Cell Therapy Manufacturing Market (2nd Edition), 2018-2030
Cell-based therapies have gained significant attention in the overall biopharmaceutical industry. The personalized nature of these treatment options render them highly specific and, according to a number of clinical studies, safe and efficacious. Such therapies are considered to possess the potential to address various unmet medical needs associated with the treatment of several types of physiological disorders and clinical conditions. A number of pharmaceutical companies and investors have already invested significant capital towards the development and commercialization of such products. Around 20 such therapies have been approved; recent approvals include Alofisel® (2018), YESCARTA® (2017) and Kymriah® (2017). It is also worth highlighting that over 500 cell-based therapy candidates are in different stages of clinical development, and are being evaluated in more than 1,000 active clinical studies across various regions of the globe.
The growing number of cell therapy candidates, coupled to their rapid progression through various phases of clinical development, continues to create an increasing demand for facilities that offer manufacturing services for these complex therapies. There is a wide array of industry players, including well-established companies, mid-sized firms and start-ups, as well as academic institutes that are significantly contributing to the production of GMP grade cell therapies. In addition, several players offer novel technology solutions, aimed at improving and upgrading existing cell-based therapies and their manufacturing processes. Most of these players have signed multiple partnerships / collaborations with an aim to optimize, scale-up and expand the capabilities for the production of cell-based therapies. Additionally, stakeholders have received significant support from governments worldwide, in terms of funding and establishment of consortiums, to accelerate the transition of these therapies from laboratories to clinics. Looking at the evolutionary trend so far, we believe that the cell therapy manufacturing market is poised to steadily grow, driven by a robust pipeline of therapy candidates and technological advances aimed to mitigate challenges posed by the conventional methods of production.
SCOPE OF THE REPORT
The “Cell Therapy Manufacturing Market (2nd Edition), 2018-2030” report provides an extensive study of the rapidly growing market of cell therapy manufacturing, focusing on contract manufacturers, as well as cell therapy developers with in-house manufacturing facilities. The study presents an in-depth analysis of various organizations that are engaged in this domain across different regions of the globe. Amongst other elements, the report includes:
A review of the current status of the market with respect to key players, along with information on the location of their manufacturing facilities, scale of production, type of cells manufactured (immune cells (such as T cells, dendritic cells, NK cells), stem cells (such as adult stem cells, human embryonic stem cells and induced pluripotent stem cells) and others), purpose of production (fulfilling in-house requirements / as a contract service provider), type of organization (industry / non-industry), source of cell-based therapies (autologous / allogeneic), cGMP regulatory compliance, and availability of fill / finish services for cell-based therapies.
A discussion on roadmaps published by different agencies across the globe to provide strategies to advance cell therapy manufacturing.
Elaborate profiles of key players (industry and non-industry) that offer contract manufacturing services for cell-based therapies; each profile presents an overview of the company, information on its manufacturing facilities, and recent collaborations.
A discussion on the role of non-profit organizations that have aided in the advancement of cell-based therapies, as well as manufacturing processes.
Detailed information on the role of automation technologies in improving current manufacturing methods, along with a qualitive comparative analysis of cost differences between manual and automated processes.
An analysis of the recent collaborations (signed since 2014) focused on the manufacturing of cell-based therapies; the analysis is based on various parameters, such as the year in which the agreement was signed, type of agreement, and scale of operation (clinical and / or commercial).
An estimate of the overall installed capacity for manufacturing cell-based therapies of various organizations, based on information reported by industry stakeholders in the public domain (wherever available) and affiliated data collated via both secondary and primary research. The analysis highlights the distribution of the global capacity of industry and non-industry players on the basis of scale of operation (clinical and commercial), regions (North America, EU and Asia Pacific) and size of the organization (small-sized, mid-sized and large-sized organizations).
An analysis of the various factors that are likely to influence the pricing of cell-based therapies, featuring different models / approaches that may be adopted by manufacturers to decide the prices of these therapies.
An in-depth analysis of the cell-based therapy manufacturers, featuring three schematic representations; these include [A] a three dimensional grid analysis, representing the distribution of cell-based therapy manufacturers on the basis of the type of cells manufactured, scale of operation and purpose of production (in-house operations / contract manufacturing services), [B] a logo landscapes of cell therapy manufacturers based on the type of cells manufactured, geographical location (North America, EU and Asia Pacific) and the type / size of organization (non-industry players, and small-sized, mid-sized and large companies), and [C] a schematic world map representation, highlighting the geographical locations of cell therapy manufacturing facilities of industry and non-industry stakeholders.
A discussion on affiliated trends, key drivers and challenges, which are likely to impact the industry’s evolution, under a comprehensive SWOT framework. It also includes a Harvey ball analysis, highlighting the relative effect of each SWOT parameter on the overall market.
A survey analysis featuring inputs solicited from various experts who are directly / indirectly involved in development and / or manufacturing of cell-based therapies.
One of the key objectives of the report was to understand the primary growth drivers and estimate the future size of the market. Based on parameters, such as increase in number of clinical studies, target patient population, anticipated adoption of cell-based therapies and expected variation in manufacturing costs, we have provided an informed estimate of the likely evolution of the market in the short to mid-term and mid to long term, for the period 2018-2030. In addition, to account for the uncertainties associated with the manufacturing of cell-based therapies and to add robustness to our model, we have provided three forecast scenarios, portraying the conservative, base and optimistic tracks of the market’s evolution.
The opinions and insights presented in the report were also influenced by discussions held with senior stakeholders in the industry. The study includes detailed transcripts of discussions held with
Arnaud Deladeriere (Manager, Business Development & Operations-cGMP Manufacturing Unit, C3i Center for Commercialization of Cancer Immunotherapy)
Tim Oldham (Chief Executive Officer, Cell Therapies)
Gerard MJ Bos (Chief Executive Officer, CiMaas)
Victor Lietao Li (Co-Founder and Chief Executive Officer, Lion TCR)
Brian Dattilo (Manager of Business Development, Waisman Biomanufacturing)
Mathilde Girard (Department Leader, Cell Therapy Innovation and Development, YposKesi)
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.
1. During our research, we identified over 145 organizations that are actively involved in manufacturing cell-based therapies. The current market landscape features a mix of industry players and non-industry players. Amongst the industry players, over 45 are large or mid-sized firms (with more than 50 employees) involved in the production of cell-based therapies. Further, the growing demand for such therapy products has spurred the establishment of several start-ups as well; examples of organizations that have recently entered the domain include (in the order of year of establishment) Gates Biomanufacturing Facility, IncoCell Tianjin, Mustang Bio, Nikon CeLL innovation, Advent Bioservices, Laboratory for Cell and Gene Medicine (University of Stanford), Cell Therapy Manufacturing Facility (MedStar Georgetown University Hospital), YPOSKESI and The Elisa Linton Center for Rare Disease Therapies.
2. More than 60 non-industry players, including universities, research institutes and hospitals, are currently involved in manufacturing of cell-based therapies. Examples of such organizations include (in alphabetical order) Biological and Cellular GMP Manufacturing Facility (City of Hope), Cell Therapy Facility (UMC Utrecht), Cellular Therapy Integrated Services (Case Western Reserve University), Dana-Farber / Harvard Cancer Center Cell Manipulation Core, Interdisciplinary Stem Cell Institute, Miller School of Medicine (University of Miami), Molecular and Cellular Therapeutics (University of Minnesota), Scottish National Blood Transfusion Service Cellular Therapy Facility, The Michael G. Harris Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering Cancer Center and Upstate Stem Cell cGMP Facility (University of Rochester).
3. As majority of cell therapy products are in the clinical phases of development, most manufacturing facilities presently have the capacity to support clinical scale production requirements. However, some players (53) have already developed / are developing commercial scale capacity for the production of cell therapies. Examples include (in alphabetical order) 3P Biopharmaceuticals, apceth Biopharma, BioNTech Innovative Manufacturing Services, Brammer Bio, CELLforCURE, Cognate BioServices, Guy's and St Thomas' Facility, Lonza, MaSTherCell and SOTIO.
4. More than 60% of the organizations engaged in this domain, possess the capability to manufacture stem cell therapies (including induced pluripotent stem cells) and immune cell-based therapies (such as T-cell immunotherapies and dendritic cell cancer vaccines). Of the total, more than 50 players claim to have the facilities for manufacturing both adult stem cell therapies and immunotherapies . Examples include (in alphabetical order) Center for Gene and Cell Processing (Takara Bio), Cryosite, Centre for Stem Cells Research, Cooperative Research Centre for Cell Therapy Manufacturing, Gamida Cell, GC Cell, MEDINET and Pharmicell.
5. Although the current market landscape is dominated by contract manufacturers (97 manufacturers), some well-established cell therapy developers have set up in-house manufacturing capabilities to support proprietary requirements for cGMP grade cells. Examples of such organizations include (in alphabetical order) Adaptimmune, Argos Therapeutics, Cell Medica, Cellular Biomedicine Group, Kite Pharma (a subsidiary of Gilead Sciences) and Sumitomo Dainippon Pharma. In addition, we identified over 24 organizations that not only manufacture cell-based therapies for their own use, but also offer their capabilities by providing contract services to other players in this domain. Prominent examples include (in alphabetical order) Center for Cell and Gene Therapy, Baylor College of Medicine, Children's GMP / GMP facility (St. Jude Children's Research Hospital), Cook Myosite, FUJIFILM Cellular Dynamics, John Goldmann Centre for Cellular Therapy (Imperial College London), MolMed and Oxford BioMedica.
6. Although, the global installed capacity for cell therapy production is well-distributed between major regions across the globe, we identified that approximately 41% of 195 manufacturing facilities are located in Europe; this is followed by North America, where approximately 38% of the world's cell therapy manufacturing facilities are based. Other emerging pockets for cell therapy manufacturing include Australia, China, Japan, Singapore, South Korea and Israel; it is wort highlighting that facilities in these regions primarily cater to markets in the Asia-Pacific region only.
7. Automation is considered to be a key enabler in this domain and many service providers offering solutions to reduce manual effort have emerged. We identified close to 15 companies that are actively providing support to cell therapy developers to improve their manufacturing process; these include (in alphabetical order) Berkeley Lights, Cesca Therapeutics, Ferrologix, FluDesign Sonics, GE Healthcare and Terumo BCT. Further, we identified five players, namely (in alphabetical order) Fraunhofer Institute for Manufacturing Engineering and Automation IPA, Invetech, KMC Systems, Mayo Clinic Center for Regenerative Medicine and RoosterBio, that offer consultancy solutions related to automation.
8. Over 150 collaborations have been inked in this domain since 2014; of these, 32% were observed to have been associated with the supply of cell-based therapy products for clinical trials. It is worth highlighting that in the last three years, there has been a marked increase (from 32 in 2016 to 49 in 2018) in number of collaborations focused on upgrading existing manufacturing processes. Examples of the companies that have entered into such deals include (in alphabetical order) ATMI, GE Healthcare, Hielscher Ultrasonics, Invetech, Pall, Reinnervate, Terumo BCT and Tokyo Electron. Other type of collaborations that were observed include additional services agreement (24%), joint venture (9%) and acquisitions (3%).
9. Driven by the rapidly evolving pipeline of advanced therapies and the increasing adoption of automated technologies, the cell therapy manufacturing market is expected to grow at an accelerated pace. T-cell therapies, followed by dendritic cell and tumor cell-based cancer vaccines, currently capture the largest shares in the market. This trend is unlikely to change during the forecast period. Further, autologous cell therapies are expected to capture a significant share of the market, given the fact that such therapies have lesser side effects (lower risk of graft rejections), and have high prices which directly translate into high revenue generation potential.
The data presented in this report has been gathered via secondary and primary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and technology segments. Where possible, the available data has been checked for accuracy from multiple sources of information.
The secondary sources of information include
News releases from company websites
Government policy documents
Industry analysts’ views
While the focus has been on forecasting the market till 2030, the report also provides our independent view on various emerging trends in the industry. This opinion is solely based on our knowledge, research and understanding of the relevant market gathered from various secondary and primary sources of information.
Chapter 2 is an executive summary of the insights captured in our research. The summary offers a high-level view on the likely evolution of the cell-based therapy manufacturing market in the short to mid-term, and long term.
Chapter 3 provides a general introduction to the cell-based therapies and ATMPs. It includes a detailed discussion on the manufacturing process of cell-based therapies, associated challenges, and applications of currently available cell therapies. It also provides information on the manufacturing models (centralized and decentralized) that are being considered for the production of cell-based therapies, along with a discussion on their advantages and disadvantages. Further, it provides details on the scalability of these cell-based therapies. The chapter also includes a brief overview on the role of automation and supply chain management with respect to cell-based therapies.
Chapter 4 features a list of all the contract service providers / in-house manufacturers that are actively involved in the manufacturing of cell-based therapies. It provides information on the type of organizations and the geographic location of their facilities, and details on their cell-based therapy manufacturing capabilities, specifically focusing on scale of operation, type of cells manufactured, purpose of manufacturing (in-house requirement / contract manufacturing), source of cells (autologous / allogeneic) and availability of fill / finish services.
Chapter 5 provides a detailed description on the regulatory landscape related to cell therapies across various geographies, such as the US, Europe and other regions. Further, it presents an analysis of the manufacturing facilities on basis of the certifications awarded (for manufacturing cell-based therapies) to individual sites by various regulatory bodies across the globe.
Chapter 6 describes the strategies that are likely to be adopted to accelerate the translation of cell-based therapies from laboratory to clinics. It provides details on roadmaps published by different organizations in various geographies, specifically in the US.
Chapter 7 discusses the role of automation technologies that are likely to optimize the current manufacturing practices with the use of closed and single use systems. Further, it features a roadmap that provides information on the steps to develop automation devices. It also presents a qualitive analysis of the cost incurred while manufacturing cell-based therapies using manual versus automated manufacturing approaches. In addition, it features a list of organizations that offer automated technologies for manufacturing operations or provide services to therapy developers to automate their production processes.
Chapter 8 offers detailed profiles of industry players that offer contract manufacturing services at the clinical and / or commercial scales. Each profile provides a brief overview of the company, details on its manufacturing capabilities and facilities, and the relevant collaborations that have been inked over the last few years.
Chapter 9 offers profiles of the non-industry players that offer contract manufacturing services for cell therapies. Each profile provides a brief overview of the organization, and details on manufacturing capabilities and facilities.
Chapter 10 discusses the role of non-profit organizations in this domain. It provides a list of organizations that are actively involved in the development and production of cell-based therapies, across different global regions. Further, it includes profiles of organizations that provide financial and / or technological support to cell therapy manufacturers and developers. Additionally, the chapter provides information on various international / national societies that help in disseminating knowledge about the advancement of these therapies to the general community.
Chapter 11 features an elaborate analysis and discussion of the various collaborations and partnerships that have been inked amongst players in this market. It includes a brief description on the various types of partnership models (which include manufacturing agreements, technology upgrade and manufacturing process development and testing agreements, additional services agreements, joint ventures and acquisitions) that are employed by stakeholders in this domain, and analysis on the trend of partnerships inked since 2014. It also consists of a schematic representation showcasing the players that have established the maximum number of alliances related to the manufacturing of cell-based therapies. Furthermore, we have provided a world map representation of all the deals inked in this field, highlighting those that have been established within and across different continents.
Chapter 12 features a comprehensive analysis of the overall installed capacity of cell-based therapy manufacturers. The analysis is based on meticulous data collection of reported capacities, via both secondary and primary research, of various small-sized, mid-sized and large-sized companies, and non-industry players distributed across their respective facilities. The results of this analysis were used to establish an informed opinion on the cell-based therapy production capabilities of organizations across different types of organization (industry and non-industry), scale of operation (clinical and commercial), geographies (North America, EU, Asia Pacific and the rest of the world) and size of the organization (small-sized, mid-sized and large-sized organizations).
Chapter 13 highlights our views on the various factors, including manufacturing costs, that may be taken into consideration while pricing cell-based therapies. It features discussions on different pricing models / approaches, which a manufacturer may choose to adopt to decide the price of its proprietary products.
Chapter 14 presents a comprehensive market forecast analysis, highlighting the likely growth of the cell therapy manufacturing market till the year 2030. We have segregated the opportunity by scale of operation (clinical and commercial), type of cell therapy (T-cell immunotherapies, dendritic cell-based therapies, stem cell therapies and other ATMPs), source of cells (autologous and allogeneic) and geography (North America, EU and Asia Pacific).
Chapter 15 presents a collection of key insights derived from the study. It includes a grid analysis, highlighting the distribution of cell-based therapy manufacturers on the basis of type of cells manufactured, scale of production and purpose of manufacturing (fulfilling in-house requirement / contract service provider). In addition, it consists of two logo landscapes, representing the distribution of cell-based therapy manufacturers based on the type of cells manufactured (immune cells and stem cells), geographical regions (North America, EU and Asia Pacific) and the type / size of organization (non-industry, small-sized, mid-sized and large companies). The chapter also consists of two schematic world map representations to highlight the locations of various cell-based therapy manufacturing facilities across different continents.
Chapter 16 provides a detailed analysis capturing the key parameters and trends that are likely to influence the future of cell therapy manufacturing, under a comprehensive SWOT framework.
Chapter 17 summarizes the entire report. It presents a list of key takeaways and offers our independent opinion on the current market scenario and evolutionary trends that are likely to determine the future of this segment of the industry.
Chapter 18 presents insights from the survey conducted for this study. We invited over 100 stakeholders involved in the development and / or manufacturing of different types of cell therapies. The participants, who were primarily Director / CXO level representatives of their respective companies, helped us develop a deeper understanding on the nature of their services and the associated commercial potential.
Chapter 19 is a collection of interview transcripts of the discussions held with key stakeholders in the industry. We have presented details of interviews held with Arnaud Deladeriere (Manager, Business Development & Operations-cGMP Manufacturing Unit, C3i Center for Commercialization of Cancer Immunotherapy), Tim Oldham (Chief Executive Officer, Cell Therapies), Gerard MJ Bos (Chief Executive Officer, CiMaas), Victor Lietao Li (Co-Founder and Chief Executive Officer, Lion TCR), Brian Dattilo (Manager of Business Development, Waisman Biomanufacturing) and Mathilde Girard (Department Leader, Cell Therapy Innovation and Development, YposKesi)
Chapter 20 is an appendix, which provides tabulated data and numbers for all the figures in the report.
Chapter 21 is an appendix, which presents the list of companies and organizations that have been mentioned in the report.
LIST OF COMPANIES / LIST OF COMPANIES AND ORGANIZATIONS
The following companies and organizations have been mentioned in the report.
1. 3P Biopharmaceuticals
2. A2 Healthcare
4. Acerta Pharma
6. Adva Biotechnology
7. Advanced Cell Therapy Laboratory, Yale School of Medicine
8. Advanced Regenerative Manufacturing Institute
9. Advent Bioservices
10. Agios Pharmaceuticals
12. Akron Biotech
13. Alberta Cell Therapy Manufacturing, University of Alberta
14. Allele Biotechnology & Pharmaceuticals
15. Alliance for Regenerative Medicine
17. Altor BioScience
18. American Productivity & Quality Center
19. American Society of Gene and Cell Therapy
20. American Society of Mechanical Engineers
22. Amsterdam Biotherapeutics Unit
23. Andalusian Initiative for Advanced Therapies
24. Angiocrine Bioscience
26. Aokai (Suzhou) Biomedical
27. apceth Biopharma
28. Argos Therapeutics
29. ARIAD Pharmaceuticals
30. Asahi Glass Company
31. Asterias Biotherapeutics
34. Atara Biotherapeutics
36. Atlantic Bio GMP
37. ATVIO Biotechnology
38. Australasian Gene and Cell Therapy Society
39. Austrian Network for Gene Therapy
41. Azellon Cell Therapeutics
42. Bavarian Nordic
44. Be The Match BioTherapies
45. Bellicum Pharmaceuticals
46. Berkeley Lights
47. Bio Elpida
50. BioLife Solutions
51. Biological and Cellular GMP Manufacturing Facility, City of Hope
52. biologistex CCM
53. BioNTech Innovative Manufacturing Services
54. Biosafe Group
55. bluebird bio
56. Boehringer Ingelheim
57. Bone Therapeutics
58. Brammer Bio
59. Bristol-Myers Squibb
60. British Society for Gene and Cell Therapy
61. Caladrius Biosciences
62. California Institute of Regenerative Medicine
63. Cancer Research UK
64. Capricor Therapeutics
67. Cell and Gene Therapy Catapult
68. Cell Manipulation Core, Dana-Farber / Harvard Cancer Center
69. Cell Medica
70. Cell Tech Pharmed
71. Cell Therapies
72. Cell Therapy and Regenerative Medicine, University of Utah
73. Cell Therapy Facility, UMC Utrecht
74. Cell Therapy Manufacturing Cooperative Research Center
75. Cell Therapy Suite, University of Birmingham
80. Cellin Technologies
81. Cells Cure Foundation
82. Cells for Sight, Stem Cell Therapy Research Unit, University College London
83. Cellular Biomedicine Group
84. Cellular Therapeutics
85. Cellular Therapy Core, University of Texas
86. Cellular Therapy Integrated Services, Case Western Reserve University
88. Censo Biotechnologies
89. Center for Biomedical Engineering and Advanced Manufacturing, McMaster University
90. Center for Cell and Gene Therapy, Baylor College of Medicine
91. Center for Gene and Cell Processing, Takara Bio
92. Center for International Blood and Marrow Transplant Research
93. Centre for Biological Engineering, Loughborough University
94. Centre for Cell and Vector Production
95. Centre for Cell Manufacturing Ireland, NUI Galway
96. Centre for Commercialization of Regenerative Medicine
97. Centre for Stem Cell Research
98. Centre for Commercialization of Cancer Immunotherapy (C3i)
99. Centre multidisciplinaire de développement du génie tissulaire
100. Centre of Genomics and Policy, McGill University
101. Cesca Therapeutics
103. Chiesi Farmaceutici
104. Children’s Medical Research Institute
105. Children's GMP, St. Jude Children's Research Hospital
106. China Life Health Industry Group
107. China Regenerative Medicine International
109. City of Hope Alpha Clinic for Cell Therapy
110. Clinical Biomanufacturing Facility, University of Oxford
111. Clinical Cell and Vaccine Production Facility
112. Clinical Research Facility, South London and Maudsley
113. Closed Cell Systems
114. Cognate BioServices
115. Commonwealth Scientific and Industrial Research Organization
116. Cook MyoSite
117. CRISPR Therapeutics
121. Cynata Therapeutics
123. Cytori Therapeutics
125. DanDrit Biotech
129. Eli Lilly
131. Emory Personalized Immunotherapy Core
132. European Bank for induced pluripotent Stem Cells
133. European Society of Gene and Cell Therapy
134. Federal Economic Development Agency for Southern Ontario
137. Finnish Gene Therapy Society
138. Fisher BioServices
139. FloDesign Sonics
140. Fortuna Fix
141. Fosun Pharma
142. Foundation for the Accreditation of Cellular Therapy
143. Foundation of Croatian Association for Regenerative Medicine and Stem Cell Therapy
144. Fraunhofer Institute for Cell Therapy and Immunology IZI
145. French Society of Cellular and Gene Therapy
148. FUJIFILM Cellular Dynamics
149. Gamida Cell
150. Gates Biomanufacturing Facility
151. GC Cell
152. GE Healthcare
154. Gene and Cell Therapy Lab, Institute of Translational Health Sciences
156. Georgia Institute of Technology
157. Georgia Research Alliance
158. German Gene Therapy Society
159. Gilead Sciences
161. Glycostem Therapeutics
162. GPB Scientific
164. Great Ormond Street Hospital Cellular Therapy Laboratories, University College London
165. Guy's and St Thomas' Facility
166. Haematological Sciences, Institute of Cellular Medicine
167. Harvard University Stem Cell Institute
168. Health Sciences Authority
169. Hielscher Ultrasonics
171. Hitachi Chemical Advanced Therapeutics Solutions
172. Holostem Terapie Avanzate
173. Hospital of University of Pennsylvania
174. Houston Methodist Hospital Foundation
175. Houston Methodist Institute of Technology, Innovation and Education
176. Houston Methodist Research Institute
177. Human Islet and Cellular Transplant Facility
178. Human Stem Cells Institute
179. Immatics Biotechnologies
180. ImmunoCellular Therapeutics
182. Immunovative Therapies
183. IncoCell Tianjin
184. Innovate UK
185. Innovative Cellular Therapeutics
186. IntelliCell BioSciences
187. Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami
188. International Cellular Medicine Society
189. International Society for Cancer Gene Therapy
190. International Society for Cellular Therapy
191. International Society for Stem Cell Research
192. International Stem Cell Corporation
194. Iovance Biotherapeutics
195. IQVIA Stem Cell Center
196. Irish Society for Gene and Cell Therapy
197. Irish Stem Cell Foundation
198. Israeli Society for Gene and Cell Therapy
199. Isto Biologics
200. Japan Society for Gene Therapy
201. Japan Tissue Engineering
202. Jazz Pharmaceuticals
203. JCR Pharmaceuticals
204. John Goldmann Centre for Cellular Therapy, Imperial College London
205. Juno Therapeutics
206. JW CreaGene
207. Kawasaki Heavy Industries
208. KBI Biopharma
209. Kiadis Pharma
210. Kids Research Institute
211. Kite Pharma
212. KMC Systems
213. Kolon TissueGene
214. Korean Society of Gene and Cell Therapy
215. Laboratory for Cell and Gene Medicine, University of Stanford
216. Lexicon Pharmaceuticals
217. Lion TCR
219. Maisonneuve-Rosemont Hospital
222. Mayo Clinic Center for Regenerative Medicine
227. Medistem Panama (Stem Cell Institute)
229. MedStar Georgetown University Hospital
232. Michael Smith Laboratories, University of British Columbia
233. Millennium Pharmaceuticals
234. Millipore Sigma
235. Miltenyi Biotec
236. MNX Global Logistics
237. Moffitt Cancer Center
238. Molecular and Cellular Therapeutics, University of Minnesota
240. Mustang Bio
241. Nantes University Hospital
242. National Cell Manufacturing Consortium
243. National Centre for Biomedical Engineering Sciences
244. National Eye Institute
245. National Gene Vector Laboratory
246. National Institute of Health Research
247. National Institute of Standards and Technologies
248. National Stem Cell Foundation
249. National Stem Cell Foundation of Australia
250. Neon Therapeutics
251. Netherlands Cancer Institute
252. Networks of Centres of Excellence
254. NewLink Genetics
255. NHSBT Birmingham
257. Nikon CeLL innovation
258. Nohla Therapeutics
259. Northwest Biotherapeutics
260. Norwegian Radium Hospital
264. Octane Medical Group
266. Ontario Institute of Regenerative Medicine
267. Onyx Pharmaceuticals
268. Opexa Therapeutics
269. Orchard Therapeutics
272. Ospedale Pediatrico Bambino Gesù
273. Ottawa Hospital Research Institute, University of Ottawa
274. Oxford BioMedica
275. Oxford MEStar
276. Pall Corporation
278. PCI Services
279. PCT Cell Therapy Services
280. Peter Couche Foundation
281. Peter MacCallum Cancer Centre
286. Pluristem Therapeutics
287. Praxis Pharmaceutical
288. Production Assistance for Cellular Therapies
289. Promethera Biosciences
290. Provia Laboratories
291. Puma Biotech
292. Q-GEN Cell Therapeutics, QIMR Berghofer Medical Research Institute
293. Rayne Cell Therapy Suite, King's College London
294. Regenerative Medicine Foundation
295. Regenerative Medicine Institute
298. Reliance Life Sciences
301. Research and Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation
302. Riyadh Pharma
303. Robertson Clinical and Translational Cell Therapy, Duke University
304. Roche Diagnostics
305. Rooster Bio
306. Roslin Cells
307. Roswell Park Cancer Institute
308. Royal Free Hospital, Centre for Cell and Gene Tissue Therapeutics
309. Royal Prince Alfred Hospital
312. Sartorius Stemdim
313. SAVSU Technologies
315. Scottish Centre for Regenerative Medicine
316. Scottish National Blood Transfusion Service Cellular Therapy Facility
318. Shanghai Sunway Biotech
319. Shenzhen SiBiono GeneTech
320. Shibuya Corporation
322. Smilow Translational Research Center
323. Smith & Nephew
325. Spanish Society of Gene and Cell Therapy
326. Spark Therapeutics
327. Stage Cell Therapeutics
328. Stanford Children's Health, Stanford Health Care
329. Stanford School of Medicine
330. Stemedica Cell Technologies
331. Sumitomo Dainippon Pharma
332. Swedish Society for Gene and Cell Therapy
333. Sydney Cell and Gene Therapy
335. Takeda Pharmaceutical
336. TAP Biosystems
338. TC Biopharm
339. T-Cell Factory
341. Terumo BCT
343. Texas Children’s Hospital
344. Texas Medical Center
345. The Children’s Hospital at Westmead
346. The Elisa Linton Center for Rare Disease Therapies
347. The Michael G. Harris Cell Therapy and Cell Engineering Facility, Memorial Sloan Kettering Cancer Center
348. The Netherlands Society of Gene and Cell Therapy
349. The New York Stem Cell Foundation
350. The Ottawa Hospital Research Institute
351. The Philip S Orsino Facility for Cell Therapy, Princess Margaret Hospital
352. The University of Texas Health Science Center
353. Therapeutic Cell Production Core, Seattle Children's Hospital
354. Thermo Fisher Scientific
357. Tokyo Electron
359. Trinity Partners
360. Turkish Society for Gene and Cell Therapy
361. TVAX Biomedical
363. Tyne Hospitals NHS Foundation Trust
364. UC Davis GMP Laboratory
365. UCLA Human Gene and Cell Therapy
366. UCLA-UCI Alpha Stem Cell Clinic
367. UK Stem Cell Foundation
368. University Hospital Basel
369. University Medical Center Groningen
370. University of California
371. University of Leeds
372. University of Manchester
373. University of Newcastle
374. University of North Carolina Lineberger Comprehensive Cancer Center
375. University of Tennessee
376. University of Wisconsin–Madison
377. Upstate Stem Cell cGMP Facility, University of Rochester
379. Valeant Pharmaceuticals
380. Vecura, Karolinska University Hospital
383. Vitruvian Networks
385. Waisman Biomanufacturing
386. Westmead Hospital
387. Westmead Millennium Institute
388. World Courier
389. WuXi Advanced Therapies
390. WuXi AppTec
394. Zelluna Immunotherapy
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