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The Protein Therapeutics Market: The Science and Business of a Growing Sector

The protein therapeutics sector is a story of triumphant science, representing both life-saving treatments for millions and a multi-billion dollar industry. This report details both the scientific and business aspects of the protein therapeutics marketplace, including market size and growth, competitive market share, geographical segmentation, top products, and forecasts to 2010 for each of the following individual product areas:

  • Monoclonal Antibodies
  • Erythropoietins
  • Insulin
  • Interferons
  • Growth Factors
  • Interleukins
  • Blood Clotting Factors
  • Tissue Plasminogen Activator
  • Human Growth Hormones
  • Reproductive Hormones
  • Recombinant BMP-2
  • Replacement Enzymes

In addition, the report discusses the major operational and strategic challenges this market presents, including

  • financing
  • pricing and reimbursement,
  • manufacturing
  • marketing, and
  • regulatory issues

Profiles of 21 key competitors—including their products, pipeline, technology platforms, and alliances—round out the comprehensive review.


  • Executive Summary
    • BACKGROUND
    • SIZE OF THE MARKET AND GROWTH
    • GEOGRAPHICAL DISTRIBUTION
    • LEADING MARKET SEGMENTS
    • LEADING PRODUCTS
      • Table Sales and Growth of Top Ten Protein Therapeutics
    • LEADING PLAYERS
      • Table Revenues, Growth, and Market Share of Top Ten Protein
    • KEY INDUSTRY DRIVERS
      • Strong Product Innovation
      • Lower Generic Threat
      • Better Pricing Power
      • Access to Capital
        • Table Amount of Protein Therapeutics Capital Sources (U.S.)
    • CONCLUSIONS
    • SCOPE AND METHODOLOGY
  • Science as Value Creator
    • BACKGROUND
    • PROTEIN SYNTHESIS
    • PROTEIN GLYCOSYLATION
    • PROTEINS AND THEIR TYPES
    • THERAPEUTIC PROTEINS
      • Monoclonal Antibodies
        • Table Classification of Commercial Monoclonal Antibody Products by Type
      • Erythropoietin
      • Insulin
        • Table Commercially Available Insulins in the United States (Classification, Source, Brand, Manufacturer, Preparation)
      • Cytokines
        • Table Types of Cytokines (Name, Principal Source, Primary Activity)
      • Growth Hormones
      • Blood Factors
      • Enzyme Therapy
      • Bone Repair Proteins
      • Reproductive Hormones
      • Tissue Plasminogen Activators
      • Stem Cell Therapy
  • Strategic Perspectives
    • BACKGROUND
    • RESEARCH AND DEVELOPMENT DYNAMICS
      • Geographical Trends
      • Biological Agents in Clinical Trials
      • Current Challenges in R&D
      • Low Probability of Success for Small Molecule Drugs
      • Biotechnology Innovation
    • STRATEGIES TO ENHANCE R&D PRODUCTIVITY FOR BIOTECHNOLOGY FIRMS
      • FDA Strategies
      • FDA Initiatives to Increase Industry R&D Productivity-Critical Path Initiative
      • R&D Process Improvisation Initiatives
      • Clinical Trial Management: Strategic Options
    • GOVERNMENT GRANTS/FUNDS FOR RESEARCH AND DEVELOPMENT
      • CRADA
      • A Clinical Trial CRADA
    • MANUFACTURING DYNAMICS
      • Protein Manufacturing Challenges
      • Protein Production
      • New Directions in Protein Manufacturing
    • COMPETITIVE DYNAMICS
      • Biosimilars
      • Pricing and Reimbursement
    • MERGERS, ACQUISITIONS, COLLABORATIONS AND DEAL DYNAMICS
      • Deal Valuations and Trends
        • Table Leading Protein Therapeutic Deals by Dollar Value
      • Mergers and Acquisitions
        • Table Leading Protein Therapeutic M & A
      • Deal Structures
      • Licensing and Alliances
    • INDUSTRY FUNDAMENTALS AND VALUATIONS
      • Negative Drivers of Valuation
      • Industry Capital Sources
        • Table U.S. Biotech Public Funding by Type
        • Table U.S. Biotech Private Funding by Type
        • Table Total Capital Sources for the U.S. Biotech Industry by Type
      • IPO financing
        • Table U.S. Biotechnology Sector Initial Public Offerings (Number, Amount
      • Venture Capital Financing
        • Table Venture Capital Investments in U.S. Biotech as a Percentage of Total
    • FINANCIAL PERFORMANCE
      • Table Biotechnology Industry Financial Snapshot
  • Commercial Perspectives
    • INDUSTRY BACKGROUND
      • Initial Era (1970s)
      • Early Commercial Era (1980s)
      • 1990s
      • Early 2000s
    • COMMERCIAL OUTLOOK
      • Market Size and Growth
      • Geographical Distribution
      • Therapeutic Segmentation
      • Leading Protein Products
        • Table Protein Therapeutics Market Segments and Leading Products
        • Table Sales and Growth of Top Ten Protein Therapeutics
      • Leading Players
        • Table Revenues, Growth, and Market Share of Top Ten Protein
      • Future Market Size and Growth
    • MARKET SEGMENT ANALYSIS
      • Monoclonal Antibody Market
        • Table World Monoclonal Antibody Market
        • Table Top Monoclonal Antibody Products (Product, Company, Sales, Market Share, Growth)
      • Erythropoietin Market
        • Table World Erythropoietin Market
        • Table Top Erythropoietin Products
      • Insulin Market
        • Table World Insulin Market
        • Table Top Insulin Products
      • Interferon Market
        • Table World Interferon Market
        • Table Top Interferon Products
      • Growth Factors Market
        • Table World Growth Factors Market
        • Table Top Growth Factor Products
      • Interleukin Market
        • Table World Interleukin Market
        • Table Leading Interleukin Products (Product,
      • Blood Clotting Factors Market
        • Table World Clotting Factors Market
        • Table Top Clotting Factor Products (Product, Company, Sales,
      • Tissue Plasminogen Activator Market
        • Table World Tissue Plasminogen Activators Market
        • Table Top Tissue Plasminogen Activator Products (Product, Company, Sales, Market Share, Growth)
      • Human Growth Hormone Market
        • Table World Human Growth Hormone Market
        • Table Top Human Growth Hormone Products (Product, Company, Sales, Market Share, Growth)
      • Reproductive Hormones Market
        • Table World Reproductive Hormones Market
        • Table Top Reproductive Hormone Products (Product, Company, Sales, Market Share, Growth)
      • Recombinant BMP-2 Market
        • Table World BMP-2 Market
        • Table Top BMP-2 Products
      • Enzyme Replacement Market
        • Table World Enzyme Replacement Market
        • Table Top Enzyme Replacement Products
      • Other Replacement Enzymes Market
        • Table World Glucocerebrosidase Deficiency Enzyme Market
        • Table Top Glucocerebrosidase Deficiency Enzyme Products
  • Company Profiles
    • AMGEN, INC.
      • Background
      • Marketed Products
      • Research and Development
    • AMYLIN PHARMACEUTICALS, INC.
      • Background
      • Research and Development Expertise
      • Collaborations
    • BlOGEN IDEC
      • Background
      • Marketed Products
    • BIOMARIN PHARMACEUTICAL INC.
      • Background
      • Marketed Products
      • Product Pipeline
    • CHIRON CORPORATION
      • Background
      • Marketed Products
      • Product Pipeline
    • CELL GENESYS, INC.
      • Background
      • Product Platforms
      • Oncolytic Virus Therapies
    • COLEY PHARMACEUTICAL GROUP
      • Background
      • Product Pipeline
    • DENDREON CORPORATION
    • ENZON
    • GENENTECH, INC.
      • Background
      • Marketed Products
    • GENZYME CORP.
      • Background
      • Marketed Products
    • HUMAN GENOME SCIENCES
      • Background
      • Product Pipeline
    • OSI PHARMACEUTICALS, INC
      • Background
      • Marketed Products
      • Product Pipeline
    • MEDIMMUNE
      • Background
      • Product Pipeline
    • PDL BlOPHARMA
      • Background
      • Collaborations
    • RAVEN BIOTECHNOLOGIES, INC.
      • Background
      • Discover Platform
      • Product Pipeline
    • SERONO INTERNATIONAL S.A.
      • Background
      • Product Pipeline
      • Marketed Products
    • SEATTLE GENETICS, INC.
      • Background
      • Product Pipeline
      • Technology
    • VERNALIS PHARMACEUTICALS INC
      • Background
      • Product Pipeline
    • WYETH
      • Background
      • Marketed Products
      • Product Pipeline
    • XOMA
      • Background
      • Technology
      • Licensees

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