Pharmaceutical Spray Drying Market (2nd Edition), 2018-2028
The origins of spray drying can be traced back to 1872, when the first patent related to the technique was registered in the US. The first commercial use of this form of drying was reported in the 1920s when powdered milk was introduced into the market. Spray drying, which is already established in the food and chemical sector, is also considered to be a rapid, cost-effective, and scalable process for the production of dry powder formulations of pharmacological material. Owing to characteristics, such as reproducibility and its continuous mode of operation, the technique has become very popular in the pharmaceutical and biotechnology industry. It offers several advantages over alternate drying technologies, such as lyophilization (characterized by high dependence on cold chain for storage and logistics, which is prone to failure due to human error) and vacuum foam drying (characterized by volumetric restrictions due to the properties of foam, which limits the quantity of sample that can be dried in a single run) that are currently deployed in the pharmaceutical industry.
Amongst other merits, spray drying is known to be suitable for drying heat-sensitive products such as biologics. Moreover, this method imparts improved properties to the formulations that can be administered through more efficient and less invasive modes of delivery, such as oral, and inhalation routes. The technology also aids in improving the compression properties of drugs, allowing developers to design concentrated dose variants of medications and reduce tablet size. Such alterations have the potential to improve patient compliance. Given the flexibility offered in terms of drug development and formulation, the economics of the technique, the introduction of aseptic methods, and the recent approval of the first spray dried biologic, Raplixa®, the adoption of spray drying is anticipated to increase steadily in the pharmaceutical industry.
SCOPE OF THE REPORT
The ‘Pharmaceutical Spray Drying Market (2nd Edition), 2018-2028’ report provides an extensive study on the use of spray drying in the pharmaceutical sector. The key focus of the report is primarily to estimate the future potential of spray drying in the manufacturing of APIs, inhalables, injectables, biologics and other pharmaceutical products. The study presents an in-depth analysis of a diverse set of companies that provide spray drying equipment and services across different regions of the globe. Amongst other elements, the report includes:
A detailed discussion the applications of spray drying in the pharmaceutical industry; these include enhancement of solubility and bioavailability, formulation of inhalables, taste masking, development of controlled release formulations, and aseptic production of biopharmaceuticals.
An assessment of the various players that are engaged in the manufacturing of spray dryers used in the pharmaceutical industry, including a detailed analysis of their products based on inlet temperature, type of nozzle (fluid, pressure, rotary disc, centrifugal and others), size of the dryer (lab, clinical and commercial) and atomizing gas (air, nitrogen and inert gases).
An overview of the current market landscape of spray drying service providers, featuring an analysis based on the location of their operating facilities, type of spray dryers used, scale of operation (lab, clinical and commercial), information on cGMP status of their facilities and availability of fill / finish services.
An insightful 2X2 analysis of different spray drying service providers. This analysis is based on the spray drying capabilities (represented in terms of number of manufacturing sites, scale of operation and the types of spray dryers used) and the company size. In addition, similar analysis has been done to compare the spray dryer manufacturers. This assessment is based on the company’s spray drying portfolio (number of spray dryers offered and availability of spray drying services), company’s year of establishment and the geographical coverage of its client base.
Tabulated profiles of the players offering spray drying services, featuring company overview, service portfolio, spray dryers used, and key developments related to its spray drying capabilities.
Detailed profiles of spray dryer manufacturers, featuring an overview of the company, its financial information (if available), types of spray dryers in their respective product portfolios, recent developments and a comprehensive future outlook.
A case study on the lyophilization of biologics, highlighting the underlying process, its applications, and merits and demerits. It features a detailed list of companies offering lyophilization services with information on location of facilities, types of drug candidates lyophilized, scale of operation and the containment systems utilized for such operations.
A detailed analysis of the mergers and acquisitions that have taken place in this space, highlighting the trend in the number of companies acquired in the last few years, along with the geographical distribution of this activity. The analysis highlights the ownership change matrix and presents financial evaluation of these deals (revenues and respective deal multiples).
A detailed discussion on affiliated trends, key drivers and challenges, under a SWOT framework.
One of the key objectives of the report was to understand the primary growth drivers and estimate the future size of the market. Based on parameters, such as trends in the pharmaceutical contract manufacturing industry, operation costs associated with spray drying and the challenges and opportunities presented by this technique, we have provided an informed estimate of the likely evolution of the market in the long term, for the period 2018-2028. In addition, we have provided insights on the likely regional evolution of the market in North America, Europe, Asia Pacific and the rest of the world. It also includes estimates regarding the likely distribution of the market based on type of industry (pharmaceuticals and biologics) and type of nozzles used in spray dryers (fluid nozzle, pressure nozzle, rotary disc atomizer, centrifugal nozzle, and others). In order to account for the uncertainties associated with some of the key parameters and to add robustness to our model, we have presented three different forecast scenarios, depicting conservative, base and optimistic tracks of the market’s evolution.
The research, analysis and insights presented in this report is backed by a deep understanding of insights gathered both from secondary and primary sources. The opinions and insights presented in this study were influenced by discussions conducted with several key players in this domain. The report features detailed transcripts of interviews held with the following key opinion leaders:
1. Sam de Costa (Stabilization Projects Manager, Nova Laboratories)
2. Manuel Leal (Business Development Director, Idifarma)
3. Anonymous (Founder, India based Manufacturer)
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.
1. Over 50 companies are offering spray drying services for pharmaceutical products. At present, the market is highly fragmented and features a mix of established companies (>500 employees, 48%), mid-sized companies (51-500 employees, 27%) and small-sized companies (<50 employees, 25%). Of the total number of service providers, 26 companies offer spray drying services at all three (laboratory, clinical and industrial) scales of operation. Examples of these companies include (in alphabetical order, no selection criteria) Catalent Pharma Solutions, Evotec, Patheon, Pulse Combustion Systems and Siegfried.
2. The market is also characterized by presence of over 20 manufacturers that have, so far, developed 86 spray dryers for use in the pharmaceutical industry. Of these, 35% of companies are established players, 30% are mid-sized companies and 35% are small-sized companies. Majority of the spray dryers being developed by these manufacturers (38%) use a fluid nozzle (particularly 2-fluid nozzles), while others use rotary disc atomizers (8%), and centrifugal (7%) and pressure nozzles (7%). Interestingly, the rest of the spray dryers are compatible with multiple nozzle types.
3. With respect to maximum inlet temperature, most of the spray dryers (48%) can operate at temperatures ranging from 151◦C to 250◦C. Around 11% of the dryers have maximum inlet temperatures of more than 350◦C. Of all the systems that we identified, 70% use air as the atomizing gas. However, in the rest (30%) of the spray dryers, the mode of operation is aseptic and is carried out in a closed loop configuration, using nitrogen or other inert gases.
4. A significant number of companies (close to 70% of the facilities captured in our database) offering pharmaceutical spray drying services are based in North America and Europe. Notable examples of mid-sized and small-sized players based in North America and the US include (in alphabetical order) Coriolis Pharma, Formurex, Leukocare, North Star Processing, Norwich Pharmaceuticals, Nova Laboratories, PacMoore, Richman Chemical, Spray-Tek, Summit Custom Spray Drying, Ufag Laboratorien, Upperton and Vectura. Within Europe, majority of the contract service providers are located in Italy, Germany, France, Spain and the UK. Examples of established players that have business operations in these geographies include (in alphabetical order) AMRI Global, Capsugel (now a part of Lonza), Catalent Pharma Solutions, Juniper Pharma Services and Siegfried. Asia Pacific has 25% of the players offering spray drying services for pharmaceuticals, while 6% of service providers are based in Africa, Latin America, South America and rest of the world.
5. Several CMOs (close to 30) have installed spray dryers developed by GEA Niro in their facilities. Amongst the 15 types of spray dryers offered by GEA Niro, its PSD and GEA Niro Mobile Minor™ models are most commonly used. In addition, spray dryers developed by Buchi (B-290 and B-90 models) are being used by a number of service providers. Spray dryers offered by SPX and ProCepT are also gaining popularity amongst the service providers.
6. We expect the pharmaceutical spray drying services market to grow at an annualized rate of ~20% between 2018 and 2028. North America (primarily US) and Europe currently capture the largest market share (close to 70%) in the spray drying contract services market. This is followed by Asia Pacific and rest of the world. Markets in Asia-Pacific are expected to grow at a relatively higher CAGR owing to inherent advantages such as relatively low labor costs and less stringent regulatory constraints.
7. The current market is driven, to a large extent (over 80%), by pharmaceutical products (such as APIs and intermediate products). The future advances will be jointly led by the steady rise of the biopharmaceuticals’ market; emergence of new technologies / applications is likely to provide the necessary impetus to fuel this growth.
The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and technology segments. Where possible, the available data has been checked for accuracy from multiple sources of information.
The secondary sources of information include
News releases from company websites
Government policy documents
Industry analysts’ views
While the focus has been on forecasting the market till 2028, the report also provides our independent view on various trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.
Chapter 2 provides an executive summary of the insights captured in our research. It offers a high-level view on the likely evolution of the spray drying market in the long term.
Chapter 3 provides an introduction to the spray drying approach, including a detailed discussion on the principle / process of spray drying, highlighting the key steps associated with the process. It highlights the important applications of the technique and the various features that distinguish it from alternative drying technologies. The chapter also features a discussion on the various advantages and limitations associated with spray drying.
Chapter 4 provides an overview of the applications of spray drying in the pharmaceutical industry, from generation of extremely fine particles for pulmonary administration to large agglomerated powders for oral formulations. Specifically, the different applications discussed in the chapter include enhancement of solubility and bioavailability, formulation of inhalables, taste masking, development of controlled release formulations, and aseptic production of biopharmaceuticals.
Chapter 5 includes a comprehensive market overview, featuring information on various types of spray dryers used in the pharmaceutical industry. It provides information on their respective manufacturers (company size and year of establishment) and presents an analyses of spray dryers on the basis of inlet temperature, type of nozzle (fluid, pressure, rotary disc and others) used, size of the unit (lab, clinical and commercial), and atomizing gas (air, nitrogen and inert gases) used. Further, the chapter includes a discussion on companies that offer pharmaceutical spray drying services. It presents an analysis of various spray drying service providers on the basis of the geographical location of their facilities, scale of operation (lab, clinical and commercial) and information on cGMP statuses of their facilities.
Chapter 6 presents the key insights derived from the study. It features detailed 2X2 matrices, comparing the spray drying capabilities and the supplier power of different spray drying service providers. A similar analysis comparing the spray dryer portfolio and the establishment year of different manufacturers of spray dryers, is also included in the chapter. In addition, the chapter features a comprehensive geographical landscape analysis, which highlights the spray drying activity across the globe, in terms of presence of both manufacturers and service providers.
Chapter 7 features tabular profiles of the most active service providers (as identified in chapter 6) in the pharmaceutical industry. It highlights the expertise of these players in terms of their spray drying capabilities. Each profile provides a brief overview of the company, highlighting its employee strength (if available), its product / service portfolio, spray dryers used (if available) and the key developments related to spray drying (if available).
Chapter 8 provides detailed profiles of the most active spray dryer manufacturers (as identified in chapter 6) in the pharmaceutical industry. Each profile provides a brief overview of the company, its financial information (if available), its portfolio of spray dryers, recent developments, and a comprehensive future outlook.
Chapter 9 features a case study on lyophilization of biologics, the key competing technique to spray drying. The chapter elaborates on the steps involved in lyophilization, and lyophilization cycle development and optimization. It includes an exemplary list of service providers offering lyophilization services with information on location of facilities, type of drug candidates lyophilized, scale of operation and the containment systems utilized for such operations.
Chapter 10 presents a detailed analysis of the mergers and acquisitions that have taken place within this industry. The chapter highlights the information on the acquiring and the acquired company (headquarters and the ownership (public / private)), along with the year of acquisition, acquiring amount (if available), and the financial status of the acquired company, at the time of acquisition. It features a detailed ownership change matrix depicting the distribution of mergers and acquisitions across private firms, public firms and sole proprietorships. It also includes an evaluation of the financials of these deals (revenues of the acquired firms at the time of acquisition and their respective deal multiples).
Chapter 11 presents a comprehensive market forecast analysis, highlighting the future potential of the spray drying services market till the year 2028. The chapter also presents detailed market segmentation on the basis of geographical regions (North America, Europe, Asia Pacific and the rest of the world), type of industry (pharmaceuticals and biologics), and type of nozzles used in spray dryers (fluid nozzle, pressure nozzle, rotary disc atomizer, centrifugal nozzle and others).
Chapter 12 presents a detailed analysis capturing the key parameters and trends that are likely to influence the future of the spray drying market, under a comprehensive SWOT framework. The chapter also features a schematic Harvey ball analysis to highlight the relative impact of each SWOT parameter on the overall market.
Chapter 13 is a summary of the overall report. In this chapter, we have provided a list of the key takeaways from the report, and expressed our independent opinion related to the research and analysis described in the previous chapters.
Chapter 14 is a collection of transcripts of interviews held with key stakeholders in this market. In this chapter, we have presented the details of our conversations with Sam de Costa (Stabilisation Projects Manager, Nova Laboratories), Manuel Leal (Business Development Director, Idifarma), Anonymous (Founder, India based Manufacturer).
Chapter 15 is an appendix, which provides tabulated data and numbers for all the figures included in the report.
Chapter 16 is an appendix, which contains the list of companies and organizations mentioned in the report.
LIST OF COMPANIES AND ORGANIZATIONS
The following companies and organizations have been mentioned in the report:
1. Acmefil Engineering Systems
2. Advanced Drying Systems
3. Aesica Pharmaceuticals
4. Agere Pharmaceuticals
5. Aizant Drug Research Solutions
7. Albion Manufacturing
8. Alembic Pharmaceuticals
9. Almac Group
10. Althea Technologies
14. Anteco Pharma
16. Aridis Pharmaceuticals
18. Ascendia Pharmaceuticals
19. Ashland Specialty Ingredients
20. Astron Research
21. Axcellerate Pharma
23. BASF Pharma Solutions
25. BEC Chemicals
26. Bend Research
27. Berkshire Sterile Manufacturing
28. BETE Fog Nozzle
29. Bharat Serum and Vaccines
34. Biopharma Technology
35. Biotech Investment Group
37. BioZed Engineering
38. Birla Institute of Technology and Science
39. Boehringer Ingelheim
40. Botanic Innovations
41. Bovogen Biologicals
42. Büchi Labortechnik
44. Catalent Pharma Solutions
45. CEPiA Sanofi
46. ChangZhou Lemar Drying Engineering
49. Claris Lifesciences
50. Consort Medical
51. Cook Pharmica
52. Coriolis Pharma
53. DisperSol Technologies
54. Dr. Reddy's Laboratories
55. Dry Tech India
56. Drytec Contract Processing
57. Earthrise Nutritionals
58. East India Pharmaceutical
59. Eli Lilly
60. Emergent BioSolutions
61. European SprayDry Technologies
63. Evonik Industries
70. Foundation for Revitalisation of Local Health Traditions
71. Fuji Chemical Industries
72. G-Con Manufacturing
73. GEA Niro
74. General Spray Drying Services
77. Glenmark Pharmaceuticals
78. Green Ridge Consulting
80. Hindustan Unilever
82. Idifarma Desarrollo Farmacéutico
83. Indiana Group
84. Indofil Industries
85. Intas Pharmaceuticals
86. International Specialty Products
87. Intran Technologies
88. Iran Panam
89. Italian Ceram
90. Janssen Pharmaceuticals
92. Jay Instruments and Systems
93. Jubilant Life Sciences
94. Juniper Pharmaceuticals
95. Kelkar Education Trust's Scientific Research Centre
97. L A B International
99. Labultima Process Technologies
100. Legacy BioDesign
101. Lesaffre Ingredients Services
104. Liquidia Technologies
106. LSNE Contract Manufacturing
108. Lupin Pharmaceuticals
111. Lyophilization Technology
113. Meggle Pharma
114. Metrics Contract Services
115. Microchem Silliker
119. Juniper Pharmaceuticals
121. Mycenax Biotech
122. NanoMaterials Technology
123. New AVM Systech
124. North Star Processing
125. Norwich Pharma Services
126. Nova Laboratories
128. Ohkawara Kakohki
129. Omega Flavour Technology
130. OmniActive Health Technologies
132. Orbite Technologies
134. Panacea Biotec
135. Particle Sciences
138. Pawana Engineering Projects
139. BV Patel Pharmaceutical Education and Research Development Centre
141. Pharma Spray Drying
142. Pharmachem Laboratories
144. Pharmatek Laboratories
146. Piramal Pharma Solutions
147. Plant Lipids
148. Proalgen Biotech
150. Pulse Combustion Systems
151. Quality Bioresources
152. Quay Pharma
153. Quest Life Sciences
154. Quotient Sciences
155. Raj Process Equipments And Systems
156. Ranbaxy Laboratories
157. Reliance Industries
158. Richman Chemical
160. Samsung BioLogics
163. Shungeng Drying Equipment
164. Siam Bioscience
168. Spray Drying Systems
170. SPX FLOW
172. Sulphur Mills
173. Summit Custom Spray Drying
174. Sun Pharmaceutical Industries
175. Symbiotec Pharmalab
176. Synthite Industrial Chemicals
177. Takeda Pharmaceutical
178. Techni Process
179. Technical University of Denmark
180. Tecpro Australia
181. TEFIC BIOTECH
183. The Himalaya Drug Company
184. Themis Laboratories
185. Toption Instrument
186. Torrent Pharmaceuticals
187. UFAG LABORATORIEN
188. Unitop Chemicals
189. Upperton Pharma Solutions
191. Vectura Group
192. Veer Narmad South Gujarat University
193. Vetter Pharma
194. Wannemacher Total Logistics
195. Wockhardt Research Centre
196. WuXi AppTec
198. Xi'an Hongchang Pharmaceuticals
199. Zydus Cadila