Global Transdermal Drug Delivery Market To 2020 Strategic Analysis, Technologies, Competitor Profiles, Financial Evaluation, Product Pipeline Assessment And Swot Investigation

Global Transdermal Drug Delivery Market To 2020 Strategic Analysis, Technologies, Competitor Profiles, Financial Evaluation, Product Pipeline Assessment And Swot Investigation

Today the global drug delivery market (DDM) was worth just under $160 billion, a significant jump from $131 billion in 2010. The transdermal drug delivery market (TDDM) is worth $25 billion globally and is one of the fastest growing segments of the total drug delivery sector. This area is set to grow vertically over the next five years, propelled mainly by an unmet need in the market for less invasive and more convenient delivery systems. These delivery systems are paramount within the pediatric, geriatric and dementia market spaces.

Transdermal patches are gaining market penetration since primary physicians and patients alike put more trust in easy to use delivery methods. By 2018, the TDDM is forecast to generate $40 billion annually.

The transdermal drug delivery market contributes to the following key markets:

  • Smoking cessation market
  • Analgesic/Pain market
  • Neuropathic Pain market
  • Generics market
  • Women’s health market
Bestselling transdermal systems include narcotic analgesics, antihypertensives, Alzheimer’s disease agents, hormone replacement patches within women’s healthcare and nicotine patches for smoking cessation.

This report gives a comprehensive account of the market size, segmentation, key players, SWOT analysis, influential technologies, and business and economic environments. It is supported by 320 tables & figures over 260 pages and is analysed as follows:
  • By Geography (Global, USA)
  • By Parent Market (Drug Delivery Systems, Advanced Drug Delivery Systems)
  • By Sub-market (Generics, Women’s Health, Analgesics, Neuropathic Pain, )

1.0 Executive Summary
1.1 Objectives of Report
1.2 Data Sources & Methodology
1.3 Key Findings & Observations
1.3.1 The Global Drug Delivery Market has a Growth Rate of 5%
1.3.2 The Transdermal Drug Delivery Market is Growing Vertically
1.3.3 Who are the Leading Players in the Market?
1.3.4 Neurodegenerative Disorders Such as Alzheimer’s and Parkinson’s Disease Will Propel the Future Market
1.3.5 Why is the Transdermal Drug Delivery Market so Promising?
1.3.6 What are the Main Drivers of the Market?
1.3.7 First, Second and Third Generation Drug Delivery Systems
1.3.8 The Niche Market of Commercially Available Skin Models
1.3.9 Transdermal Drug Delivery Technologies are Providing the Market with Niche Spaces
1.3.10 Nanotechnology is Transforming Transdermal Drug Delivery
1.3.11 Can Transdermal Drug Delivery be Applied to Cancer Vaccination?
1.3.12 Gene Therapy Advancement Using Transdermal Delivery
2.0 Transdermal Drug Delivery
2.1 Introduction
2.2 Developments of Transdermal Drug Delivery to Date
2.3 The Skin – Anatomy and Physiology
2.3.1 Drug Administration via the Intracellular Pathway
2.3.2 Drug Administration via the Intercellular Pathway
2.3.3 Fick’s Law
2.4 Factors that Influence Transdermal Drug Delivery
2.4.1 Parameters Influencing Skin Permeability The Vehicle Drug Concentration Partition Coefficient
2.5 Strategies to Enhance Transdermal Drug Delivery
2.5.1 1st Generation Delivery Systems
2.5.2 2nd Generation Delivery Systems
2.5.3 Chemical Enhancers
2.5.4 3rd Generation Delivery Systems
2.6 Comparison of Transdermal Delivery with Other Methods
2.7 Advantages of Transdermal Drug Delivery
2.7.1 First-Pass Metabolism
2.8 Disadvantages of Transdermal Delivery
2.9 Complications of Transdermal Therapy
2.9.1 Overdose
2.9.2 Skin Sensitivity and Reactions
2.9.3 MRI-Induced Skin Burns
3.0 Biomechanical and Pharmacological Elements Effecting Transdermal Drug Delivery
3.1 Factors That Influence Transdermal Drug Delivery
3.1.1 Rate of Permeation Across the Skin
3.1.2 Skin Characteristics
3.1.3 Drug Characteristics
3.1.4 pH and Pharmacokinetics
3.2 Transdermal Drug Design
3.2.1 Factors That Affect the Absorption of the Drug Hydration and Temperature Biotransformation of the Drug in the Skin
3.2.2 Selecting Drug and Vehicle
3.2.3 Drug Modification Ion-Pair Formation Drug Complexation
3.2.4 Thermodynamic Activity of the Drug within the Vehicle Eutectic Systems Vehicle Formulation Modification of the Stratum Corneum
3.3.1 Static Franz Diffusion Cell
3.4 Commercially Available Skin Models for Transdermal Drug Testing
3.5 In vivo Testing of Transdermal Drug Delivery Systems
3.5.1 In vivo Testing of Drug Delivery Systems
3.5.2 Modelling of Transport Through the Skin
4.0 Transdermal Drug Delivery Technologies
4.1 Introduction
4.1.1 Local Application Formulations
4.1.2 Liquid Crystals for Transdermal Drug Delivery
4.1.3 Microemulsions for Transdermal Drug Delivery
4.1.4 Nanoemulsions for Transdermal Drug Delivery
4.1.5 Transdermal Gel Technology
4.1.6 Biphasix System
4.1.7 Penetration Enhancers
4.1.8 Chemical Enhancers
4.1.9 Nitric Oxide-Based Transdermal Drug Delivery
4.2 Vesicular transdermal carriers
4.2.1 Liposomes
4.2.2 Transfersomes
4.2.3 Ethosomes
4.2.4 Elastic Vesicles
4.3 Transdermal Patch
4.3.1 Types of Transdermal Patch
4.3.1a Single-layer Drug-in-Adhesive
4.3.1b Multi-layer Drug-in-Adhesive
4.3.1c Reservoir
4.3.1d Matrix Patch
4.3.1e Vapour Patch
4.3.1 Transdermal Patches Adhesives
4.3.2 New Technologies
4.3.3 h-Patch™ Controlled Release Micropump System
4.4 Patchless Transdermal Delivery System
4.5 Metered-Dose Transdermal System
4.6 Polymers for Transdermal Drug Delivery
4.6.2 Film Forming Polymeric Solutions
4.7 Physical Methods to Promote Transdermal Delivery
4.7.1 Electrotransport
4.7.2 Electroporation Drug delivery by Electroporation Electrochemotherapy
4.7.3 Cryoelectrophoresis
4.7.4 Iontophoresis Application of Iontophoresis for Drug Delivery Companies with Technologies for Drug Delivery by Iontophoresis
4.8 How Combining Electrophoresis and Iontophoresis Impacts Drug Delivery
4.9 Dermaportation
4.9.1 Radiofrequency-Driven Transdermal Delivery
4.9.2 Transcutaneous Drug Delivery by Electropulsation
4.9.3 Skin Patch Systems and Electrostatic Force
4.9.4 Heat-Aided Drug Delivery
4.9.5 Ultrasound
4.9.6 Magnetophoresis
4.10 Use of Lasers for Transdermal Drug Delivery
4.10.1 Laser-Induced Microporation
4.10.2 Painless Laser Injection
4.10.3 Laser-Induced Pressure Waves Transdermal Drug Delivery by Laser-Assisted Changes in Skin
4.11 How Pressurized Gas is Transforming Transdermal Drug Delivery
4.12 Microscission Induced by Gas
4.13 Role of Microelectromechanical Systems (MEMS) in Transdermal Drug Delivery
4.14 Microneedles and Dermal Microinjection
4.15 Microneedle Arrays for Drug Delivery
4.15.1 Microneedle Patch
4.15.2 Applications of Microneedles
4.15.3 AdminPatch® Microneedle Array
4.15.4 Dissolving Microneedles
4.16 Biodegradable Microneedles
4.17 Ceramic Microneedle Arrays
4.18 Dissolvable Microneedle Patches
4.18.1 MicorCor
4.18.2 MicroPyramid™
4.19 Microstructured Transdermal Systems
4.20 Microneedle Transdermal Chip
4.21 Microneedle Applicator Device
4.22 DebioJect ™ Microneedle Technology
4.23 Silk Microneedles
4.24 Tattooing
4.25 ZP Patch Microprojections Technology
4.26 Other Microneedle Products Currently Available
4.27 Needlefree injections
4.28 Glide SDI® Solid Dose Injector
4.29 Jet Injection
4.29.1 Why is Needle-Free so Important?
4.29.2 Mini-Ject Needlefree Delivery System
4.29.3 PharmaJet Stratis
4.29.4 MicroJet for Painless Injections
4.29.5 Nanoliter-Volume Pulsed Microjets
4.30 SUMAVEL™ DosePro™ Needle-Less Injection
4.31 Skin Abrasion
5.0 How Nanotechnology is Transforming Transdermal Drug Delivery
5.1 Overview
5.2 Nanotechnology-Based Transdermal Drug Delivery
5.2.1 Nanobiotechnology for Transdermal Application
5.3 Nanoparticles and Nanoemulsions for Skin Disorders
5.4 Nanopatches
5.4.1 Vaxxas Nanopatch Technology
5.4.2 Effect of Mechanical Flexion on Penetration of Bucky Amino Acids Through the Skin
5.5 Inocyte™ Epidermal Drug Delivery System
5.6 Ionic Nanoparticle Technology
5.7 Solid Lipid Nanoparticles (SLN) Gels
5.8 siRNA- Nanoparticle Conjugates
5.9 Transdermal Nanoparticle Preparations for Systemic Effect
5.10 Micellar Nanoparticle Estradiol Emulsion (MNPEE)
5.11 Transferosomes
5.12 Nanocarriers
5.13 Nanotechnology for Vaccination and Immunotherapy
5.14 Safety Issues of Applications of Nanomaterial Carriers on the Skin
5.15 Comparison of Current Transdermal Drug Delivery Systems
6.0 Transdermal Drug Delivery and Disease States
6.1 Antiaging Products
6.2 Cancer
6.2.1 δ-Amino Levulinic Acid
6.2.2 Breast Cancer & Afimoxifene Gel
6.2.3 Cervical Cancer & Interferon α2b
6.2.4 Prostate Cancer & Nitroglycerine
6.2.5 Prostate Cancer & Estradiol Gel
6.2.6 Prostate Cancer & Leuprolide Acetate
6.2.7 Skin Cancer & Caffeine
6.2.6 Cancer Vaccines Intradermal Delivery Using Adenoviral Vectors Peptide Cancer Vaccines Electroporation of Anticancer Agents
6.3 Cardiovascular Disease
6.3.1 Transdermal Anticoagulants
6.3.2 Angina Pectoris
6.3.3 Atherosclerotic Cardiovascular Disease Transdermal Oestrogen for Prevention of Atherosclerotic Cardiovascular Disease
6.3.4 Congestive Heart Failure
6.3.5 Hypertension Clonidine β-Blockers Calcium Channel Blockers
6.4 Chronic Fatigue Syndrome
6.5 Contraception
6.5.1 Female Contraception Agile Therapeutics AG200-15 BAY86-5016 / FC Patch Low BAY86-5016 Desogestrel Ortho Evra™
6.5.2 Male Contraception Transdermal Progestin Plus Testosterone
6.6 Diabetes
6.6.1 Insulin Drug Delivery V-Go GLP1 Agonist
6.7 Men’s Health
6.7.1 Benign Prostatic Hypertrophy Tamsulosin Transdermal Drug Delivery System
6.7.2 Erectile Dysfunction Topical and Transdermal Preparation for Erectile Dysfunction
6.7.3 Hypogonadism Topical Testosterone
6.8 Musculoskeletal Disease
6.8.1 Osteoarthritis
6.8.2 Osteoporosis Alendronate Estrogen Human Parathyroid Hormone
6.9 Nausea and Vomiting
6.9.1 Chemotherapy-Induced
6.9.2 Motion Sickness
6.9.3 Postoperative Vomiting
6.10 Neurological Disease
6.10.1 Alzheimer's Disease Arecoline Rivastigmine Donepezil
6.11 Attention Deficit Hyperactivity Disorder
6.11.1 Methylphenidate
6.12 Bipolar Disorder
6.12.1 Lithium
6.13 Depression
6.13.1 Antidepressants
6.13.2 Selective Serotonin-Reuptake Inhibitors
6.13.3 Fluoxetine
6.13.4 Monoamine Oxidase Inhibitors
6.13.5 Selegiline
6.13.6 Trazodone Hydrochloride
6.13.7 Venlafaxine
6.13.8 Bupropion
6.14 Epilepsy
6.15 Migraine
6.15.1 Sumatriptan
6.15.2 Zolmitriptan
6.16 Parkinson's Disease
6.16.1 Introduction
6.16.2 Dopamine Agonists Levodopa Rotigotine
6.16.3 Other Agents
6.17 Restless Leg Syndrome
6.17.1 Rotigotine
6.18 Schizophrenia
6.18.1 Haloperidol
6.18.2 Risperidone
6.18.3 Blonanserin
6.19 Tinnitus/Vertigo
6.22.1 Nicotine
6.20 Tourette syndrome
6.21 Multiple Sclerosis
6.22 Respiratory diseases
6.22.1 Asthma and Chronic Obstructive Pulmonary Disease (COPD)
6.23 Skin disorders
6.23.1 Cutaneous Leishmaniasis
6.23.2 Hair Loss
6.23.3 Iontophoretic Drug Delivery for Nail Disorders
6.23.4 Psoriasis Nanoemulsions for Paxitacel in Psoriasis Iontophoresis for Treatment of Psoriasis
6.24 Overactive Bladder and Urinary Incontinence
6.24.1 Oxybutynin
6.25 Pain
6.25.1 Chronic Pain
6.25.2 Transdermal Local Anesthetics
6.25.3 Transdermal Fentanyl for the Management of Postoperative Pain
6.25.4 Fibromyalgia
6.25.5 Minor Medical Procedures
6.25.6 Neuralgia Lidoderm
6.25.7 Nonsteroidal Anti-Inflammatory Drugs Topical NSAIDs
6.25.8 Ketoprofen
6.25.9 Opioids
6.25.10 Cancer Pain Fentanyl Nitroglycerine Buprenorphine
6.26 Smoking Cessation
6.26.1 Nicotine Replacement Therapy
6.26.2 Nicotine Patch in Pregnancy
6.27 Viral infections
6.27.1 Transdermal Nanoparticles for Immune Enhancement in HIV
6.28 Women's Health
6.28.1 Dysmenorrhea
6.28.2 Female Infertility
6.28.3 Female Sexual Arousal Disorder
6.28.4 Menopause Hormone Replacement Therapy Estradiol Parathyroid Hormone for Postmenopausal Osteoporosis Testosterone and Low Libido
6.29 Transdermal Nutraceuticals
7.0 Gene Therapy and Transdermal Drug Delivery
7.1 Overview
7.2 Plasmid DNA and Electroporation
7.2.1 TriGrid™ Delivery System
7.2.3 Magnetic Pulse Electroporation
7.3 Antisense Therapy
8.0 Vaccines and Transdermal Drug Technology
8.1 Introduction
8.1.1 The Skin as an Immune Organ Langerhans Cells- Epidermal Antigen Presenting Cells Keratinocytes- Immune Competent Epithelial cells Dendritic Epidermal T Cells (DETC) γδ T cells -Specialised Resident Epithelial Cells Epidermotropic T lymphocytes-Circulating T Cells that home to the Epidermis Melanocytes-Epidermal Pigment Cells With Immune Properties
8.2 Current Technologies
8.2.1 Dissolvable Microneedle Array
8.2.2 Electroporation for Administering DNA Vaccines
8.2.3 Microneedles for Transdermal Vaccine Delivery
8.2.4 Needle-Free Delivery of Vaccines
8.3 Applications for Transdermal Vaccination
8.3.1 HIV/AIDS Vaccine
8.3.2 Transdermal DNA Influenza Vaccine
8.3.3 Transdermal Aβ Vaccine for Alzheimer’s Disease
8.3.4 Transdermal Vaccine for Traveller’s Diarrhoea
9.0 Global Drug Delivery Market
9.1 Overview and Analysis
9.2 USA Drug Delivery Market
9.3 European Drug Delivery Market
9.4 Emerging Drug Delivery Markets
9.5 The Advanced Drug Delivery Landscape
9.6 Transdermal Drug Delivery Market
9.7 Smoking Cessation Drug Market
9.7.1 Nicotine Replacement Therapeutics
9.7.2 Non-Nicotine Containing Therapeutics
9.7.3 Smoking Cessation Products in the Pipeline
9.8 Neurodegenerative Disorders Such as Alzheimer’s & Parkinson’s disease will Propel the Future Market
9.9 How Transdermal Systems Relate to the Global Pain Market
9.9.1 Neuropathic Pain Market (US, UK, France, Germany, Japan, Spain and Italy) 2014-2020
9.9.2 Transdermal Products Within the Neuropathic Pain Market
9.10 How Transdermal Systems Relate Within the Generic Market
9.11 Duragesic and Generic Fentanyl Transdermal System Competition
9.12 Lidocaine Market Analysis
9.13 Who are the Leading Players in the Market?
9.14 What is Driving the Transdermal Drug Delivery Market?
9.15 Increased Number of Geriatric and Pediatric Patients is Propelling the Market
9.16 Unmet Needs Within the Transdermal Drug Delivery Market
9.17 Women’s Health Market
10.0 Transdermal Drug Delivery Company Business Profiles and Strategic Evaluation
10.1 Actavis
10.2 Actelion
10.3 GlaxoSmithKline
10.4 Bayer
10.5 Mylan Pharmaceuticals
10.6 Novartis
10.7 Upsher-Smith
10.8 Ascend Therapeutics
10.9 AMAG Pharmaceuticals (Lumara Health, KV Pharma/Ther-Rx Corp)
10.10 Janssen Pharmaceuticals
10.11 Noven Pharmaceuticals
10.12 ProStrakan
10.13 Shire
10.14 Hercon Pharmaceutical
10.15 Kremers Urban Pharmaceuticals
10.16 Nitto Denko
10.17 Teva Pharmaceutical Industries
10.18 Endo International
10.19 Teikoku USA
10.20 Boehringer Ingelheim
10.21 3M
10.22 UCB
10.23 ParPharm
11.0 Transdermal Drug Delivery Company Financial Analysis
11.1 Actavis
11.2 Actelion
11.3 GlaxoSmithKline
11.3.1 ViiV Healthcare
11.4 Bayer
11.5 Janssen Pharmaceuticals (Johnson & Johnson)
11.6 Shire
11.7 Nitto Dento
11.8 Teva Pharmaceuticals
11.9 Endo International
11.10 Boehringer Ingelheim
11.11 3M
11.12 UCB
11.13 ParPharm
12.0 Current Transdermal Drug Delivery Products on the Market
12.1 Actavis
12.1.1 Androderm
12.1.2 Fentanyl Transdermal System
12.1.3 Lidocaine Topical Patch
12.1.4 Oxytrol
12.2 Actelion
12.2.1 Vachlor Gel (mechlorethamine)
12.3 GlaxoSmithKline
12.3.1 Niquitin/Nicoderm
12.4 Bayer
12.5 Mylan Pharmaceuticals
12.5.1 Clonidine Transdermal System
12.5.2 EMSAM (Selegiline Transdermal System)
12.5.3 Estradiol Transdermal System
12.5.4 Fentanyl Transdermal System
12.5.5 Nitroglycerin Transdermal System
12.5.6 XULANE (Norelgestromin / Ethinyl Estradiol Transdermal System)
12.6 Novartis
12.6.1 Exelon Patch (Rivastigmine Transdermal System)
12.6.2 Duragesic - Fentanyl Patches
12.6.3 Transderm Scop - Scopolamine Patches
12.7 Upsher-Smith
12.7.1 Vogelxo – Testosterone (1%) Gel
12.8 ASCEND Therapeutics
12.8.1 EstroGel®
12.9 AMAG Pharmaceuticals (Lumara Health)
12.9.1 Evamist®
12.10.1 OrthoEvra®
12.10.2 Duragesic®
12.11 Lavipharm
12.11.1 Fentadur
12.11.2 Nicotine Transdermal Patch
12.11.3 Acne Transdermal Patch
12.11.4 Trinipatch
12.12 Noven Pharmaceuticals
12.12.1 Minivelle®
12.12.2 CombiPatch®
12.12.3 Daytrana®
12.13 ProStraken
12.13.1 Sancuso®
12.14 Shire
12.14.1 Daytrana® CII
12.15 Hercon Pharmaceuticals
12.15.1 Nitroglycerin Transdermal System
12.16 Kremers Urban Pharmaceuticals
12.16.1 Nitroglycerin Transdermal System
12.17 Nitto Dento
12.17.1 Bisono Tape
12.17.2 Penles Tape
12.17.3 Passport Advanced Drug Delivery System
12.18 Teva Pharmaceuticals
12.18.1 Zecuity
12.18.2 Transdermal Fentanyl (generic)
12.18.3 Tev Tropin
12.19 Endo International
12.19.1 Lidoderm®Patch
12.19.2 Fortesa Gel
12.20 Teikoku
12.20.1 Lidoderm® 1
12.20.2 IontoPatch®
12.21 3M
12.21.1 3M Fentanyl Transdermal Delivery System
12.21.2 3M Rivastigmine Transdermal Delivery System
12.21.3 Microneedles
12.22 UCB
12.22.1 Neupro®
12.23 ParPharm
12.23.1 Fentanyl Transdermal System
13.0 In-Depth SWOT Analysis of the Transdermal Drug Delivery Market
13.1 Drivers of the Market
13.1.1 Patent Expirations and Introduction of Generics
13.1.2 Increased Patient Compliance Rates
13.1.3 Increased Rate of Chronic Conditions and Application of Patch Technology to These Areas
13.1.4 Increased Geriatric and Pediatric Drug Administration Requirements
13.2 Restraints and Weaknesses of the Transdermal Drug Delivery Market
13.2.1 Technical Restraints
13.2.2 Drug Adverse Reactions
13.2.3 Drug Failures
13.3 Opportunities Within the Market Place
13.3.1 High number of Pharmaco & Drug Delivery Company Collaboration
13.3.2 Increasing Indications and Disease States for Transdermal Administration
13.3.3 Large Opportunity for Home Health Care Market and OTC
13.3.4 Targeted Drug Delivery
13.4 Barriers to Market Entry

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