeted therapies like erlotinib. Additionally, immunotherapy with pembrolizumab and nivolumab have shown efficacy in both non-squamous and squamous NSCLC.
""Advanced Non-Squamous & Squamous NSCLC - Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Advanced Non-Squamous & Squamous NSCLC pipeline landscape is provided which includes the disease overview and Advanced Non-Squamous & Squamous NSCLC treatment guidelines. The assessment part of the report embraces, in depth Advanced Non-Squamous & Squamous NSCLC commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Advanced Non-Squamous & Squamous NSCLC collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Advanced Non-Squamous & Squamous NSCLC R&D. The therapies under development are focused on novel approaches to treat/improve Advanced Non-Squamous & Squamous NSCLC.
This segment of the Advanced Non-Squamous & Squamous NSCLC report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II/III, II, I, preclinical and discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Advanced Non-Squamous & Squamous NSCLC Emerging Drugs
- Erfonrilimab: Jiangsu Alphamab Biopharmaceuticals
- Pyrotinib: Jiangsu HengRui Medicine
Further product details are provided in the report……..
Advanced Non-Squamous & Squamous NSCLC: Therapeutic Assessment
This segment of the report provides insights about the different Advanced Non-Squamous & Squamous NSCLC drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Advanced Non-Squamous & Squamous NSCLC
- Phases
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Intravenous
- Subcutaneous
- Oral
- Intramuscular
- Molecule Type
- Monoclonal antibody
- Small molecule
- Peptide
- Product Type
Advanced Non-Squamous & Squamous NSCLC: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Advanced Non-Squamous & Squamous NSCLC therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Advanced Non-Squamous & Squamous NSCLC drugs.
Advanced Non-Squamous & Squamous NSCLC Report Insights
- Advanced Non-Squamous & Squamous NSCLC Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Advanced Non-Squamous & Squamous NSCLC drugs?
- How many Advanced Non-Squamous & Squamous NSCLC drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Advanced Non-Squamous & Squamous NSCLC?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Advanced Non-Squamous & Squamous NSCLC therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Advanced Non-Squamous & Squamous NSCLC and their status?
- What are the key designations that have been granted to the emerging drugs?
- Jiangsu Alphamab Biopharmaceuticals
- Jiangsu HengRui Medicine
- Novartis Pharmaceuticals
- Genentech
- Erfonrilimab
- Pyrotinib
- Canakinumab
- Tiragolumab
Table of Contents
60 Pages
- Introduction
- Executive Summary
- Advanced Non-Squamous & Squamous NSCLC: Overview
- Causes
- Etiology
- Signs and Symptoms
- Disease Management/Treatment
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Advanced Non-Squamous & Squamous NSCLC– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- Pyrotinib: Jiangsu HengRui Medicine
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Advanced Non-Squamous & Squamous NSCLC Key Companies
- Advanced Non-Squamous & Squamous NSCLC Key Products
- Advanced Non-Squamous & Squamous NSCLC- Unmet Needs
- Advanced Non-Squamous & Squamous NSCLC- Market Drivers and Barriers
- Advanced Non-Squamous & Squamous NSCLC- Future Perspectives and Conclusion
- Advanced Non-Squamous & Squamous NSCLC Analyst Views
- Advanced Non-Squamous & Squamous NSCLC Key Companies
- Appendix
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