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Synthetic Blood Substitutes and Blood Products: A Market Briefing

In addition to being one of the most important tissues in the body, blood has emerged as a key vector in the transmission of the world's deadliest infectious diseases. With the rising demand for transfusions in a variety of conditions such as anemias, trauma, and high-blood-loss surgeries, supplies have been stretched and the dangers of disease transmission have added significant cost pressures to maintaining a safe supply.

One possible solution to ease the crunch, particularly in acute amergency care settings has been the development of synthetic blood substitutes and synthetic blood products. Blood products such as recombinant hemophilia factors and serum albumins are already on the market; oxygen carriers are only a few years away.

This briefing forecasts the market for synthetic blood products, including:

  • Hemoglobin based oxygen carriers (HBOCs)
  • Perflurocarbon based products (PFCs)
  • Recombinant factors for hemophilias, such as Factor VIII (TKT)
  • Synthetic platelets, and
  • Blood volume expanders, such as the albumins.

Blood demand is detailed by number of high-blood-loss procedures, acute vs chronic conditions, and geographic region, and total demand is forecasted to 2009. Market share and revenues of top products in the blood volume expander and recombinant factor markets are reported and estimated out to 2009. Oxygen transporting product revenues are forecasted to 2013, based on likely approvals and clinical acceptance trends.

In addition, product pipelines are analyzed from both technical aspects and clinical trials results, and profiles of 11 key players are provided.


  • Executive Summary
    • INTRODUCTION
    • BLOOD TRANSFUSION DEMAND AND SUPPLY
    • SYNTHETIC BLOOD PRODUCTS
    • SUMMARY MARKET FORECAST
      • Table Worldwide Demand for Red Blood Cells by Indication (Acute vs Chronic)
      • Table Summary of World Demand for RBCs 2003-2009
      • Table Number of High Blood Loss Surgical Procedures by Type
      • Table High Blood Loss Market: HBOC and PFC Agents 2007-2013
      • Table World Recombinant Factor Market Summary 2003-2009
      • Table World Market for Gene Therapy in Blood Disorders 2006-2011
    • SCOPE AND METHODOLOGY
  • Introduction: Blood, Associated Disorders, and Blood Products
    • COMPOSITION, FUNCTION AND FORMATION
      • Red Blood Cells (Erythrocytes)
      • White Blood Cells (Leukocytes)
      • Platelets
      • Plasma
  • BLOOD TRANSFUSIONS
  • SYNTHETIC BLOOD PRODUCTS: A SUITABLE ALTERNATIVE
    • Table Clinical Uses for Blood Substitutes
    • Blood Volume Expanders
    • Hemoglobin Based Oxygen Carriers
      • Table HBOCs Sources and Modification by Company
    • Perflurocarbon (PFC) Based Blood Products
    • Factor Products for Hemophilia A
    • Synthetic Platelets
    • Synthetic Blood Products Summary
  • Novel Synthetic Blood Products in Clinical Trials
    • HEMOLINK (HEMOSOL)
    • HEMOPURE (BIOPURE)
    • POLYHEME (NORTHFIELD LABORATORIES)
    • OXYGENT (ALLIANCE)
    • OXYCYTE (SYNTHETIC BLOOD INTERNATIONAL)
    • PHER-O2 (SANGUINE)
    • ALBREC (MITSUBISHI PHARMA)
    • ADVATE (BAXTER)
    • RECOMBINANT FACTORS
      • Table Recombinant Factor Products in Clinical Trials
    • SYNTHOCYTES (ANDARIS)
    • GENE THERAPY
  • Worldwide Demand and Market Analysis
    • BLOOD SHORTAGE DRIVING DEMAND FOR ALTERNATIVES
      • Table Average Blood and Component Requirements by Condition
      • Table Annual Worldwide Demand for Red Blood Cells
      • Table Geographical Distribution of RBC Demand by Region (United States, Europe, Japan, ROW) 2003
      • Table Projected World Demand for RBCs 2003-2009
      • Table Number of High Blood Loss Surgical Procedures by Type (Number of Procedures, Units of RBCs per Procedure, Total Units Transfused, Market Value) 2003
    • BLOOD VOLUME EXPANDERS
      • Table Blood Volume Expanders Market by Brand 2002-2009
    • OXYGEN CARRIER MARKET
      • Table High Blood Loss Market HBOC and PFC Agent Revenues 2007-2013
    • RECOMBINANT FACTOR MARKET
      • Table World Recombinant Factor Market by Brand 2003-2009
  • Key Players and Their Technologies
    • ALLIANCE PHARMACEUTICALS INC.
    • BIOPURE CORP.
    • BIOTIME INC.
    • HEMOSOL CORP.
    • JP LABORATORIES INC.
    • NORTHFIELD LABORATORIES
    • NOVO NORDISK A/S
    • PERFTORAN
    • SANGUINE CORP.
    • SYNTHETIC BLOOD INTERNATIONAL
  • TRANSKARYOTIC THERAPIES INC.

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