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The World Market for Anti-Infectives, Volume II: Antibacterials

For the past 60 years, antibiotic drugs have changed bacterial infections from the life-threatening scourges they once were into eminently treatable conditions. However, the effectiveness of many antibiotics is waning dramatically, as more and more types of bacteria become resistant to traditional agents. As a result, pharmaceutical companies are taking a second look at the antibiotic market, after more than two decades of relative complacency.

In addition to the scientific and technical challenges of new antibiotic development, there are significant business challenges, as well. The 2004 market for antibacterials actually posted a decline over 2003 and generic competition continues to threaten the anti-infective franchises of major manufacturers. Development cost for new anti-infectives have been shown to be higher than other therapeutic classes and political and economic pressures particular to anti-infective classes make recovering these costs challenging.

In this study, Kalorama Information segments the market for antibacterial medication into seven general categories based on drug class:

  • cephalosporins
  • macrolides
  • penicillins
  • quinolones
  • sulfonamides
  • tetracyclines
  • other misc. antibiotics

For each segment, the report provides market size, growth, and share. The base year for data was 2004. Historical data are provided for the years 2002 and 2003, with forecast data provided for 2005 through 2009, based on probability of approval and sales of products in late stage development, product marketing, and demographic trends. Compound annual growth rates (CAGRs) are provided for the 2002-2004, 2004-2009 and 2002-2009 periods for each industry segment covered. Market shares by supplier, by infection type, and by top products are provided for the year 2004. Regional breakdowns in each segment are provided for the United States, Europe, Japan, and Rest of World for the entire forecast period. All market data are provided at the manufacturers’ level in constant U.S. dollars.

In addition to market data, the report includes statistical information on bacterial infections by type worldwide, with special emphasis on the U.S. market. The market segments provide an overview, description of products on the market, and a description of products in development. The report also includes current issues and trends affecting the industry, including:

  • Antibiotic drug development and costs
  • Drug resistance and interactions
  • Antibiotic cycling
  • Incentives to develop antibiotics
  • Antibiotic use in agriculture
  • Antibiotic education
  • Special usage issues in pediatric and geriatric populations
  • Immunocompromised individuals and resistance
  • Antibiotics and atherosclerosis

The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and e-mail correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with key industry officials, consultants, health care providers, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company representatives included marketing directors, division managers, and product representatives.


  • Executive Summary
    • INTRODUCTION
    • SCOPE AND METHODOLOGY
    • SIZE AND GROWTH OF THE MARKET
      • Table The World Market for Antibacterial Drugs 2002-2009
      • Table Compound Annual Growth Rate
    • ISSUES AND TRENDS AFFECTING MARKET
    • LEADING COMPETITORS
  • Introduction
    • BACTERIAL PATHOGENS
      • Classification of Bacterial Organisms
        • Table Micro-Organisms by Class and First- and Second-Choice Antibiotics
    • ANTIBIOTIC AGENTS
      • Spectrum of Activity
      • Bacterial Resistance
      • Principles of Anti-Infective Therapy
      • Combination Therapy and Prophylactic Use
    • DEMOGRAPHICS AND EPIDEMIOLOGY
      • Table Estimated World and U.S. Incidence of Bacterial Infections
      • Table World Population by Selected Geographical Region, 2004–2050
      • Table Estimated World Population by Age and Geographical Region, 2004
  • Issues and Trends
    • ANTIBIOTIC DRUG DEVELOPMENT AND COSTS
    • DRUG RESISTANCE AND INTERACTIONS
    • ANTIBIOTIC CYCLING
    • ADDRESSING RESISTANCE AND OVERUSE
    • INCENTIVES TO DEVELOP ANTIBIOTICS
      • Infectious Disease Society of America
      • BioShield I, II
    • ANTIBIOTIC USE IN AGRICULTURE
    • ANTIBIOTIC EDUCATION
    • CHILDREN AND BACTERIAL RESISTANCE
    • THE ELDERLY AND BACTERIAL RESISTANCE
    • IMMUNOCOMPROMISED POPULATIONS AND BACTERIAL RESISTANCE
    • ANTIBIOTIC USE IN PEDIATRIC ASTHMA
    • SCREENING HOSPITALIZED PATIENTS
    • ANTIBIOTICS AND ATHEROSCLEROSIS
    • SIDE EFFECTS
  • Cephalosporin Antibiotics
    • OVERVIEW
    • DESCRIPTION OF PRODUCTS
      • Table Currently Available Cephalosporin Antibiotics by Generation (Type, Brand, and Manufacturer)
      • First Generation Cephalosporins
    • RESEARCH AND DEVELOPMENT
      • Table Cephalosporin Antibiotics in Development (Product, Developer, Development Phase, Earliest Approval Date)
    • MARKET SIZE AND GROWTH
      • Table The Market for Cephalosporin Antibiotics 2002-2009
      • Table MARKET SIZE AND GROWTH
      • Table Cephalosporin Antibiotic Market Estimated Revenues by Infection Type 2004
      • Table Cephalosporin Antibiotic Market Estimated Products Sales by Geographic Region, 2004
    • COMPETITIVE ANALYSIS
      • Table Cephalosporin Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
      • Table Cephalosporin Antibiotic Market Estimated Sales and Market Share of Top Cephalosporin Antibiotic Product Brands 2004
  • Macrolide Antibiotics
    • OVERVIEW
    • DESCRIPTION OF PRODUCTS
      • Table Currently Available Macrolide Antibiotics (Type, Brand, and Manufacturer)
    • RESEARCH AND DEVELOPMENT
      • Table Macrolide Antibiotics in Development (Product, Dev eloper, Indication, Development Phase, Earliest Approval Date)
    • MARKET SIZE AND GROWTH
      • Table The Market for Macrolide Antibiotics 2002-2009
      • Table MARKET SIZE AND GROWTH
      • Table Macrolide Antibiotic Market Estimated Products Sales by Infection Type, 2004
      • Table Macrolide Antibiotic Market Estimated Products Sales by Geographic Region, 2004
    • COMPETITIVE ANALYSIS
      • Table Macrolide Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
      • Table Macrolide Antibiotic Market Estimated Sales of Top Macrolide Antibiotic Products 2004
  • Penicillin Antibiotics
    • OVERVIEW
    • DESCRIPTION OF PRODUCTS
      • Natural Penicillins
      • Penicillinase-Resistant Penicillins
      • Broad –Spectrum Penicillins
      • Extended-Spectrum Penicillins
        • Table Currently Available Penicillin Antibiotics (Type, Brand, and Manufacturer)
      • Natural Penicillins
      • Penicillinase-Resistant Penicillins
      • Broad-Spectrum Penicillins
      • Extended-Spectrum Penicillins
    • RESEARCH AND DEVELOPMENT
      • Table Penicillin Antibiotics in Development (Product, Developer, Development Phase, Earliest Approval Date)
    • MARKET SIZE AND GROWTH
      • Table The Market for Penicillin Antibiotics 2002-2009
      • Table Compound Annual Growth Rate
      • Table Penicillin Antibiotic Market Estimated Products Sales by Infection Type, 2004
      • Table Penicillin Antibiotic Market Estimated Products Sales by Geographic Region, 2004
    • COMPETITIVE ANALYSIS
      • Table Penicillin Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
      • Table Penicillin Antibiotic Market Estimated Sales of Top Penicillin Antibiotic Products 2004
  • Quinolone Antibiotics
    • OVERVIEW
    • DESCRIPTION OF PRODUCTS
      • Table Currently Available Quinolone Antibiotics (Type, Brand, and Manufacturer)
    • RESEARCH AND DEVELOPMENT
      • Table Quinolone Antibiotics in Development
    • MARKET SIZE AND GROWTH
      • Table The Market for Quinolone Antibiotics 2002-2009
      • Table Compound Annual Growth Rate
      • Table Quinolone Antibiotic Market Estimated Products Sales by Infection Type, 2004
      • Table Quinolone Antibiotic Market Estimated Products Sales by Geographic Region, 2004
    • COMPETITIVE ANALYSIS
      • Table Quinolone Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
      • Table Quinolone Antibiotic Market Estimated Sales of Top Quinolone Antibiotics 2004
  • Sulfonamide Antibiotics
    • OVERVIEW
    • DESCRIPTION OF PRODUCTS
      • Table Currently Available Sulfonamide Antibiotics (Type, Brand, and Manufacturer)
    • MARKET SIZE AND GROWTH
      • Table The Market for Sulfonamide Antibiotics 2002-2009
      • Table Compound Annual Growth Rate
      • Table Sulfonamide Antibiotic Market Estimated Products Sales by Infection Type, 2004
      • Table Sulfonamide Antibiotic Market Estimated Products Sales by Geographic Region, 2004
    • COMPETITIVE ANALYSIS
  • Tetracycline Antibiotics
    • OVERVIEW
    • DESCRIPTION OF PRODUCTS
      • Table Currently Available Tetracycline Antibiotics (Type, Brand, and Manufacturer)
    • RESEARCH AND DEVELOPMENT
      • Table Tetracycline Antibiotics in Development
    • MARKET SIZE AND GROWTH
      • Table The Market for Tetracycline Antibiotics 2002-2009
      • Table Compound Annual Growth Rate
      • Table Tetracycline Antibiotic Market Estimated Products Sales by Infection Type, 2004
      • Table Tetracycline Antibiotic Market Estimated Products Sales by Geographic Region, 2004
    • COMPETITIVE ANALYSIS
  • Other Miscellaneous Antibiotics
    • OVERVIEW
    • DESCRIPTION OF PRODUCTS
      • Table Currently Available Other Miscellaneous Antibiotics (Type, Brand, and Manufacturer)
      • Aminoglycosides
      • Lincomycin
      • Chloramphenicol
      • Glycopeptides
      • Monobactams
      • Carbapenems
      • Carbacephems
      • Metronidazole
      • Antituberculars
      • Oxazolidinones
      • Ketolides
    • RESEARCH AND DEVELOPMENT
      • Table Other Miscellaneous Antibiotics in Development
    • MARKET SIZE AND GROWTH
      • Table The Market for Other Miscellaneous Antibiotics 2002-2009
      • Table Compound Annual Growth Rate
      • Table Other Miscellaneous Antibiotic Market Estimated Products Sales by Infection Type, 2004
      • Table Other Miscellaneous Antibiotic Market Estimated Products Sales by Geographic Region, 2004
    • COMPETITIVE ANALYSIS
      • Table Other Miscellaneous Antibiotic Market Estimated Revenues and Market Share of Leading Suppliers 2004
      • Table Other Miscellaneous Antibiotic Market Estimated Sales of Top Other Miscellaneous Antibiotics 2004
  • Total Market Size and Forecast Summary
    • OVERVIEW
    • TOTAL MARKET SIZE AND FORECAST
      • Table The World Market for Antibacterial Drugs 2002-2009
      • Table Compound Annual Growth Rate
      • Table Antibacterial Drug Market by Type 2002-2009
      • Table Compound Annual Growth Rate
  • Corporate Profiles
    • INTRODUCTION
    • ABBOTT LABORATORIES
    • ASTRAZENECA PLC
    • BRISTOL-MYERS SQUIBB COMPANY
    • DAIICHI PHARMACEUTICAL COMPANY LTD
    • FUJISAWA PHARMACEUTICAL COMPANY, LTD.
    • GLAXOSMITHKLINE
    • JOHNSON & JOHNSON GROUP
    • MERCK & COMPANY, INC.
    • PFIZER, INC.
    • ROCHE
    • SANOFI-AVENTIS
    • WYETH
  • Company Names and Addresses

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