Viral Vectors, Non-Viral Vectors and Gene Therapy Manufacturing Market (4th Edition) by Scale of Operation (Preclinical, Clinical and Commercial), Type of Vector (AAV Vector, Adenoviral Vector, Lentiviral Vector, Retroviral Vector, Plasmid DNA and Others)

Viral Vectors, Non-Viral Vectors and Gene Therapy Manufacturing Market (4th Edition) by Scale of Operation (Preclinical, Clinical and Commercial), Type of Vector (AAV Vector, Adenoviral Vector, Lentiviral Vector, Retroviral Vector, Plasmid DNA and Others), Application Area (Gene Therapy, Cell Therapy and Vaccine), Therapeutic Area (Oncological Disorders, Inflammation & Immunological Diseases, Neurological Disorders, Ophthalmic Disorders, Muscle Disorders, Metabolic Disorders, Cardiovascular Disorders and Others), and Geographical Regions (North America, Europe, Asia Pacific, MENA, Latin America and Rest of the World): Industry Trends and Global Forecasts, 2021-2030

Over the past few years, a number of advanced therapy medicinal products, including cell and gene therapies, have been developed and approved for the treatment of a variety of disease indications. In fact, as of 2020, close to 15 such therapeutics have received marketing approval across different regions worldwide. Further, over 1,000 clinical trials focused on the evaluation of cell and gene therapies have been registered globally. It is worth noting that the clinical success of these therapies heavily relies on the design and type of gene delivery vector used (in therapy development and / or administration). At present, several innovator companies are actively engaged in developing / producing viral and / or non-viral vectors for gene therapies. In this context, it is worth mentioning that multiple viral and non-viral vector based vaccine candidates are being developed against the novel coronavirus (SARS-CoV-2). As of January 2021, the WHO revealed that more than 55 such vaccines are under evaluation, while two viral vector based vaccines (AZD1222 and Sputnik V), being developed by AstraZeneca / Oxford University and Gamaleya Research Institute / Acellena Contract Drug Research and Development, have been approved. , , This is indicative of the lucrative opportunities for companies that have the required capabilities to manufacture vectors and gene therapies.

Vaccine production is a challenging process and dealing with vectors (viral and non-viral) further adds to the complexity. Therefore, outsourcing is a common practice among biopharmaceutical companies when it comes to vector development and / or manufacturing. Several players have developed / are developing versatile technology platforms for designing and manufacturing different types of gene delivery vehicles. Innovation in this segment of the pharmaceutical industry is presently focused on the enhancement of transduction efficiency and improving gene delivery efficiencies. In fact, some vector-related technology providers claim that their proprietary solutions have the ability to enable further improvements in existing genetically modified therapeutic products, and / or optimize affiliated manufacturing processes. The viral / non-viral vectors and gene therapy manufacturing market has also witnessed significant partnership activity in the recent past, especially now that COVID-19 vaccine developers are actively approaching such companies for their services. Given the growing demand for interventions that require genetic modification, the vector and gene therapy manufacturing market is poised to witness substantial growth in the foreseen future.

SCOPE OF THE REPORT
The “Viral Vectors, Non-Viral Vectors and Gene Therapy Manufacturing Market (4th Edition) by Scale of Operation (Preclinical, Clinical and Commercial), Type of Vector (AAV Vector, Adenoviral Vector, Lentiviral Vector, Retroviral Vector, Plasmid DNA and Others), Application Area (Gene Therapy, Cell Therapy and Vaccine), Therapeutic Area (Oncological Disorders, Inflammation & Immunological Diseases, Neurological Disorders, Ophthalmic Disorders, Muscle Disorders, Metabolic Disorders, Cardiovascular Disorders and Others), and Geographical Regions (North America, Europe, Asia Pacific, MENA, Latin America and Rest of the World): Industry Trends and Global Forecasts, 2021-2030” report features an extensive study of the rapidly growing market of vector and gene therapy manufacturing, focusing on contract manufacturers, as well as companies having in-house manufacturing facilities. The study presents an in-depth analysis of the various firms / organizations that are engaged in this domain, across different regions of the globe. Amongst other elements, the report includes:
An overview of the current status of the market with respect to the players engaged (both industry and non-indutry) in the manufacturing of viral, non-viral and other novel types of vectors, and gene therapies. It features information on the year of establishment, company size, location of headquarters, type of product manufactured (vector and gene therapy / cell therapy / vaccine), location of manufacturing facilities, purpose of production (in-house and contract services), scale of production (preclinical, clinical and commercial), type of vector manufactured (AAV, adenoviral, lentiviral, retroviral, plasmid DNA and others) and application area (gene therapy, cell therapy, vaccine and others).
An analysis of the technologies offered / developed by the companies enagaged in this domain, based on the type of technology (viral vector and non-viral vector related platform), purpose of technology (vector manufacturing, gene delivery, product manufacturing, transduction / transfection, vector packaging and other), scale of production (preclinical, clinical and clinical), type of vector (AAV, adenoviral, lentiviral, retroviral, non-viral and other viral vectors), application area (gene therapy, cell therapy, vcaccine and others). It also highlights the most prominent players within this domain, in terms of number of technologies.
A region-wise, company competitiveness analysis, highlighting key players engaged in the manufacturing of vectors and gene therapies, across key geographical areas, featuring a four-dimensional bubble representation, taking into consideration supplier strength (based on experience in this field), manufacturing strength (type of product manufactured, number of manufacturing facilites and number of application areas), service strength (scale of operation, number of vectors manufactured and geographical reach) and company size (small-sized, mid-sized and large).
Elaborate profiles of key players based in North America, Europe and Asia-Pacific (shortlisted based on proprietary criterion). Each profile features an overview of the company / organization, its financial performance (if available), information related to its manufacturing facilities, vector manufacturing technology and an informed future outlook.
An analysis of recent collaborations and partnership agreements inked in this domain since 2015; it includes details of deals that were / are focused on the manufacturing of vectors, which were analyzed on the basis of year of partnership, type of partnership (manufacturing agreement, product / technology licensing, product development, merger / acqusition, research and development agreement, process development / optimization, service alliance, production asset / facility acquisition, supply agreement and others), scale of production (laboratory, clinical and commercial), type of vector (AAV, adenoviral, lentiviral, retroviral, plasmid and others), region and most active players (in terms of number of partnerships).
An analysis of the expansions related to viral vector and non-viral vector manufacturing, which have been undertaken since 2015, based on several parameters, such as year of expansion, type of expansion (new facility / plant establishment, facility expansion, technology installation / expansion, capacity expansion and others), type of vector (AAV, adenoviral, lentiviral, retroviral, plasmid and others), application area (gene therapy, cell therapy, vaccine and others) and geographical location of the expansion project.
An analysis evaluating the potential strategic partners (comparing vector based therapy developers and vector purification product developers) for vector and gene therapy product manufacturers, based on several parameters, such as developer strength, product strength, type of vector, therapeutic area, pipeline strength (clinical and preclinical).
An overview of other viral / non-viral gene delivery approaches that are currently being researched for the development of therapies involving genetic modification.
An in-depth analysis of viral vector and plasmid DNA manufacturers, featuring three schematic representations, namely [A] a three dimensional grid analysis, representing the distribution of vector manufacturers (on the basis of type of vector) across various scales of operation and purpose of production (in-house operations and contract manufacturing services), [B] a logo landscape of viral vector and plasmid DNA manufacturers based on the type of organization (industry and non-industry) and comapny size (small-sized, mid-sized and large), and [C] a schematic world map representation, highlighting the geographical location of key vector manufacturing hubs.
An analysis of the various factors that are likely to influence the pricing of vectors, featuring different models / approaches that may be adopted by product developers / manufacturers in order to decide the prices of proprietary vectors.
An estimate of the overall, installed vector manufacturing capacity of industry players based on the information available in the public domain, and insights generated via both secondary and primary research. The analysis also highlights the distribution of the global capacity by company size (small-sized, mid-sized and large), scale of operation (clinical and commercial), type of vector (viral vector and plasmid DNA) and region (North America, Europe, Asia Pacific and the rest of the world).
An informed estimate of the annual demand for viral and non-viral vectors, taking into account the marketed gene-based therapies and clinical studies evaluating vector-based therapies; the analysis also takes into consideration various relevant parameters, such as target patient population, dosing frequency and dose strength.
A discussion on the factors driving the market and various challenges associated with the vector production process.
An insightful discussion on the impact that the recent COVID-19 pandemic is likely to have on the vector and gene therapy manufacturing market. In addition, it features various strategies that different companies have adopted / may adopt in order to mitigate the challenges affiliated to the current global crisis.

One of the key objectives of this report was to evaluate the current market size and the future opportunity associated with the vector and gene therapy manufacturing market, over the coming decade. Based on various parameters, such as the likely increase in number of clinical studies, anticipated growth in target patient population, existing price variations across different types of vectors, and the anticipated success of gene therapy products (considering both approved and late-stage clinical candidates), we have provided an informed estimate of the likely evolution of the market in the short to mid-term and long term, for the period 2021-2030. In order to provide a detailed future outlook, our projections have been segmented on the basis of [A] scale of operation (preclinical, clinical and commercial), [B] type of vector (AAV vector, adenoviral vector, lentiviral vector, retroviral vector, plasmid DNA and others), [C] application area (gene therapy, cell therapy and vaccine), [D] therapeutic area (oncological disorders, inflammation & immunological diseases, neurological disorders, ophthalmic disorders, muscle disorders, metabolic disorders, cardiovascular disorders and others) and [E] geographical region (North America, Europe, Asia Pacific, MENA, Latin America and rest of the world). In order to account for future uncertainties and to add robustness to our model, we have provided three forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.

The research, analysis and insights presented in this report are backed by a deep understanding of key insights generated from both secondary and primary research. For the purpose of the study, we invited over 180 stakeholders to participate in a survey to solicit their opinions on upcoming opportunities and challenges that must be considered for a more inclusive growth. The opinions and insights presented in this study were also influenced by discussions held with senior stakeholders in the industry. The report features detailed transcripts of interviews held with the following industry and non-industry players:
Menzo Havenga (Chief Executive Officer and President, Batavia Biosciences)
Nicole Faust (Chief Executive Officer & Chief Scientific Officer, CEVEC Pharmaceuticals)
Jeffrey Hung (Chief Commercial Officer, Vigene Biosciences)
Cedric Szpirer (Founder, Executive & Scientific Director, Delphi Genetics)
Olivier Boisteau, (Co-Founder / President, Clean Cells), Laurent Ciavatti (Ex-Business Development Manager, Clean Cells) and Xavier Leclerc (Head of Gene Therapy, Clean Cells)
Alain Lamproye (Ex-President of Biopharma Business Unit, Novasep)
Joost van den Berg (Ex-Director, Amsterdam BioTherapeutics Unit)
Bakhos A Tannous (Director, MGH Viral Vector Development Facility, Massachusetts General Hospital)
Eduard Ayuso, DVM, PhD (Scientific Director, Translational Vector Core, University of Nantes)
Colin Lee Novick (Managing Director, CJ Partners)
Semyon Rubinchik (Scientific Director, ACGT)
Astrid Brammer (Senior Manager Business Development, Richter-Helm)
Marco Schmeer (Project Manager, Plasmid Factory) and Tatjana Buchholz (Ex-Marketing Manager, Plasmid Factory)
Brain M Dattilo (Business Development Manager, Waisman Biomanufacturing)
Beatrice Araud (ATMP Key Account Manager, EFS-West Biotherapy)
Nicolas Grandchamp (R&D Leader, GEG Tech)

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.

1.2. KEY QUESTIONS ANSWERED
Who are the leading players (contract service providers and in-house manufacturers) engaged in the development of vectors and gene therapies?
Which region are the current manufacturing hubs for vectors and gene therapies?
Which type of technologies are presently offered / being developed by the stakeholders engaged in this domain?
Which companies are likely to partner with viral and non-viral vector contract manufacturing service providers?
Which partnership models are commonly adopted by stakeholders engaged in this industry?
What type of expansion initiatives are being undertaken by players in this domain?
Which are the emerging viral and non-viral vectors used by players for the manufacturing of genetically modified therapies?
How is the recent COVID-19 pandemic likely to impact the viral and non-viral vector, and gene therapy manufacturing market?
What is the current, global demand for viral and non-viral vector, and gene therapies?
How is the current and future market opportunity likely to be distributed across key market segments?

1.3. RESEARCH METHODOLOGY
The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market may evolve across different regions and technology segments. Wherever possible, the available data has been checked for accuracy from multiple sources of information.

The secondary sources of information include:
Annual reports
Investor presentations
SEC filings
Industry databases
News releases from company websites
Government policy documents
Industry analysts’ views

While the focus has been on forecasting the market over the period 2021-2030, the report also provides our independent view on various technological and non-commercial trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.

1.4. CHAPTER OUTLINES
Chapter 2 is an executive summary of the insights captured in our research. It offers a high-level view on the likely evolution of the vector and gene therapy manufacturing market in the short to mid-term, and long term.

Chapter 3 is a general introduction to the various types of viral and non-viral vectors. It includes a detailed discussion on the design, manufacturing requirements, advantages, limitations and applications of the currently available gene delivery vehicles. The chapter also features the clinical and approved pipeline of genetically modified therapies. Further, it includes a review of the latest trends and innovations in the contemporary vector manufacturing market.
Chapter 4 provides a detailed overview of more than 115 companies, featuring both contract service providers and in-house manufacturers that are actively involved in the production of viral vectors and / or gene therapies utilizing viral vectors. The chapter provides details on the the year of establishment, company size, location of headquarters, type of product manufactured (vector and gene therapy / cell therapy vaccine), location of manufacturing facilities, purpose of production (in-house and contract services), scale of production (preclinical, clinical and commercial), type of vector manufactured (AAV, adenoviral, lentiviral, retroviral, plasmid DNA and others) and application area (gene therapy, cell therapy, vaccine and others).

Chapter 5 provides an overview of around 65 industry players that are actively involved in the production of plasmid DNA and other non-viral vectors and / or gene therapies utilizing non-viral vectors. The chapter provides details on the the year of establishment, company size, location of headquarters, type of product manufactured (vector and gene therapy / cell therapy vaccine), location of plasmid DNA manufacturing facilities, purpose of production (in-house and contract services), scale of production (preclinical, clinical and commercial) and application area (gene therapy, cell therapy, vaccine and others).

Chapter 6 provides an overview of close to 90 non-industry players (academia and research institutes) that are actively involved in the production of vectors (both viral and non-viral) and / or gene therapies. The chapter provides details on the year of establishment, purpose of production (in-house and contract services), scale of production (preclinical, clinical and commercial), location of headquarters, type of vector manufactured (AAV, adenoviral, lentiviral, retroviral, plasmid DNA and others) and application area (gene therapy, cell therapy, vaccine and others).

Chapter 7 features an in-depth analysis of the technologies offered / developed by the companies engaged in this domain, based on the type of technology (viral vector and non-viral vector related platform), purpose of technology (vector manufacturing, gene delivery, product manufacturing, transduction / transfection, vector packaging and other), scale of production (preclinical, clinical and clinical), type of vector (AAV, adenoviral, lentiviral, retroviral, non-viral and other viral vectors), application area (gene therapy, cell therapy, vaccine and others) and leading technology providers.

Chapter 8 presents a detailed competitiveness analysis of vector manufacturers across key geographical areas, featuring a four-dimensional bubble representation, taking into consideration supplier strength (based on its experience in this field), manufacturing strength (type of product manufactured, number of manufacturing facilities and number of application area), service strength (scale of production, number of vectors manufactured and geographical reach) and company size (small-sized, mid-sized and large).

Chapter 9 features detailed profiles of some of the key players that have the capability to manufacture viral vectors / plasmid DNA in North America. Each profile presents a brief overview of the company, its financial information (if available), details on vector manufacturing facilities, manufacturing experience and an informed future outlook.

Chapter 10 features detailed profiles of some of the key players that have the capability to manufacture viral vectors / plasmid DNA in Europe. Each profile presents a brief overview of the company, its financial information (if available), details on vector manufacturing facilities, manufacturing experience and an informed future outlook.

Chapter 11 features detailed profiles of some of the key players that have the capability to manufacture viral vectors / plasmid DNA in Asia-Pacific. Each profile presents a brief overview of the company, its financial information (if available), details on vector manufacturing facilities, manufacturing experience and an informed future outlook.

Chapter 12 features in-depth analysis and discussion of the various partnerships inked between the players in this market, during the period, 2015-2020, covering analysis based on parameters such as year of partnership, type of partnership(manufacturing agreement, product / technology licensing, product development, merger / acquisition, research and development agreement, process development / optimization, service alliance, production asset / facility acquisition, supply agreement and others), scale of production (laboratory, clinical and commercial) and type of vector (AAV, adenoviral, lentiviral, retroviral, plasmid and others) most active players (in terms of number of partnerships).

Chapter 13 features an elaborate discussion and analysis of the various expansions that have been undertaken, since 2015. Further, the expansion activities in this domain have been analyzed on the basis of year of expansion, type of expansion (new facility / plant establishment, facility expansion, technology installation / expansion, capacity expansion and others), geographical location of the facility, type of vector (AAV, adenoviral, lentiviral, retroviral, plasmid and others) and application area (gene therapy, cell therapy, vaccine and others).

Chapter 14 highlights potential strategic partners (vector based therapy developers and vector purification product developers) for vector and gene therapy product manufacturers, based on several parameters, such as developer strength, product strength, type of vector, therapeutic area, pipeline strength (clinical and preclinical). The analysis aims to provide the necessary inputs to the product developers, enabling them to make the right decisions to collaborate with industry stakeholders with relatively more initiatives in the domain.

Chapter 15 provides detailed information on other viral / non-viral vectors (including alphavirus vectors, Bifidobacterium longum vectors, Listeria monocytogenes vectors, myxoma virus based vectors, Sendai virus based vectors, self-complementary vectors (improved versions of AAV), and minicircle DNA and Sleeping Beauty transposon vectors (non-viral gene delivery approach)) that are currently being utilized by pharmaceutical players to develop gene therapies, T-cell therapies and certain vaccines, as well. This chapter presents overview on all the aforementioned types of vectors, along with examples of companies that use them in their proprietary products. It also includes examples of companies that are utilizing specific technology platforms for the development / manufacturing of some of these novel vectors.

Chapter 16 presents a collection of key insights derived from the study. It includes a grid analysis, highlighting the distribution of viral vectors and plasmid DNA manufacturers on the basis of their scale of production and purpose of manufacturing (fulfilling in-house requirement / contract service provider). In addition, it consists of a logo landscape, representing the distribution of viral vector and plasmid DNA manufacturers based on the type of organization (industry / non-industry) and company size. The chapter also consists of six world map representations of manufacturers of viral / non-viral vectors (lentiviral, adenoviral, AAV and retroviral vectors, and plasmid DNA), depicting the most active geographies in terms of the presence of the organizations. Furthermore, we have provided a schematic world map representation to highlight the geographical locations of key vector manufacturing hubs across different continents.

Chapter 17 highlights our views on the various factors that may be taken into consideration while pricing viral vectors / plasmid DNA. It features discussions on different pricing models / approaches that manufacturers may choose to adopt to decide the prices of their proprietary products.
Chapter 18 features an informed analysis of the overall installed capacity of the vectors and gene therapy manufacturers. The analysis is based on meticulously collected data (via both secondary and primary research) on reported capacities of various small-sized, mid-sized and large companies, distributed across their respective facilities. The results of this analysis were used to establish an informed opinion on the vector production capabilities of the organizations by company size (small-sized, mid-sized and large), scale of operation (clinical and commercial), type of vector (viral vector and plasmid DNA) and region (North America, Europe, Asia Pacific and the rest of the world).

Chapter 19 features an informed estimate of the annual demand for viral and non-viral vectors, taking into account the marketed gene-based therapies and clinical studies evaluating vector-based therapies. This section offers an opinion on the required scale of supply (in terms of vector manufacturing services) in this market. For the purpose of estimating the current clinical demand, we considered the active clinical studies of different types of vector-based therapies that have been registered till date. The data was analyzed on the basis of various parameters, such as number of annual clinical doses, trial location, and the enrolled patient population across different geographies. Further, in order to estimate the commercial demand, we considered the marketed vector-based therapies, based on various parameters, such as target patient population, dosing frequency and dose strength.

Chapter 20 presents a comprehensive market forecast analysis, highlighting the likely growth of vector and gene therapy manufacturing market till the year 2030. We have segmented the financial opportunity on the basis of [A] type of vectors (AAV vector, adenoviral vector, lentiviral vector, retroviral vector, plasmid DNA and others), [B] applications (gene therapy, cell therapy and vaccine), [C] therapeutic area (oncological disorders, inflammation & immunological diseases, neurological disorders, ophthalmic disorders, muscle disorders, metabolic disorders, cardiovascular disorders and others), [D] scale of operation (preclinical, clinical and commercial) and [E] geography (North America, Europe, Asia Pacific, MENA, Latin America and rest of the world). Due to the uncertain nature of the market, we have presented three different growth tracks outlined as the conservative, base and optimistic scenarios.

Chapter 21 highlights the effect of recent coronavirus outbreak on the vector and gene therapy manufacturing market. It includes a brief discussion on the short-term and long-term impact of COVID-19 on the supply chain and market opportunity for vector and gene therapy manufacturers. In addition, it includes a brief section on strategies and action plans that pharmaceutical and biopharmaceutical companies are likely to adopt in order to prepare for supply chain disruptions in future.

Chapter 22 provides details on the various factors associated with popular viral vectors and plasmid DNA that act as market drivers and the various challenges associated with the production process. This information has been validated by soliciting the opinions of several industry stakeholders active in this domain.

Chapter 23 presents insights from the survey conducted on over 180 stakeholders involved in the development of different types of gene therapy vectors. The participants, who were primarily Director / CXO level representatives of their respective companies, helped us develop a deeper understanding on the nature of their services and the associated commercial potential.

Chapter 24 summarizes the overall report. The chapter presents a list of key takeaways and offers our independent opinion on the current market scenario and evolutionary trends that are likely to determine the future of this segment of the industry.

Chapter 25 is a collection of transcripts of the interviews conducted with representatives from renowned organizations that are engaged in the vector and gene therapy manufacturing domain. In this study, we spoke to Menzo Havenga (Chief Executive Officer and President, Batavia Biosciences), Nicole Faust (Chief Executive Officer & Chief Scientific Officer, CEVEC Pharmaceuticals), Jeffrey Hung (Chief Commercial Officer, Vigene Biosciences), Cedric Szpirer (Founder, Executive & Scientific Director, Delphi Genetics), Olivier Boisteau, (Co-Founder / President, Clean Cells), Laurent Ciavatti (Ex-Business Development Manager, Clean Cells) and Xavier Leclerc (Head of Gene Therapy, Clean Cells), Alain Lamproye (Ex-President of Biopharma Business Unit, Novasep), Joost van den Berg (Ex-Director, Amsterdam BioTherapeutics Unit), Bakhos A Tannous (Director, MGH Viral Vector Development Facility, Massachusetts General Hospital), Eduard Ayuso, DVM, PhD (Scientific Director, Translational Vector Core, University of Nantes), Colin Lee Novick (Managing Director, CJ Partners), Semyon Rubinchik (Scientific Director, ACGT), Astrid Brammer (Senior Manager Business Development, Richter-Helm), Marco Schmeer (Project Manager, Plasmid Factory) and Tatjana Buchholz (Ex-Marketing Manager, Plasmid Factory), Brain M Dattilo (Business Development Manager, Waisman Biomanufacturing), Beatrice Araud (ATMP Key Account Manager, EFS-West Biotherapy) and Nicolas Grandchamp (R&D Leader, GEG Tech)

Chapter 26 is an appendix, which provides tabulated data and numbers for all the figures in the report.

Chapter 27 is an appendix that provides the list of companies and organizations that have been mentioned in the report.

LIST OF COMPANIES
1. 4D Molecular Therapeutics
2. Abbott
3. AbbVie
4. Abeona Therapeutics
5. Abintus Bio
6. Accinov(acquired by ABL Europe)
7. Acucela
8. Adaptimmune Therapeutics
9. AdaptVac
10. Addgene
11. Aduro Biotech
12. Advanced BioScience Laboratories
13. Advanced Biotherapeutics Consulting
14. Advantagene
15. Advaxis
16. Advent
17. Adverum Biotechnologies
18. Aevitas Therapeutics (a subsidiary of Fortress Biotech)
19. AffyImmune Therapeutics
20. AGC Biologics
21. Agenzia Italiana del Farmaco
22. Agilent Technologies
23. Agilis Biotherapeutics (acquired by PTC Therapeutics)
24. Applied Genetic Technologies (AGTC)
25. Ajinomoto Althea
26. Akdeniz University
27. Akron Biotech
28. Aldevron
29. Allele Biotechnology
30. Allergan
31. Allife Medicine
32. Allogene Therapeutics
33. Alma Bio Therapeutics
34. AlphaVax
35. ALSTEM
36. Althea Technologies
37. Altimmune
38. Altor BioScience
39. American Gene Technologies
40. Amgen
41. Amicus Therapeutics
42. Ampersand Capital Partners
43. AMSBIO
44. Amsterdam BioTherapeutics Unit
45. Amsterdam Molecular Therapeutics ( acquired by uniQure)
46. Anaeropharma Science
47. Anemocyte
48. AnGes
49. Angionetics
50. Annapurna Therapeutics ( acquired by Avalanche Biotechnologies)
51. apceth Biopharma
52. ApollobBo
53. Applied Biological Materials
54. Applied Viromics
55. Arcellx
56. ARCO Design/Build
57. ArcticZymes Technologies
58. Areta International
59. Aruvant Sciences
60. ASC Therapeutics
61. Asklepios BioPharmaceutical
62. Astellas Pharma
63. AstraZeneca
64. Atara Biotherapeutics
65. Atlantic Bio
66. Atsena Therapeutics
67. ATVIO Biotech
68. Audentes Therapeutics
69. Aurora Biopharma
70. Autolus Therapeutics
71. Avecia Biologics
72. AveXis
73. AVROBIO
74. Axovant Gene Therapies
75. Bamboo Therapeutics
76. Batavia Biosciences
77. Baylor College of Medicine
78. BCM Families Foundation
79. Beam Therapeutics
80. Beckman Research Institute
81. Beijing Biohealthcare Biotechnology
82. Beijing Doing Biomedical
83. Beijing HuiNengAn Biotech
84. Beijing Immunochina Medical Science & Technology
85. Beijing Mario Biotechnology
86. Beijing Sanwater Biological Technology
87. Bellicum Pharmaceuticals
88. Benitec Biopharma
89. BIA Separations
90. Bioceltech Therapeutics
91. BioCentriq
92. Biogen
93. Bio-Gene Technology
94. BioInvent International
95. BioMarin Pharmaceutical
96. Biomay
97. Biomiga
98. Bionic Sight
99. BioNTech Innovative Manufacturing Service
100. Bio-Rad Laboratories
101. BioReliance
102. BioVec Pharma
103. Bioverativ
104. Biovian
105. BioVision
106. Blue Sky BioServices
107. bluebird bio
108. Boehringer Ingelheim BioXcellence
109. BoYuan RunSheng Pharma
110. Brain Neurotherapy Bio
111. Brammer Bio
112. LNBio
113. Bristol Myers Squibb
114. California Institute of Technology
115. Cambridge Gene Therapy
116. Cancer Research UK
117. Candel Therapeutics
118. Carina Biotech
119. Carmine Therapeutics
120. CARsgen Therapeutics
121. Cartesian Therapeutics
122. Casey Eye Institute
123. Castle Creek Biosciences
124. Catalent Biologics
125. Celgene
126. Cell and Gene Therapy Catapult
127. Cell Biolabs
128. Cellectis
129. CellGenTech
130. Cellular Biomedicine Group
131. CellVec
132. Celonic
133. Celsion
134. Celyad Oncology
135. Center for Breakthrough Medicines
136. Centre for Commercialization of Regenerative Medicine
137. Centre for Process Innovation
138. CEVEC Pharmaceuticals
139. CG Oncology
140. Children’s Medical Research Institute (CMRI)
141. China Immunotech (Beijing) Biotechnology
142. Chongqing Precision Biotech
143. Choroideremia Research Foundation
144. Cincinnati Children's Hospital Medical Center
145. City of Hope
146. Clean Cells
147. Clino
148. Cobra Biologics
149. Cognate BioServices
150. CombiGene
151. Copernicus Therapeutics
152. Cornell University
153. Creative Biogene
154. Creative Biolabs
155. CSL Behring
156. Cytiva
157. CytoMed Therapeutics
158. Daiichi Sankyo
159. Delphi Genetics
160. Denali Therapeutics
161. DINAQOR
162. DNAtrix
163. Duke University
164. Dyno Therapeutics
165. Editas Medicine
166. ElevateBio
167. Elixirgen Scientific
168. Emergent BioSolutions
169. Emory University School of Medicine
170. enGene
171. Epeius Biotechnologies
172. Errant Gene Therapeutics
173. Esteve
174. eTheRNA immunotherapies
175. EUFETS
176. Eureka Biotechnology
177. Eurofins Genomics
178. Eurofins Scientific
179. ExcellGene
180. Exothera
181. Expression Therapeutics
182. Eyevensys
183. Fate Therapeutics
184. FerGene
185. FIMA
186. FinVector
187. Five Prime Therapeutics
188. Flash Therapeutics
189. Flexion Therapeutics
190. Florida Biologix
191. Formula Pharmaceuticals
192. Fortress Biotech
193. Fosun Pharma
194. Foundation Fighting Blindness
195. Fraunhofer Institute for Toxicology and Experimental Medicine
196. Freeline Therapeutics
197. FUJIFILM Diosynth Biotechnologies
198. Fundamenta Therapeutics
199. GE Healthcare Life Sciences
200. GEG Tech
201. Genable Technologies
202. Gene Therapy Research Institution
203. GeneCopoeia
204. GeneCure Biotechnologies
205. GeneDetect
206. GeneImmune Biotechnology
207. Genelux
208. GeneMedicine
209. GeneOne Life Science
210. Genethon
211. GENEWIZ
212. Genexine
213. Genezen Laboratories
214. GenIbet Biopharmaceuticals
215. Genprex
216. GenScript
217. GenSight Biologics
218. GenVec
219. Gen-X
220. Genzyme
221. GeoVax Labs
222. GIGA
223. GlaxoSmithKline
224. Gracell Biotechnologies
225. Gradalis
226. Green Cross LabCell
227. Grousbeck Gene Therapy Center
228. Guangdong Xiangxue Precision Medical Technology
229. Guangdong Zhaotai InVivo Biomedicine
230. Guangzhou Anjie Biomedical Technology
231. Guangzhou FineImmune Biotechnology
232. Gyroscope Therapeutics
233. Hadassah Medical Organization
234. Handl Therapeutics
235. Harvard Gene Therapy Initiative
236. Hebei Senlang Biotechnology
237. Heidelberg University Hospital
238. Helixmith
239. Hemera Biosciences
240. Henan Hualong Biotechnology
241. Herantis Pharma
242. Hitachi Chemical Advanced Therapeutics Solutions
243. Holostem Terapie Avanzate
244. Homology Medicines
245. Hookipa Biotech
246. HORAMA
247. Hrain Biotechnology
248. Huadao biomedical
249. Huapont Life Sciences
250. Human Stem Cells Institute (HSCI)
251. Hunan Zhaotai Yongren Medical Innovation
252. International AIDS Vaccine Initiative (IAVI)
253. Icahn School of Medicine at Mount Sinai
254. iCAR Bio Therapeutics
255. iCarTAB BioMed
256. iCell Gene Therapeutics
257. ID Pharma
258. Ilya Pharma
259. Immatics
260. Immune Design
261. Immune Technology
262. Immunocore
263. Immunomic Therapeutics
264. Imperial Innovations
265. Indiana University
266. Innovative Cellular Therapeutics
267. Inovio Pharmaceuticals
268. InProTher
269. Institute of Medical Science Research Hospital
270. Institute of Translational Health Sciences
271. Instituto de Tecnologia Química e Biológica (ITQB)
272. InvivoGen
273. IPPOX Foundation
274. IVERIC bio
275. Janssen Pharmaceuticals
276. Juno Therapeutics
277. Juventas Cell Therapy
278. JW Therapeutics
279. KAEDI
280. Kaneka Eurogentec
281. Karolinska Institutet
282. Kecellitics Biotech
283. King’s College London
284. Kite Pharma
285. Kobe Biomedical Innovation Cluster
286. Kolon TissueGene
287. Kriya Therapeutics
288. Krystal Biotech
289. Kuur Therapeutics
290. Laboratory of Digital Sciences of Nantes
291. LakePharma
292. Legend Biotech
293. Lentigen Technology
294. Leucid Bio
295. Leuven Viral Vector Core
296. LEXEO Therapeutics
297. Lion TCR
298. Lipigon Pharmaceuticals
299. LogicBio Therapeutics
300. Lokon Pharma
301. Lonza
302. Louisiana State University School of Veterinary Medicine
303. Luina Bio
304. Luminous BioSciences
305. Lund University
306. Lysogene
307. Magee-Womens Research Institute
308. Maine Medical Center Research Institute (MMCRI)
309. Marino Biotechnology
310. Massachusetts Eye and Ear
311. Massachusetts General Hospital
312. MassBiologics
313. MaxCyte
314. Mayflower Bioscience
315. Mayo Clinic Cancer Center
316. MD Anderson Cancer Institute
317. Medac
318. Medigene
319. MedImmune
320. MeiraGTx
321. Memorial Sloan Kettering Cancer Center
322. Merck
323. Microsoft
324. Mila’s Miracle Foundation
325. MilliporeSigma
326. Milo Biotechnology
327. Miltenyi Biotec
328. Minerva Biotechnologies
329. MingJu Therapeutics
330. Mitsubishi Tanabe Pharma
331. Molecular Diagnostic Services
332. MolMed
333. Momotaro-Gene
334. MultiVir
335. Mustang Bio
336. Myeloma Crowd
337. Nanjing Bioheng Biotech
338. Nantes Gene Therapy Institute
339. Naobios
340. National Cancer Institute
341. National Center for Advancing Translational Sciences
342. National Eye Institute
343. National Human Genome Research Institute
344. National Institute of Allergy and Infectious Diseases
345. National Institute of Environmental Health Sciences
346. Nationwide Children's Hospital
347. Nature Technology
348. Naval Medical Research Center
349. Neurimmune
350. NeuroCure
351. Neurophth Therapeutics
352. Neuroscience Center Zurich
353. New Jersey Innovation Institute (NJII)
354. NewLink Genetics
355. NHS Blood and Transplant
356. Nikon CeLL innovation
357. Noga Therapeutics
358. Norgen Biotek
359. Nouscom
360. Novartis
361. Novasep
362. Odylia Therapeutics
363. Okairos
364. Omnia Biologics
365. Oncolys BioPharma
366. OncoSec
367. OncoSenX
368. ORCA Therapeutics
369. Orchard Therapeutics
370. Oregon Health & Science University
371. OS Therapies (OST)
372. Otonomy
373. Oxford BioMedica
374. Oxford Genetics
375. OXGENE
376. OZ Biosciences
377. PACT Pharma
378. Pall Biotech
379. Paragon Bioservices
380. PeriphaGen
381. PersonGen BioTherapeutics
382. Pfizer
383. PharmaCell
384. PhorMed
385. Pinze Lifetechnology
386. PlasmidFactory
387. Poseida Therapeutics
388. Precigen
389. Precision BioSciences
390. Prevail Therapeutics
391. ProBioGen
392. Progenics Pharmaceuticals
393. ProMab Biotechnologies
394. Protheragen
395. Provecs Medical
396. PsiOxus Therapeutics
397. PTC Therapeutics
398. Puresyn
399. Quethera
400. Regeneron Pharmaceuticals
401. REGENXBIO
402. ReiThera
403. Renova Therapeutics
404. Rentschler Biotechnologie
405. Richter-Helm BioLogics
406. Roche
407. Rocket Pharmaceuticals
408. Roswell Park Comprehensive Cancer Center
409. Rubius Therapeutics
410. SAB Technology
411. SAFC
412. Saiba
413. Salk Institute for Biological Studies
414. Sanford Burnham Prebys Medical Discovery Institute
415. Sangamo Therapeutics
416. Sanofi
417. Santen Pharmaceutical
418. Sarepta Therapeutics
419. Sartorius Stedim Biotech
420. Scancell
421. Seattle Children's Research Institute
422. Selecta Biosciences
423. Servier
424. Shanghai Biomed-union Biotechnology
425. Shanghai Bioray Laboratory
426. Shanghai Cell Therapy
427. Shanghai GeneChem
428. Shanghai Longyao Biotechnology
429. Shanghai PerHum Therapeutics
430. Shanghai Sunway Biotech
431. Shanghai Unicar-Therapy Bio-medicine Technology
432. Shenzhen Binde Biotechnology
433. Shenzhen SiBiono GeneTech
434. SignaGen Laboratories
435. SillaJen
436. Simcere Pharmaceutical
437. Sinobioway Cell Therapy
438. SIRION Biotech
439. Solid Biosciences
440. Sorrento Therapeutics
441. Spark Therapeutics
442. SQZ Biotechnologies
443. San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget)
444. St. Jude Children's Research Hospital
445. Stanford University
446. Symbiosis Pharmaceutical Services
447. Synpromics
448. Synthace
449. System Biosciences
450. Takara Bio
451. Takeda Pharmaceutical
452. Targovax
453. TCRCure Biopharma
454. TCR2 Therapeutics
455. tebu-bio
456. Telethon Institute of Genetics and Medicine (TIGEM)
457. Terry Fox Laboratory
458. Tessa Therapeutics
459. The Beijing Pregene Science and Technology
460. Children's Hospital of Philadelphia
461. Hong Kong Institute of Biotechnology
462. The Jenner Institute
463. The Michael J. Fox Foundation
464. The Native Antigen
465. The Pregene (ShenZhen) Biotechnology
466. The University of Tennessee Health Science Center
467. TheraBiologics
468. Theravectys
469. Thermo Fisher Scientific
470. Tianjin Mycure Medical Technology
471. Timmune Biotech
472. Tmunity Therapeutics
473. Tolerion
474. Touchlight Genetics
475. Transgene
476. Treeway
477. Trizell
478. Twist Bioscience
479. TxCell
480. UC Davis
481. UK Cystic Fibrosis Gene Therapy Consortium
482. Ultragenyx Pharmaceutical
483. uniQure
484. Universitat Autònoma de Barcelona-Vall d'Hebrón Institut de Recerca
485. University College London
486. University Medical Center Groningen
487. University of Adelaide
488. University of Eastern Finland
489. University of Florida
490. University of Iowa Carver College of Medicine
491. University of Massachusetts Medical School
492. University of Michigan Medical Center
493. University of Minnesota
494. University of North Carolina
495. Clinical BioManufacturing Facility (University of Oxford)
496. University of Pennsylvania
497. University of Pittsburgh
498. University of South Carolina School of Medicine
499. University of Southampton
500. University of Tokyo
501. University of Virginia School of Medicine
502. Unum Therapeutics (now Cogent Biosciences)
503. Urovant Sciences
504. UC San Diego School of Medicine
505. USC School of Pharmacy
506. UWELL Biopharma
507. Vaccine Manufacturing and Innovation Centre (VMIC)
508. Vaccitech
509. VBL Therapeutic
510. VCN Biosciences
511. Vector Biolabs
512. Vecura
513. VGXI
514. Vibalogics
515. Vical
516. Vigene Biosciences
517. Vineti
518. The Jackson Laboratory
519. Viralgen
520. Virapur
521. ViraQuest
522. ViroMed
523. Virovek
524. VirusTech
525. VIVEbiotech
526. Voyager Therapeutics
527. Waisman Biomanufacturing
528. Washington University School of Medicine
529. Wellington Zhaotai Therapies
530. Wuhan Bio-Raid Biotechnology
531. Wuhan Sian Medical Technology
532. WuXi AppTec
533. Wyvern Pharmaceuticals
534. Yufan Biotechnology
535. Xiangxue Life Sciences
536. Xpress Biologics
537. XyloCor Therapeutics
538. Xyphos Biosciences
539. Yake Biotechnology
540. Yposkesi
541. Ziopharm Oncology