Protein kinases play an important role in the catalytic activity and signaling functional transduction of critical cellular processes. TTK, also called monopolar spindle 1 (Mps1), is a dual specificity kinase that causes the phosphorylation of both tyrosine and serine/threonine residues. It is one of the spindle assembly checkpoint (SAC) that facilitates the alignment of chromosomes on the metaphase plate in mitosis which is associated with the progression of the cell cycle. TTK is essential for the right alignment of all chromosomes, and subsequently, correct attachment to the mitotic spindle. Targeting this kinase may effectively block chromosome segregation during mitosis, and it could be a great invention for cancer therapy.
Market Dynamics
The increased per capita healthcare spending has enhanced research and development activities for the treatment of chronic diseases, which is expected to drive the global dual specificity protein kinase TTK inhibitors market growth over the forecast period. According to the World Bank estimates in 2019, the per capita healthcare expenditure increased significantly in Latin America. The healthcare expenditure in Latin America was around US$ 638 Mn in 2016, which increased to US$ 666 Mn by 2018.
Increasing approvals for product launches by the regulatory bodies is also expected to drive the market growth over the forecast period. For instance, in January 2019, Dacomitinib, a selective and irreversible inhibitor of EGFR by Pfizer Inc., a leading research-based biopharmaceutical company, received approval from the Ministry of Health, Labour and Welfare of Japan for the treatment of EGFR mutation-positive inoperable or recurrent non-small cell lung cancer (NSCLC).
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