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Cell Culture: The World Market for Media, Sera, and Reagents


Attention: There is an updated edition available for this report.

As the biopharmaceutical market grows, so will the cell culture products market. Cell culture is a major foundation of biopharmaceutical development, bioprocessing and manufacturing. Biopharmaceutical products are developed from large, complex protein molecules, which require equally complex manufacturing methods and an array of analytical techniques. As growing cells for biopharmaceutical production is slow, expensive and complicated, optimizing cell culture development is of paramount concern to companies developing biopharmaceuticals.

This report is focused on cell culture used in the research and production of biopharmaceuticals, analyzing the world cell culture market and the major trends driving this market in three specific segments:

  • Media,
  • Sera, and
  • Reagents

In addition to a thorough discussion of the technologies and techniques currently employed and emerging in the cell culture area, the Kalorama's exhaustive report provides specific information on:

  • Market Size, growth, and forecasts of the segments through 2011
  • Competitive Market Share by leading supplier as of 2005.
  • Estimated Market Share by Media Type (this is not available in other reports)
  • Key Market Drivers and Restraints for suppliers, including discussions of biopharmaceutical pipelines, seasonal vaccine production, biomedical R&D directions, and the future of transgenic plant and animal production.
  • Review of the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the biopharmaceutical product manufactured by these systems
  • Discussion of the trends and preferences in media types vying for dominance in the market, including the following:
    • ADCF - animal derived component free media
    • CD - chemically defined media
    • CSFM - complete serum free medium
    • PF - protein free media
    • SF - serum free media
    • SFM - serum free medium
  • Profiles of 28 leading suppliers and information about M&A activities since 2003.

The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with key industry officials, consultants, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company and cell culture supply company representatives included marketing directors, division managers, and product representatives.


  • Executive Summary
    • SCOPE AND METHODOLOGY
    • CELLS FOR BIOPHARMACEUTICAL PRODUCTION
      • Bacteria and Yeasts Systems
      • Animal Cell Systems
      • Insect Cell Systems
    • CELL LINES AND CELL BANKS
    • FERMENTORS AND BIOREACTORS
      • Stirred-Tank Reactors
      • Airlift Fermentors
      • Packed Bed Reactors
      • Hollow-Fiber Reactor
      • Disposable Systems
    • FERMENTATION PROCESSES
      • Batch and Fed-Batch Fermentation
      • Suspended vs. Anchored Cells
      • Microencapsulation
    • CELL CULTURE ENVIRONMENT: FUNCTIONS AND COMPONENTS OF BASAL MEDIA
      • pH and Osmotic Pressure
      • Energy Sources
      • Nutrients
    • CELL CULTURE MEDIA
      • Lysogeny broth (LB)
      • Classical Media
      • Serum-Free Media
      • Protein-Free Media
      • Chemically Defined Media
      • Specialty Media
    • SERA
    • REAGENTS
      • Shifting Towards Non-Animal Derived Reagents
      • Addressing Reagent Safety Issues
    • WORLD CELL CULTURE MARKET
      • Impact of Shift to Serum-free Products on Cell Culture Suppliers
      • Impact of Shift to Serum-Free Products On Research
      • Impact of Shift to Serum-Free Products on Biopharmaceutical Manufacturers
      • Market Drivers
      • Cell Culture Market Forecast
        • Table Market Summary: World Cell Culture Market 2002-2011
    • TRENDS IMPACTING THE CELL CULTURE MARKET
  • Genetically Modified Cells for Biopharmaceutical Development
    • OVERVIEW
      • Growing Demand for Biopharmaceuticals
        • Table Biopharmaceuticals Appoved in the US or the EU in 2005 (Product, Expression, Indications, Company)
      • Demand Increasing for Cell Culture Products
      • A Brief History of Biotechnology
      • Science of Genetic Manipulation
    • FROM PETRI DISH TO BIOPHARMACEUTICAL
      • Upstream Bioprocessing: Cell Culture Expression Systems
      • Cells for Biopharmaceutical Production
      • Advantages/Disadvantages of Cell Culture Systems
        • Table Approximate Times from Introduced Gene to Protein Production at Useable Levels by Expression System (Bacteria, Yeast, Mammilian, Insect)
        • Table Disadvantages/Advantages of Cell Culture Systems by Expression System (Bacteria, Yeast, Animal, Insect)
      • Cell Lines and Cell Banks
      • Biopharmaceuticals Produced from Cell Culture
        • Table Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells (Expression System, Product, Manufacturer, Indication)
    • CELL CULTURE PRACTICES AND REGULATORY GUIDELINES
      • Validation of Facilities
      • Maintaining Sterilization Standards
  • Cell Culture Technology
    • INTRODUCTION AND OVERVIEW
    • CELL LINES FOR BIOPRODUCTION
      • Predominant Cell Lines
      • Sources: Largest Collections of Cell Lines
    • FERMENTORS AND BIOREACTORS
      • Types of Bioreactors/Fermentors
      • Fermentation Processes
    • CELL CULTURE ENVIRONMENT:
      • pH and Osmotic Pressure
      • Energy Sources
      • Nutrients
    • CELL CULTURE MEDIA
      • Lysogeny Broth (LB)
      • Classical Media
      • Serum-Free Media
      • Protein-Free Media
      • Chemically Defined Media
      • Specialty Media
    • SERA
      • Sources of Sera
      • Bovine Serum Safety Issues and Regulations
      • Shift to Serum-Free Media
        • Table Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma, Myeloma, and CHO cell lines (Company, Product, Type [ADCF, CD, CSFM, PF, SF, SFM], Cell Line)
    • REAGENTS
      • Major Types of Biologic Reagents
      • Shifting Towards Non-animal Derived Reagents
      • Addressing Reagent Safety Issues
  • Trends and Market Analysis
    • SHIFT AWAY FROM SERUM-BASED CELL CULTURE
      • Impact of Shift to Serum-Free Products on Cell Culture Suppliers
      • Impact of Shift to Serum-Free Products on Research
        • Table Selected Brand Name Serum-Free Formulations of Cell Culture Products Currently on the Market (Brand, Product, Manufactuer)
      • Impact of Shift Serum-Free Products on Biopharmaceutical Manufacturers
    • CELL CULTURE MARKET
      • Market Drivers
      • Cell Culture Market and Forecast
        • Table World Cell Culture Market Revenues and Growth 2002-2011
        • Table Cell Culture World Market Share by Geographical Region 2006
      • Segment Analysis
        • Table Estimated Share of Cell Culture Media Market by Media Type (Animal Sourced vs Animal Free and Animal Free vs Chemically Defined)
        • Table World Cell Culture Market Revenues by Segment (Media, Sera, Reagents) 2002-2011
      • Market Characteristics
        • Table Major Acquisitions in the Cell Culture Industry 2003-2006
      • Competitive Market Share
        • Table Cell Culture Revenues and Market Share by Leading Competitor 2005
    • TRENDS IMPACTING THE CELL CULTURE MARKET
      • Stem Cell Research
      • Cell Culture-Based Vaccine Production
      • Transgenically Produced Biopharmaceuticals
  • Company Profiles
    • ADVANCED BIOTECHNOLOGIES, INC.
      • History and Lines of Business
      • Cell Culture Products and Services
    • AMRESCO, INC.
      • History and Lines of Business
      • Cell Culture Products
    • ANALYTICAL BIOLOGICAL SERVICES INC.
      • History and Lines of Business
      • Cell Culture Products
    • ATLANTA BIOLOGICALS, INC.
      • History and Lines of Business
      • Cell Culture Products
    • ATHENA ENZYME SERVICES
      • History and Lines of Buiness
      • Cell Culture Products
    • BIOCHROM AG
      • History and Lines of Business
      • Cell Culture Products
    • BD BIOSCIENCES
      • History and Lines of Business
      • Cell Culture Products
      • Clinical and Clinical Research Reagents, which include:
      • Financial Information
    • CAMBREX CORPORATION
      • History and Lines of Business
      • Cell Culture Products
      • Financial Information
    • CELL ESSENTIALS, INC.
      • History and Lines of Business
      • Cell Culture Products
    • CELLGENIX TECHNOLOGIE TRANSFER GMBH
      • History and Lines of Business
      • Cell Culture Products and Services
    • FISHER SCIENTIFIC INTERNATIONAL, INC.
      • History and Lines of Business
      • Cell Culture Products
      • Financial Information
    • INVITROGEN CORPORATION
      • History and Lines of Business
      • Cell Culture Products
      • Financial Information
    • IRVINE SCIENTIFIC
      • History and Lines of Business
      • Cell Culture Products
    • J R SCIENTIFIC, INC.
      • History and Development
      • Cell Culture Products
    • HYCLONE LABORATORIES
      • History and Lines of Business
      • Cell Culture Products
    • KEMP BIOTECHNOLOGIES, INC.
      • History and Lines of Business
      • Cell Culture Products
    • MEDIATECH, INC.
      • History and Lines of Business
      • Cell Culture Products
    • MILLIPORE CORPORATION
      • History and Lines of Business
      • Cell Culture Products
      • Financial Information
    • PAA LABORATORIES, INC.
      • History and Lines of Business
      • Cell Culture Products
    • PROMOCELL GMBH
      • History and Lines of Business
      • Cell Culture Products
    • QUALITY BIOLOGICAL, INC.
      • History and Lines of Business
      • Cell Culture Products
    • R&D SYSTEMS, INC.
      • History and Lines of Business
      • Cell Culture Products
    • SBH SCIENCES
      • History and Lines of Business
      • Cell Culture Products
    • SELEXIS SA
      • History and Lines of Business
      • Cell Culture Products
    • SERACARE LIFE SCIENCES, INC.
      • History and Lines of Business
      • Cell Culture Products
    • SIGMA-ALDRICH CORPORATION
      • History and Lines of Business
      • Cell Culture Products
      • Financial Information
    • USB CORPORATION
      • History and Lines of Business
      • Cell Culture Products
    • WISENT, INC.
      • History and Lines of Business
      • Cell Culture Products
  • Company Directory

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