Methyl sequencing is primarily done to understand the methylation pattern in a DNA. DNA methylation is said to be the first discovered epigenetic mark. DNA methylation is the most commonly studied in epigenetics. The DNA is treated with different chemicals such as bisulfite which manifests changes in the DNA sequence which are dependent on the methylation pattern of individual cytosine residues, this leads to single nucleotide resolution information on the methylation status of the test DNA segment. Many different techniques have been identified for methyl sequencings such as Direct sequencing, pyrosequencing, methylation – sensitive single stranded conformation analysis, high resolution melting analysis, methylation – sensitive single-nucleotide primer extension, base specific cleavage, and methylation-based microarray-based methods. The major methods being used currently for methyl; sequencing is whole-genome bisulfite sequencing (WGBS), reduced representation bisulfite sequencing (RRBS), methylated DNA immunoprecipitation sequencing (MeDIP – Seq) Methylation sequencing is used to elucidate the methylation pattern of CpG, CHH, CHG regions across the entire genome. Methyl sequence helps in identification of full sample diversity with only small amount of DNA.
The increasing growth rate in Next-generation sequencing is expected to propel the growth of Methyl sequencing market. Increasing applications in clinical diagnosis is boosting the market growth. The Drug discovery applications demanding NGS technology are the major factors driving the growth of the market. The increasing technological advancement, increasing funding for research and development in biotechnology and more companies investing towards the development of advanced gene sequencing technique is going to propel the growth of the market.
The Roche Holding AG, Illumina, Qiagen, Thermo Fisher Scientific, Agilent Technologies are the key players .
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