High-Content Analysis (HCA) or High-Content Screening (HCS) is a method for obtaining quantitative multi-parametric data from a single cell by combining high-throughput automated imaging with analysis. High-content screening is now established in a much broader area of the life science space as an impartial imaging method to assess cellular function. It was initially developed as a technology to complement conventional biochemical high-throughput screening (HTS) in drug discovery.When compared to high-content screening, high-content imaging (HCI) is typically defined as automated microscopy with a lower throughput (less than 100,000 samples or data points). However, the terms high-content screening and high-content analysis are frequently used interchangeably with high-content imaging.
Market dynamics:
High content screening is on the rise for screening, imaging and identification of molecular entities. For instance, in 2023, Cytiva, a biotechnology and lifesciences company, designed Typhoon laser-scanner platform for versatile imaging and precise quantitation of fluorescent, colorimetric, and radiolabeled nucleic acids and proteins. This was a line of Cytiva’s screening laser products that included Amersham Typhoon IP, Amersham Typhoon IP, Amersham Typhoon 5. Cytiva is Sglobal provider of technologies and services that advances and accelerates the development, manufacture, and delivery of therapeutics.
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