Global Hepatitis Treatment and Diagnostics

TABLE OF CONTENTS

CHAPTER ONE: EXECUTIVE SUMMARY

Market Potential

Epidemiology

Technology

Scope and Methodology

CHAPTER TWO: THE BASICS OF HEPATITIS, VIRUSES, ETIOLOGY AND PATHOLOGY

Hepatitis A

• The Virus
• Etiology
• Pathology

Hepatitis B

• The Virus
• Etiology Pathology

Hepatitis C

• The Virus
• Etiology
• Pathology

Hepatitis D

• The Virus
• Etiology
• Pathology

Hepatitis E

• The Virus
• Etiology
• Pathology

CHAPTER THREE: EPIDEMILOGY

Hepatitis A

• Geographic Patterns
• Age of Infection
• U.S. Hepatitis A Cases

Hepatitis B

• Geographic Patterns
• Risk to Children and Infants
• Vaccines

Hepatitis C

• Geographic Patterns

Hepatitis D

• Geographic Patterns

Hepatitis E

• Geographic Patterns

CHAPTER FOUR: HEPATITIS DIAGNOSIS, PROPHYLAXIS AND THERAPEUTICS

Hepatitis A

• Diagnosis
• Prophylaxis
• Therapeutics

Hepatitis B

• Diagnosis
• Prophylaxis
• Therapy

Hepatitis C

• Diagnosis
• Prophylaxis
• Therapy

Hepatitis D

• Diagnosis
• Prophylaxis
• Therapy

Hepatitis E

• Diagnosis
• Prophylaxis
• Therapy

CHAPTER FIVE: STRATEGIC ASSESSMENT AND MARKET ANALYSIS

Hepatitis Policy

Comprehensive Prevention Strategy

Hepatitis C Prevention

Market Potential

Theoretical Market Assessment

Diagnostics and Screening Markets

Therapeutics: Vaccines and Antivirals

Pricing Considerations

Realistic Market Assessment TABLE OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

Table 1-1: Estimated Theoretical Global Market Potentials for Hepatitis (All Types) Testing Products and Therapeutics: 2006

Figure 1-1: Theoretical Distribution of Global Hepatitis (All Types) Testing Products and Therapeutics Market Potential: 2006

Table 1-2: Estimated Theoretical Global Market Potentials for Hepatitis (All Types) Testing Products: 2006 (Millions)

Figure 1-2: Theoretical Distribution of Global Hepatitis (All Types) Testing Products (Screening and Diagnosis) Market Potential: 2006

Table 1-3: Estimated Theoretical Global Market Potentials for Hepatitis (All Types) Therapeutics: 2006

Figure 1-3: Theoretical Distribution of Global Hepatitis (All Types) Therapeutic Products Market Potential: 2006

Table 1-4: A Realistic Estimation Global Market Potentials for Hepatitis (All Types) Testing Products and Therapeutics: 2006 (Millions)

Figure 1-4 The Distribution of Realistic Estimates of Global Hepatitis (All Types) Testing Products and Therapeutics Market Potential: 2006

Table 1-5 A Realistic Estimation Global Market Potentials for Hepatitis (All Types) Testing Products: 2006 (Millions)

Figure 1-5: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Testing Products Market Potential: 2006

Table 1-6 A Realistic Estimation Global Market Potentials for Hepatitis (All Types) Therapeutics: 2006

Figure 1-6 The Distribution of Realistic Estimates of Global Hepatitis (All Types) Therapeutics Market Potential: 2006

Table 1-7: Global Prevalence of Hepatitis (All Types): 2006 (Millions)

Figure 1-7: The Distribution of Global Hepatitis (All Types) Prevalence: 2006

CHAPTER TWO: THE BASICS OF HEPATITIS, VIRUSES, ETIOLOGY AND PATHOLOGY

Table 2-1 The Hepatitis Viruses

CHAPTER THREE: EPIDEMILOGY

Table 3-1 Worldwide Endemicity of HAV Infection

Table 3-2: Prevalence of Hepatitis B in Various regions of the World

Table 3-3: Hepatitis C Estimated Prevalence and Number Infected by WHO Region: 2000

Table 3-2: Prevalence of Hepatitis B in Various regions of the World

CHAPTER FOUR: HEPATITIS DIAGNOSIS, PROPHYLAXIS AND THERAPEUTICS

Table 4-1: HBV Serological Markers in Hepatitis Patients

Table 4-2: Commercially Available HBV (Antigen and Antibody) Assays

Table 4-3: Significance of Serological Marker Tests for HBV (HBsAg, antiHBs, anti HBc and Interpretation)

Table 4-4: Serological Test Findings at Different Stages of HBV Infection and in Convalescence

Table 4-5: Key Hepatitis B Vaccines* Available Internationally (Producer, Vaccine, Country, Type)

Table 4-6: General Description of Useful Assay Technologies in the Diagnosis of Hepatitis C

Table 4-7 Commercially Available HCV (Antigen and Antibody) Assays

CHAPTER FIVE: STRATEGIC ASSESSMENT AND MARKET ANALYSIS

Table 5-1: Estimated Theoretical Global Market Potentials for Hepatitis (All Types) Testing Products and Therapeutics: 2006

Figure 5-1: Theoretical Distribution of Global Hepatitis (All Types) Testing Products and Therapeutics Market Potential: 2006

Table 5-2: Estimated Theoretical Global Market Potentials for Hepatitis (All Types) Testing Products: 2006

Figure 5-2: Theoretical Distribution of the Total Global Hepatitis (All Types) Testing Products Market Potential: 2006

Figure 5-3: Theoretical Distribution of Global Hepatitis (All Types) Testing Products Market Potential for Screening: 2006

Figure 5-4: Theoretical Distribution of Global Hepatitis (All Types) Testing Products Market Potential for Diagnosis: 2006

Table 5-3: Estimated Theoretical Global Market Potentials for Hepatitis (All Types) Therapeutics: 2006

Figure 5-5: Theoretical Distribution of Global Hepatitis (All Types) Therapeutic Products Market Potential: 2006

Figure 5-6: Theoretical Distribution of Global Hepatitis (All Types) Vaccine Market Potential: 2006

Figure 5-7: Theoretical Distribution of Global Hepatitis (All Types) Antiviral Drug Market Potential: 2006

Table 5-4: A Realistic Estimation Global Market Potentials for Hepatitis (All Types) Testing Products and Therapeutics: 2006 (in millions)

Figure 5-8: The Distribution of Realistic Estimates of Global Hepatitis (All Types)

Testing Products and Therapeutics Market Potential: 2006

Table 5-5: A Realistic Estimation Global Market Potentials for Hepatitis (All Types) Testing Products: 2006

Figure 5-9: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Market Potential for Testing Products: 2006

Figure 5-10: The Distribution of Realistic Estimates of Global Hepatitis (All Types)

Market Potential for Testing Products in Screening: 2006

Figure 5-11: The Distribution of Realistic Estimates of Global Hepatitis (All Types)

Market Potential for Testing Products in Diagnosis: 2006

Table 5-6: A Realistic Estimation Global Market Potentials for Hepatitis (All Types) Therapeutics: 2006

Figure 5-12: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Therapeutics Market Potential: 2006

Figure 5-13: The Distribution of Realistic Estimates of Global Hepatitis (All Types)

Therapeutics Market Potential --- Vaccines: 2006

Figure 5-14: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Therapeutics Market Potential --- Antiviral Drugs: 2006

Table 5-1: Estimated Theoretical Global Market Potentials for Hepatitis (All Types) Testing Products and Therapeutics: 2006

Figure 5-1: Theoretical Distribution of Global Hepatitis (All Types) Testing Products and Therapeutics Market Potential: 2006

Table 5-2: Estimated Theoretical Global Market Potentials for Hepatitis (All Types) Testing Products: 2006

Figure 5-2: Theoretical Distribution of the Total Global Hepatitis (All Types) Testing Products Market Potential: 2006

Figure 5-3: Theoretical Distribution of Global Hepatitis (All Types) Testing Products Market Potential for Screening: 2006

Figure 5-4: Theoretical Distribution of Global Hepatitis (All Types) Testing Products Market Potential for Diagnosis: 2006

Table 5-3: Estimated Theoretical Global Market Potentials for Hepatitis (All Types) Therapeutics: 2006

Figure 5-5: Theoretical Distribution of Global Hepatitis (All Types) Therapeutic Products Market Potential: 2006

Figure 5-6: Theoretical Distribution of Global Hepatitis (All Types) Vaccine Market Potential: 2006

Figure 5-7 Theoretical Distribution of Global Hepatitis (All Types) Antiviral Drug Market Potential: 2006

Table 5-4: A Realistic Estimation Global Market Potentials for Hepatitis (All Types) Testing Products and Therapeutics: 2006

Figure 5-8: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Testing Products and Therapeutics Market Potential: 2006

Table 5-5: A Realistic Estimation Global Market Potentials for Hepatitis (All Types) Testing Products: 2006

Figure 5-9: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Market Potential for Testing Products: 2006

Figure 5-10: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Market Potential for Testing Products in Screening: 2006

Figure 5-11: The Distribution of Realistic Estimates of Global Hepatitis (All Types)

Market Potential for Testing Products in Diagnosis: 2006

Table 5-6: A Realistic Estimation Global Market Potentials for Hepatitis (All Types) Therapeutics: 2006

Figure 5-12: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Therapeutics Market Potential: 2006

Figure 5-13: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Therapeutics Market Potential --- Vaccines: 2006

Figure 5-14: The Distribution of Realistic Estimates of Global Hepatitis (All Types) Therapeutics Market Potential --- Antiviral Drugs: 2006

The unrecognized importance, danger and costs of hepatitis in the 21st century cannot be understated or underestimated. The impact of the disease on world society is highly significant and now presenting a major crisis in public health circles.

In his exhaustive analysis of the potential diagnosis, screening and therapeutic markets for hepatitis, Ken Krul, PhD. advises companies to think on a global basis. In this study, Global Hepatitis Strategies Krul examines the potential market, epidemiology (hepatitis patient trends) and technology to provide a clear understanding of the opportunities and challenges awaiting companies competing in this market.

As part of the market analysis this report includes

• Extensive Statistics of Incidence and Prevalence of Hepatitis Across the 6 Major WHO Regions (Americas, Europe, Africa, Western Pacific, Southeast Asia, Eastern Mediterranean)
• Etiology, Prophylaxis, and Therapy for Hepatitis A, B, C, D and E.
• Theoretical Revenues for Diagnosis, Screening and Therapeutics representing the potential marketplace if all screening options are pursued.
• Realistic Market Revenues representing the likely marketplace.
• Global Distribution of Therapeutics and Diagnostics Revenues across Major 6 WHO regions
• Over 40 Figures and Tables making information accessible.

Product managers, Marketing executives at pharmaceutical and diagnostic companies; as well as investment professionals are among those who will find this survey a critical resource.