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Cell Culture: The Market for Media, Sera and Reagents

Cell Culture: The Market for Media, Sera and Reagents

The growth in biopharmaceuticals is creating an unprecedented increase in demand for cell culture products. Biopharmaceutical products are developed from large, complex protein molecules, which require equally complex manufacturing methods and an array of analytical techniques.  This Kalorama Information report, Cell Culture; The Market for Media, Sera and Reagents, analyzes the world market for media, sera and reagents and the major trends and drivers.  Authored by Anne Anscomb, it is the fifth time Kalorama Information has looked at this market since 2007.

As growing cells for biopharmaceutical production is slow, expensive and complicated, optimizing cell culture development is of paramount concern to companies developing biopharmaceuticals. The report contains market size projections, product offerings of major companies, current culture practice trends and company market share. The report focuses on three segments of the cell culture market

Media Market

Different kinds of cells require different types of media. Serum based media are widely used to grow a broad range of animal cell types and cell lines such as Chinese hamster ovaries (CHO) or murine myeloma cells (NS0) cells.  This report provides market size and forecast to 2019 for the following categories of media:

  • Animal-Free Media
  • Serum-Free Media
  • Chemically Defined Media
Sera Market

Serum has traditionally been used as the major supplement to cell culture media. Serum is a complex mix of albumins, growth factors and growth inhibitors. Serum is one of the most important components of cell culture media and serves as a source for amino acids, proteins, vitamins (particularly fat-soluble vitamins such as A, D, E, and K), carbohydrates, lipids, hormones, growth factors, minerals, and trace elements. This report provides market size and forecast to 2019 for the following categories of sera:
  • Newborn Calf
  • Other Bovine
  • Fetal Bovine Serum
  • Other Sera
Reagents Market

Cultured cells require a sterile environment and a supply of nutrients for growth. An alternative to purchasing prepared defined media, is to purchase reagents and other cell culture components to create an optimum environment for a particular cell line. Biological reagents are an intrinsic component in every research laboratory and research project. This report provides market size and forecast to 2019 for the following categories of reagents:
  • Buffers and Salt Solution
  • Cytokines and Growth Factors
  • Cell Dissociation Reagents
  • Others
Eleven cell culture-derived biopharmaceutical drugs were launched in the US and European markets in 2014. Biopharmaceuticals (recombinant proteins, monoclonal antibody and nucleic acid-based products) represent the fastest growing sector in the pharmaceutical industry. Driving the extraordinary interest in biopharmaceuticals is the ability of these large proteins to target diseases in a very specific manner, thus maximizing efficacy while minimizing side effects. The report discusses key market drivers and restraints for suppliers, including discussions of biopharmaceutical pipelines, biomedical R&D directions, and the future of transgenic plant and animal production. It also discusses late-breaking trends such as 3D cell Culture. In addition, the report reviews the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the biopharmaceutical product manufactured by these systems.

Country Cell Culture Markets

A global report, market estimates for the overall cell culture market are segmented by geography. The report offers the following regions/countries:
  • North America
  • UK/Ireland
  • Rest of Europe
  • Asia
  • China
  • Japan
  • Singapore/Malaysia
  • Rest of World


The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with key industry officials, consultants, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company and cell culture supply company representatives included marketing directors, division managers, and product representatives.

 Companies Profiled in This Report Include:

Advanced Biotechnologies, Inc.  

Affymetrix, Inc.  

AMRESCO, Inc.  

Analytical Biological Services Inc.  

Atlanta Biologicals, Inc.  

Athena Enzyme Systems  

BD Biosciences  

Bioreclamation Inc  

Cell Essentials, Inc.  

CellGenix Technologie Transfer GmbH  

ClonTech Laboratories, inc.  

Corning Life Sciences  

EMD Millipore  

GE Healthcare Life Sciences  

Gemini Bio-Products  

invitria  

Irvine Scientific  

J R Scientific, Inc.  

Life Technologies 

Lonza Bioscience  

MP Biomedicals  

Novozymes Biopharma US Inc  

PromoCell GmbH  

Quality Biological, Inc.  

SBH Sciences  

Selexis SA  

SeraCare Life Sciences, Inc.  

Sera Laboratories International  Ltd  

Sigma-Aldrich  

Stemcell Technologies Inc.  

Thermo Fisher Scientific, Inc.  

Tico Europe  

Wisent Bioproducts


  • Executive Summary
    • SCOPE AND METHODOLOGY
    • CELLS FOR BIOPHARMACEUTICAL PRODUCTION
      • Bacteria and Yeasts Systems
      • Animal Cell Systems
      • Insect Cell Systems
    • CELL LINES AND CELL BANKS
    • FERMENTORS AND BIOREACTORS
      • Stirred-tank Reactors
      • Airlift Fermentors
      • Packed Bed Reactors
      • Hollow-fiber Reactor
      • Single-use Disposable Systems
      • Perfusion Bioreactor
    • FERMENTATION PROCESSES
      • Batch and Fed-Batch Fermentation
      • Suspended vs. Anchored Cells
      • Microencapsulation
    • ADVANCEMENT IN CELL CULTURE TECHNIQUES: 3D CELL CULTURE
      • Growing Cells In Three Dimensional Systems
    • CELL CULTURE ENVIRONMENT
    • FUNCTIONS AND COMPONENTS OF BASAL MEDIA
      • pH and Osmotic Pressure
      • Energy Sources
      • Nutrients
      • Cell Culture Media
      • Lysogeny broth (LB)
      • Classical Media
      • Serum-free Media
      • Protein-free Media
      • Chemically Defined Media
      • Specialty Media
    • Sera
    • Reagents
    • SHIFTING TOWARDS NON-ANIMAL DERIVED REAGENTS
    • ADDRESSING REAGENT SAFETY ISSUES
      • Global Cell Culture Market
    • CELL CULTURE MARKET AND FORECAST
      • Table Global Cell Culture Market, 2009-2019
    • CURRENT AND FUTURE TRENDS
  • Genetically Modified Cells for Biopharmaceutical Development
    • GROWING DEMAND FOR BIOPHARMACEUTICALS
    • BIOPHARMACEUTICAL GROWTH INCREASES DEMAND FOR CELL CULTURE PRODUCTS
    • A BRIEF HISTORY OF BIOTECHNOLOGY
    • SCIENCE OF GENETIC MANIPULATION
    • BIOPHARMACEUTICAL MARKET AND PRODUCTION
      • Biopharmaceutical Production
    • TOP SELLING BIOPHARMACEUTICALS IN 2012, 2013 AND 2014
      • Table Top Selling Biological Drugs in 2012 and 2013
      • Table Top Selling Biological Drugs in 2014
    • FDA-APPROVED BIOPHARMACEUTICALS
      • Table FDA Biopharmaceutical Product Approvals, 2013
      • Table FDA Biopharmaceutical Product Approvals, 2014
    • UPSTREAM BIOPROCESSING: CELL CULTURE EXPRESSION SYSTEMS
    • CELLS FOR BIOPHARMACEUTICAL PRODUCTION
      • Bacteria and Yeasts Systems
      • Animal Cell Systems
      • Insect Cell Systems
    • ADVANTAGES/DISADVANTAGES OF CELL CULTURE SYSTEMS
      • Table Approximate times from Introduced Gene to Protein Production at Useable Levels
      • Table Disadvantages/Advantages of Cell Culture Systems
    • CELL LINES AND CELL BANKS
    • BIOPHARMACEUTICALS PRODUCED FROM CELL CULTURE
    • Cell Culture Practices and Regulatory Guidelines
      • Table Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells
    • VALIDATION OF FACILITIES
    • MAINTAINING STERILIZATION STANDARDS
  • Cell Culture Technology
    • INTRODUCTION AND OVERVIEW
    • MILESTONES IN CELL CULTURE DEVELOPMENT
    • CELL LINES FOR BIOPRODUCTION
    • PREDOMINANT CELL LINES
      • Chinese Hamster Ovary (CHO)
      • SP2/0, and NS0
      • HEK 293 and PER. C6
    • SOURCES: LARGEST COLLECTIONS OF CELL LINES
    • BIOREACTORS
    • TYPES OF BIOREACTORS/FERMENTORS
      • Stirred-tank Reactors
      • Airlift Fermentors
      • Packed Bed Reactors
      • Hollow-fiber Reactor
      • Single-use/Disposable Systems
      • Perfusion Bioreactor
    • Fermentation Processes
    • BATCH AND FED-BATCH FERMENTATION
    • SUSPENDED VS. ANCHORED CELLS
    • MICROENCAPSULATION
    • ADVANCEMENT IN CELL CULTURE TECHNIQUES: 3D CELL CULTURE
      • Growing Cells in Three Dimensional Systems
        • Table Five Types of 3D Cell Culture Methods
    • FUNCTIONS AND COMPONENTS OF BASAL MEDIA
      • pH and Osmotic Pressure
      • Energy Sources
      • Nutrients
    • Cell Culture Media
    • TYPES OF MEDIA
      • Lysogeny broth (LB)
      • Classical Media
      • Serum-free Media
      • Protein-free Media
      • Chemically Defined Media
      • Specialty Media
    • Sera
    • SOURCES OF SERA
    • BOVINE SERUM SAFETY ISSUES AND REGULATIONS
    • SHIFT TO SERUM-FREE MEDIA
      • Table Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma, Myeloma and CHO cell lines
    • Reagents
    • MAJOR TYPES OF BIOLOGIC REAGENTS
      • Amino Acids
      • Growth Factors and Cytokines
      • Albumin
      • Transferrin
      • Thrombin
      • Growth Supplements
      • Protease Inhibitor
      • Attachment Factors
    • SHIFTING TOWARDS NON-ANIMAL DERIVED REAGENTS
    • ADDRESSING REAGENT SAFETY ISSUES
  • Cell Culture Market; Current and Future Trends
    • OVERVIEW
    • CELL CULTURE MARKET
      • Market Drivers
      • Cell Culture Market Forecast
        • Table Global Cell Culture Market, 2009-2019
    • GLOBAL CELL CULTURE MARKET SHARE, BY REGION
      • Global Market Share, by Region, 2014 and 2019
        • Table Global Market Share, 2014 and 2019 (US $)
    • ASIA PACIFIC REGION GAINING MARKET SHARE
      • Singapore: Fastest Growing Region
    • MARKET SEGMENT ANALYSIS
      • Table Global Cell Culture Market by Segment: Media, Sera and Reagents, 2009-2019
    • MEDIA
      • Table Media Sales, 2014-2019
      • Percentage of Market by Media Type
      • Advantages and Disadvantages of Using Serum
        • Table Advantages and Disadvantages of using Serum in Media
      • Liquid Versus Powdered Media
    • SERA
      • Table Sera Sales, 2009-2019
    • REAGENTS
      • Table Reagent Sales, 2009-2019
    • REAGENT TYPES
      • Cytokines and growth factors
      • Cell Dissociation Reagents
      • Buffers and Salt Solutions
      • Other Reagents
    • CELL CULTURE SUPPLIER MARKET SHARE
    • MARKET LEADERS IN CELL CULTURE, 2014
      • Table Cell Culture Market Share, by Competitor, 2014
    • CURRENT AND FUTURE TRENDS
    • SHIFT TO SERUM-FREE AND ANIMAL PRODUCT-FREE MEDIA
    • CELL CULTURE-BASED VACCINE PRODUCTION
      • Cell Culture-based Seasonal Vaccines
    • STEM CELL RESEARCH DRIVING CELL CULTURE MARKET
      • Sigma-Aldrich
      • ThermoFisher Scientific
      • Lonza Bioscience
      • EMD Millipore
      • BD Bioscience
    • IMPACT OF GENERIC BIOPHARMACEUTICALS ON CELL CULTURE MARKET
  • Company Profiles
    • ADVANCED BIOTECHNOLOGIES, INC.
      • History and Lines of Business
      • Cell Culture Products and Services
    • AFFYMETRIX, INC.
      • History and Lines of Business
      • Cell Culture Products, Reagents and Biochemicals
    • AMRESCO, INC.
      • History and Lines of Business
      • Cell Culture Products
    • ANALYTICAL BIOLOGICAL SERVICES INC.
      • History and Lines of Business
      • Cell Culture Products
    • ATLANTA BIOLOGICALS, INC.
      • History and Lines of Business
      • Atlanta Biological's Cell Culture Products
    • ATHENA ENZYME SYSTEMS
      • History and Lines of Business
      • Cell Culture Products
    • BD BIOSCIENCES
      • History and Lines of Business
      • Cell Culture Products
    • BIORECLAMATION INC
      • History and Lines of Business
      • Cell Culture Products
    • CELL ESSENTIALS, INC.
      • History and Lines of Business
      • Cell Culture Products
    • CELLGENIX TECHNOLOGIE TRANSFER GMBH
      • History and Lines of Business
      • Cell Culture Products and Services
    • CLONTECH LABORATORIES, INC.
      • History and Lines of Business
      • Cell Culture Products
    • CORNING LIFE SCIENCES
      • History and Lines of Business
      • Cell Culture Products
    • EMD MILLIPORE
      • History and Lines of Business
      • Cell Culture Products
    • GE HEATHCARE LIVE SCIENCES
      • History and Lines of Business
      • Cell Culture Products
    • GEMINI BIO-PRODUCTS
      • History and Lines of Business
      • Cell Culture Products
    • INVITRIA
      • History and Lines of Business
      • Cell Culture Products
    • IRVINE SCIENTIFIC
      • History and Lines of Business
      • Cell Culture Products
    • J R SCIENTIFIC, INC.
      • History and Development
      • Cell Culture Products
    • LIFE TECHNOLOGIES
      • History and Lines of Business
      • Cell Culture Products
    • LONZA BIOSCIENCE
      • History and Lines of Business
      • Cell Culture Products and Services
    • MP BIOMEDICALS
      • History and Lines of Business
      • Cell Culture Products
    • NOVOZYMES BIOPHARMA US INC
      • History and Lines of Business
      • Cell Culture Products
    • PROMOCELL GMBH
      • History and Lines of Business
      • Cell Culture Products
    • QUALITY BIOLOGICAL, INC.
      • History and Lines of Business
      • Cell Culture Products
    • R&D SYSTEMS, INC.
      • History and Lines of Business
      • Cell Culture Products
    • SBH SCIENCES
      • History and Lines of Business
      • Cell Culture Products
    • SELEXIS SA
      • History and Lines of Business
      • Cell Culture Products and Technology
    • SERACARE LIFE SCIENCES, INC.
      • History and Lines of Business
      • Cell Culture Products
    • SERA LABORATORIES INTERNATIONAL LTD
      • History and Lines of Business
      • Cell Culture Products
      • Product Categories
    • SIGMA-ALDRICH
      • History and Lines of Business
      • Cell Culture Products
    • STEMCELL TECHNOLOGIES INC.
      • History and Lines of Business
      • Cell Culture Products
    • THERMO FISHER SCIENTIFIC, INC.
      • History and Lines of Business
      • Cell Culture Products
    • TICO EUROPE
      • History and Lines of Business
      • Cell Culture Products
    • WISENT BIOPRODUCTS
      • History and Lines of Business
      • Cell Culture Products
  • Company Directory

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