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Pharmaceutical Spray Drying Market (2nd Edition), 2018-2028

Pharmaceutical Spray Drying Market (2nd Edition), 2018-2028

The origins of spray drying can be traced back to 1872, when the first patent related to the technique was registered in the US. The first commercial use of this form of drying was reported in the 1920s when powdered milk was introduced into the market. Spray drying, which is already established in the food and chemical sector, is also considered to be a rapid, cost-effective, and scalable process for the production of dry powder formulations of pharmacological material. Owing to characteristics, such as reproducibility and its continuous mode of operation, the technique has become very popular in the pharmaceutical and biotechnology industry. It offers several advantages over alternate drying technologies, such as lyophilization (characterized by high dependence on cold chain for storage and logistics, which is prone to failure due to human error) and vacuum foam drying (characterized by volumetric restrictions due to the properties of foam, which limits the quantity of sample that can be dried in a single run) that are currently deployed in the pharmaceutical industry.

Amongst other merits, spray drying is known to be suitable for drying heat-sensitive products such as biologics. Moreover, this method imparts improved properties to the formulations that can be administered through more efficient and less invasive modes of delivery, such as oral, and inhalation routes. The technology also aids in improving the compression properties of drugs, allowing developers to design concentrated dose variants of medications and reduce tablet size. Such alterations have the potential to improve patient compliance. Given the flexibility offered in terms of drug development and formulation, the economics of the technique, the introduction of aseptic methods, and the recent approval of the first spray dried biologic, Raplixa®, the adoption of spray drying is anticipated to increase steadily in the pharmaceutical industry.

SCOPE OF THE REPORT
The ‘Pharmaceutical Spray Drying Market (2nd Edition), 2018-2028’ report provides an extensive study on the use of spray drying in the pharmaceutical sector. The key focus of the report is primarily to estimate the future potential of spray drying in the manufacturing of APIs, inhalables, injectables, biologics and other pharmaceutical products. The study presents an in-depth analysis of a diverse set of companies that provide spray drying equipment and services across different regions of the globe. Amongst other elements, the report includes:

A detailed discussion the applications of spray drying in the pharmaceutical industry; these include enhancement of solubility and bioavailability, formulation of inhalables, taste masking, development of controlled release formulations, and aseptic production of biopharmaceuticals.

An assessment of the various players that are engaged in the manufacturing of spray dryers used in the pharmaceutical industry, including a detailed analysis of their products based on inlet temperature, type of nozzle (fluid, pressure, rotary disc, centrifugal and others), size of the dryer (lab, clinical and commercial) and atomizing gas (air, nitrogen and inert gases).

An overview of the current market landscape of spray drying service providers, featuring an analysis based on the location of their operating facilities, type of spray dryers used, scale of operation (lab, clinical and commercial), information on cGMP status of their facilities and availability of fill / finish services.

An insightful 2X2 analysis of different spray drying service providers. This analysis is based on the spray drying capabilities (represented in terms of number of manufacturing sites, scale of operation and the types of spray dryers used) and the company size. In addition, similar analysis has been done to compare the spray dryer manufacturers. This assessment is based on the company’s spray drying portfolio (number of spray dryers offered and availability of spray drying services), company’s year of establishment and the geographical coverage of its client base.

Tabulated profiles of the players offering spray drying services, featuring company overview, service portfolio, spray dryers used, and key developments related to its spray drying capabilities.

Detailed profiles of spray dryer manufacturers, featuring an overview of the company, its financial information (if available), types of spray dryers in their respective product portfolios, recent developments and a comprehensive future outlook.

A case study on the lyophilization of biologics, highlighting the underlying process, its applications, and merits and demerits. It features a detailed list of companies offering lyophilization services with information on location of facilities, types of drug candidates lyophilized, scale of operation and the containment systems utilized for such operations.

A detailed analysis of the mergers and acquisitions that have taken place in this space, highlighting the trend in the number of companies acquired in the last few years, along with the geographical distribution of this activity. The analysis highlights the ownership change matrix and presents financial evaluation of these deals (revenues and respective deal multiples).

A detailed discussion on affiliated trends, key drivers and challenges, under a SWOT framework.

One of the key objectives of the report was to understand the primary growth drivers and estimate the future size of the market. Based on parameters, such as trends in the pharmaceutical contract manufacturing industry, operation costs associated with spray drying and the challenges and opportunities presented by this technique, we have provided an informed estimate of the likely evolution of the market in the long term, for the period 2018-2028. In addition, we have provided insights on the likely regional evolution of the market in North America, Europe, Asia Pacific and the rest of the world. It also includes estimates regarding the likely distribution of the market based on type of industry (pharmaceuticals and biologics) and type of nozzles used in spray dryers (fluid nozzle, pressure nozzle, rotary disc atomizer, centrifugal nozzle, and others). In order to account for the uncertainties associated with some of the key parameters and to add robustness to our model, we have presented three different forecast scenarios, depicting conservative, base and optimistic tracks of the market’s evolution.

The research, analysis and insights presented in this report is backed by a deep understanding of insights gathered both from secondary and primary sources. The opinions and insights presented in this study were influenced by discussions conducted with several key players in this domain. The report features detailed transcripts of interviews held with the following key opinion leaders:
1. Sam de Costa (Stabilization Projects Manager, Nova Laboratories)
2. Manuel Leal (Business Development Director, Idifarma)
3. Anonymous (Founder, India based Manufacturer)
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.

EXAMPLE HIGHLIGHTS
1. Over 50 companies are offering spray drying services for pharmaceutical products. At present, the market is highly fragmented and features a mix of established companies (>500 employees, 48%), mid-sized companies (51-500 employees, 27%) and small-sized companies (<50 employees, 25%). Of the total number of service providers, 26 companies offer spray drying services at all three (laboratory, clinical and industrial) scales of operation. Examples of these companies include (in alphabetical order, no selection criteria) Catalent Pharma Solutions, Evotec, Patheon, Pulse Combustion Systems and Siegfried.

2. The market is also characterized by presence of over 20 manufacturers that have, so far, developed 86 spray dryers for use in the pharmaceutical industry. Of these, 35% of companies are established players, 30% are mid-sized companies and 35% are small-sized companies. Majority of the spray dryers being developed by these manufacturers (38%) use a fluid nozzle (particularly 2-fluid nozzles), while others use rotary disc atomizers (8%), and centrifugal (7%) and pressure nozzles (7%). Interestingly, the rest of the spray dryers are compatible with multiple nozzle types.

3. With respect to maximum inlet temperature, most of the spray dryers (48%) can operate at temperatures ranging from 151◦C to 250◦C. Around 11% of the dryers have maximum inlet temperatures of more than 350◦C. Of all the systems that we identified, 70% use air as the atomizing gas. However, in the rest (30%) of the spray dryers, the mode of operation is aseptic and is carried out in a closed loop configuration, using nitrogen or other inert gases.

4. A significant number of companies (close to 70% of the facilities captured in our database) offering pharmaceutical spray drying services are based in North America and Europe. Notable examples of mid-sized and small-sized players based in North America and the US include (in alphabetical order) Coriolis Pharma, Formurex, Leukocare, North Star Processing, Norwich Pharmaceuticals, Nova Laboratories, PacMoore, Richman Chemical, Spray-Tek, Summit Custom Spray Drying, Ufag Laboratorien, Upperton and Vectura. Within Europe, majority of the contract service providers are located in Italy, Germany, France, Spain and the UK. Examples of established players that have business operations in these geographies include (in alphabetical order) AMRI Global, Capsugel (now a part of Lonza), Catalent Pharma Solutions, Juniper Pharma Services and Siegfried. Asia Pacific has 25% of the players offering spray drying services for pharmaceuticals, while 6% of service providers are based in Africa, Latin America, South America and rest of the world.

5. Several CMOs (close to 30) have installed spray dryers developed by GEA Niro in their facilities. Amongst the 15 types of spray dryers offered by GEA Niro, its PSD and GEA Niro Mobile Minor™ models are most commonly used. In addition, spray dryers developed by Buchi (B-290 and B-90 models) are being used by a number of service providers. Spray dryers offered by SPX and ProCepT are also gaining popularity amongst the service providers.

6. We expect the pharmaceutical spray drying services market to grow at an annualized rate of ~20% between 2018 and 2028. North America (primarily US) and Europe currently capture the largest market share (close to 70%) in the spray drying contract services market. This is followed by Asia Pacific and rest of the world. Markets in Asia-Pacific are expected to grow at a relatively higher CAGR owing to inherent advantages such as relatively low labor costs and less stringent regulatory constraints.

7. The current market is driven, to a large extent (over 80%), by pharmaceutical products (such as APIs and intermediate products). The future advances will be jointly led by the steady rise of the biopharmaceuticals’ market; emergence of new technologies / applications is likely to provide the necessary impetus to fuel this growth.

RESEARCH METHODOLOGY
The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and technology segments. Where possible, the available data has been checked for accuracy from multiple sources of information.

The secondary sources of information include
Annual reports
Investor presentations
SEC filings
Industry databases
News releases from company websites
Government policy documents
Industry analysts’ views

While the focus has been on forecasting the market till 2028, the report also provides our independent view on various trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.

CHAPTER OUTLINES
Chapter 2 provides an executive summary of the insights captured in our research. It offers a high-level view on the likely evolution of the spray drying market in the long term.

Chapter 3 provides an introduction to the spray drying approach, including a detailed discussion on the principle / process of spray drying, highlighting the key steps associated with the process. It highlights the important applications of the technique and the various features that distinguish it from alternative drying technologies. The chapter also features a discussion on the various advantages and limitations associated with spray drying.

Chapter 4 provides an overview of the applications of spray drying in the pharmaceutical industry, from generation of extremely fine particles for pulmonary administration to large agglomerated powders for oral formulations. Specifically, the different applications discussed in the chapter include enhancement of solubility and bioavailability, formulation of inhalables, taste masking, development of controlled release formulations, and aseptic production of biopharmaceuticals.

Chapter 5 includes a comprehensive market overview, featuring information on various types of spray dryers used in the pharmaceutical industry. It provides information on their respective manufacturers (company size and year of establishment) and presents an analyses of spray dryers on the basis of inlet temperature, type of nozzle (fluid, pressure, rotary disc and others) used, size of the unit (lab, clinical and commercial), and atomizing gas (air, nitrogen and inert gases) used. Further, the chapter includes a discussion on companies that offer pharmaceutical spray drying services. It presents an analysis of various spray drying service providers on the basis of the geographical location of their facilities, scale of operation (lab, clinical and commercial) and information on cGMP statuses of their facilities.

Chapter 6 presents the key insights derived from the study. It features detailed 2X2 matrices, comparing the spray drying capabilities and the supplier power of different spray drying service providers. A similar analysis comparing the spray dryer portfolio and the establishment year of different manufacturers of spray dryers, is also included in the chapter. In addition, the chapter features a comprehensive geographical landscape analysis, which highlights the spray drying activity across the globe, in terms of presence of both manufacturers and service providers.

Chapter 7 features tabular profiles of the most active service providers (as identified in chapter 6) in the pharmaceutical industry. It highlights the expertise of these players in terms of their spray drying capabilities. Each profile provides a brief overview of the company, highlighting its employee strength (if available), its product / service portfolio, spray dryers used (if available) and the key developments related to spray drying (if available).

Chapter 8 provides detailed profiles of the most active spray dryer manufacturers (as identified in chapter 6) in the pharmaceutical industry. Each profile provides a brief overview of the company, its financial information (if available), its portfolio of spray dryers, recent developments, and a comprehensive future outlook.

Chapter 9 features a case study on lyophilization of biologics, the key competing technique to spray drying. The chapter elaborates on the steps involved in lyophilization, and lyophilization cycle development and optimization. It includes an exemplary list of service providers offering lyophilization services with information on location of facilities, type of drug candidates lyophilized, scale of operation and the containment systems utilized for such operations.

Chapter 10 presents a detailed analysis of the mergers and acquisitions that have taken place within this industry. The chapter highlights the information on the acquiring and the acquired company (headquarters and the ownership (public / private)), along with the year of acquisition, acquiring amount (if available), and the financial status of the acquired company, at the time of acquisition. It features a detailed ownership change matrix depicting the distribution of mergers and acquisitions across private firms, public firms and sole proprietorships. It also includes an evaluation of the financials of these deals (revenues of the acquired firms at the time of acquisition and their respective deal multiples).

Chapter 11 presents a comprehensive market forecast analysis, highlighting the future potential of the spray drying services market till the year 2028. The chapter also presents detailed market segmentation on the basis of geographical regions (North America, Europe, Asia Pacific and the rest of the world), type of industry (pharmaceuticals and biologics), and type of nozzles used in spray dryers (fluid nozzle, pressure nozzle, rotary disc atomizer, centrifugal nozzle and others).

Chapter 12 presents a detailed analysis capturing the key parameters and trends that are likely to influence the future of the spray drying market, under a comprehensive SWOT framework. The chapter also features a schematic Harvey ball analysis to highlight the relative impact of each SWOT parameter on the overall market.

Chapter 13 is a summary of the overall report. In this chapter, we have provided a list of the key takeaways from the report, and expressed our independent opinion related to the research and analysis described in the previous chapters.

Chapter 14 is a collection of transcripts of interviews held with key stakeholders in this market. In this chapter, we have presented the details of our conversations with Sam de Costa (Stabilisation Projects Manager, Nova Laboratories), Manuel Leal (Business Development Director, Idifarma), Anonymous (Founder, India based Manufacturer).

Chapter 15 is an appendix, which provides tabulated data and numbers for all the figures included in the report.

Chapter 16 is an appendix, which contains the list of companies and organizations mentioned in the report.

LIST OF COMPANIES AND ORGANIZATIONS

The following companies and organizations have been mentioned in the report:

1. Acmefil Engineering Systems
2. Advanced Drying Systems
3. Aesica Pharmaceuticals
4. Agere Pharmaceuticals
5. Aizant Drug Research Solutions
6. Ajinomoto
7. Albion Manufacturing
8. Alembic Pharmaceuticals
9. Almac Group
10. Althea Technologies
11. Amatsigroup
12. AMRI
13. Anhydro
14. Anteco Pharma
15. Aptuit
16. Aridis Pharmaceuticals
17. Arrake
18. Ascendia Pharmaceuticals
19. Ashland Specialty Ingredients
20. Astron Research
21. Axcellerate Pharma
22. Balchem
23. BASF Pharma Solutions
24. Baxter
25. BEC Chemicals
26. Bend Research
27. Berkshire Sterile Manufacturing
28. BETE Fog Nozzle
29. Bharat Serum and Vaccines
30. Bio-Botanica
31. Biocon
32. BioConnection
33. BioDuro
34. Biopharma Technology
35. Biotech Investment Group
36. BioXcellence
37. BioZed Engineering
38. Birla Institute of Technology and Science
39. Boehringer Ingelheim
40. Botanic Innovations
41. Bovogen Biologicals
42. Büchi Labortechnik
43. Capsugel
44. Catalent Pharma Solutions
45. CEPiA Sanofi
46. ChangZhou Lemar Drying Engineering
47. CinnaGen
48. Cipla
49. Claris Lifesciences
50. Consort Medical
51. Cook Pharmica
52. Coriolis Pharma
53. DisperSol Technologies
54. Dr. Reddy's Laboratories
55. Dry Tech India
56. Drytec Contract Processing
57. Earthrise Nutritionals
58. East India Pharmaceutical
59. Eli Lilly
60. Emergent BioSolutions
61. European SprayDry Technologies
62. Eurotherm
63. Evonik Industries
64. Evotec
65. Exquiron
66. FAMAR
67. FDC
68. Formex
69. Formurex
70. Foundation for Revitalisation of Local Health Traditions
71. Fuji Chemical Industries
72. G-Con Manufacturing
73. GEA Niro
74. General Spray Drying Services
75. Gen-Plus
76. GlaxoSmithKline
77. Glenmark Pharmaceuticals
78. Green Ridge Consulting
79. Hemraj
80. Hindustan Unilever
81. Hovione
82. Idifarma Desarrollo Farmacéutico
83. Indiana Group
84. Indofil Industries
85. Intas Pharmaceuticals
86. International Specialty Products
87. Intran Technologies
88. Iran Panam
89. Italian Ceram
90. Janssen Pharmaceuticals
91. Jetpharma
92. Jay Instruments and Systems
93. Jubilant Life Sciences
94. Juniper Pharmaceuticals
95. Kelkar Education Trust's Scientific Research Centre
96. Kuecept
97. L A B International
98. Labplant
99. Labultima Process Technologies
100. Legacy BioDesign
101. Lesaffre Ingredients Services
102. LEUKOCARE
103. Lipomize
104. Liquidia Technologies
105. Lonza
106. LSNE Contract Manufacturing
107. Lubrizol
108. Lupin Pharmaceuticals
109. LYOCONTRACT
110. Lyofal
111. Lyophilization Technology
112. Medreich
113. Meggle Pharma
114. Metrics Contract Services
115. Microchem Silliker
116. Micromacinazione
117. Micro-Sphere
118. MINAKEM
119. Juniper Pharmaceuticals
120. Muskat-Plyus
121. Mycenax Biotech
122. NanoMaterials Technology
123. New AVM Systech
124. North Star Processing
125. Norwich Pharma Services
126. Nova Laboratories
127. Novartis
128. Ohkawara Kakohki
129. Omega Flavour Technology
130. OmniActive Health Technologies
131. OmniChem
132. Orbite Technologies
133. PacMoore
134. Panacea Biotec
135. Particle Sciences
136. PATH
137. Patheon
138. Pawana Engineering Projects
139. BV Patel Pharmaceutical Education and Research Development Centre
140. Pfizer
141. Pharma Spray Drying
142. Pharmachem Laboratories
143. PharmaForm
144. Pharmatek Laboratories
145. Pharmaterials
146. Piramal Pharma Solutions
147. Plant Lipids
148. Proalgen Biotech
149. ProCepT
150. Pulse Combustion Systems
151. Quality Bioresources
152. Quay Pharma
153. Quest Life Sciences
154. Quotient Sciences
155. Raj Process Equipments And Systems
156. Ranbaxy Laboratories
157. Reliance Industries
158. Richman Chemical
159. Roche
160. Samsung BioLogics
161. Sandoz
162. Siegfried
163. Shungeng Drying Equipment
164. Siam Bioscience
165. SiccaDania
166. Solvias
167. Sono-Tek
168. Spray Drying Systems
169. Spray-Tek
170. SPX FLOW
171. StemProtein
172. Sulphur Mills
173. Summit Custom Spray Drying
174. Sun Pharmaceutical Industries
175. Symbiotec Pharmalab
176. Synthite Industrial Chemicals
177. Takeda Pharmaceutical
178. Techni Process
179. Technical University of Denmark
180. Tecpro Australia
181. TEFIC BIOTECH
182. Temmler
183. The Himalaya Drug Company
184. Themis Laboratories
185. Toption Instrument
186. Torrent Pharmaceuticals
187. UFAG LABORATORIEN
188. Unitop Chemicals
189. Upperton Pharma Solutions
190. USV
191. Vectura Group
192. Veer Narmad South Gujarat University
193. Vetter Pharma
194. Wannemacher Total Logistics
195. Wockhardt Research Centre
196. WuXi AppTec
197. XEDEV
198. Xi'an Hongchang Pharmaceuticals
199. Zydus Cadila


1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. The Spray Drying Process
3.1.1. Feed Preparation
3.1.2. Atomization
3.1.3. Feed Drying
3.1.4. Separation of the Powder, Cooling and Packaging
3.2. Applications of Spray Drying
3.3. Spray Drying of Biopharmaceuticals
3.4. Alternatives to Spray Drying
3.4.1. Lyophilization
3.4.2. Spray Freeze Drying
3.4.3. Atmospheric Spray Freeze Drying
3.4.4. Vacuum Foam Drying
3.5. Advantages and Limitations of Spray Drying
4. SPRAY DRYING: KEY APPLICATIONS IN THE PHARMACEUTICAL INDUSTRY
4.1. Chapter Overview
4.2. Enhancement of Solubility and Bioavailability
4.3. Distribution of Particle Size of Inhalable Drugs
4.4. Modified Release and Taste Masking
4.5. Aseptic Production of Pharmaceuticals
5. PHARMACEUTICAL SPRAY DRYING: MARKET OVERVIEW
5.1. Chapter Overview
5.2. Pharmaceutical Spray Dryers: List of Manufacturers
5.2.1. Distribution by Type of Nozzles
5.2.2. Distribution by Inlet Temperature
5.2.3. Distribution by Atomizing Gas
5.2.4. Key Manufacturers
5.3. Pharmaceutical Spray Drying: Service Providers
5.3.1. Distribution by Scale of Operation
5.3.2. Distribution by cGMP Availability
6.3.3. Popularly Used Spray Dryers
5.4. Pharmaceutical Spray Drying: Companies with In-house Facilities
5.5. Pharmaceutical Spray Drying: Companies Involved in Bioavailability Enhancement
6. SPRAY DRYING SERVICE AND EQUIPMENT PROVIDERS: COMPETITIVE LANDSCAPE
6.1. Chapter Overview
6.2. Pharmaceutical Spray Drying Service Providers: Competitive Landscape
6.3. Pharmaceutical Spray Dryer Manufacturers: Competitive Landscape
6.4. Pharmaceutical Spray Drying: Geographical Landscape
7. SPRAY DRYING SERVICE PROVIDERS: COMPANY PROFILES
7.1. Chapter Overview
7.2 Ajinomoto (Omnichem)
7.3. Almac Group
7.4. Biotech Investment Group (Formex)
7.5. Catalent Pharma Solutions
7.6. Coriolis Pharma
7.7. Evotec
7.8. Fuji Chemical Industry
7.9. Hovione
7.10. Idifarma
7.11. Lonza (Capsugel / Bend Research)
7.12. Micro-Sphere
7.13. Nova Laboratories
7.14. Patheon (Agere Pharmaceuticals)
7.15. Pulse Combustion Systems
7.16. Richman Chemical
7.17. Siegfried
7.18. Upperton
8. SPRAY DRYER MANUFACTURERS: COMPANY PROFILES
8.1. Chapter Overview
8.2. Buchi Labortechnik
8.2.1. Company Overview
8.2.2. Portfolio of Spray Dryers and Services
8.2.3. Recent Developments
8.2.4. Future Outlook
8.3. GEA Niro
8.3.1. Company Overview
8.3.2. Financial Information
8.3.3. Portfolio of Spray Dryers and Services
8.3.4. Recent Developments
8.3.5. Future Outlook
8.4. Hemraj India
8.4.1. Company Overview
8.4.2. Portfolio of Spray Dryers
8.4.3. Future Outlook
8.5. SPX (SPX FLOW)
8.5.1. Company Overview
8.5.2. Financial Information
8.5.3. Portfolio of Spray Dryers
8.5.4. Future Outlook
8.6. Techni Process
8.6.1. Company Overview
8.6.2. Portfolio of Spray Dryers
8.6.3 Future Outlook
8.7. Labultima
8.7.1. Company Overview
8.7.2. Portfolio of Spray Dryers
8.7.3 Future Outlook
8.8. Other Manufacturers
8.8.1. Advanced Drying Systems
8.8.2. ProCepT
8.8.3. Raj Process Equipments
8.8.4. Spray Drying Systems (SDS)
9. CASE STUDY ON THE KEY COMPETING STRATEGY: LYOPHILIZATION
9.1. Chapter Overview
9.2. Historical Background
9.3. Underlying Principle
9.4. Equipment
9.5. Advantages and Disadvantages
9.6. Applications of Lyophilization
9.6.1. Pharmaceutical and Biotechnology Industry
9.6.2. Food Industry
9.6.3. Microbiology
9.6.4. Chemical Industry
9.6.5. Dairy Industry
9.6.6. Nutraceutical Industry
9.6.7. Floral Lyophilization
9.6.8. Other Applications
9.7. Lyophilization Process for Biopharmaceuticals
9.7.1. Formulation and Filling
9.7.2. Freezing
9.7.3. Primary Drying
9.7.4. Secondary Drying
9.8. Lyophilization Service Providers for Biopharmaceuticals
10. MERGERS AND ACQUISITIONS
10.1. Chapter Overview
10.2. Pharmaceutical Spray Drying: Mergers and Acquisitions
10.2.1. Year-wise Trend
10.2.2. Geographical Activity
10.2.3. Ownership Change Matrix
10.3. Key Acquisitions: Deal Multiples
11. MARKET SIZING AND FORECAST
11.1. Chapter Overview
11.2. Forecast Methodology
11.3. Pharmaceutical Spray Drying Services Market, 2018-2028 (USD Billion)
11.4. Pharmaceutical Spray Drying Services Market, 2018-2028: Distribution by Product Type (Pharmaceuticals / Biologics) (USD Billion)
11.5. Pharmaceutical Spray Drying Services Market, 2018-2028: Distribution by Region (USD Billion)
11.5.1. Pharmaceutical Spray Drying Services Market: North America (USD Billion)
11.5.2. Pharmaceutical Spray Drying Services Market: Europe (USD Billion)
11.5.3. Pharmaceutical Spray Drying Services Market: Asia Pacific and Rest of the World (USD Billion)
11.6. Pharmaceutical Spray Drying Services Market, 2018-2028: Distribution by Type of Nozzle (USD Billion)
12. SWOT ANALYSIS
12.1. Chapter Overview
12.2. Strengths
12.3. Weaknesses
12.4. Opportunities
12.5. Threats
12.6. Concluding Remarks
13. CONCLUSION
13.1. Given its Benefits Over Alternative Formulation Technologies, the Applications of Spray Drying Are Likely to Increase in the Pharmaceutical and Biotechnology Sector
13.2. Several Stakeholders with Spray Drying Capabilities Have Established their Presence Across Different Regions; North America and Europe have Emerged as Key Hubs
13.3. Players are Actively Procuring Spray Drying Facilities and Capabilities; This is Evident From the Number of Acquisitions that have Recently Taken Place
13.4 Advanced Technologies, such as Aseptic Spray Drying, Are Expected to Positively Impact the Future Adoption
13.5. Despite Various Challenges and Competition from Legacy Drying Technologies, the Market is Anticipated to Grow at an Annualized Rate of 17% Between 2018 and 2028
14. EXECUTIVE INSIGHTS
14.1. Chapter Overview
14.2. Manuel Leal, Business Development Director, Idifarma
14.3. Sam De Costa, Stabilisation Projects Manager, Nova Laboratories
14.4. Anonymous, Founder, Mid-sized India Based Spray Dryer Manufacturer
15. APPENDIX 1: TABULATED DATA
16. APPENDIX 2: LIST OF COMPANIES
LIST OF FIGURES
Figure 3.1 Spray Drying: A Schematic View of Equipment
Figure 3.2 Spray Drying: Key Steps Involved in the Process
Figure 3.3 Spray Drying: Advantages and Limitations
Figure 4.1 Spray Drying: Key Applications in Pharmaceutical Industry
Figure 4.2 Biopharmaceutics Classification System
Figure 4.3 Dispersion Mechanism for Inhalable Nanoparticles
Figure 5.1 Pharmaceutical Spray Dryers: Distribution by Type of Nozzles
Figure 5.2 Pharmaceutical Spray Dryers: Distribution by Inlet Temperature
Figure 5.3 Pharmaceutical Spray Dryers: Distribution by Atomizing Gas
Figure 5.4 Pharmaceutical Spray Dryers: Key Manufacturers
Figure 5.5 Pharmaceutical Spray Drying Service Providers: Distribution by Scale of Operation
Figure 5.6 Pharmaceutical Spray Drying Service Providers: Distribution by cGMP Availability
Figure 5.7 Pharmaceutical Spray Drying Service Providers: Popularly Used Spray Dryers
Figure 6.1 Pharmaceutical Spray Drying Service Providers: Competitive Landscape
Figure 6.2 Pharmaceutical Spray Dryer Manufacturers: Competitive Landscape
Figure 6.3 Pharmaceutical Spray Drying Capabilities: Geographical Landscape
Figure 8.1 Buchi: Annual Revenues, 2012- 2017 (EUR Billion)
Figure 8.2 GEA Niro: Annual Revenues, 2012- 2017 (USD Billion)
Figure 8.3 SPX: Annual Revenues, 2012- 2017 (USD Billion)
Figure 9.1 Lyophilization: Historical Timeline
Figure 9.2 Phase Diagram of Water
Figure 9.3 Sublimation of Ice Crystals
Figure 9.4 Components of a Lyophilizer
Figure 9.5 Applications of Lyophilization
Figure 9.6 Formulation and Filling of Biopharmaceuticals: Key Steps
Figure 9.7 Freezing of Biopharmaceuticals: Key Steps
Figure 10.1 Pharmaceutical Spray Drying Mergers and Acquisitions: Year-Wise Trend
Figure 10.2 Pharmaceutical Spray Drying Mergers and Acquisitions: Geographical Activity
Figure 10.3 Pharmaceutical Spray Drying Mergers and Acquisitions: Distribution by Local and International Acquisitions
Figure 10.4 Pharmaceutical Spray Drying Mergers and Acquisitions: Ownership Change Matrix
Figure 11.1 Pharmaceutical Spray Drying Services Market, 2018-2028: Base Scenario (USD Billion)
Figure 11.2 Pharmaceutical Spray Drying Services Market, 2018, 2023, 2028: Distribution by Product Type (Pharmaceuticals / Biologics), (USD Billion)
Figure 11.3 Pharmaceutical Spray Drying Services Market, 2018, 2023 and 2028: Distribution by Region
Figure 11.5 Pharmaceutical Spray Drying Services Market, 2018-2028: North America, Base Scenario (USD Billion)
Figure 11.6 Pharmaceutical Spray Drying Services Market, 2018-2028: Europe, Base Scenario (USD Billion)
Figure 11.7 Pharmaceutical Spray Drying Services Market, 2018-2028: Asia Pacific and Rest of the World, Base Scenario (USD Billion)
Figure 11.8 Pharmaceutical Spray Drying Services Market, 2018-2028: Distribution by Type of Nozzle, Base Scenario (USD Billion)
Figure 12.1 Pharmaceutical Spray Drying Market: SWOT Analysis
Figure 12.2 Pharmaceutical Spray Drying Market: Comparison of SWOT Factors, Harvey Ball Analysis
Figure 13.1 Pharmaceutical Spray Drying Services Market: 2018, 2022 and 2028 (USD Billion)
LIST OF TABLES
Table 3.1 Types of Atomizers Used in Spray Dryers
Table 3.2 Spray Dryers: Modes of Operation
Table 3.3 Comparison of Spray Drying and Lyophilization
Table 3.4 Comparison of Spray Drying and Spray Freeze Drying
Table 4.1 Examples of Spray Dried Drugs for Improved Solubility and Bioavailability
Table 4.2 Examples of Spray Dried Inhalation Drugs
Table 4.3 Polymers Used for Drug Encapsulation
Table 4.4 Polymers Used for Controlled and Immediate Release
Table 4.5 Examples of Spray Dried Drugs for Taste Masking
Table 5.1 Pharmaceutical Spray Drying Service Providers: Capabilities
Table 5.2 Pharmaceutical Spray Dryer Manufacturers: Competitive Landscape
Table 5.3 Pharmaceutical Spray Drying Manufacturers and Service Providers: Geographical Distribution
Table 6.1 Pharmaceutical Spray Dryers: List of Manufacturers
Table 6.2 Pharmaceutical Spray Drying: List of Service Providers
Table 6.3 Pharmaceutical Spray Drying Service Providers: Scale of Operation
Table 6.4 Pharmaceutical Spray Drying: Companies with In-house Facilities
Table 6.5 Pharmaceutical Spray Drying: Companies Involved in Bioavailability Enhancement
Table 7.1 Pharmaceutical Spray Drying Service Providers: List of Companies Profiled
Table 7.2 Company Profile: Ajinomoto (Omnichem)
Table 7.3 Company Profile: Almac Group
Table 7.4 Company Profile: Biotech Investment Group (Formex)
Table 7.5 Company Profile: Catalent Pharma Solutions
Table 7.6 Company Profile: Coriolis Pharma
Table 7.7 Company Profile: Evotec (Aptuit / Kuecept)
Table 7.8 Company Profile: Fuji Chemical Industry
Table 7.9 Company Profile: Hovione
Table 7.10 Company Profile: Idifarma
Table 7.11 Company Profile: Lonza (Capsugel / Bend Research)
Table 7.12 Company Profile: Micro-Sphere
Table 7.13 Company Profile: Nova Laboratories
Table 7.14 Company Profile: Patheon (Agere Pharmaceuticals)
Table 7.15 Company Profile: Pulse Combustion Systems
Table 7.16 Company Profile: Richman Chemical
Table 7.17 Company Profile: Siegfried
Table 7.18 Company Profile: Upperton
Table 8.1 Pharmaceutical Spray Dryer Manufacturers: List of Companies Profiled
Table 8.2 Buchi Labortechnik Spray Dryers Portfolio: Key Features
Table 8.3 Buchi Spray Dryers: Clients
Table 8.4 GEA Spray Dryers Portfolio: Key Features
Table 8.5 GEA Spay Drying Services: Clients
Table 8.6 Hemraj India Spray Dryers Portfolio: Key Features
Table 8.7 Hemraj India: Clients
Table 8.8 SPX Spray Dryers Portfolio: Key Features
Table 8.9 SPX: MicraSpray Dryer Models
Table 8.10 Labultima Portfolio: Key Features
Table 8.11 Labultima Spay Drying Services: Clients
Table 8.12 Advanced Drying Systems Spray Dryers Portfolio: Key Features
Table 8.13 SDS Spray Dryers Portfolio: Key Features
Table 9.1 Lyophilization: Advantages and Disadvantages
Table 9.2 List of Lyophilization Service Providers for Biopharmaceuticals
Table 9.3 Lyophilization Service Providers for Biopharmaceuticals: Type of Biopharmaceuticals Lyophilized
Table 9.4 Lyophilization Service Providers for Biopharmaceuticals: Scale of Operation
Table 10.1 Pharmaceutical Spray Drying: List of Mergers and Acquisitions
Table 10.2 Pharmaceutical Spray Drying: Deal Multiples of Mergers and Acquisitions
Table 15.1 Pharmaceutical Spray Dryers: Distribution by Type of Nozzles
Table 15.2 Pharmaceutical Spray Dryers: Distribution by Inlet Temperature
Table 15.3 Pharmaceutical Spray Dryers: Distribution by Atomizing Gas
Table 15.4 Pharmaceutical Spray Dryers: Key Manufacturers
Table 15.5 Pharmaceutical Spray Drying Service Providers: Distribution by Scale of Operation
Table 15.6 Pharmaceutical Spray Drying Service Providers: Distribution by cGMP Availability
Table 15.7 Pharmaceutical Spray Drying Service Providers: Popularly Used Spray Dryers
Table 15.8 Buchi: Annual Revenues, 2012-2017 (EUR Billion)
Table 15.9 GEA: Annual Revenues, 2012- 2017 (EUR Billion)
Table 15.10 SPX: Annual Revenues, 2012- 2017 (USD Billion)
Table 15.11 Pharmaceutical Spray Drying Mergers and Acquisitions: Year-Wise Trend
Table 15.12 Pharmaceutical Spray Drying Mergers and Acquisitions: Key Geographical Regions
Table 15.13 Pharmaceutical Spray Drying Services Market, 2018, 2023, 2028: Distribution by Product Type (Pharmaceuticals / Biologics), (USD Billion)
Table 15.14 Pharmaceutical Spray Drying Services Market, 2018, 2023 and 2028: Distribution by Region (USD Billion)
Table 15.15 Pharmaceutical Spray Drying Services Market, 2018-2028: North America, Conservative Scenario (USD Billion)
Table 15.16 Pharmaceutical Spray Drying Services Market, 2018-2028: North America, Base Scenario (USD Billion)
Table 15.17 Pharmaceutical Spray Drying Services Market, 2018-2028: North America, Optimistic Scenario (USD Billion)
Table 15.18 Pharmaceutical Spray Drying Services Market, 2018-2028: Europe, Conservative Scenario (USD Billion)
Table 15.19 Pharmaceutical Spray Drying Services Market, 2018-2028: Europe, Base Scenario (USD Billion)
Table 15.20 Pharmaceutical Spray Drying Services Market, 2018-2028: Europe, Optimistic Scenario (USD Billion)
Table 15.21 Pharmaceutical Spray Drying Services Market, 2018-2028: Asia Pacific and Rest of the World, Conservative Scenario (USD Billion)
Table 15.22 Pharmaceutical Spray Drying Services Market, 2018-2028: Asia Pacific and Rest of the World, Base Scenario (USD Billion)
Table 15.23 Pharmaceutical Spray Drying Services Market, 2018-2028: Asia Pacific and Rest of the World, Optimistic Scenario (USD Billion)
Table 15.24 Pharmaceutical Spray Drying Services Market, 2018-2028: Distribution by Type of Nozzle (USD Billion)
Table 15.25 Pharmaceutical Spray Drying Services Market: 2018, 2022 and 2028 (USD Billion)

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