Hematopoietic cell transplantation (also called bone marrow transplantation or stem cell transplantation) is a type of treatment for cancer (and a few other conditions as well). A review of the normal function of the bone marrow will help in the understanding of stem cell transplantation. Hematopoietic cell transplantation is the most effective treatment for cancer. Other treatments, such as chemotherapy and radiation, are toxic to the bone marrow. In general, the higher the dose, the more toxic the effects on the bone marrow.
There are two main types of hematopoietic cell transplantation: autologous and allogeneic. In autologous transplantation, the patient’s own hematopoietic stem cells are removed before high-dose chemotherapy or radiation is given, and they are then frozen for storage and later use. After chemotherapy or radiation is complete, the harvested cells are thawed and returned to the patient. In allogeneic transplantation, the hematopoietic stem cells come from a donor, ideally a brother or sister with a similar genetic makeup.
Market Dynamics
The increasing organic growth strategies, such as product launches by key market players to expand their product portfolio are expected to drive market growth over the forecast period. For instance, in January 2020, Bluebird Bio, Inc., a company providing gene therapy products, announced the launch of ZYNTEGLO (autologous CD34+ cells encoding βA-T87Q-globin gene), a one-time gene therapy for patients 12 years of age and older with transfusion-dependent β-thalassemia (TDT) for hematopoietic stem cell (HSC) transplantation in Germany. The full common name for ZYNTEGLO is a genetically modified autologous CD34+ cell-enriched population that contains hematopoietic stem cells transduced with a lentiviral vector encoding the βA-T87Q-globin gene.
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