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Outsourcing in Drug Discovery: The Contract Research Organization (CRO) Market, Forecasts to 2018, 6th Edition


Attention: There is an updated edition available for this report.

For six editions, this authoritative resource has defined the market opportunity for companies assisting in the beginning phase of the drug development process.

This Kalorama Information Report, Outsourcing in Drug Discovery, t provides an in depth look into the trends that have shaped the drug discovery outsourcing market today, and details the current and future global market. As part of its coverage, the report provides markets and forecasts for the following segments.
  • Chemistry Services Market: Building Blocks, Compound
  • Synthesis, Libraries, Process Research, and Other Services,
  • Biology Market Revenue by Protein Expression, Structural
  • Analysis, Target Validation, Pathways Analysis, and Other Service
  • Screening Services Market: Assay Development, Primary
  • Screening, Secondary Screening
  • Lead Optimization Services Market: Early ADMET/Tox, Create Analogues, Computational Support, and Other Services
The drug discovery process consists of iterative cycles between chemistry and biology that begin with the target finding phase, or selecting a protein (a drug target) leading to the identification of a chemical compound with biological activity (a hit). After confirmation of biological activity and chemical feasibility, the hit becomes a lead structure, which is improved through chemical modifications until it fulfills the criteria for a clinical candidate. A drug candidate then moves into the next stage of drug development, the preclinical phase.

The drug discovery process is long, arduous and costly, which has driven outsourcing in this field. The first phase is discovery of a lead compound, a molecule that affects biological function by binding to a target protein or nucleic acid in a way that is useful for treatment of disease. The process by which molecules are identified for their therapeutic value involves synthesis and analysis of many derivatives of the original leads. There are several steps in the drug discovery process including hit confirmation, lead generation, lead optimization, and other studies. Drug discovery is a high-cost, risky business because only a fraction of the therapeutic targets selected for study will actually yield products that achieve regulatory approval by the Food & Drug Administration (FDA).Since the last edition of Kalorama's Report on the outsourcing of discovery, major trends that have led to an increase in demand for contract services in drug discovery include:The following companies are profiled in the report:
  • Albany Molecular Research, Inc.
  • Aptuit, LLC
  • Argenta Discovery, Ltd.
  • Asclepia MedChem Solutions
  • Asinex Ltd.
  • AsisChem, Inc.
  • Axxam SpA
  • BioDuro
  • BioFocus DPI
  • Caliper Life Sciences
  • Charles River Laboratories, Inc.
  • ChemBridge Corp.
  • Chemical Diversity Inc.
  • Covance, Inc.
  • CreaGen Biosciences, Inc.
  • Crown Bioscience
  • Cyprotex PLC
  • Domainex
  • Emerald Biostructures
  • Enamine Ltd.
  • Evotec AG
  • Exelgen Discovery
  • GVK Biosciences Private Limited
  • GenScript USA Inc.
  • Graffinity Pharmaceuticals GmbH
  • Hutchison MediPharma Ltd.
  • Jubilant Biosys Ltd
  • Nanosyn, Inc.
  • Pharmaron Inc.
  • Ricerca Biosciences, LLC
  • Scynexis, Inc.
  • Selcia Limited
  • Selvita S.A.
  • Shanghai ChemPartner Co., Ltd.
  • Shanghai Medicilon Inc.
  • Sundia Meditech Company, Ltd.
  • Sygnature Discovery Limited
  • TCG Lifesciences Limited
  • Viva Biotech, Ltd
  • WuXI AppTec Co. Ltd.


  • Executive Summary
    • OVERVIEW
    • SCOPE AND METHODOLOGY
    • INTRODUCTION
      • Pharmaceutical Industry Challenges
      • Number of NMEs and BLAs Approved between 1993-2013
      • Reducing R&D Spending
        • Table PhRMA Members R&D Spending, 1995 through 2012 (US billions)
    • THE DRUG DISCOVERY PROCESS
      • Accelerating the Drug Discovery Process
      • Bottlenecks Within the Drug Discovery Process
    • OUTSOURCING TO INCREASE EFFICIENCY
    • OUTSOURCING DRUG DISCOVERY
      • The Outsourcing Decision
      • Developing an Outsourcing Plan
    • CONTRACT RESEARCH ORGANIZATIONS
      • Strategic Versus Tactical Outsourcing Model
      • Effective Communication Is Essential
      • Mitigating the Challenges of Protecting IP Rights
    • OFFSHORING CONTRACT DRUG DISCOVERY
      • Factors to Consider in Offshore Outsourcing
      • Benefits of Global Outsourcing
      • Concerns about Global Outsourcing
    • OUTSOURCING TO CHINA
      • Chinese Contract Research Organizations
      • FDA Offices in China
    • OUTSOURCING TO INDIA
      • Drug Discovery Services in India
    • OUTSOURCING TO EASTERN EUROPE
    • DRUG DISCOVERY OUTSOURCING MARKET
      • Global Economic Downturn Has Minimal Affect on Drug Discovery
      • Current Market and Forecast
        • Table Global Drug Discovery Outsourcing Market, 2008-2018 (US billions)
      • Market Analysis by Segment
  • Introduction to Outsourcing Drug Discovery
    • BACKGROUND
      • Number of NMEs and BLAs Approved between 1993-2013
      • Reducing R&D Spending
        • Table PhRMA Members R&D Spending, 1995 through 2012 (US billions)
      • Ramping up the Pipelines
    • OUTSOURCING DRUG DISCOVERY
    • THE OUTSOURCING DECISION
      • Developing an Outsourcing Plan
      • Decision Criteria
    • FACTORS TO CONSIDER IN OFFSHORE OUTSOURCING
      • Benefits of Global Outsourcing
      • Concerns about Global Outsourcing
    • SELECTING A CONTRACT RESEARCH ORGANIZATION
      • Introduction
      • Choosing the Right CRO
      • Contract Pharma's Outsourcing Survey
    • GLOBAL OUTSOURCING
  • The Drug Discovery Process
    • INTRODUCTION
      • Drug Discovery Stages
    • ACCELERATING THE DRUG DISCOVERY PROCESS
      • Technologies Utilized in Drug Discovery
      • Bottlenecks Within the Drug Discovery Process
    • OUTSOURCING TO INCREASE EFFICIENCY
    • OUTSOURCING TO ACCESS NOVEL TECHNOLOGIES
      • Bioinformatics
      • Lab-on-a-Chip: Microfluidics in Drug Discovery
  • Outsourcing Drug Discovery
    • OVERVIEW
      • Is the Traditional Drug Discovery Model Changing?
      • Outsourcing Drug Discovery Useful Core Management Tool
    • CONTRACT RESEARCH ORGANIZATIONS
      • Introduction
      • Role of a CRO
      • Outsourcing Models
      • Effective Communication Is Essential for a Successful Partnership
      • Mitigating the Challenges of Protecting IP Rights
    • OFFSHORING CONTRACT DRUG DISCOVERY
      • Introduction
      • Robust Growth of Outsourcing Drug Discovery in Asia
    • OUTSOURCING TO CHINA
      • Introduction
      • Multi-National Pharmaceutical Companies Establish Research and Development Facilities in China
      • Chinese Contract Research Organizations
      • First Chinese CRO Alliance
      • FDA Offices in China
      • China's Management of Counterfeit Pharmaceuticals, IP Rights and Laws
    • OUTSOURCING TO INDIA
      • Introduction
      • Drug Discovery Services in India
      • India's Handling of IP Rights and Laws
      • FDA Offices in India
    • OUTSOURCING TO EASTERN EUROPE
      • Introduction
      • Russian and Ukraine CROs
  • Drug Discovery Outsourcing Market
    • OVERVIEW
    • DRUG DISCOVERY OUTSOURCING MARKET
      • Global Economic Downturn Has Minimal Affect on Drug Discovery
      • Current Market and Forecast
        • Table Global Drug Discovery Outsourcing Market, 2008-2018 (US billions)
        • Table Contract Drug Discovery Services, by Market Segment, 2008-2018 (US billions)
    • MARKET ANALYSIS BY SEGMENT
      • Chemistry Services Market
        • Table Chemistry Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2008-2018 (US billions)
        • Table Chemistry Market Revenue by: Building Blocks, Compound Synthesis, Libraries, Process Research, and Other Services, 2014 (US billions)
      • Biology Services Market
        • Table Biology Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2008-2018 (US billions)
        • Table Biology Market Revenue by: Protein Expression, Structural Analysis, Target Validation, Pathways Analysis, and Other Service, 2014 (US billions)
      • High Throughput Screening Services Market
        • Table Screening Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2008-2018 (US billions)
        • Table Screening Services Market: Assay Development, Primary Screening, Secondary Screening, 2014 (US millions)
      • Lead Optimization Services Market
        • Table Lead Optimization Services Market: Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market, 2008-2018 (US billions)
        • Table Lead Optimization Services Market: Early ADMET/Tox, Create Analogues, Computational Support, and Other Services, 2014 (US billions)
    • CONTRACT DRUG DISCOVERY COMPETITORS
    • THE EVOLVING OPEN-INNOVATION MODEL GAINING TRACTION IN DRUG DISCOVERY
      • Alliances between Academic Organizations and CROs
      • Academic CROs
      • Alliances between CROs
    • MARKET GROWTH EXPANDING GLOBAL REACH AND SCALE OF DRUG DISCOVERY SERVICES
  • Competitor Profiles
    • ALBANY MOLECULAR RESEARCH, INC.
      • History and Lines of Business
      • Drug Discovery Services
      • Financial Information
    • APTUIT, LLC
      • History and Lines of Business
      • Drug Discovery Services
    • ARGENTA DISCOVERY, LTD.
      • History and Lines Business
      • Drug Discovery Services
    • ASCLEPIA MEDCHEM SOLUTIONS
      • History and Lines of Business
      • Drug Discovery Services
    • ASINEX LTD.
      • History and Lines of Business
      • Drug Discovery Services
    • ASISCHEM, INC.
      • History and Lines of Business
      • Drug Discovery Services
    • AXXAM SPA
      • History and Lines of Business
      • Drug Discovery Services
    • BIODURO
      • History and Lines of Business
      • Drug Discovery Services
    • BIOFOCUS DPI
      • History and Lines of Business
      • Drug Discovery Services
    • CALIPER LIFE SCIENCES
      • History and Lines of Business
      • Drug Discovery Services
    • CHARLES RIVER LABORATORIES, INC.
      • History and Lines of Business
      • Drug Discovery Services
      • Financial Information
    • CHEMBRIDGE CORP.
      • History and Background
      • Drug Discovery Services
    • CHEMICAL DIVERSITY INC.
      • History and Lines of Business
      • Drug Discovery Services
    • COVANCE, INC.
      • History and Lines of Business
      • Drug Discovery Services
      • Financial Information
    • CREAGEN BIOSCIENCES, INC.
      • History and Lines of Business
      • Drug Discovery Services
    • CROWN BIOSCIENCE
      • History and Lines of Business
      • Drug Discovery Services
    • CYPROTEX PLC
      • History and Lines of Business
      • Drug Discovery Services
    • DOMAINEX
      • History and Lines of Business
      • Drug Discovery Services
    • EMERALD BIOSTRUCTURES
      • History and Lines of Business
      • Drug Discovery Services
    • ENAMINE LTD.
      • History and Lines of Business
      • Drug Discovery Services
    • EVOTEC AG
      • History and Lines of Business
      • Drug Discovery Services
      • Financial Information
    • EXELGEN DISCOVERY
      • History and Lines of Business
      • Drug Discovery Services
    • GVK BIOSCIENCES PRIVATE LIMITED
      • History and Lines of Business
      • Drug Discovery Services
    • GENSCRIPT USA INC.
      • History and Lines of Business
      • Drug Delivery Services
    • GRAFFINITY PHARMACEUTICALS GMBH
      • History and Lines of Business
      • Drug Discovery Services
    • HUTCHISON MEDIPHARMA LTD.
      • History and Lines of Business
      • Drug Discovery Services
    • JUBILANT BIOSYS LTD
      • History and Lines of Business
      • Drug Discovery Services
    • NANOSYN, INC.
      • History and Lines of Business
      • Drug Delivery Services
    • PHARMARON INC.
      • History and Lines of Business
      • Drug Discovery Services
    • RICERCA BIOSCIENCES, LLC
      • History and Lines of Business
      • Drug Discovery Services
    • SCYNEXIS, INC.
      • History and Lines Business
      • Drug Discovery Services
    • SELCIA LIMITED
      • History and Lines of Business
      • Drug Delivery Services
    • SELVITA S.A.
      • History and Lines of Business
      • Drug Discovery Services
    • SHANGHAI CHEMPARTNER CO., LTD.
      • History and Lines of Business
      • Drug Discovery Services
    • SHANGHAI MEDICILON INC.
      • History and Lines of Business
      • Drug Discovery Services
    • SUNDIA MEDITECH COMPANY, LTD.
      • History and Lines of Business
      • Drug Discovery Services
    • SYGNATURE DISCOVERY LIMITED
      • History and Lines of Business
      • Drug Discovery Services
    • TCG LIFESCIENCES LIMITED
      • History and Lines of Business
      • Drug Discovery Services
    • VIVA BIOTECH, LTD
      • History and Lines of Business
      • Drug Delivery Services
    • WUXIAPPTEC CO. LTD.
      • History and Lines of Buisness
      • Drug Discovery Services
      • Financial Information

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