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Non-Opioid Drugs for Chronic Pain and Pain Management Devices Market, 2018-2025

Non-Opioid Drugs for Chronic Pain and Pain Management Devices Market, 2018-2025

Chronic pain refers to the psychophysiological response to an underlying clinical condition, which is observed to persist for a duration greater than six months and is generally unresponsive to multiple treatment regimens. It is estimated that more than 1.5 billion individuals across the world suffer from this type of pain. Some of the most common physiological conditions that are characterized by a chronic sensation of pain include migraine, lower back pain, pain associated with cancer, arthritis-related pain and neurogenic pain. Owing to the rapid onset of their medicinal effect, which offers immediate relief with high efficacy, opioids are still considered to be one of the most widely used pharmacological interventions for the management of moderate to severe forms of pain. However, these drugs are known to induce a euphoric state upon intake, often causing patients to abuse them; increased recreational use of opioids has also been shown to lead to drug addiction. The over-prescription of such medicinal products, which promotes their misuse, is considered as one of the root causes of the opioid crisis. In a recent article, published in 2017, 11.5 million individuals were reported to have been caught misusing prescription opioids, while over 42,000 died from opioid overdose, in the US alone. Moreover, opioid abuse was estimated to have been responsible for over USD 500 billion worth of economic deficit (in the US) due to loss of productivity and healthcare costs.

The opioid crisis has prompted drug manufacturers to develop non-addictive, non-narcotic-based therapeutics / analgesics for the management of pain. Unlike opioids, non-opioid drugs do not affect receptors present in the brain and, thus, are not addictive. These drugs work directly on injured / diseased body tissues and generally block the production of prostaglandins by inhibiting the cyclooxygenase (COX) enzyme at the site of injury / infection, thereby, decreasing the generation of pain mediators within the peripheral nervous system. Additionally, there are various pain management devices that have been reported to significantly reduce or eliminate the need for pharmacological interventions. Such devices are increasingly being used to treat a variety of clinical conditions that are characterized by chronic pain and offer the convenience of being used in the homecare setting as well. However, it is imperative for patients to consult qualified healthcare professionals, who have the required understanding of such therapeutic options, prior to using such devices.

SCOPE OF THE REPORT
The “Non-Opioid Drugs for Chronic Pain and Pain Management Devices Market, 2018-2025” report provides an extensive study on the marketed, clinical and preclinical products / product candidates for management of chronic pain. The report also features a detailed overview of the devices that are used for the treatment / management of pain associated with chronic clinical conditions. Amongst other elements, the report includes:

A detailed assessment of the current market landscape of drugs being developed for the treatment of chronic pain, providing information on their respective developer(s), phase of development (clinical, and preclinical / discovery), type of molecule (small molecule and biologic), indication (nociceptive and neuropathic), mechanism of action (channel blockers, receptor antagonists, protein pathway modulators and others) and route of administration (intra-articular, intravenous, intranasal, intranasal, intrathecal, oral, subcutaneous, topical and transdermal).

An in-depth analysis of the product pipeline and developer companies, featuring [A] a mirror analysis highlighting the relative popularity of different disease indications based on the number of molecules available / under development for each indication and the number of companies involved, [B] a logo landscape of the various industry players involved in this domain, distributed on the basis of location of headquarters and company size (small-sized, mid-sized and large), [C] a heptagon representation highlighting the distribution of marketed and pipeline molecules based on their respective mechanisms of action, and [D] a funnel analysis highlighting the distribution of molecules on the basis of stage of development, route of administration and treatment type.

An analysis highlighting the key unmet needs across chronic pain, featuring insights generated from data sourced from patient blogs, recent scientific publications, social media posts and the views of key opinion leaders expressed on various online platforms.

An elaborate discussion on lifecycle management strategies, describing how different companies are using various methods to prolong patent age and, thereby, expand marketing exclusivity in order to exploit the revenue generation potential of their proprietary products. The section also includes detailed case studies elaborating on diverse lifecycle management strategies of marketed drugs that are nearing patent expiry.

Comprehensive profiles of drugs that are in phase III of clinical development, with information on developer companies (including location of headquarters and year of establishment), type of molecule, mechanism of action, current status of development, route of administration, information on clinical trials and key developments (if available).

A detailed assessment of the current market landscape of various devices that are being developed for chronic pain management, highlighting information on developer (size of company and location of headquarters), mechanism of action (electrical stimulation, electromagnetic pulse, heat therapy, light therapy, radiofrequency stimulation and others), site of application on the body (head, arm, knees and other areas), modality of the device (invasive and non-invasive), and treatment requirements (at home and at hospitals / outpatient clinics), and type of device (wearable, hand-held and implants).

An insightful 2X2 competitive analysis for the various devices, highlighting the most important products based on the modality of device, treatment requirement, type of device, and supplier power (based on size of employee base of the company). The chapter also includes profiles of devices that emerged as relatively superior (based on the analysis); each profile features details on the developer (location of headquarters and year of establishment), approval year, mechanism of action, key features and key developments.

An analysis of the partnerships that have been established in the recent past, covering R&D collaborations, licensing agreements (related to both technology platforms and product candidates), product development and commercialization agreements, manufacturing agreements and others

An analysis of investments made at various stages of product development; these include seed financing, venture capital financing, debt financing and grants / awards, received by companies that are operating in this domain.

One of the key objectives of the report was to understand the primary growth drivers and estimate the future size of the market. Based on parameters, such as target consumer segments, likely adoption rates and expected pricing, we have provided an informed estimate of the likely evolution of the market in the short to mid-term, for the period 2018-2025. The report includes a detailed market segmentation on the basis of indication (chronic back pain, lumbar radiculopathy, migraine, osteoarthritis and neuropathic pain), type of molecule (small molecule and biologic), mechanism of action (CGRP inhibitors, COX/ NGF inhibitors, TRPV1 receptor antagonists, channel blockers and others) and geography (North America, Europe, Asia Pacific and rest of the World). In addition, the report features an opportunity analysis for the chronic pain management devices market. The opinions and insights presented in this study were influenced by inputs solicited via a comprehensive survey and discussions conducted with several key players in this domain. The report features detailed transcripts of interviews held with Ryan Jeffcoat (Director of Clinical Affairs & New Markets, AVACEN Medical), Lisa Robin (Chief Advocacy Officer, Federation of State Medical Boards), Nelson Hendler (Chief Executive Officer, Mensana Clinic Diagnostics) and Mark Wiederhold (Chief Executive Officer, Virtual Reality Medical Center). All actual figures have been sourced and analyzed from publicly available information forums and inputs from primary research. Financial figures mentioned in this report are in USD, unless otherwise specified.

EXAMPLE HIGHLIGHTS
1. An analysis of content presented on informal (over 200 patient blogs and over 10,000 social media posts) and formal (over 200 scientific literature studies) literary sources, and the opinions express by industry experts, confirm the existence of a significant unmet need within the chronic pain management market. Some of the unaddressed concerns highlighted on multiple portals include improper diagnosis, poor quality of life, and unavailability of non-addictive therapies to manage chronic pain.

2. Presently, over 145 non-opioid product candidates are marketed / under evaluation across various stages of development for the management of chronic pain caused due to various clinical conditions. There are eight commercialized products; of these, three drugs received approval post 2017, namely Zilretta® (2017), ZTlido™ (2018) and Aimovig™ (2018). Amongst the drugs that are in clinical development, 15% are in phase III, 30% in phase II, and 19% in phase I. Nearly 30% of the molecules are in preclinical or discovery phase.

3. It is worth noting that 31% candidates induce pain relief by inhibiting the action of receptors such as TRPV 1 and serotonin, 20% molecules act as channel blockers (primarily calcium, potassium and sodium channel blockers), while 18% of product candidates are protein inhibitors (which include COX-2 and NGF). 31% of the pipeline includes anti-inflammatory, anti-CGRP and pathway modulating molecules.

4. Majority of the drugs (54%) are being developed for management of neuropathic pain (which includes indications such as diabetic neuropathic pain, post-herpetic neuralgia, fibromyalgia, cancer-related neuropathic pain, and HIV-related neuropathic pain). It is worth mentioning that three out of the seven commercialized drugs are designed for treatment of post-herpetic neuralgia. Nearly 35% of molecules are being developed for managing nociceptive pain, of which, majority of the candidates are meant for the treatment of osteoarthritis and migraine. Rest (11%) of the drugs are being developed for managing chronic pain, for which specific indications are not known.

5. The market landscape is characterized by the presence of large (29%), mid-sized (18%) and small-sized companies (49%). Of the established pharmaceutical companies, two players have recently received approval for their non-opioid drugs for chronic pain management; namely (in alphabetical order, no selection criteria) Arbor Pharmaceuticals and Horizon Pharma. In addition, four mid-sized players, which include (in alphabetical order) Acorda Therapeutics, DepoMed, Flexion Therapeutics and Sorrento Therapeutics have also received the FDA’s approval and marketed their non-opioid candidates across various geographies. The growing unmet need for efficient non-opioid drugs for chronic pain management have spurred the establishment of many start-ups in recent years; examples include (in alphabetical order, no selection criteria) 4P Therapeutics, Acorda Therapeutics, Adynxx, Anavex, Araim Pharmaceuticals, BioHealthonomics, DermaXon, Hydra Biosciences, Levicept, Mapi Pharma, Regulonix, Saniona, Solasia Pharma and Winsantor.

6. In addition to pharmacological interventions, there are over 120 devices available for chronic pain management. Of these, 30% pf products need to be surgically placed inside the body, these include products such as (in alphabetical order, no selection criteria) Algovita®, Axium™ Neurostimulator System, Eon Mini™, Genesis, Halo CFNS System, Intellis™ System, Precision Spectra™, Proclaim™ DRG, RestoreAdvanced™ Surescan™ MRI, StimQ PNS System, SynchroMed™ II, VersaStim®, and Vivendi. Further, 25% of the products that we came across were wearable devices, such as (in alphabetical order, no selection criteria) Aleve Direct Therapy (worn at the back), ElectroMesh Garments (worn at the site of pain), Neuro-stim System (applied in the ear) and Quell Relief (wrapped around the leg). In addition, 17% of the devices pipeline featured handheld devices that can be applied at the location of pain in the body, such as (in alphabetical order, no selection criteria) BioBeam™ 940, Handy Pulse Laser, Iovera, LaserTouchOne™, MyACT®, NexWave, Sanakey and Silk’n Relif. We also observed that probes, such as such as (in alphabetical order, no selection criteria) COOLIEF, Dolphin Neurostim™, Intracept® Intraosseous Nerve Ablation System, presently constitute 7% of the total number of device based therapeutic options in the pipeline. It is also worth pointing out that a significant number of devices (21%) could not be classified under any of the aforementioned categories, these include products such as (in alphabetical order, no selection criteria) COOL! And GLOW!, NeuroCare (Digital) and Freedom (Analog), sTMS mini and The WellnessPro™ Plus.

7. The pain management devices landscape is characterized by the presence of large (8), mid-sized (13) and small sized (46) companies. Some of the noteworthy large sized device developers include (in alphabetical order, no selection criteria) Bayer, Boston Scientific, Chattem, Medtronic and St Jude Medical. Of these, St Jude Medical was observed to have the maximum pain management devices in its database. In addition, 13 mid-sized companies have developed 18 pain relief devices; notable examples of these companies include (in alphabetical order, no selection criteria) Bioness, Flownix, Gradient Medical, Mainstay Medical, Neuvectra, PainPod and Zynex. Interestingly, several small-sized companies have taken initiatives in developing the pain management devices; examples include (in alphabetical order, no selection criteria) AcuKnee, AVACEN Medical, BioElectronics. BlueWind Medical, cafaly Tecchnologies, DavaRay, ElectroCore, LightStim, Meagan Medical, Med-Ally, Prizm Medical, Renewal Technologies, Syrolight, TENS Rx, Vital Motion and Xavant Technology.

8. Stakeholders in the industry have forged several strategic partnerships in the recent past; we observed that over 26% of the agreements that have been signed between 2012 and 2018 were related to the commercialization of products. These were followed by acquisitions (23%), research and development collaborations (12%), licensing agreements (12%), product development and commercialization agreements (11%), product development agreements (8%), clinical trial collaborations (2%) and product distribution agreements (2%). Examples of recently inked deals include collaboration between Alder BioPharmaceuticals and Teva Pharmaceutical (January 2018), Grünenthal and Mundipharma (January 2018), Saniona and Proximagen (January 2018).

9. Drug development initiatives by start-ups have received financial support in terms of venture funding and research grants. In fact, more than USD 1.5 billion across 81 instances of grants, venture capital rounds and public offerings have been invested in these companies since 2000. Alta Partners, ARCH Venture Partners, Abingworth Management, Advanced Technology Ventures, Biovenutures Investors, Frazier Healthcare Partners, Lilly Ventures, Montreux Equity Partners and Walden International have emerged as some of the prominent investors, in terms of their participation in the maximum number of funding instances observed in the given time period.

10. We expect the non-opioid drugs for chronic pain management market to grow at an annualized rate of ~40% between 2018 and 2025. North America (primarily US) capture the largest market share (close to 80%), followed by Europe (France, Germany, Italy, Spain and the UK) Australia, South Korea and Japan. With three approved drugs, osteoarthritis currently captures the highest market share amongst all the indications. By 2025, in addition to osteoarthritis, the market is likely to be driven by indications such as migraine and neuropathic pain.

11. Product candidates, such as Aimovig™, fasinumab, fremanezumab, galcanezumab and tanezumab, which have received or are expected to receive approval for the treatment of migraine by late 2018 / early 2019 are most likely to achieve blockbuster status in the future. With respect to the drug class, the current market share is distributed between anti-CGRP drugs (41%) and histamine receptor antagonists (32%). By 2025, the market share is likely to be distributed amongst anti-CGRP drugs (54%), followed by NGF inhibitors (20%) and calcium / sodium channel blockers (16%).

RESEARCH METHODOLOGY
The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and technology segments. Where possible, the available data has been checked for accuracy from multiple sources of information.

The secondary sources of information include
Annual reports
Investor presentations
SEC filings
Industry databases
News releases from company websites
Government policy documents
Industry analysts’ views

While the focus has been on forecasting the market till 2025, the report also provides our independent view on various trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.

CHAPTER OUTLINES
Chapter 2 provides an executive summary of the insights captured in our research. It offers a high-level view on the likely evolution of the non-opioid drugs and pain management devices market, in the mid-long term.

Chapter 3 provides an introduction to chronic pain and associated disease indications. It features a detailed discussion on the classification of pain, and affiliated symptoms and causes. The section also highlights the available therapeutic options for the treatment / management of this clinical condition. In addition, it summarizes the reasons for the opioid crisis, and the steps being taken within healthcare domain to develop and introduce alternative, non-opioid-based therapeutic strategies.

Chapter 4 highlights the key unmet needs associated with the management and treatment of chronic pain. The chapter provides a detailed analysis of such needs as identified from views expressed by patients / industry experts across different platforms, such as patient blogs, recent scientific publications, social media posts and as discussed by key opinion leaders at various conferences / symposiums. The chapter also presents an insightful sentiment analysis and word cloud analyses, summarizing the diverse opinions expressed across the aforementioned public portals.

Chapter 5 includes information on over 160 non-opioid molecules that are currently approved / under development for therapeutic use. It features a comprehensive analysis of marketed and pipeline molecules, highlighting the phase of development (clinical and preclinical / discovery stage) of product candidates, type of molecule (small molecule and biologic), sub-indication (nociceptive and neuropathic) mechanism of action, route of administration and information on the developer companies (including location of headquarters and year of establishment). In addition, it presents a set of key insights derived from a mirror analysis, highlighting the relative popularity of the different indications based on the number of molecules available / under development for each indication and the number of companies involved. The chapter also features a heptagon representation highlighting the distribution of the marketed and pipeline molecules based on different mechanisms of action and a logo landscape of the various industry players involved in this market, distributed on the basis of location of headquarters and company size (small-sized, mid-sized and large). Additionally, the chapter features a funnel analysis highlighting the distribution of molecules on the basis of stage of development, route of administration and treatment type.

Chapter 6 includes a detailed discussion on product life cycle management strategies that are being considered by developers of already approved / marketed drugs. It focuses on specific strategies, which are used by drug developers in this domain, to expand patent protection and retain the revenue generation potential of their proprietary products without having to contend with the competition that is likely to be generated by generic versions.

Chapter 7 contains detailed profiles of drugs that are in phase III of clinical development. Each profile features an overview of the developer, information on the route of administration, type of molecule, mechanism of action, current status of development, key clinical trials and key recent developments (wherever available).

Chapter 8 includes information on close to 120 devices that are currently approved / under investigation for the treatment / management of chronic pain. It also features a comprehensive analysis of the information on developer (size of company and location of headquarters), mechanism of action, site of application on the body (head, arm, knees and other areas), modality of the device (invasive and non-invasive), treatment requirement (at home and at hospitals / outpatient clinics), type of device (wearable, hand-held and implants) and mechanism of action of device (electrical stimulation, radiofrequency stimulation, heat therapy and others) .

Chapter 9 provides a comprehensive 2X2 analysis featuring a comparative overview of all the available / under development devices for chronic pain management. The analysis compares the products based on the modality of device, treatment requirement, type of device, supplier power (based on size of employee base of the company). Further, the chapter features detailed profiles of devices which appeared to be relatively superior to other products / product candidates. Each of these profiles include details on their developer (location of headquarters and year of establishment), approval year of the product, mechanism of action, key features and key developments.

Chapter 10 features an analysis of the various collaborations and partnerships that have been inked amongst players in this market. We have also discussed the different partnership models (including product development and commercialization, R&D agreements, technology / product licensing agreements, other licensing agreements, mergers / acquisitions and clinical trial collaborations) and the most common forms of deals / agreements that have been established between 2012 to 2018.

Chapter 11 presents details on various investments received by small sized companies that are engaged in this domain. It also includes a detailed analysis of the funding instances that have taken place between January 2001 and April 2018, highlighting the growing interest of the venture capital community and other strategic investors in this domain.

Chapter 12 presents a comprehensive market forecast analysis, highlighting the future potential of non-opioid drugs in chronic pain market, till the year 2025. We have segregated the opportunity on the basis of indication (chronic back pain, lumbar radiculopathy, migraine, osteoarthritis and neuropathic pain), type of molecule (small molecule and biologic), mechanism of action (CGRP inhibitors, COX/ NGF inhibitors, TRPV1 receptor antagonists, channel blockers and others) and geography (North America, Europe, Asia Pacific and rest of the World). Future sales potential and growth opportunity were estimated based on likely adoption rates and the anticipated price of products. The report features an opportunity analysis for chronic pain management devices as well.

Chapter 13 summarizes the overall report. In this chapter, we have provided a list of key takeaways from the report, and expressed our independent opinion related to the research and analysis described in the previous chapters.

Chapter 14 is a collection of interview transcripts of the discussions held with key stakeholders in this market. In this chapter, we have presented the details of our conversations with (in alphabetical order of company name) Ryan Jeffcoat (Director of Clinical Affairs & New Markets, AVACEN Medical), Lisa Robin (Chief Advocacy Officer, Federation of State Medical Boards), Nelson Hendler (Chief Executive Officer, Mensana Clinic Diagnostics), and Mark Wiederhold (Chief Executive Officer, Virtual Reality Medical Center).

Chapter 15 is an appendix, which provides tabulated data and numbers for all the figures included in the report.

Chapter 16 is an appendix, which contains the list of companies and organizations mentioned in the report.

LIST OF COMPANIES AND ORGANIZATIONS

The following companies / institutes / government bodies and organizations have been mentioned in this report.

1. 1st Order Pharmaceuticals
2. 23andMe
3. 4P Therapeutics
4. 6 Dimensions Capital
5. Abbott
6. AbbVie
7. Abingworth
8. AcelRx Pharmaceuticals
9. Achelios Therapeutics
10. Acorda Therapeutics
11. Actavis Generics
12. AcuKnee
13. Advanced Technology Ventures
14. AdynXX
15. Alder BioPharmaceuticals
16. Algiax Pharmaceuticals
17. Algorithm Technologies
18. Alkermes
19. Allergan
20. Allodynic Therapeutics
21. Almirall de Mexico
22. Alta Partners
23. American College of Rheumatology
24. Amgen
25. Amura Therapeutics
26. Amway
27. Anavex Life Sciences
28. Angenieux
29. Anulex Technologies
30. AppliedVR
31. Aptinyx
32. Araim Pharmaceuticals
33. Arbor Pharmaceuticals
34. ARCH Venture Partners
35. ArrowMark Partners
36. Arteaus Therapeutics
37. Astellas Pharma
38. AstraZeneca
39. Autonomic Technology
40. Avacare Health
41. AVACEN Medical
42. Avanir Pharmaceuticals
43. Axiobionics
44. Axxam
45. Bain Capital Life Sciences
46. Bayer
47. BDC Venture Capital
48. BIAL
49. BioCare Systems
50. BioElectronics
51. Biogen
52. Biogen New Ventures
53. BioHealthonomics
54. Bioness
55. BioVentures Investors
56. BioWave
57. Bluegrass Angels
58. BlueWind Medical
59. Boehringer Ingelheim
60. Boston Medical Investors
61. Boston Scientific
62. Bristol-Myers Squibb
63. Calchan
64. Calmare Therapeutics
65. Calox de Costa Rica
66. Canaan Partners
67. Cara Therapeutics
68. CDA Research Group
69. Cedars-Sinai Medical Centre
70. Cefaly Technology
71. Centrexion Therapeutics
72. CerSci Therapeutics
73. CEVEC Pharmaceuticals
74. Chattem
75. Clough Capital Partners
76. Cmxtwenty
77. Cold Laser Relief
78. CoLucid Pharmaceuticals
79. Commence Bio
80. Concentric Analgesics
81. Convergence Pharmaceuticals
82. Cornell University
83. Cosman Medical
84. Crinetics Pharmaceuticals
85. Cryopak
86. Cross Creek Advisors
87. CTI Life Sciences Fund
88. Daewoong Pharmaceuticals
89. Daiichi Sankyo
90. DavaRay
91. Deerfield Management
92. Delphi Ventures
93. Depomed
94. DermaXon
95. Diamond Capital Management
96. Dolphin Neurostim
97. Domain Associates
98. Dr. Reddy’s Laboratory
99. Duke University
100. DURECT Corporation
101. Efung Capital
102. Eisai
103. electroCore
104. ElectroMedical Technologies
105. Electronic Wave Form Labs
106. Eli Lilly
107. ELvation Medical
108. EMS
109. eNeura
110. Epimed International
111. Epirus Biopharmaceuticals
112. Esteve
113. Eupraxia Pharmaceuticals
114. Exogear
115. Extrazell
116. Federation of State Medical Boards
117. Firsthand Technology
118. Fisher Wallace Laboratories
119. Flexion Therapeutics
120. Flowonix
121. Frazier Healthcare Partners
122. Frontier Biotech
123. Fukuda Denshi
124. Fyrsta Innovations
125. Galápagos
126. Genentech
127. GeneQuine Biotherapeutics
128. Genesys Capital
129. Genexbio
130. Georgetown Translational Pharmaceuticals
131. Gilead Sciences
132. GiMer Medical
133. GL PharmTech
134. GlaxoSmithKline
135. Global Life Science Ventures
136. Gradient
137. Green Park & Golf Ventures
138. Grove Street Advisors
139. Grünenthal
140. GT Biopharma
141. Haylard Health
142. HBM Healthcare Investments
143. Hema Enterprises
144. Heptares Therapeutics
145. Hercules Capital
146. H.I.G Capital
147. High-Tech Gründerfonds
148. Hinge Health
149. Horizon Pharma
150. Humanitarian Innovation Fund
151. Hungarian Academy of Sciences
152. Hydra Biosciences
153. Immune Pharmaceuticals
154. Incepta Pharmaceuticals
155. InMed Pharmaceuticals
156. Innovate UK
157. Innovative Med Concepts
158. Inspirion Delivery Sciences
159. INSYS Therapeutics
160. InterWest Partners
161. InterX Technologies
162. Iroko Pharmaceuticals
163. Jeil Pharmaceuticals
164. Johari Digital
165. Johnson & Johnson
166. JT Pharmaceuticals
167. KAI Pharmaceuticals
168. KfW Group
169. Kineta
170. Knight Therapeutics
171. Labrys Biologics (Subsidiary of Teva Pharmaceutical)
172. Landsteiner Scientific
173. Levicept
174. Lexicon Pharmaceuticals
175. LightStim
176. Lilly Ventures
177. Longitude Capital
178. Lupin
179. Mainstay Medical
180. Mallinckrodt Pharmaceuticals
181. Mapi Pharma
182. Maxim Pharmaceuticals
183. MAXONA Pharmaceuticals
184. Mayo Clinic
185. MD Biosciences
186. Meagan Medical
187. Med-Ally
188. Medical Devices
189. Medifron DBT
190. MedImmune Ventures
191. Medincell
192. Medtronic
193. Mensana Clinics Daignostics
194. Merck
195. Mesoblast
196. Mitsubishi Tanabe Pharma
197. Moebius Medical
198. Montreux Equity Partners
199. Morulaa HealthTech
200. Multisana
201. Mundipharma
202. Mylan
203. MyoScience
204. National Institute of Neurological Disorders and Stroke
205. National Institute on Drug Abuse
206. National Institutes of Health
207. Neumentum
208. Neuraxon
209. NeurAxon Pharma
210. NeuroVentures
211. Neuro Vigor
212. NeurogesX
213. NeuroMetrix
214. NeurOp
215. Neuros Medical
216. Neurova
217. Nevro
218. New Enterprise Associates
219. New Jersey Packaging Executives Club
220. New Leaf Venture Partners
221. Newron Pharmaceuticals
222. Nice & Green
223. Nicox
224. Novaremed
225. Novartis
226. NuPathe
227. Nuvectra
228. Nuvo Pharmaceuticals
229. Octusa Spine
230. Oculus
231. Ogeda
232. OliPass
233. OMRON Healthcare
234. Optimus Medical
235. Optinose
236. Orbimed Advisors
237. Osage University
238. Oska Wellness
239. Otsuka Pharmaceutical
240. PainPod BioTechnology
241. Pamoja Capital
242. Par Pharmaceutical
243. Patheon
244. PeriphaGen
245. Pfizer
246. Pharmaleads
247. Polaris Partners
248. POZEN
249. Prismic Pharmaceuticals
250. Prizm Medical
251. Proximagen
252. PT Pratapa Nirmala (Renamed to Fahrenheit)
253. Pulse Laser Relief
254. Purdue Pharma
255. Quan Capital
256. Reata Pharmaceuticals
257. Recro Pharma
258. Regenacy Pharmaceuticals
259. Regeneron Pharmaceuticals
260. Regulonix
261. Relief Therapeutics
262. Relievant Medsystems
263. Renewal Technologies
264. Ritmedic
265. Roche
266. Saluda Medical
267. Samsung Electronics America
268. Samyang Biopharmaceuticals
269. Saniona
270. Sanofi
271. Scenarworld
272. Scintilla Pharmaceuticals
273. Semnur Pharmaceuticals
274. Servier
275. Shionogi
276. Silk'n Therapy
277. Solasia Pharma
278. Sorrento Therapeutics
279. Sosei Group
280. Sphaera Pharma
281. SPR Therapeutics
282. St. Jude Medical
283. StimRelieve
284. Stimwave Technologies
285. SUBLIMED
286. Sumitomo Dainippon Pharma
287. Sun Pharmaceutical Industries
288. Sutter Hill Ventures
289. SV Health Investors
290. SWITCH Biotech
291. SyroLight
292. Teachers Insurance and Annuity Association
293. Teikoku Pharma
294. TENS Rx
295. Teva Pharmaceutical Industries
296. Thar Pharmaceuticals
297. The Apex Practice
298. The Ontario Capital Growth
299. Theravance Biopharma
300. Toray Industries
301. TPG Biotech
302. Trigemina
303. TŰV SŰD
304. UCB Pharma
305. University of North Carolina
306. Upsher-Smith Laboratories
307. Valeant Pharmaceuticals
308. Vanway
309. Vapogenix
310. Vault Bioventures
311. Ventures West Capital
312. Vertex Pharmaceuticals
313. ViaTherm Therapeutics
314. Virobay
315. Vista Healthcare Technologies
316. Virtual Reality Medical Centre
317. Visualase
318. Vital Motion
319. Vivo Capital
320. Walden International
321. Wasatch Advisors
322. WEX Pharmaceuticals
323. WinSanTor
324. Winston Pharmaceuticals
325. Xavant Technology
326. Xenon Pharma
327. XenoPort
328. Yuhan
329. Zalicus
330. Zydus Pharmaceuticals
331. Zynex Medical


1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Definition of Pain
3.2. Classification of Pain
3.2.1. Acute Pain
3.2.2. Chronic Pain
3.2.2.1. Classification of Chronic Pain
3.2.2.2. Chronic Pain and Mental Health
3.3. Pain Management
3.3.1. Therapeutics for Pain Management
3.3.2. Devices for Pain Management
3.3.3. Other Therapeutic Modalities and Interventions for Pain Management
3.4. Future Prospects
4. CHRONIC PAIN MANAGEMENT: UNMET NEED ANALYSIS
4.1. Chapter Overview
4.2. Unmet Need Analysis
4.2.1. Introduction
4.2.2. Patient Blogs
4.2.2.1. Methodology
4.2.2.2. Key Insights
4.2.3. Published Literature
4.2.3.1. Methodology
4.2.3.2. Key Insights
4.2.4. Social Media Platforms
4.2.4.1. Methodology
4.2.4.2. Key Insights
4.2.5. Expert Opinions
4.2.5.1. Jeffrey Curtis, MD, University of Alabama
4.2.5.2. Stephan Silberstein, MD, Jefferson University Hospital
4.2.5.3. Jeffrey Gudin, MD, Englewood Hospital and Medical Center
4.2.5.4. Kevin Zacharoff, MD, SUNY Stonybrook School of Medicine
4.2.5.5. Philip J Mease, MD, University of Washington School of Medicine
4.2.5.6. John D Reveille, MD, McGovern Medical School
4.2.5.7. Christopher R McCurdy, PhD, University of Florida
4.2.6. Concluding Remarks: Key Unmet Needs in Chronic Pain Management
5. PIPELINE REVIEW: MARKETED AND DEVELOPMENT DRUGS
5.1. Chapter Overview
5.2. Non-Opioid Drugs for Chronic Pain Management: Marketed and Development Pipeline
5.3. Non-Opioid Drugs for Chronic Pain Management: Pipeline Analysis
5.3.1. Analysis by Phase of Development
5.3.2. Analysis by Type of Molecule
5.3.3. Analysis by Mechanism of Action
5.3.4. Analysis by Route of Administration
5.3.5. Analysis by Target Therapeutic Indication(s)
5.3.6. Analysis by Size of Employee Base of Developer
5.3.7. Pipeline Analysis: Leading Players
5.3.8. Developer Logo Landscape: Distribution by Size and Location
5.3.9. Mirror Analysis: Distribution by Type of Indication, Number of Molecules and Manufacturer
5.3.10. Heptagon Representation: Distribution by Target Disease Indication and Phase of Development
5.3.11. Funnel Analysis: Distribution by Target Disease Indications, Route of Administration and Phase of Development
6. LIFECYCLE MANAGEMENT STRATEGIES FOR MARKETED PRODUCTS
6.1. Introduction
6.2. Product Profile: Duexis® (Horizon Pharma)
6.2.1. Overview
6.2.2. Mechanism of Action
6.2.3. Life Cycle Management Strategies
6.2.3.1. Strategic Pricing
6.2.3.2. Geographical Expansion
6.2.3.3. Indication Expansion
6.2.3.4. Extension of Patent Exclusivity
6.2.3.5. Authorized Generics
6.2.3.6. Awareness Campaigns
6.2.4. Partnerships and Collaborations
6.2.4.1. Mallinckrodt
6.2.4.2. Grünenthal
6.3. Product Profile: Gralise® (Depomed)
6.3.1. Overview
6.3.2. Mechanism of Action
6.3.3. Life Cycle Management Strategies
6.3.3.1. New Dose Strength
6.3.4. Legal Defense
6.3.4.1. Authorized Generics
6.3.5. Partnerships and Collaborations
6.3.5.1. Actavis
6.3.5.2. Abbott
6.4. Product Profile: Horizant® (Arbor Pharmaceuticals)
6.4.1. Overview
6.4.2. Mechanism of Action
6.4.3. Life Cycle Management Strategies
6.4.3.1. Extension of Patent Exclusivity
6.4.3.2. Indication Expansion
6.4.4. New Dose Strength
6.4.5. Partnerships and Collaborations
6.4.5.1. GlaxoSmithKline
6.4.5.2. Arbor Pharmaceutical
6.5. Product Profile: Vimovo® (AstraZeneca and Pozen)
6.5.1. Overview
6.5.2. Mechanism of Action
6.5.3. Life Cycle Management Strategies
6.5.3.1. Pricing
6.5.3.2. Geographical Expansion
6.5.4. Legal Defense
6.5.5. Partnerships and Collaborations
6.5.5.1. AstraZeneca
6.5.5.2. Horizon Pharma
7. DRUG PROFILES: LATE STAGE MOLECULES
7.1. Chapter Overview
7.2. Drug Profile: Aimovig™ / Erenumab
7.3. Drug Profile: Analgecine
7.4. Drug Profile: Atogepant / AGN 241689 / MK 8031
7.5. Drug Profile: Civamide / Civanex / Zucapsaicin
7.6. Drug Profile: CNTX-4975
7.7. Drug Profile: Eptinezumab / ALD403
7.8. Drug Profile: Fasinumab
7.9. Drug Profile: Fremanezumab
7.10. Drug Profile: Galcanezumab / LY2951742
7.11. Drug Profile: Lasmiditan / COL-144
7.12. Drug Profile: Mirogabalin / DS-5565
7.13. Drug Profile: MPC-06-ID
7.14. Drug Profile: Neridronate
7.15. Drug Profile: NTM-001
7.16. Drug Profile: NTM-002
7.17. Drug Profile: Perampanel (E2007)
7.18. Drug Profile: POSIMIR (SABER-Bupivacaine)
7.19. Drug Profile: Ralfinamide
7.20. Drug Profile: SP-102
7.21. Drug Profile: T-121
7.22. Drug Profile: Tanezumab
7.23. Drug Profile: Tetrodotoxin / TTX
7.24. Drug Profile: Ubrogepant / MK-1602
7.25. Drug Profile: YHD1119 / PREGABALIN
8. CHRONIC PAIN MANAGEMENT DEVICES: MARKET LANDSCAPE
8.1. Chapter Overview
8.2. Devices for Pain Management: Database
8.3. Devices for Pain Management: Database Analysis
8.3.1. Analysis by Type of Devices
8.3.2. Analysis by Mechanism of Action
8.3.3. Analysis by Modality of Device
8.3.4. Analysis by Site of Application on Body
8.3.5. Analysis by Convenience of Use
8.3.6. Analysis by Location of Developer(s)
8.3.7. Analysis by Company Size
9. DEVICE COMPETITIVENESS ANALYSIS AND PROFILES
9.1. Chapter Overview
9.2. Methodology
9.3. Implants
9.3.1. Assumptions, Limitations and Key Evaluable Parameters
9.3.2. Device Competitive Analysis for Implants: Results
9.3.3. Device Profiles
9.3.3.1. Freedom SCS System (Stimwave)
9.3.3.2. VIVENDI™ (BlueWind Medical)
9.4. Wearables
9.4.1. Assumptions, Limitations and Parameters Evaluated
9.4.2. Device Competitive Analysis for Wearables: Results
9.4.3. Device Profiles
9.4.3.1. Avail Wireless (Omron Healthcare)
9.4.3.2. Cefaly (Cefaly Technologies)
9.4.3.3. Micro-Z (Prizm Medical)
9.4.3.4. PainPod MI (PainPod)
9.4.3.5. PainPod XPV (PainPod)
9.4.3.6. Quell Relief (Neurometrix)
9.4.3.7. SENSUS® Pain Management System (Neurometrix)
9.4.3.8. Smart Relief Back (Chattem)
9.5. Other Devices
9.5.1. Assumptions, Limitations and Parameters Evaluated
9.5.2. Devices Competitive Analysis for Other Devices: Results
9.5.3. Device Profiles
9.5.3.1. Silk’n Relief (Silk’n Therapy)
9.5.3.2. The Wellness Pro™ Plus (ElectroMedical Technologies)
10. PARTNERSHIPS AND COLLABORATIONS
10.1. Chapter Overview
10.2. Partnership Models
10.3. Non-Opioid Drugs and Devices for Chronic Pain Management: Recent Partnerships and Collaborations
10.3.1. Analysis by Year of Agreement
10.3.2. Analysis by Quarterly Trends
10.3.3. Analysis by Type of Partnership
10.3.4. Analysis by Most Active Players
10.3.5. Analysis by Geographical Activity
11. FUNDING AND INVESTMENT ANALYSIS
11.1. Chapter Overview
11.2. Types of Funding
11.3. Non-Opioid Drugs for Chronic Pain Management: Funding and Investment Analysis
11.3.1. Analysis by Cumulative Number of Funding Instances
11.3.2. Analysis by Cumulative Amount Invested
11.3.3. Analysis by Type of Funding
11.3.4. Analysis by Most Active Players
11.3.5. Analysis by Most Active Investors
11.4. Concluding Remarks
12. MARKET FORECAST AND OPPORTUNITY ANALYSIS
12.1. Chapter Overview
12.2. Key Assumptions
12.3. Forecast Methodology
12.4. Overall Non-Opioids Drugs for Chronic Pain Management Market, 2018-2025
12.4.1. Non-Opioid Drugs Market: Distribution by Therapeutic Area
12.4.2. Non-Opioid Drugs Market: Distribution by Molecule Type
12.4.3. Non-Opioid Drugs Market: Distribution by Mechanism of Action
12.4.4. Non-Opioid Drugs Market: Distribution by Geography
12.5. Non-Opioid Drugs Market: Product-Wise Sales Forecasts
12.5.1. Qutenza® (Accorda Therapeutics)
12.5.1.1. Drug Overview and Target Patient Population
12.5.1.2. Sales Forecast
12.5.2. Vimovo® (Horizon Pharma)
12.5.2.1. Drug Overview and Target Patient Population
12.5.2.2. Sales Forecast
12.5.3. Duexis® (Horizon Pharma)
12.5.3.1. Drug Overview and Target Patient Population
12.5.3.2. Sales Forecast
12.5.4. Gralise® (Depomed)
12.5.4.1. Drug Overview and Target Patient Population
12.5.4.2. Sales Forecast
12.5.5. Horizant® (Arbor Pharmaceuticals)
12.5.5.1. Drug Overview and Target Patient Population
12.5.5.2. Sales Forecast
12.5.6. Zilretta® (Flexion Therapeutics)
12.5.6.1. Drug Overview and Target Patient Population
12.5.6.2. Sales Forecast
12.5.7. Ztlido™ (Sorrento Therapeutics)
12.5.7.1. Drug Overview and Target Patient Population
12.5.7.2. Sales Forecast
12.5.8. Aimovig™ (Amgen)
12.5.8.1. Drug Overview and Target Patient Population
12.5.8.2. Sales Forecast
12.5.9. Fremanezumab (Teva Pharmaceuticals)
12.5.9.1. Drug Overview and Target Patient Population
12.5.9.2. Sales Forecast
12.5.10. Galcanezumab (Eli Lilly)
12.5.10.1. Drug Overview and Target Patient Population
12.5.10.2. Sales Forecast
12.5.11. Mirogabalin (DS-5565) (Daiichi Sankyo)
12.5.11.1. Drug Overview and Target Patient Population
12.5.11.2. Sales Forecast
12.5.12. YHD1119 (Yuhan corporation)
12.5.12.1. Drug Overview and Target Patient Population
12.5.12.2. Sales Forecast
12.5.13. GLA5PR (GL PharmTech)
12.5.13.1. Drug Overview and Target Patient Population
12.5.13.2. Sales Forecast
12.5.14. Eptinezumab (Alder Biopharmaceuticals)
12.5.14.1. Drug Overview and Target Patient Population
12.5.14.2. Sales Forecast
12.5.15. ALLOD-2 (Allodynic Therapeutics)
12.5.15.1. Drug Overview and Target Patient Population
12.5.15.2. Sales Forecast
12.5.16. PainBrake® (GT Biopharma)
12.5.16.1. Drug Overview and Target Patient Population
12.5.16.2. Sales Forecast
12.5.17. Neridronate (Grunenthal)
12.5.17.1. Drug Overview and Target Patient Population
12.5.17.2. Sales Forecast
12.5.18. Fasinumab (Regeneron Pharmaceuticals)
12.5.18.1. Drug Overview and Target Patient Population
12.5.18.2. Sales Forecast
12.5.19. SP-102 (Semnur Pharmaceuticals)
12.5.19.1. Drug Overview and Target Patient Population
12.5.19.2. Sales Forecast
12.5.20. CNTX-4975 (Centrexion Therapeutics)
12.5.20.1. Drug Overview and Target Patient Population
12.5.20.2. Sales Forecast
12.5.21. MPC-06-ID (Mesoblast)
12.5.21.1. Drug Overview and Target Patient Population
12.5.21.2. Sales Forecast
12.5.22. Tanezumab
12.5.22.1. Drug Overview and Target Patient Population
12.5.22.2. Sales Forecast
12.6. Overall Pain Management Devices Market, 2018-2025
12.6.1. Pain Management Devices Market: Distribution by Geography
12.6.2. Pain Management Devices Market: Distribution by Mechanism of Action
13. CONCLUSION
13.1. The Opioid Crisis is Responsible for a Number of Fatalities Due to the Abuse of Controlled Substances; Drug Developers are Actively Attempting to Develop Alternative Pain Management Solutions
13.2. The Non-Opioid Therapeutics Market is Characterized by a Robust Pipeline of Candidate Drugs Being Developed for a Variety of Chronic Clinical Conditions
13.3. A Variety of Innovative Devices are also Available for the Management of Various Clinical Conditions Characterized by Chronic Pain
13.4. Increasing Partnership Activity and Financial Support from Various Investors are Indicative of Lucrative Future Potential
13.5. Given the Existing Unmet Needs, the Market is Anticipated to Grow at a Steady Pace in the Foreseen Future
14. EXECUTIVE INSIGHTS
14.1. Chapter Overview
14.2. Mark Wiederhold, Chief Executive Officer, Virtual Reality Medical Center (Q2 2018)
14.3. Lisa Robin, Chief Advocacy Officer, Federation of State Medical Boards (Q2 2018)
14.4. Nelson Hendler, Chief Executive Officer, Mensana Clinic Diagnostics (Q2 2018)
14.5. Ryan Jeffcoat, Director of Clinical Affairs and New Markets, AVACEN Medical (Q1 2018)
LIST OF FIGURES
Figure 3.1 Classification of Pain: Acute and Chronic Pain
Figure 3.2 Acute and Chronic Pain: Key Biological Pathways
Figure 3.3 Patient Assessment for Pain Intensity Pre- and Post-Operation
Figure 3.4 Chronic Pain: Primary Symptoms and Causes
Figure 3.5 Types of Chronic Pain: ICD Classification
Figure 3.6 Medications used for Chronic Pain Management in US, 2014-2015
Figure 3.7 Pain Management Therapeutics: Mode of Action
Figure 3.8 Primary Routes of Administration for Opioid Intake
Figure 3.9 Types of Pain Management Devices
Figure 4.1 Unmet Need Analysis: Overview of the Methodology
Figure 4.2 Unmet Needs in Chronic Pain Management: Word Cloud Analysis of Patient Blogs
Figure 4.3 Unmet Needs in Chronic Pain Management: Number of Publications, Year-wise Trend
Figure 4.4 Unmet Needs in Chronic Pain Management: Unmet Needs Highlighted in Published Literature
Figure 4.5 Social Media Analysis: Overview of the Keywords
Figure 4.6 Unmet Needs in Chronic Pain Management: Social Media Sentiment Analysis
Figure 4.7 Unmet Needs in Chronic Pain Management: Social Media Word Cloud on Total Tweets
Figure 4.8 Unmet Needs in Chronic Pain Management: Trends on Social Media
Figure 4.9 Unmet Needs in Chronic Pain Management: Most Prolific Authors on Social Media
Figure 4.10 Unmet Needs in Chronic Pain Management: Social Media Word Clouds on Most Popular Keywords
Figure 4.11 Summary of Key Unmet Needs in Chronic Pain
Figure 5.1 Pipeline Analysis: Distribution by Phase of Development
Figure 5.2 Pipeline Analysis: Distribution by Type of Molecule
Figure 5.3 Pipeline Analysis: Distribution by Mechanism of Action
Figure 5.4 Pipeline Analysis: Distribution by Route of Administration
Figure 5.5 Pipeline Analysis: Distribution by Target Therapeutic Indications(s)
Figure 5.6 Pipeline Analysis: Distribution by Size of Employee Base of Developer
Figure 5.7 Pipeline Analysis: Distribution by Leading Players
Figure 5.8 Developer Logo Landscape: Distribution by Size and Location
Figure 5.9 Mirror Analysis: Distribution by Target Therapeutics Indication(s), Number of Molecules and Number of Developers
Figure 5.10 Heptagon Representation: Distribution by Target Disease Indications Indication(s) and Development Stage
Figure 5.11 Funnel Analysis: Distribution by Target Disease Indication, Route of Administration and Phase of Development
Figure 6.1 Types of Life Cycle Management Strategies
Figure 6.2 Duexis®: Mechanism of Action
Figure 6.3 Duexis®: Life Cycle Management Strategies
Figure 6.4 Gralise®: Mechanism of Action
Figure 6.5 Gralise®: Life Cycle Management Strategies
Figure 6.6 Horizant®: Mechanism of Action
Figure 6.7 Horizant®: Life Cycle Management Strategies
Figure 6.8 Vimovo®: Mechanism of Action
Figure 6.9 Vimovo®: Life Cycle Management Strategies
Figure 8.1 Devices for Pain Management: Distribution by Type
Figure 8.2 Devices for Pain Management: Distribution by Mechanism of Action
Figure 8.3 Devices for Pain Management: Distribution by Administration Modality
Figure 8.4 Devices for Pain Management: Distribution by Site of Application on Body
Figure 8.5 Devices for Pain Management: Distribution by Convenience of Use
Figure 8.6 Devices for Pain Management: Distribution by Location of Developer(s)
Figure 8.7 Devices for Pain Management: Distribution by Company Size
Figure 9.1 Pain Management Device Competitiveness Analysis: Methodology
Figure 9.2 Device Competitiveness Analysis for Implants: Dot-Plot Representation
Figure 9.3 Device Competitiveness Analysis for Wearables: Dot-Plot Representation
Figure 9.4 Device Competitiveness Analysis for Other Devices: Dot-Plot Representation
Figure 10.1 Recent Collaborations: Distribution by Year of Agreement
Figure 10.2 Recent Collaborations: Distribution by Quarterly Trends
Figure 10.3 Recent Collaborations: Distribution by Type of Partnership
Figure 10.4 Recent Collaborations: Distribution by Most Active Players
Figure 10.5 Recent Collaborations: Distribution by Geographical Activity
Figure 11.1 Non-Opioid Drugs for Chronic Pain Management: Cumulative Number of Funding Instances, 2010-2018
Figure 11.2 Non-Opioid Drugs for Chronic Pain Management: Cumulative Distribution of Amount Invested by Year, 2010-2018 (USD Million)
Figure 11.3 Non-Opioid Drugs for Chronic Pain Management: Distribution by Type of Funding, 2010-2018
Figure 11.4 Non-Opioid for Chronic Pain Management: Distribution of Total Amount Invested by Type of Funding, 2010-2018 (USD Million)
Figure 11.5 Non-Opioid Drugs for Chronic Pain Management: Most Active Players by Number of Funding Instances
Figure 11.6 Non-Opioid Drugs for Chronic Pain Management: Most Active Investors by Number of Funding Instances
Figure 11.7 Non-Opioid Drugs for Chronic Pain Management: Funding and Investment Summary
Figure 12.1 Non-Opioid Drugs for Chronic Pain Management Market: Base Scenario, 2018-2025 (USD Billion)
Figure 12.2 Non-Opioid Drugs for Chronic Pain Management Market: Distribution by Therapeutic Area, 2018-2025 (USD Billion)
Figure 12.3 Non-Opioid Drugs for Chronic Pain Management Market: Distribution by Molecule Type, 2018-2025 (USD Billion)
Figure 12.4 Non-Opioid Drugs for Chronic Pain Management Market: Distribution by Geography, 2018-2025 (USD Billion)
Figure 12.5 Qutenza® Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.6 Vimovo® Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.7 Duexis® Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.8 Gralise® Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.9 Horizant® Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.10 Zilretta® Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.11 Ztlido™ Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.12 Aimovig™ Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.13 Fremanezumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.14 Galcanezumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.15 Mirogabalin Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.16 YHD1119 Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.17 GLA5PR Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.18 Eptinezumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.19 ALLOD-2 Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.20 PainBrake® Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.21 Neridronate Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.22 Fasinumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.23 SP-102 Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.24 CNTX-4975 Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.25 MPC-06-ID Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.26 Tanezumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Figure 12.27 Chronic Pain Management Devices Market: Base Scenario, 2018-2025 (USD Billion)
Figure 12.28 Chronic Pain Management Devices Market: Distribution by Geography, 2018-2025 (USD Billion)
Figure 12.29 Chronic Pain Management Devices Market: Distribution by Mechanism of Action, 2018-2025 (USD Billion)
Figure 13.1 Non-Opioid Drugs for Chronic Pain Management Market: Summary of Base, Conservative and Optimistic Scenarios, 2018, 2022 and 2025 (USD Million)
LIST OF TABLES
Table 3.1 A Comparison of Chronic and Acute Pain
Table 3.2 Pain Management: WHO Pain Ladder
Table 3.3 A Comparison of Opioid and Non-Opioid Drugs
Table 3.4 Interventional Strategies for Pain Management
Table 5.1 Non-Opioid Drugs for Chronic Pain Management: Marketed and Development Pipeline
Table 7.1 Non-Opioid Drugs for Chronic Pain Management: Late-Stage Molecules
Table 7.2 Drug Profile: Aimovig™ / Erenumab
Table 7.3 Drug Profile: Analgecine
Table 7.4 Drug Profile: Atogepant / AGN 241689 / MK 8031
Table 7.5 Drug Profile: Civanex / Civamide / Zucapsaicin
Table 7.6 Drug Profile: CNTX-4975
Table 7.7 Drug Profile: Eptinezumab / ALD403
Table 7.8 Drug Profile: Fasinumab
Table 7.9 Drug Profile: Fremanezumab
Table 7.10 Drug Profile: Galcanezumab / LY2951742
Table 7.11 Drug Profile: Lasmiditan / COL-144
Table 7.12 Drug Profile: Mirogabalin / DS-5565
Table 7.13 Drug Profile: MPC-06-ID
Table 7.14 Drug Profile: Neridronate
Table 7.15 Drug Profile: NTM-001
Table 7.16 Drug Profile: NTM-002
Table 7.17 Drug Profile: Perampanel (E2007)
Table 7.18 Drug Profile: POSIMIR (SABER-Bupivacaine)
Table 7.19 Drug Profile: Ralfinamide
Table 7.20 Drug Profile: SP-102
Table 7.21 Drug Profile: T-121
Table 7.22 Drug Profile: Tanezumab
Table 7.23 Drug Profile: Tetrodotoxin / TTX
Table 7.24 Drug Profile: Ubrogepant / MK-1602
Table 7.25 Drug Profile: YHD1119 / Pregabalin
Table 8.1 List of Pain Management Devices
Table 9.1 Device Profiles: Implants
Table 9.2 Device Profile: Freedom SCS System
Table 9.3 Device Profile: VIVENDI™
Table 9.4 Device Profiles: Wearables
Table 9.5 Device Profile: Avail Wireless
Table 9.6 Device Profile: Cefaly
Table 9.7 Device Profile: Electro-Mesh Garments
Table 9.8 Device Profile: Micro-Z
Table 9.9 Device Profile: PainPod MI
Table 9.10 Device Profile: PainPod XPV
Table 9.11 Device Profile: Quell Relief
Table 9.12 Device Profile: SENSUS® Pain Management System
Table 9.13 Device Profile: Smart Relief Back
Table 9.14 Device Profiles: Other Devices
Table 9.15 Device Profile: Silk’n Therapy
Table 9.16 Device Profile: The Wellness Pro™ Plus
Table 10.1 Non-Opioid Drugs and Devices for Chronic Pain Management: Recent Partnerships and Collaborations
Table 11.1 Non-Opioid Drugs and Devices for Chronic Pain Management: Funding and Investments
Table 11.2 Non-Opioid Drugs and Devices for Chronic Pain Management: Summary of Investments
Table 12.1 Non-Opioid Drugs for Chronic Pain Management Market: Forecasted Candidates
Table 15.1 Patient Assessment for Pain Intensity Pre- and Post-Operation
Table 15.2 Medication used for Chronic Pain Management in US, 2014-2015
Table 15.3 Unmet Needs in Chronic Pain Management: Number of Publications, Year-wise Trend
Table 15.4 Unmet Needs in Chronic Pain Management: Information Available in Published Literature
Table 15.5 Social media Analysis: Overview of the Keywords
Table 15.6 Unmet Needs in Chronic Pain Management: Social Media Sentiment Analysis
Table 15.7 Unmet Needs in Chronic Pain Management: Most Prolific Authors on Social Media
Table 15.8 A Summary of Key Unmet Needs in Chronic Pain
Table 15.9 Pipeline Analysis: Distribution by Phase of Development
Table 15.10 Pipeline Analysis: Distribution by Type of Molecule
Table 15.11 Pipeline Analysis: Distribution by Mechanism of Action
Table 15.12 Pipeline Analysis: Distribution by Route of Administration
Table 15.13 Pipeline Analysis: Distribution by Target Therapeutic Indication(s)
Table 15.14 Pipeline Analysis: Distribution by Size of Employee Base of Developer
Table 15.15 Pipeline Analysis: Distribution by Leading Players
Table 15.16 Mirror Analysis: Distribution by Type of Indications, Number of Molecules and Manufacturer
Table 15.17 Heptagon Representation: Distribution by Target Disease Indication and Phase of Development
Table 15.18 Devices for Pain Management: Distribution by Type
Table 15.19 Devices for Pain Management: Distribution by Mechanism of Action
Table 15.20 Devices for Pain Management: Distribution by Administration Modality
Table 15.21 Devices for Pain Management: Distribution by Site of Application on Body
Table 15.22 Devices for Pain Management: Distribution by Convenience of Use
Table 15.23 Devices for Pain Management: Distribution by Location of Developer(s)
Table 15.24 Devices for Pain Management: Distribution by Company Size
Table 15.25 Device Competitive Analysis for Implants: Dot-Plot Representation
Table 15.26 Device Competitive Analysis for Wearables: Dot-Plot Representation
Table 15.27 Device Competitive Analysis for Other Devices: Dot-Plot Representation
Table 15.28 Non-Opioid Drugs and Devices for Chronic Pain Management: Distribution by Year of Agreement
Table 15.29 Non-Opioid Drugs and Devices for Chronic Pain Management: Distribution by Quarterly Trends
Table 15.30 Non-Opioid Drugs and Devices for Chronic Pain Management: Distribution by Type of Partnership
Table 15.31 Non-Opioid Drugs for Chronic Pain Management: Cumulative Number of Funding Instances, 2010–2018
Table 15.32 Non-Opioid Drugs for Chronic Pain Management: Cumulative Distribution of Amount Invested by Year, 2010–2018 (USD Million)
Table 15.33 Non-Opioid Drugs for Chronic Pain Management: Distribution by Type of Funding (2010-2018)
Table 15.34 Non-Opioid Drugs for Chronic Pain Management: Distribution of Total Amount Invested by Type of Funding, 2010-2018 (USD Million)
Table 15.35 Non-Opioid Drugs for Chronic Pain Management: Most Active Players by Number of Funding Instances
Table 15.36 Non-Opioid Drugs for Chronic Pain Management: Most Active Investors by Number of Funding Instances
Table 15.37 Non-Opioid Drugs for Chronic Pain Management: Funding and Investment Summary (USD Million)
Table 15.38 Non-Opioid Drugs for Chronic Pain Market: Base Scenario, 2018-2025 (USD Billion)
Table 15.39 Non-Opioid Drugs for Chronic Pain Market: Conservative Scenario, 2018-2025 (USD Billion)
Table 15.40 Non-Opioid Drugs for Chronic Pain Management Market: Optimistic Scenario, 2018-2025 (USD Billion)
Table 15.41 Non-Opioid Drugs for Chronic Pain Management Market: Distribution by Therapeutic Area, 2018-2025 (USD Billion)
Table 15.42 Non-Opioid Drugs for Chronic Pain Management Market: Distribution by Mechanism of Action, 2018-2025 (USD Billion)
Table 15.43 Non-Opioid Drugs for Chronic Pain Management Market: Distribution by Geography, 2018-2025 (USD Billion)
Table 15.44 Qutenza® Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.45 Qutenza® Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.46 Qutenza® Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.47 Vimovo® Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.48 Vimovo® Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.49 Vimovo® Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.50 Duexis® Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.51 Duexis® Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.52 Duexis® Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.53 Gralise® Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.54 Gralise® Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.55 Gralise® Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.56 Horizant® Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.57 Horizant® Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.58 Horizant® Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.59 Zilretta® Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.60 Zilretta® Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.61 Zilretta® Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.62 Ztlido™ Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.63 Ztlido™ Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.64 Ztlido™ Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.65 Aimovig™ Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.66 Aimovig™ Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.67 Aimovig™ Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.68 Fremanezumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.69 Fremanezumab Sales Forecast (2018-2025): Conservative Scenario (USD
Million)
Table 15.70 Fremanezumab Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.71 Galcanezumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.72 Galcanezumab Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.73 Galcanezumab Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.74 Mirogabalin (DS-5565) Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.75 Mirogabalin (DS-5565) Sales Forecast (2018-2025): Conservative Scenario (USD
Million)
Table 15.76 Mirogabalin (DS-5565) Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.77 YHD1119 Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.78 YHD1119 Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.70 YHD1119 Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.80 GLA5PR Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.81 GLA5PR Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.82 GLA5PR Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.83 Eptinezumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.84 Eptinezumab Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.85 Eptinezumab Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.86 ALLOD-2 Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.87 ALLOD-2 Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.88 ALLOD-2 Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.89 PainBrake® Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.90 PainBrake® Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.91 PainBrake® Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.92 Neridronate Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.93 Neridronate Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.94 Neridronate Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.95 Fasinumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.96 Fasinumab Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.97 Fasinumab Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.98 SP-102 Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.99 SP-102 Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.100 SP-102 Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.101 CNTX-4975 Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.102 CNTX-4975 Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.103 CNTX-4975 Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.104 MPC-06-ID Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.105 MPC-06-ID Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.106 MPC-06-ID Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.107 Tanezumab Sales Forecast (2018-2025): Base Scenario (USD Million)
Table 15.108 Tanezumab Sales Forecast (2018-2025): Conservative Scenario (USD Million)
Table 15.109 Tanezumab Sales Forecast (2018-2025): Optimistic Scenario (USD Million)
Table 15.110 Chronic Pain Management Devices Market: Base Scenario, 2018-2025 (USD Billion)
Table 15.111 Chronic Pain Management Devices Market: Conservative Scenario, 2018-2025 (USD Billion)
Table 15.112 Chronic Pain Management Device Market: Optimistic Scenario, 2018-2025 (USD Billion)
Table 15.113 Chronic Pain Management Device Market: Distribution by Geography, 2018-2025 (USD Billion)
Table 15.114 Chronic Pain Management Device Market: Distribution by Mechanism of Action, 2018-2025 (USD Billion)
Table 15.115 Non-Opioid Drugs for Chronic Pain Management Market: Summary of Base, Conservative and Optimistic Scenarios, 2018, 2022 and 2025 (USD Million)

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