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Macular Degeneration (AMD) & Diabetic Retinopathy (DR) Market Forecast 2017-2027

Macular Degeneration (AMD) & Diabetic Retinopathy (DR) Market Forecast 2017-2027

Macular Degeneration, Diabetic Retinopathy and Other Retinal Diseases – our new study reveals trends, R&D progress, and predicted revenues

Where is the Retinal disease therapeutic market heading? If you are involved in this sector you must read this newly updated report. Visiongain’s report shows you the potential revenues streams to 2027, assessing data, trends, opportunities and business prospects there.

Discover How to Stay Ahead

Our 169-page report provides 80 tables, charts, and graphs. Read on to discover the most lucrative areas in the industry and the future market prospects. Our new study lets you assess forecasted sales at overall world market and regional level. See financial results, trends, opportunities, and revenue predictions. Much opportunity remains in this growing Retinal Disease market. See how to exploit the opportunities.

Forecasts from 2017-2027 and other analyses reveal the commercial prospects

  • In addition to revenue forecasting to 2027, our new study provides you with recent results, growth rates, and market shares.
  • You find original analyses, with business outlooks and developments.
  • Discover qualitative analyses (including SWOT and STEP analysis), product profiles and commercial developments.
Discover sales predictions for the world market and submarkets

Along with revenue prediction for the overall world market, you find revenue forecasts to 2027 for the following submarkets:
  • Wet age-related macular degeneration (wAMD)
  • Dry AMD (dAMD)
  • Diabetic retinopathy (DR)
  • Other retinal diseases (grouped forecast).
Our investigation discusses what stimulates and restrains business. Understand the dynamics of the industry and assess its potential future sales, discovering the critical factors likely to achieve success.

Predictions of leading products’ sales – what’s possible for those eye drug revenues?

How will individual retinal medicines perform from 2017 to 2027 at world level? Our study forecasts revenues of four prominent brands:
  • Lucentis
  • Eylea
  • Avastin
  • Visudyne
Discover how high revenues can go. See what's happening, understanding the trends, challenges and opportunities.

Our analysis also divides the main global forecast into geographical markets.

What are the prospects in the leading regions and countries?

You will discover individual revenue forecasts for 10 leading national markets from 2017-2027:
  • United States (US)
  • Japan
  • Germany, France, the UK, Italy and Spain (EU5 group)
  • Brazil, Russia, India and China (BRIC countries).
Leading companies and the potential for market growth

Our analysis forecasts that the world market for retinal drugs will reach $11.98bn in 2017. It will achieve strong revenue expansion from 2017 to 2027. Our report reveals how high sales will go over the next 10 years.

Research and development - assess innovation, trends and possibilities

There you can also investigate R&D, appraising technological, clinical and commercial possibilities.

In our study explore the research and development in slowing vision loss and restoring sight. You can examine these advances and others:
  • Combination therapies, including neovascularisation disrupters
  • Angiogenesis inhibition by blocking pericyte recruitment
  • Anti-inflammatory mechanisms (inc. corticosteroids)
  • Targeting VEGF and PDGF (inc. receptors, kinases and angiogenesis pathways)
  • Monoclonal antibodies, mAb fragments, DARPins (designed ankyrin repeat proteins) and visual cycle modulators.
Explore the other agents and possibilities, too, including these:
  • Oligonucleotides and siRNA therapy
  • Anti-integrin oligopeptide treatment
  • Complement factor inhibition and serotonin modifiers
  • Angiotensin receptor blockers and converting enzyme inhibitors
  • Biosimilars and other follow-on biologicals and next generation therapeutics
  • Regenerative medicine, neural stem cells (NSCs), cellular and gene therapies.
Information found nowhere else

With our survey you are less likely to fall behind in knowledge or miss opportunity. See how you could benefit your research, analyses, and decisions. Also see how you can save time and receive recognition for commercial insight.

Visiongain’s study is for everybody needing commercial analyses for the Biosimulation market and leading companies. You will find data, trends and predictions.

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The publisher is using a password system to access all reports. Single user (non-printable) and departmental licenses expires after 12 month period. In the case of departmental site license purchases, the publisher requires all email addresses for the licensed users prior to fulfillment.

1. Report Overview
1.1 Why You Should Read This Report
1.2 How This Report Delivers
1.3 Main Questions Answered by This Analysis
1.4 Who Is This Study For?
1.5 Methods of Research and Analysis
1.6 Frequently Asked Questions (FAQs)
1.7 Some Associated Reports
1.8 About Visiongain
2. World AMD and Other Disease Market, 2016
2.1 What are Retinal Diseases?
2.2 Types of Retinal Diseases
2.3 Diagnostics and Treatments for AMD and Other Retinal Diseases
2.4 Nearly 200 Million People with AMD?
2.5 Over 100 Million with DR
2.6 First RVO Estimates Suggest Patient Population of 16 Million
2.7 Market to Make Rapid Pace to 2027
2.8 Eylea Stood as the Leading Drug in the Market
2.9 Regeneron the Leading Presence in the Market
2.10 Which are the Most Significant Disease Areas for the Market?
3. Retinal Disease Market Subsectors, 2016
3.1 Wet AMD Still the Main Source of Revenue in the Market
3.2 Wet AMD: Angiogenic Processes Offer Well-Defined Drug Targets
3.2.1 Revenue Forecasting for Wet AMD segment, 2016-2027
3.3 Dry AMD: Unmet Need to Arrest or Reverse Damage to RPE
3.3.1 Dry AMD Segment to Emerge in the Forecast Period
3.4 DR: Coming Into Clinical Focus, with DME the Main Target
3.4.1 Segment to Grow in Importance as Diabetes Epidemic Continues
3.5 Lucentis and Eylea Label Extensions Highlight Possibilities in Other Disease Areas
3.6 Projections for All Segments, 2016-2027
4. Approved Products in the AMD and Other Retinal Diseases Market, 2016-2027
4.1 Will the Current Products Dominate the Market Through 2027?
4.2 Lucentis: Second Leading Drug in the Market
4.2.1 Positive Revenue Growth Shown in Past: 2012-2016
4.2.2 Shadow of Avastin Still Hangs Over Lucentis
4.2.3 CATT Study Results: Clinical Differences Still Have Yet to Emerge
4.2.4 Eylea: The Bigger Threat to Lucentis?
4.2.5 Extending the Label, Widening the Battleground: Lucentis Moves Into DME and Beyond
4.2.6 Improving Cost and Compliance for Lucentis
4.2.7 Lucentis Revenue Forecast 2016-2027
4.2.8 Will Loss of Physician Goodwill Harm Lucentis’ Growth?
4.3 Eylea: Holds the Throne?
4.3.1 Increasing Revenue Growth in Past: Outside US Sale Amplified
4.3.2 VIEW 1 and VIEW 2: Is Eylea Superior or Just Non-Inferior to Lucentis?
4.3.3 First Wave of Eylea’s Expansion Finally Beginning to Break?
4.3.4 Eylea into DME and Other New Indications
4.3.5 Eylea Revenue Forecast 2016-2027
4.3.6 How Far Can Eylea’s Momentum Carry It?
4.4 Avastin: No Formal wAMD Approval but Still the Most-Used Product
4.4.1 Past Revenue illustrates Increasing Use of Avastin for wetAMD
4.4.2 Judicial Review Averted in the UK by Price Adjustment
4.4.3 Multiple Attempts to Block Off-Label Avastin Since 2007
4.4.4 Roche and Novartis Challenge CATT’s Headline Conclusions
4.4.5 Will Eylea/Zaltrap Affect Avastin’s Place in the Market?
4.4.6 Avastin Revenue Forecast, 2016-2027
4.4.7 Will Anything Dislodge Avastin from its Central Position?
4.5 Visudyne (Valeant/Novartis): Declining Sales throughout the Forecast Period
4.5.1 Visudyne Revenue Forecast, 2016-2027
4.6 Jetrea (ThromboGenics/Novartis): Disappointing Launch in 2013
5. Pipeline for Wet AMD Segment, 2016-2027
5.1 The Leading Pipeline Candidates
5.2 Fovista (Ophthotech Corporation/ Novartis): The Next Big Thing?
5.2.1 Three Phase 3 Trials to Confirm Fovista’s Outstanding Phase 2 Results
5.2.2 Ophthotech Goes Public to Fund Phase 3 Effort
5.2.3 Ophthotech Partners with Novartis for Fovista
5.2.4 Improving Angiogenesis Inhibition by Blocking Pericyte Recruitment
5.2.5 The Move toward Combination Therapies
5.2.6 Biosmiliars of Lucentis: FYB201 & PF-582
5.2.7 TK001/sevacizumab (Jiangsu T-Mab Biopharma)‘s recombinant humanized anti-VEGF monoclonal antibody
5.2.8 Roche’s RG7716 (RO-6867461), an anti- VEGF A monoclonal antibody
5.2.9 Opthea’s OPT-302, a VEGFR inhibitor
5.2.10 Daiichi Sankyo’s DS7080, an angiogenesis inhibitor
5.3 Other Growth Factor Targets in the Pipeline
5.3.1 Squalamine (OHR Pharmaceutical): Combination Targeting in a Single Eyedrop
5.3.2 Allergan and Molecular Partners: Preclinical DARPin Hits VEGF and PDGF
5.3.3 NT-506 (Neurotech Pharmaceutical): Sustained-Release VEGF/PDGF Options
5.3.4 Regeneron’s REGN910-3 (Nesvacumab + Aflibercept) and REGN910 (Nesvacumab)
5.3.5 iSONEP (Lpath): Pfizer Interested in Anti-S1P Monoclonal Antibody
5.4 Conbercept (Chengdu Kanghong Biotech): Launched in China for wAMD
5.4.1 A Chinese Competitor: Where Will Conbercept Fit In?
5.4.2 Binding Affinity Comparable to Eylea
5.5 Do We Need New Anti-VEGFR Agents or Delivery Systems?
5.5.1 Abicipar Pegol (Allergan): Novel Protein with Extended Half-Life
5.5.2 Brolucizumab (Alcon): Single-Chain Monoclonal Antibody Fragment
5.5.3 PDS 1.0 (ForSight Vision4): A New Option for Lucentis Delivery
5.5.4 NT-503 (Neurotech): New Delivery Platform for Anti-VEGF Agent
5.5.5 Pan-90806 (PanOptica): Anti-VEGF Eyedrop
5.5.6 Iontophoretic Delivery: EyeGate Pharmaceuticals Leading the Way
5.6 Novel Delivery Systems to Rejuvenate Anti-Inflammatory Approaches
5.6.1 Verisome System and IBI-30089 (Icon Bioscience)
5.7 Other Targets Under Investigation in wAMD Drug Development
5.7.1 Are Kinase Inhibitors Still a Going Concern in wAMD?
5.7.2 Pazopanib (GlaxoSmithKline) and TG100801 (Sanofi): Two Eyedrop Kinase Inhibitors Drop Out of the Running
5.7.3 X-82 Pill (Tyrogenex): Dual Kinase Inhibitor
5.7.4 Factor C5: A More Promising Target Addressed by Zimura (Ophthotech) and LFG316 (Novartis)
5.7.5 Integrins: Another Blockable Component of the Neovascularisation Cascade?
5.7.6 Luminate (Allegro Ophthalmics): Novel Anti-Integrin Oligopeptide
5.7.7 SF0166 (SciFluor Life Sciences): an integrin αvβ3 inhibitor for Wet AMD
5.7.7 Jetrea (ThromboGenics/Novartis): Can Pharmacologic Vitreolysis Help wAMD Patients?
5.7.8 Novel Anti-Angiogenic Treatments in Development: Ora Bio’s ORA102 and CoMentis’ ATG003
5.7.9 Zybrestat (Mateon Therapeutics Oxigene, formerly OxiGENE): New Mechanism of Action Offers Way to Disrupt Neovascularisation
5.7.10 Alcon’s LMG324 and LHA510 for wAMD
5.7.11 hI-con1 (Iconic Therapeutics), VII-IgGFc chimeric protein targeting tissue factor
5.7.12 Synthetic Biologics: Oligonucleotides and SiRNAs for wAMD
5.8 Regenerative Medicine Approaches
5.8.1 Allogeneic Stem Cells (Mesoblast): Potential Synergistic Treatment for Use alongside Lucentis
5.8.2 AVA-101 and AVA-201(Avalanche Biotechnologies): Ocular BioFactory for wAMD
5.8.3 RetinoStat (Oxford BioMedica): LentiVector Technology to Deliver Anti-Angiogenic Genes
5.8.5 Gene Therapy (RGX-314) for Neovascular AMD
5.8.6 Stem cell therapy with Pfizer’s PF05206388
5.8.7 Diffusion Pharmaceuticals’ Palomid-529
5.8.8 MT-0814 (Mitsubishi Tanabe Pharma), CC chemokine receptor 3 antagonist for AMD
5.8.9 Undisclosed MoA of Boehringer Ingelheim’s BI 144807 for Wet AMD
6. Pipeline for Dry AMD Segment, 2016
6.1 Who Will Achieve the Big Breakthrough in Dry AMD?
6.2 MC-1101 (MacuCLEAR): Leading the Pack?
6.2.1 Increasing Choroidal Blood Flow with Repurposed Product
6.2.2 Novel Endpoints in Phase 3 Study
6.2.3 Can MacuCLEAR Make It?
6.3 ACU-4429 (Acucela): Visual Cycle Modulator in Phase 3
6.3.1 Disappointing results of Phase 2/3 trial
6.4 High Hopes for Complement Inhibition in Dry AMD
6.4.1 Lampalizumab (Roche): The Big News of ARVO 2013
6.4.2 MAHALO Study Indicates GA Progression Slowed by Lampalizumab
6.5 Corticosteroids: Targeting Inflammation’s Role in Dry AMD Pathogenesis
6.5.1 Iluvien (Alimera Sciences): Study terminated
6.5.2 AGN208397 (Allergan): New Potent Steroid Expected to Undergo Trials in Dry AMD
6.6 Neuroprotection: One of Modern Medicine’s Holy Grails
6.6.1 Tandospirone (Alcon): Not effective in GA
6.6.2 Neurotech’s Renexsus: Possibly Promising Data in Dry AMD Studies
6.6.3 Novadur (Allergan): Possible Efficacy with Longer Duration of Action
6.7 Regenerative Medicine: Dry AMD One of the Biggest Disease Targets
6.7.1 MA09-hRPE Cellular Therapy (Ocata Therapeutics): Signs of Efficacy in Landmark ESC Human Trial
6.7.2 HuCNS-SC (StemCells): Leading Company in Neural Stem Cell Space
6.7.3 Stemedyne-RPE (Stemedica Cell Technologies): Low-Oxygen Cells for Dry AMD Repair
6.7.4 OpRegen (Biotime): Stem Cell leader with Dry AMD Interests
6.7.5 First iPSC Trial in Japan in Dry AMD Patients
6.7.6 Ophthotech’s Zimura for Geographic Atrophy
6.7.7 Gene Therapies Less Prominent Than Stem Cells in Dry AMD
6.8 Other Treatments for Dry AMD
7. Pipeline for Diabetic Retinopathy Segment, 2016
7.1 Ozurdex/Posurdex (Allergan): Approved for General DME Patient Population
7.2 Lucentis: The Game Changer for DR?
7.3 New Anti-VEGF Additions
7.3.1 Is Eylea Better than Lucentis and Avastin for DME?
7.4 Steroids in Development for DR
7.4.1 Iluvien (Alimera/pSivida): New Option in European Markets
7.4.2 A New Hope? Optina (Ampio Pharmaceuticals)
7.4.3 Betamethasone Microsphere (Santen): Late-Stage Steroid Candidate
7.4.4 Clearside Biomedical’s CLS-TA/ CLS1004
7.4.5 IBI-20089 (Icon Bioscience): Sustained-Release Formulation of Triamcinolone Acetonide
7.4.6 Kala Pharmaceuticals’ KPI-121
7.5 Other Products in Development for DR
7.5.1 Angiotensin Receptor Blockers/Angiotensin-Converting Enzyme Inhibitors: Some Off-Label Validation
7.5.2 Vitreosolve (Innovations in Sight): Will a Phase 3 Trial Be Initiated?
7.5.3 TriLipix (Abbott): No New Development for Promising Drug
7.5.4 Jetrea (ThromboGenics /Novartis): Possibilities in DME?
7.5.5 SF0166 (SciFluor Life Sciences): an integrin αvβ3 inhibitor for DME
7.5.6 Pan-90806 (PanOptica): Anti-VEGF Eyedrop
7.5.7 Teprotumumab (Horizon Pharma): an insulin-like growth factor-1 receptor antagonist
7.6 Undisclosed MoA of Boehringer Ingelheim’s BI 1026706 for DME
8. Regional Market Breakdown, 2016
8.1 Which Markets Hold the Most Revenue Growth Potential?
8.2 The US: Leading Market for Retinal Diseases
8.3 Japan: Strong Market Potential
8.4 EU5: Ageing Populations to Drive Market Growth
8.5 BRIC Nations: The Biggest Growth Driver for the Market
9. Qualitative Industry and Market Analysis, 2017-2027
9.1 Strengths: The Most Dynamic Area of the Ophthalmics Market
9.2 Weaknesses: Heavily Dependent on Anti-VEGF Approach
9.3 Opportunities: New Markets and R&D Synergies
9.4 Threats: Prevention and Management Better Than Drug Treatment for Dry AMD and DR?
9.5 Social: Low Diagnosis, Low Compliance
9.6 Technological: Innovation for the Eye
9.7 Economic: Off-Label Treatment and Reimbursement Issues
9.8 Political: The Demography and Diabetes Challenges
10. Report Conclusions
10.1 The Age of Lucentis: Nearing Its Conclusion?
10.2 Lucentis vs. Eylea vs. Avastin: The Three-Way Anti-VEGF Market
10.3 Indications Outside Wet AMD to Gain in Importance
10.4 Dry AMD Market Has Huge Potential
10.5 Fovista Most Prominent Among the Pipeline Candidates
10.6 Retinal Diseases to Continue to Be the Leading Area of Ophthalmics
Associated Visiongain Reports
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About Visiongain
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List of Figures
Figure 2.1 Overall World AMD and Other Retinal Diseases Pharmaceutical Market Forecast: Revenue ($bn), 2016-2027
Figure 2.2 Market Breakdown by Product Revenue ($bn), Market Share (%), 2016
Figure 2.3 Market Breakdown by Company: Market Share (%), 2016
Figure 2.4 Leading Causes of Blindness Worldwide, Proportion of Total (%), 2010
Figure 2.5 Leading Causes of Visual Impairment (Inclusive of Blindness) Worldwide, Proportion of Total (%), 2010
Figure 3.1 Market Breakdown by Disease Segment: Revenues ($bn), 2016
Figure 3.2 Market Breakdown by Disease Segment: Market Share (%), 2016
Figure 3.3 Wet AMD Segment Forecast: Revenue ($bn), 2016-2027
Figure 3.4 Dry AMD Segment Forecast: Revenue ($bn), 2016-2027
Figure 3.5 DR Segment Forecast: Revenue ($bn), 2016-2027
Figure 3.6 Retinal Diseases Market Breakdown by Segment: Revenue ($bn), 2016-2027
Figure 3.7 Retinal Diseases Market Breakdown by Segment: Revenue ($bn), 2016, 2021 and 2027
Figure 3.8 Market Breakdown by Disease Segment: Market Share (%), 2021
Figure 3.9 Market Breakdown by Disease Segment: Market Share (%), 2027
Figure 4.1 Market Breakdown by Product: Revenue ($bn), Market Share (%), 2021
Figure 4.2 Market Breakdown by Product: Revenue ($bn), Market Share (%), 2027
Figure 4.3 Market Forecast by Product: Revenue ($bn), 2016-2027
Figure 4.4 Market Breakdown by Product: Revenue ($bn), 2016, 2021 and 2027
Figure 4.5 Lucentis: Revenues Forecast ($bn), 2016-2027
Figure 4.6 Drivers and Restraints for Lucentis, 2016
Figure 4.7 Eylea Forecast: Revenue ($bn), 2016-2027
Figure 4.8 Drivers and Restraints for Eylea, 2016
Figure 4.9 Avastin Forecast: Revenue ($bn), 2016-2027
Figure 4.10 Drivers and Restraints for Avastin, 2016
Figure 4.11 Visudyne Forecast: Revenues ($bn), 2016-2027
Figure 8.1 Regional Breakdown: Revenue ($bn), 2016-2027
Figure 8.2 Regional Breakdown: Revenue ($bn), 2016, 2021 and 2027
Figure 8.3 Regional Market Share (%), 2016
Figure 8.4 Regional Market Share (%), 2021
Figure 8.5 Regional Market Share (%), 2027
Figure 8.6 US Market: Revenue ($bn), 2016-2027
Figure 8.7 Japan: Revenue ($bn), 2016-2027
Figure 8.8 EU5: Grouped Revenue ($bn), 2016-2027
Figure 8.9 EU5 Breakdown Forecasts: Revenue ($bn), 2016-2027
Figure 8.10 EU5 Breakdown: Market Share (%), 2016
Figure 8.11 EU5 Breakdown: Market Share (%), 2021
Figure 8.12 EU5 Breakdown: Market Share (%), 2027
Figure 8.13 BRIC Nations Forecast: Grouped Revenue ($bn), 2016-2027
Figure 8.14 BRIC Nations Forecasts: Revenue ($bn), 2016-2027
Figure 8.15 Market Share (%) within BRIC Group by Country, 2016
Figure 8.16 Market Share (%) within BRIC Group by Country, 2021
Figure 8.17 Market Share (%) within BRIC Group by Country, 2027

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