Toxoplasmosis is an infection caused by a parasite called Toxoplasma gondii. Currently recommended toxoplasmosis drugs target the tachyzoite stage of the parasite and do not remove the parasite from the tissues. Pyrimethamine is considered the most effective anti-toxoplasmosis drug, and it is a standard component of treatment. Pyrimethamine is a folic acid antagonist and can cause dose-dependent bone marrow suppression, which is alleviated by the concomitant administration of folic acid (leucovorin). Leucovorin protects the bone marrow from the toxic effects of pyrimethamine. If the patient experiences a hypersensitive reaction to sulfa medications, another medication, such as sulfadiazine or clindamycin, should be added. As an alternative, a fixed combination of trimethoprim with sulfamethoxazole and other drugs such as atovaquone and pyrimethamine and azithromycin are used for toxoplasmosis treatment.
Market Dynamics
Medicines are used to treat active infections. These factors include the severity of your illness, the state of your immune system, and the location of the infection. Another aspect is pregnancy's stage. For example, on November 3, 2022, a U.S.-based hospital, Mayo Clinics published an article explaining pyrimethamine (Daraprim), which fights against infections caused by microscopic organisms. It can block the body's use of folic acid. Other possible side effects of its long-term use include bone marrow suppression and liver toxicity. Leucovorin calcium helps correct the effect of pyrimethamine on folic acid. Sulfadiazine is an antibiotic often prescribed with pyrimethamine. Other medications include clindamycin (Cleocin), azithromycin (Zithromax), and others. To diagnose toxoplasmosis in a newborn baby, blood tests are prescribed if infection is suspected. A baby with a positive test result will undergo many tests to identify and monitor the disease.
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