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Global Dravet Syndrome Market: Industry Analysis & Outlook (2019-2023)

Global Dravet Syndrome Market: Industry Analysis & Outlook (2019-2023)

Dravet syndrome, formerly known as severe myoclonic epilepsy of infancy (SMEI), is a severe kind of epilepsy which causes seizures. High fever is usually a trigger for these seizures. It is a rare disorder that affects an estimated 1 in every 20,000–40,000 births. It usually develops in the six month of age. It is caused by loss-of-function mutations in one copy of the SCN1A gene. Patients with Dravet syndrome are not able to produce sufficient levels of functional Nav1.1 sodium channel, preventing inhibitory neurons from firing properly.

The disorder is considered orphan indication. And there are very limited treatment options available in the market. However, several therapeutics for Dravet syndrome are in pipeline. The drugs in development are getting orphan drug designation by FDA and EMA. The Dravet syndrome market in Europe and the U.S. is likely to exhibit significant growth in the next five years due to increasing research and development activities conducted by several companies. Several companies are making alliances for developing therapeutics for Dravet syndrome. Currently, the U.S and Europe are holding the potential growth for Dravet Syndrome market due to increasing R&D into new drug development for Dravet syndrome and approval for these drugs in these regions.

Key players of the market include Zogenix, Zynerba, GW Pharmaceuticals, and OPKO. Currently, only GW Pharmaceuticals’ Epidiolex is commercially available. Other players are currently developing their drugs or seeking for commercial approval by FDA and EMA. Zogenix’s ZX008 is expected to penetrate market in 2019 and create competition for GW Pharmaceuticals. Currently, the market is dominated by generic drugs.


1. Overview
1.1 Dravet Syndrome
2. Global Dravet Syndrome Drug Market
2.1 ZX008 Sales Value Forecast
Table 1: Global ZX008 Sales Value Forecast (2019-2023)
2.2 Epidiolex Sales Value Forecast
Table 2: Global Epidiolex Sales Value Forecast (2019-2023)
3. Regional Dravet Syndrome Drug Market
3.1 The U.S.
3.1.1 The U.S. Dravet Syndrome Patient Volume Forecast
Table 3: The U.S. Dravet Syndrome Patient Volume Forecast (2018-2023)
3.1.2 ZX008 Sales Value Forecast in the U.S. Dravet Syndrome Market
Table 4: ZX008 Sales Value Forecast in the U.S. Dravet Syndrome Market (2019-2023)
3.1.3 Treated Dravet Syndrome Patients with ZX008 in the U.S. Forecast
Table 5: Treated Dravet Syndrome Patients with ZX008 in the U.S. Forecast (2019-2023)
3.1.4 ZX008 Penetration Forecast in the U.S. Dravet Syndrome Market
Table 6: ZX008 Penetration Forecast in the U.S. Dravet Market (2019-2023)
3.1.5 Epidiolex Sales Value Forecast in the U.S. Dravet Syndrome Market
Table 7: Epidiolex Sales Value Forecast in the U.S. Dravet Syndrome Market (2019-2023)
3.1.6 Treated Dravet Syndrome Patients with Epidiolex in the U.S. Forecast
Table 8: Treated Dravet Syndrome Patients with Epidiolex in the U.S. Forecast (2019-2023)
3.1.7 Epidiolex Penetration Forecast in the U.S. Dravet Syndrome Market
Table 9: Epidiolex Penetration Forecast in the U.S. Dravet Syndrome Market (2019-2023)
3.2 Europe
3.2.1 Europe Dravet Syndrome Patient Volume Forecast
Table 10: Europe Dravet Syndrome Patient Volume Forecast (2018-2023)
3.2.2 ZX008 Sales Value Forecast in Europe Dravet Syndrome Market
Table 11: ZX008 Sales Value Forecast in Europe Dravet Syndrome Market (2020-2023)
3.2.3 Treated Dravet Syndrome Patients with ZX008 in Europe Forecast
Table 12: Treated Dravet Syndrome Patients with ZX008 in Europe Forecast (2020-2023)
3.2.4 ZX008 Penetration Forecast in Europe Dravet Syndrome Market
Table 13: ZX008 Penetration Forecast in Europe Dravet Syndrome Market (2020-2023)
3.2.5 Epidiolex Sales Value Forecast in Europe Dravet Syndrome Market
Table 14: Epidiolex Sales Value Forecast in Europe Dravet Syndrome Market (2019-2023)
3.2.6 Treated Dravet Syndrome Patients with Epidiolex in Europe Forecast
Table 15: Treated Dravet Syndrome Patients with Epidiolex in Europe Forecast (2019-2023)
3.2.7 Epidiolex Penetration Forecast in Europe Dravet Syndrome Market
Table 16: Epidiolex Penetration Forecast in Europe Dravet Syndrome Market (2019-2023)
4. Market Dynamics
4.1 Growth Drivers
4.1.1 Attractive Orphan Drug Policies
Table 17: Orphan Drug Policies
4.1.2 Rising Healthcare Expenditure
Table 18: Global Healthcare Expenditure Per Capita (2014-2018)
4.1.3 Accelerating Economic Growth
Table 19: Global GDP Per Capita (2014-2018)
4.1.4 Rising Strategic Alliances
4.2 Key Trends
4.2.1 Development of New Therapeutics
Table 20: Dravet Syndrome Therapeutics Pipeline
4.2.2 Approval of Cannabidiol Drugs for Dravet Syndrome
4.3 Challenges
4.3.1 Regulatory Challenges
4.3.2 Associated Risks
4.3.3 Insufficient Disease Information and Research Participants
4.3.4 Rising Competition from Generic Industry
5. Competition
5.1 Global Market
5.1.1 Revenue Comparison of Key Players
Table 21: Revenue Comparison of Key Players (2017)
5.1.2 Market Cap Comparison of Key Players
Table 22: Market Cap Comparison of Key Players
5.1.3 Comparison of Epidiolex and ZX008
Table 23: Pivotal Phase Data of Epidiolex and ZX008
6. Company Profiles
6.1 Zogenix
6.1.1 Business Overview
6.1.2 Financial Overview
Table 24: Zogenix Total Revenue and Net Loss/Income (2013-2017)
6.1.3 Business Strategies
Table 25: Zogenix R&D Expenditure (2015-2017)
6.2 Zynerba
6.2.1 Business Overview
Table 26: Zynerba Product Pipeline
6.2.2 Financial Overview
Table 27: Zynerba Revenue & Net Loss (2013-2017)
6.2.3 Business Strategies
Table 28: Zynerba R&D Expenditure (2015-2017)
6.3 OPKO
6.3.1 Business Overview
Table 29: OPKO Revenue by Segment (2017)
6.3.2 Financial Overview
Table 30: OPKO Revenue and Net Loss (2013-2017)
6.3.3 Business Strategies
Table 31: OPKO R&D Expenditure (2015-2017)
6.4 GW Pharmaceuticals
6.4.1 Business Overview
Table 32: GW Pharmaceuticals Revenue by Segment (2017)
6.4.2 Financial Overview
Table 33: GW Pharmaceuticals Revenue and Loss of the year (2013-2017)
6.4.3 Business Strategies

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