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Library Preparation and Target Enrichment for Next Generation Sequencing Product Markets


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Library Preparation and Target Enrichment for Next Generation Sequencing Product Markets

This report, Library Preparation and Target Enrichment for Next Generation Sequencing Product Markets is a detailed analysis of the market opportunity for this important part of next generation sequencing applications

The report includes:

Market Estimate and Projection for Library Preparation and Target Enrichment
Market Share by Company and Competitive Situation
More Than 300 Partnerships and Deals in LP/TE
New Library Preparation and Target Enrichment Products
Significant Trends in the Industry
Lawsuit and IP Analysis
Conclusions from the Analyst

NGS systems are capable of a great range of applications, and labs have taking advantage of that. In some cases, the same system is often used for five or ten distinct applications. The protocols can sometimes require different steps. These factors have created a market for a large range of products catering to all of the different variations.

As part of its coverage of the report, several major competitors are profiled. Companies profiled in the report are

Fluidigm
Illumina
Agilent Technologies
Roche
Pacific Biosciences
Qiagen
Thermo Fisher Scientific

As the price of DNA sequencing drops and the technologies improve to more user-friendly models, their usage has increased in science research. The range of applications is broad, with life science research being the most important category. Various clinical applications have been established and there are certain areas, such as cancer, where increased usage of systems is expected.

To get to the clinical future of NGS, Library Preparation and Target Enrichment technologies are needed. The capabilities of systems, and the availability of vast sequence data, have allowed researchers to undertake a wider range of experiments.


  • Executive Summary
    • INTRODUCTION
    • BACKGROUND
    • TRENDS
      • Market Growth in Library Preparation and Target Enrichment
      • Acceleration of Product Introductions
      • A Period of Rapid Adoption, But Lower Prices
      • Likelihood of Longer-Term Challenges
      • Rapid Growth Overall, But Intense Competition
      • Customers' Research Models Evolving
    • SCOPE AND METHODOLOGY
    • APPLICATIONS AND DEFINITIONS
      • Applications
      • Experiments
      • Promising Opportunities
      • Gaps in Scientific Knowledge
      • High Priority Research Areas
      • DNA Fragmentation
      • DNA Size Selection
      • Target Enrichment
  • Trends
    • TRENDS RELATING TO SEQUENCING, TARGET ENRICHMENT AND LIBRARY PREP
      • Rapid Adoption of Smaller Systems Driving Applications
      • Decline in Array-Based Target Enrichment Techniques
      • Stability Despite Possibility of Disruptive Technologies
      • Sequencer Sales Continue Dramatic Growth
      • Inherited Diseases and Cancer Driving Clinical Adoption
      • Regulatory Situation Unclear But Evolving Somewhat
  • Products
    • Table Products for Library Preparation and Target Enrichment
    • 2015 PRODUCT INTRODUCTIONS
      • BGI NGS System Launch
      • Illumina HiSeq X Five
    • 2014 PRODUCT INTRODUCTIONS
      • Fluidigm
      • Eznymatics Archer Fusion Plex
      • Illumina Launches New HiSeq X Ten Reagent Kits
      • Roche SeqCap RNA
      • Agilent Sure Select Focused Exome
      • Beckman Coulter NEBNext UltraDirectional RNA
      • Fluidigm Single-Cell Exome Sequencing Workflow
      • Clear Seq AML
      • Lexogen QuantSeq3
      • Agilent SureSelect Clinical Research Exome
      • NextFlex Cell Free DNA
      • Enzymatics Archer FusionPlex Sarcoma Panel
      • Multiplicom STARGARDT MASTR
      • Qiagen GeneRead DNAseq V2
      • Agilent SureSelectQXT
      • HTG Molecular Diagnostics EdgeSeq miRNA
      • NuGEN Ovation Custom Target Enrichment System
      • Illumina V4 Reagents Kits for HiSeq
      • Illumina VeriSeq
      • Kapa Biosystems Hyper Prep Kit
      • Lexogen QuantSeq 3 mRNA-seq Library Prep kit
      • Life Technologies Ion Chef
      • NuGEN Insert Dependent Adaptor Cleavage
      • Qiagen QIAexpert
      • Guardant Health 360 Test
      • Integrated DNA Technologies Launches Panels
      • Kapa Biosystems Adds Amplification Primers
      • Zymor Research Launches PicoMethyl Seq Library Prep and RRHP 5hmC Library Prep kits.
      • Bioo Scientific NextFlex Dual
      • Covaris TruXtrac High Throughput FFPE
      • Enzymatics Archer ALK/RET/ROS1
      • epMotion for TruSeq
      • Life Technologies HID-Ion AmpliSeq
      • Qiagen REPLI-g WTA
      • RainDance ThunderBolts Cancer Panel
      • Rubicon Genomics PicoPlex DNA Seq
      • Illumina NextSeq 500
      • 2013 Product Introductions
      • 2012 Product Introductions
  • Library Preparation and Target Enrichment Market
    • REVENUES FORECAST
      • Cost of Sequencing a Genome
      • Library Preparation and Target Enrichment Market
        • Table Library Preparation and Target Enrichment Market
        • Table Library Preparation and Target Enrichment Growth Rate
        • Table Revenues by Region, 2014
    • GROWTH DRIVERS
    • ILLUMINA CONSUMABLES REVENUES AS BELLWETHER
      • Table Illumina Quarterly Consumables Revenues (2012-2014)
      • Table Illumina Annual Consumables Revenues for Sequencing and for Other Purposes (2012-2014)
      • Table Illumina Consumables Growth Rates for Seqeuncing Consumables (2012-2014)
  • Competitive Analysis
    • INTRODUCTION
    • SEQUENCER SYSTEM BATTLES TURN SOMEWHAT CALM
    • LIBRARY PREPARATION AND TARGET ENRICHMENT MARKET SHARES
      • Table Library Preparation and Target Enrichment Market Shares
    • SMALLER COMPANIES EXPERIENCING MIXED SUCCESS
  • Intellectual Property and Litigation
    • IMPORTANT LITIGATION AND IPDEVELOPMENTS
      • Sequenom and Other NIPT Companies Suing Each Other
      • Sequenom Shareholder Sues Over Price "Capping"
      • Class Action Shareholder Lawsuit Filed Against Pacific Biosciences
      • Helicos' Patent Infringement Suit Against PacBio, Life Technologies, and Illumina
      • Illumina's Two Lawsuits Against Complete Genomics for Infringement
      • Life Technologies and Illumina Dispute Over Amplification on Solid Surfaces
      • Life Technologies Files Infringement Suit Against Promega
      • Enzo Biochem Disputes CalTech Sequencing Patents
      • Azco Biotech Sues Qiagen and Intelligent Bio-Systems
      • Intelligent Bio-Systems (Qiagen) and Columbia University Sue Illumina for Infringement
      • LabCorp's Esoterix Sues Life Technologies
      • Genetic Technologies Sues Several Firms for Infringement of Haplotype Determination Technique
      • Illumina Sues Life Technologies Over Ion Torrent Systems
      • Affymetrix Dismisses Suit Against Pacific Biosciences and Former Employees
      • Life Technologies Defeats VisiGen Stakeholders After Arbitration
      • Catalyst Assets Sues Life Technologies for Infringement
      • Patent Interference Between Life Technologies and Pacific Biosciences
      • LadaTech Sues Illumina Over DNA Amplification Patent
      • Illumina Files `841 Patent Infringement Suit Against Affymetrix
      • Affymetrix and Illumina Settle Case Over `243, `432, `531, `365, and `716
      • Applied Biosystems and Illumina Claims and Counter-claims Over Sequencing-by-Ligation Both Unsuccessful
      • Fluidigm and Applied Biosystems Agree to End Case
      • Beckman Coulter and Applied Biosystems Settle Outstanding Legal Disputes
      • Cepheid and Idaho Technology Settle Dispute Over PCR Patents
      • Huang v. CalTech
      • Applied Biosystems and Amersham plc (GE Healthcare) Settle Sequencing Patent Litigation
      • Early ABI (Life Technologies) Patents
  • 340 Deals in LP/TE & Next Generation Sequencing
  • Corporate Profiles
    • AGILENT TECHNOLOGIES
      • Total 2014 Revenues: $7B
    • F. HOFFMANN-LAROCHE AG
    • FLUIDIGM
    • ILLUMINA
    • PACIFIC BIOSCIENCES
    • QIAGEN
    • THERMO FISHER SCIENTIFIC
  • Challenges and Strategic Recommendations
    • CHALLENGES
      • Highly Concentrated Sequencer Market Increases Risks
      • Many Labs Opting for Services over Purchasing Sequencers
      • Shortcomings and Pitfalls Require Solutions
      • Low Barriers Leading to Increased Competition
      • Uncertainty Regarding LDT Regulation and Adoption
      • Dropping Price of Sequencing Causes Pressure
      • Complexity and Difficulty Restrains Broad Adoption
    • STRATEGIC RECOMMENDATIONS
      • Partner or Communicate with Leading Sequencer Companies
      • Develop Complementary Products as a Hedge
      • Prepare for Disruption, Contingencies
      • Use Services for Visibility and Monetization
      • Address or Ease Data Analysis Challenges
      • Anticipate or Position for Global Adoption

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