Tissue Dissociation Market - 2024-2031
Description
TISSUE DISSOCIATION MARKET OVERVIEW
Tissue Dissociation Market is predicted to reach at a high CAGR 18.9% during the forecast period (2024-2031). Tissue dissociation is a cell separation process that separates the human and animal tissues. It is performed with the help of isolation enzymes to maximize the outcome of functionally viable, dissociated cells.
TISSUE DISSOCIATION MARKET SCOPE
Metrics Details
Market CAGR 18.9%
Segments Covered By Tissue type, By Dissociation Enzyme, By End-user, and By Region
Report Insights Covered Competitive Landscape Analysis, Company Profile Analysis, Market Size, Share, Growth, Demand, Recent Developments, Mergers and acquisitions, New Product Launches, Growth Strategies, Revenue Analysis, and Other key insights.
Fastest Growing Region Asia Pacific
Largest Market Share North America
To Know More: Download Sample (https://www.datamintelligence.com/download-sample/tissue-dissociation-market)
TISSUE DISSOCIATION MARKET GROWTH DYNAMICS
INCREASING FOCUS ON DEVELOPING MONOCLONAL ANTIBODIES AND CUSTOMIZATION OF THE DRUG MANUFACTURING PROCESS IS DRIVING MARKET GROWTH.
N-linked glycosylation is a primary source of heterogeneity associated with recombinant monoclonal antibodies. It plays a key role in a myriad of drug properties associated with biological function. In addition, the glycosylation profile of recombinant monoclonal antibodies is determined by the order of cell culture (https://www.datamintelligence.com/research-report/cell-culture-market) inputs that are carefully controlled to engineer the desired glycan distribution. The method is shown to be linear, accurate, specific, and precise for an IgG1 and IgG4 mAb supporting relative quantitation of mannose-5 in the range 0.8–11.0% and 1.0–6.2%, respectively. The method can also be applied at several stages of the production process, from cell culture harvest to drug substance/drug product and is responsive to routine GMP batch testing in a quality control laboratory. Testing upstream during cell culture rather than for product release allows for a more advanced product quality assessment as the glycosylation profile remains unchanged during downstream purification.
LIMITATIONS OF THE HYALURONIDASE ENZYME ARE LIKELY TO HAMPER THE MARKET GROWTH
Adoptive T cell therapies, including chimeric antigen receptor T cells, have produced strong responses in patients with hematological malignancies. However, the efficacy of CAR-T cells in solid tumor patients remains uncertain, and the microenvironment of solid tumors is accepted to be a major obstacle that causes the lack of efficacy. Since low infiltration efficiency is a limitation of T cell therapy against solid cancers, and PH20 may enhance CAR-T cells' infiltrating capacity, the combination of PH20 with CAR-T cell therapy (https://www.datamintelligence.com/research-report/car-t-cell-therapy-market) is of translational potential and remains to be explored.
TISSUE DISSOCIATION MARKET COVID-19 IMPACT ANALYSIS
The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems, and the world of work. A mix of established pharmaceutical and biopharmaceutical (https://www.datamintelligence.com/research-report/biopharmaceuticals-market)companies and small startups has moved forward to advance treatments and vaccines that target the infection caused by the novel coronavirus. The COVID-19 outbreak has significantly impacted the availability of hospital resources worldwide. It has been managed by dramatically decreasing inpatient and outpatient services for other diseases and performing infection prevention and control measures. The number of cancer screening and diagnostic procedures declined precipitously, with countries worldwide being affected by the pandemic.
TISSUE DISSOCIATION MARKET SEGMENT ANALYSIS
COLLAGENASE SEGMENT IS EXPECTED TO HOLD THE LARGEST MARKET SHARE IN THIS MARKET SEGMENT.
The collagenase segment is estimated for the largest market share in 2020, according to the frontiers, published on 22 July 2021, The usage of enzymes for tissue dissociation is a common procedure that allows the retainment of cell viability and integrity by uniting proper tissue digestion. The most widely used enzyme is collagenase; however, it is used with other enzymes as collagenase belongs to the class of endopeptidases and digests collagen in the region of the triple helix. Moreover, collagen is the leading component in connective tissue; thus, collagenase is useful when isolating epithelial, endothelial, or adrenal tissue, and it is applied to isolate adipocytes, hepatocytes, cardiomyocytes, and the treatment of mammary or other soft tissues. The procedure of cell isolation with collagenase and hyaluronidase is also successful in breast cancer. Therefore, it is possible to acquire a higher cell yield.
TISSUE DISSOCIATION MARKET GEOGRAPHICAL ANALYSIS
NORTH AMERICA REGION HOLDS THE LARGEST MARKET SHARE IN THE GLOBAL TISSUE DISSOCIATION MARKET.
North America accounted for largest revenue share in 2020 and expected to dominate over the forecast period, owing to high focus on biotechnology-related research; the best research institutes, increasing demand for biopharmaceutical products in the region are expected to boost the market in the forecast period. For instance, according to the frontiers, the biopharmaceutical industry is rapidly developing in the pharmaceutical industry, with enormous opportunities and implications for healthcare. Moreover, opportunities in biopharmaceuticals have been increasing over the past decade due to the great effectiveness and the safety of these drugs. In addition, biopharmaceuticals offer several benefits, such as highly effective and potent action, fewer side effects, and the potential to cure diseases rather than merely treat the symptoms, significantly increasing the demand for biopharmaceutical products.
TISSUE DISSOCIATION MARKET COMPETITIVE LANDSCAPE
The tissue dissociation market is vast with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Miltenyi Biotec, Worthington Biochemical, Sigma-Aldrich (https://www.sigmaaldrich.com/IN/en/products/protein-biology/proteins-and-enzymes/tissue-dissociation?srsltid=AfmBOopL6ffkALt6G1LJ7rfFqV6LQAuPOR7Cn_wV5TEnE2puK9gNbjYE), F. Hoffmann-La Roche, Becton Dickinson Biosciences, Thermo Fisher Scientific, StemCell Technologies, Inc., VitaCyte (https://www.vitacyte.com/products/) and Merck KGaA. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the tissue dissociation market globally.
Tissue Dissociation Market Key Companies to Watch
Thermo Fisher Scientific:
Overview:
Thermo Fisher Scientific is an American provisioner of scientific instrumentation, reagents and consumables, and software services. Based in Waltham, Massachusetts, Thermo Fisher was formed by combining Thermo Electron and Fisher Scientific in 2006. Thermo Fisher has acquired other reagent, consumable, instrumentation, and service providers, including Life Technologies Corporation (2013), Alfa Aesar (2015), Affymetrix (2016), FEI Company (2017).
Product Portfolio:
Thermo Fisher Scientific has continuously set new standards for manufacturing products, including 101 BIO TISSUE DISSOCIATION ISOLAT DIR, MilliporeSigma ProteoExtract Tissue Dissociation Buffer Kit and others.
Tissue Dissociation Market is predicted to reach at a high CAGR 18.9% during the forecast period (2024-2031). Tissue dissociation is a cell separation process that separates the human and animal tissues. It is performed with the help of isolation enzymes to maximize the outcome of functionally viable, dissociated cells.
TISSUE DISSOCIATION MARKET SCOPE
Metrics Details
Market CAGR 18.9%
Segments Covered By Tissue type, By Dissociation Enzyme, By End-user, and By Region
Report Insights Covered Competitive Landscape Analysis, Company Profile Analysis, Market Size, Share, Growth, Demand, Recent Developments, Mergers and acquisitions, New Product Launches, Growth Strategies, Revenue Analysis, and Other key insights.
Fastest Growing Region Asia Pacific
Largest Market Share North America
To Know More: Download Sample (https://www.datamintelligence.com/download-sample/tissue-dissociation-market)
TISSUE DISSOCIATION MARKET GROWTH DYNAMICS
INCREASING FOCUS ON DEVELOPING MONOCLONAL ANTIBODIES AND CUSTOMIZATION OF THE DRUG MANUFACTURING PROCESS IS DRIVING MARKET GROWTH.
N-linked glycosylation is a primary source of heterogeneity associated with recombinant monoclonal antibodies. It plays a key role in a myriad of drug properties associated with biological function. In addition, the glycosylation profile of recombinant monoclonal antibodies is determined by the order of cell culture (https://www.datamintelligence.com/research-report/cell-culture-market) inputs that are carefully controlled to engineer the desired glycan distribution. The method is shown to be linear, accurate, specific, and precise for an IgG1 and IgG4 mAb supporting relative quantitation of mannose-5 in the range 0.8–11.0% and 1.0–6.2%, respectively. The method can also be applied at several stages of the production process, from cell culture harvest to drug substance/drug product and is responsive to routine GMP batch testing in a quality control laboratory. Testing upstream during cell culture rather than for product release allows for a more advanced product quality assessment as the glycosylation profile remains unchanged during downstream purification.
LIMITATIONS OF THE HYALURONIDASE ENZYME ARE LIKELY TO HAMPER THE MARKET GROWTH
Adoptive T cell therapies, including chimeric antigen receptor T cells, have produced strong responses in patients with hematological malignancies. However, the efficacy of CAR-T cells in solid tumor patients remains uncertain, and the microenvironment of solid tumors is accepted to be a major obstacle that causes the lack of efficacy. Since low infiltration efficiency is a limitation of T cell therapy against solid cancers, and PH20 may enhance CAR-T cells' infiltrating capacity, the combination of PH20 with CAR-T cell therapy (https://www.datamintelligence.com/research-report/car-t-cell-therapy-market) is of translational potential and remains to be explored.
TISSUE DISSOCIATION MARKET COVID-19 IMPACT ANALYSIS
The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems, and the world of work. A mix of established pharmaceutical and biopharmaceutical (https://www.datamintelligence.com/research-report/biopharmaceuticals-market)companies and small startups has moved forward to advance treatments and vaccines that target the infection caused by the novel coronavirus. The COVID-19 outbreak has significantly impacted the availability of hospital resources worldwide. It has been managed by dramatically decreasing inpatient and outpatient services for other diseases and performing infection prevention and control measures. The number of cancer screening and diagnostic procedures declined precipitously, with countries worldwide being affected by the pandemic.
TISSUE DISSOCIATION MARKET SEGMENT ANALYSIS
COLLAGENASE SEGMENT IS EXPECTED TO HOLD THE LARGEST MARKET SHARE IN THIS MARKET SEGMENT.
The collagenase segment is estimated for the largest market share in 2020, according to the frontiers, published on 22 July 2021, The usage of enzymes for tissue dissociation is a common procedure that allows the retainment of cell viability and integrity by uniting proper tissue digestion. The most widely used enzyme is collagenase; however, it is used with other enzymes as collagenase belongs to the class of endopeptidases and digests collagen in the region of the triple helix. Moreover, collagen is the leading component in connective tissue; thus, collagenase is useful when isolating epithelial, endothelial, or adrenal tissue, and it is applied to isolate adipocytes, hepatocytes, cardiomyocytes, and the treatment of mammary or other soft tissues. The procedure of cell isolation with collagenase and hyaluronidase is also successful in breast cancer. Therefore, it is possible to acquire a higher cell yield.
TISSUE DISSOCIATION MARKET GEOGRAPHICAL ANALYSIS
NORTH AMERICA REGION HOLDS THE LARGEST MARKET SHARE IN THE GLOBAL TISSUE DISSOCIATION MARKET.
North America accounted for largest revenue share in 2020 and expected to dominate over the forecast period, owing to high focus on biotechnology-related research; the best research institutes, increasing demand for biopharmaceutical products in the region are expected to boost the market in the forecast period. For instance, according to the frontiers, the biopharmaceutical industry is rapidly developing in the pharmaceutical industry, with enormous opportunities and implications for healthcare. Moreover, opportunities in biopharmaceuticals have been increasing over the past decade due to the great effectiveness and the safety of these drugs. In addition, biopharmaceuticals offer several benefits, such as highly effective and potent action, fewer side effects, and the potential to cure diseases rather than merely treat the symptoms, significantly increasing the demand for biopharmaceutical products.
TISSUE DISSOCIATION MARKET COMPETITIVE LANDSCAPE
The tissue dissociation market is vast with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Miltenyi Biotec, Worthington Biochemical, Sigma-Aldrich (https://www.sigmaaldrich.com/IN/en/products/protein-biology/proteins-and-enzymes/tissue-dissociation?srsltid=AfmBOopL6ffkALt6G1LJ7rfFqV6LQAuPOR7Cn_wV5TEnE2puK9gNbjYE), F. Hoffmann-La Roche, Becton Dickinson Biosciences, Thermo Fisher Scientific, StemCell Technologies, Inc., VitaCyte (https://www.vitacyte.com/products/) and Merck KGaA. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the tissue dissociation market globally.
Tissue Dissociation Market Key Companies to Watch
Thermo Fisher Scientific:
Overview:
Thermo Fisher Scientific is an American provisioner of scientific instrumentation, reagents and consumables, and software services. Based in Waltham, Massachusetts, Thermo Fisher was formed by combining Thermo Electron and Fisher Scientific in 2006. Thermo Fisher has acquired other reagent, consumable, instrumentation, and service providers, including Life Technologies Corporation (2013), Alfa Aesar (2015), Affymetrix (2016), FEI Company (2017).
Product Portfolio:
Thermo Fisher Scientific has continuously set new standards for manufacturing products, including 101 BIO TISSUE DISSOCIATION ISOLAT DIR, MilliporeSigma ProteoExtract Tissue Dissociation Buffer Kit and others.
Table of Contents
180 Pages
- 1. Methodology and Scope
- 1.1. Research Methodology
- 1.2. Research Objective and Scope of the Report
- 2. Market Definition and Overview
- 3. Executive Summary
- 3.1. Market Snippet by Tissue type
- 3.2. Market Snippet by Dissociation Enzyme
- 3.3. Market Snippet by End user
- 3.4. Market Snippet by Region
- 4. Market Dynamics
- 4.1. Market Impacting Factors
- 4.1.1. Drivers
- 4.1.1.1. Increasing focus on developing monoclonal antibodies and customization of the drug manufacturing process
- 4.1.1.2. The increasing prevalence of chronic disease
- 4.1.2. Restraints:
- 4.1.2.1. Limitations of the Hyaluronidase enzyme
- 4.1.3. Opportunity
- 4.1.4. Impact Analysis
- 5. Industry Analysis
- 5.1. Porter's Five Forces Analysis
- 5.2. Epidemiology Analysis
- 5.3. Supply Chain Analysis
- 5.4. Pricing Analysis
- 5.5. Regulatory Analysis
- 5.6. Reimbursement Analysis
- 5.7. Unmet Needs
- 6. COVID-19 Analysis
- 6.1. Analysis of Covid-19 on the Market
- 6.1.1. Before COVID-19 Market Scenario
- 6.1.2. Present COVID-19 Market Scenario
- 6.1.3. After COVID-19 or Future Scenario
- 6.2. Pricing Dynamics Amid Covid-19
- 6.3. Demand-Supply Spectrum
- 6.4. Government Initiatives Related to the Market During Pandemic
- 6.5. Manufacturers Strategic Initiatives
- 6.6. Conclusion
- 7. By Tissue type
- 7.1. Introduction
- 7.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tissue type
- 7.1.2. Market Attractiveness Index, By Tissue type Segment
- 7.2. Epithelial Tissue*
- 7.2.1. Introduction
- 7.2.2. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
- 7.3. Connective Tissue
- 8. By Dissociation Enzyme
- 8.1. Introduction
- 8.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dissociation Enzyme
- 8.1.2. Market Attractiveness Index, By Dissociation Enzyme Segment
- 8.2. Collagenase*
- 8.2.1. Introduction
- 8.2.2. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
- 8.3. Trypsin
- 8.4. Elastase
- 8.5. Hyaluronidase
- 8.6. Papain
- 8.7. Chymotrypsin
- 8.8. Trypsin Inhibitor
- 8.9. Animal Origin Free (AOF) Enzymes
- 8.10. Others
- 9. By End user
- 9.1. Introduction
- 9.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End user
- 9.1.2. Market Attractiveness Index, By End user Segment
- 9.2. Research Institutes*
- 9.2.1. Introduction
- 9.2.2. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028
- 9.3. Pharmaceutical Companies
- 9.4. Biotechnology Companies
- 9.5. Diagnostic Laboratories
- 10. By Region
- 10.1. Introduction
- 10.1.1. Market Size Analysis, US$ Million, 2019-2028 and Y-o-Y Growth Analysis (%), 2020-2028, By Region
- 10.1.2. Market Attractiveness Index, By Region
- 10.2. North America
- 10.2.1. Introduction
- 10.2.2. Key Region-Specific Dynamics
- 10.2.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tissue type
- 10.2.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dissociation Enzyme
- 10.2.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End user
- 10.2.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
- 10.2.6.1. U.S.
- 10.2.6.2. Canada
- 10.2.6.3. Mexico
- 10.3. Europe
- 10.3.1. Introduction
- 10.3.2. Key Region-Specific Dynamics
- 10.3.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tissue type
- 10.3.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dissociation Enzyme
- 10.3.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End user
- 10.3.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
- 10.3.6.1. Germany
- 10.3.6.2. U.K.
- 10.3.6.3. France
- 10.3.6.4. Italy
- 10.3.6.5. Spain
- 10.3.6.6. Rest of Europe
- 10.4. South America
- 10.4.1. Introduction
- 10.4.2. Key Region-Specific Dynamics
- 10.4.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tissue type
- 10.4.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dissociation Enzyme
- 10.4.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End user
- 10.4.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
- 10.4.6.1. Brazil
- 10.4.6.2. Argentina
- 10.4.6.3. Rest of South America
- 10.5. Asia Pacific
- 10.5.1. Introduction
- 10.5.2. Key Region-Specific Dynamics
- 10.5.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tissue type
- 10.5.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dissociation Enzyme
- 10.5.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End user
- 10.5.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
- 10.5.6.1. China
- 10.5.6.2. India
- 10.5.6.3. Japan
- 10.5.6.4. Australia
- 10.5.6.5. Rest of Asia Pacific
- 10.6. Middle East and Africa
- 10.6.1. Introduction
- 10.6.2. Key Region-Specific Dynamics
- 10.6.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Tissue type
- 10.6.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Dissociation Enzyme
- 10.6.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End user
- 11. Competitive Landscape
- 11.1. Key Developments and Strategies
- 11.2. Company Share Analysis
- 11.3. Product Benchmarking
- 11.4. List of Key Companies to Watch
- 11.5. List of Company with disruptive technology
- 11.6. List of Start Up Companies
- 12. Company Profiles
- 12.1. Thermo Fisher Scientific*
- 12.1.1. Company Overview
- 12.1.2. Product Portfolio and Description
- 12.1.3. Key Highlights
- 12.1.4. Financial Overview
- 12.2. Miltenyi Biotec
- 12.3. Worthington Biochemical
- 12.4. Sigma-Aldrich
- 12.5. Becton Dickinson Biosciences
- 12.6. StemCell Technologies, Inc.
- 12.7. VitaCyte
- 12.8. F. Hoffmann-La Roche
- 12.9. Merck KGaA (*LIST NOT EXHAUSTIVE)
- 13. DataM Intelligence
- 13.1. Appendix
- 13.2. About Us
- 13.3. Contact Us
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