Global Insect Cell Expression Systems Market Research Report 2023-Competitive Analysis, Status and Outlook by Type, Downstream Industry, and Geography, Forecast to 2029
Insect cells offer high levels of protein expression with posttranslational modification approaching that of mammalian cells, ease of scale-up, and simplified cell growth that can be readily adapted to high-density suspension culture for large-scale expression. Most of the posttranslational modification pathways present in mammalian systems also occur in insect cells, allowing the production of recombinant protein that is more antigenically, immunogenically, and functionally similar to the native mammalian protein than if expressed in yeast or other eukaryotes.
Expression systems are genetic constructs (a gene encoded by DNA) that are designed to produce a protein, or an RNA (ribonucleic acid), either inside or outside a cell.
Insect Cell Expression Systems are powerful and versatile systems for producing high levels of recombinant protein expression in insect cells.
The latest research study on the global Insect Cell Expression Systems market finds that the global Insect Cell Expression Systems market reached a value of USD 237.06 million in 2022. It’s expected that the market will achieve USD 439.4 million by 2028, exhibiting a CAGR of 10.83% during the forecast period.
With the rapid development of life science, more and more attention has been paid to cell engineering in the field of bioengineering technology. Insect cell culture technology, which takes insect cells as the culture object, has important value in modern experimental biology and is widely used in various fields of medicine, agriculture and biology.
With the rapid development of insect cell culture technology, molecular biology and genetic engineering research, insect cell lines have been more and more widely used in various research fields. Insect cell culture technology has gradually changed from simple in vitro culture technology to a routine research method required by many biological studies, and insect cell lines will gradually become the necessary materials for research in various research fields.
Protein hydrolysis problem. Compared with the other three traditional gene engineering expression systems, although insect baculovirus expression vector system (BEVS) has its own characteristics and advantages, it also inevitably has some disadvantages, such as the easy degradation of recombinant protein in BEVS. BEVS itself is a lytic system. During the limited time (usually 72 ~ 96 h) of production in protein, protease is expressed and secreted at every stage. After baculovirus infects insect cells, the cells themselves produce a stress reaction and express proteases, which are released with cell lysis. These proteases are undoubtedly the culprit of recombinant protein degradation. At present, most insect cell cultures use serum-free medium. Because there is no protection of serum proteins such as serum albumin and macroglobulin, the problem of protein hydrolysis becomes more serious.
In 2021, the share of the Insect Cell Expression Systems market in North America stood at 41.58%.
Merck KGaA is a global pharmaceutical and chemical company. The Company researches drugs in the areas of oncology and neurodegenerative as well as autoimmune and inflammatory diseases. Also, it markets cardiovascular, fertility, endocrinology, and over-the-counter products as well as products for flat screens and the pharmaceutical, food, cosmetics, packaging, and coatings.
Thermo Fisher Scientific
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Whether Thermo Fisher Scientific's customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, Thermo Fisher Scientific is here to support them. Thermo Fisher Scientific's global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.
Insect cell expression systems mainly include the following products and accessories: Reagents, Expression Vectors, Competent Cells and Instruments. Among them, the market share of Reagents and Expression Vectors products is obviously higher than that of other products, and their market share reached 49.51% and 29.78% respectively in 2021.
Insect Cell Expression Systems are mainly used in the following fields: Therapeutic, Industrial and Research. Among them, the market share of Therapeutic and Research fields is obviously higher, and their market share reached 59.22% and 27.46% respectively in 2021.
By 2028, the market size of Therapeutic and Research fields will be 271.88 M USD and 111.12 M USD respectively, accounting for 62.25% and 25.44% of the total market.
Key Companies in the global Insect Cell Expression Systems market covered in Chapter 3:
Oxford Expression Technologies
New England Biolabs
Thermo Fisher Scientific
GenScript Biotech Corporation
In Chapter 4 and Chapter 14.2, on the basis of types, the Insect Cell Expression Systems market from 2018 to 2029 is primarily split into:
In Chapter 5 and Chapter 14.3, on the basis of Downstream Industry, the Insect Cell Expression Systems market from 2018 to 2029 covers:
Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2018-2029) of the following regions are covered in Chapter 8 to Chapter 14:
North America (United States, Canada)
Europe (Germany, UK, France, Italy, Spain, Russia, Netherlands, Turkey, Switzerland, Sweden)
Asia Pacific (China, Japan, South Korea, Australia, India, Indonesia, Philippines, Malaysia)
Latin America (Brazil, Mexico, Argentina)
Middle East & Africa (Saudi Arabia, UAE, Egypt, South Africa)
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