Anti-neprilysin drugs are mostly used for acute heart failure, cancer pain, hypertension, Alzheimer’s disease, and other diseases. The most commonly used anti-neprilysin is Sacubitril/valsartan thatis sold under the brand name Entrest. It consists of the neprilysin inhibitor sacubitril and the angiotensin receptor blocker valsartan. Entrest was first manufactured by Novartis International AG- a biopharmaceutical compay. This drug has reduced rate of cardiovascular deaths and hospitalizations related to heart failure. Due to increasing prevalence of heart failure, the U.S. Food And Drug Administration granted fast track designation to Entresto in 2015, which supports the FDA’s efforts to facilitate the development and expedite the review of drugs to treat serious or life-threatening conditions and meet the unmet medical needs of patients.
Market Dynamics
Increasing prevalence of acute heart failure is expected to drive the antineprilysin market growth over the forecast period. For instance, according to the data published in September 2020, by PubMed, a free search engine for biological databases and medical reports, Heart failure affects more than 64 million people every year worldwide. Attempts to decrease its social and economic burden have become a major global public health priority.
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