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The World Anesthesia Drug Market

This Kalorama Information report - The World Anesthesia Drug Market - focuses on three primary segments of anesthesia:

  • General Anesthesia
  • Local Anesthesia
  • Adjunctive Therapies in Anesthesia

The report covers both currently marketed and late stage development anesthesia drugs in detail. Revenues for each segment were generated using dollar and unit sales for each product. Forecasted figures were generated using a combination of projected surgical procedures, patent and exclusivity expirations, pricing trends, new developments and other factors.

The report includes statistical information for surgical procedures, incidence of conditions requiring surgery, and other relevant information. Statistical information is presented as a worldwide overview, with special emphasis on the U.S. The market segments provide an overview, description of products on the market, description of products in development, market estimates and forecasts, and competitive analysis of leading providers. The report also includes current issues and trends affecting the industry.

The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with more than 50 key industry officials, consultants, health care providers, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company representatives included marketing directors, division managers, and product representatives.

All market data pertains to the world market at the manufacturers’ level. The base year for data was 2009. Historical data was provided for the years 2007 and 2008, with forecast data provided for 2010 through 2014. Compound annual growth rates (CAGRs) are provided for the 2007-2009, 2007-2014 and 2009-2014 periods for each industry segment covered. Competitive analysis is provided for the year 2009 with a projected competitive analysis for 2014. The forecasted market analysis for 2009-2014 was highly influenced by the probability of approval and sales of products in late stage development, product marketing, and demographic trends.


New York, April 5, 2010—Since women have different physiology than men, should we expect that they would react to anesthesia in the same way? Historically most drug development studies have been done on men and the findings applied to women. But women wake up from anesthesia up to twice as fast as men, even after controlling for their lower body weight, and they suffer more severe side effects. This gender difference, which has significant implications for clinical trials, is one of the trends in the dynamic $4.1 billion anesthesia market which pharmaceutical companies will need to address in their drug development strategy, according to The World Anesthesia Drug Market from healthcare market research publisher Kalorama Information.

“Recently there has been a renewed interest in pharmacokinetics—the study of what the body does to a drug, versus what the drug does to the body—and exploring the ways in which men and women react differently to certain drugs,” said Melissa Elder, analyst for Kalorama Information and author of the report. “Research has provided support for this gender variation, and particularly for anesthesia drugs.”

In 1993, the FDA took two important steps to ensure that new drugs are properly evaluated in women. Firstly, the FDA provided formal guidance to drug developers to emphasize its expectation that women will be appropriately represented in clinical studies and that new drug applications will include analyses to identify potential gender differences in drug actions or efficacy. Secondly, the FDA revoked a 1977 policy that excluded most women with childbearing potential from the earliest phases of clinical trials.

Duke University assessed a study in 1999 that found women to be more likely to wake-up from general anesthesia as compared to men. This suggests that women need more anesthesia pound for pound than men during procedures. In addition, Harvard University has done research in the areas of pain and anesthesia that suggest women have lower pain tolerance than men and experience more chronic pain disorders. This may be due to hormonal differences and psychosocial factors. Other studies have also found that women are more sensitive to anesthesia during recovery and tend to have more severe nausea and vomiting than men.

Research has exposed a variety of reasons for the differences in gender response to certain drugs that go beyond women’s lower body weight, and include differences in absorption, metabolizing and elimination of drugs and the effects of liver enzymes and sex hormones. These differences often result in more serious side effects for women than men, more women developing life threatening ventricular arrhythmia after taking a variety of drugs and women waking up faster than men from anesthesia.

“In clinical trials of potential anesthesia products, much closer attention is necessary to ensure that products are safe for both sexes, requiring an equal mix of men and women in trials,” says Elder. “But inclusion alone is not enough—an effort to use data from the trials to discover potential gender differences is also needed.”

The World Anesthesia Drug Market analyzes this market, and provides key information including market data and forecasts, product reviews, trends and issues, and detailed company profiles.

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  • Executive Summary
    • INTRODUCTION
    • SCOPE AND METHODOLOGY
    • SIZE AND GROWTH OF THE MARKET
      • Table The Total World Market for Anesthesia Drugs 2007-2014
    • ISSUES AND TRENDS AFFECTING MARKET
    • LEADING COMPETITORS
  • Introduction The World Anesthesia Drug Market
    • INTRODUCTION AND HISTORY TO ANESTHESIA DRUGS
    • TYPES OF ANESTHESIA
      • General Anesthesia
      • Local Anesthesia
      • Adjunctive Therapies in Anesthesia
    • ROUTES OF ADMINISTRATION
      • Inhalation
      • Mask Inhalation
      • Laryngeal Mask
      • Endotracheal Administration
      • Controlled Respiration
      • Intravenous
      • Topical Application
      • Transdermal/Transmucosal Application
    • DISTRIBUTION CHANNELS
    • DEMOGRAPHICS AND STATISTICS
      • Worldwide Demographics
        • Table World Population by Selected Geographical Region, 2010 - 2050
      • Medical Procedures by Type
        • Table Procedures by Type, Average Annually 2006-2009
      • Complications in Anesthesia
        • Table Worldwide Anesthesia Complications and Related Mortality
  • General Anesthesia
    • OVERVIEW
      • Induction of General Anesthesia
      • Preoxygenation
      • Loss of Consciousness
    • DESCRIPTION OF PRODUCTS
      • Diprivan
      • Ultane/Sevorane
      • Lusedra
      • Precedex
      • Ethrane
      • Forane
      • Pentothal
      • Suprane
      • Ketalar
      • Brevital
        • Table Marketed Brands for General Anesthesia Drugs (Brand Name, Generic Name, and Manufacturer)
    • GENERIC DRUG IMPACT AND AVAILABILITY
      • Table Selected Generic Drug Manufacturers and Products for General Anesthesia
    • RESEARCH AND DEVELOPMENT
      • Precedex
      • CNS 7056
      • AZD3043
        • Table General Anesthesia Drugs in Development
    • MARKET SIZE AND GROWTH
      • Total Market
        • Table The Market for General Anesthesia Drugs 2007-2014
      • Market by Delivery Method
        • Table The Market for General Anesthesia Drugs Estimated Products Sales by Delivery Method, 2009
      • Market by Geographical Region
        • Table The Market for General Anesthesia Drugs Estimated Products Sales by Geographic Region, 2009
    • COMPETITIVE ANALYSIS
      • Table The Market for General Anesthesia Drugs Estimated Revenues and Market Share of Leading Suppliers 2007-2009
  • Local Anesthesia
    • OVERVIEW
      • Techniques of Administration
      • Transdermal/Transmucosal
      • Simple Local Infiltration
      • Regional Injections
      • Spinal and Epidural Anesthesia
      • Intrathecal Block
      • Epidural, Peridural Block
    • DESCRIPTION OF PRODUCTS
      • AminoAmides
      • Xylocaine/LidoSite/Lidoderm/Dentipatch
      • Zingo
      • Carbocaine/Isocaine/Polocaine
      • Marcaine/Sensorcaine
      • Citanest
      • Naropin
      • Septocaine
      • Amino Esters
      • Novocaine
      • Nesacaine
      • Cocaine Hydrochloride
      • Combinations
      • Synera/Pliaglis
      • EMLA
        • Table Selected Marketed Local Anesthesia Drugs (Brand Name, Generic Name and Manufacturer)
    • GENERIC DRUG IMPACT AND AVAILABILITY
      • Table Selected Generic Drug Manufacturers and Products for Local Anesthesia
    • RESEARCH AND DEVELOPMENT
      • Table Local Anesthesia Drugs in Development
    • MARKET SIZE AND GROWTH
      • Total Market
        • Table The Market for Local Anesthesia Drugs 2004-2011
      • Market by Delivery Method
        • Table The Market for Local Anesthesia Drugs Estimated Products Sales by Delivery Method, 2009
      • Market by Geographical Region
        • Table The Market for Local Anesthesia Drugs Estimated Products Sales by Geographic Region, 2009
    • COMPETITIVE ANALYSIS
      • Table The Market for Local Anesthesia Drugs Estimated Revenues and Market Share of Leading Suppliers 2007-2009
  • Adjunctive Therapies in Anesthesia
    • OVERVIEW
    • DESCRIPTION OF PRODUCTS
      • Neuromuscular Blocking Agents
      • Preanesthetic Sedation and Anesthesia Maintenance
      • Anesthesia Reversal Agents
        • Table Selected Marketed Adjunctive Therapies in Anesthesia (Type, Brand Name, Generic Name, and Manufacturer)
    • GENERIC DRUG IMPACT AND AVAILABILITY
      • Table Selected Generic Drug Manufacturers and Products for Adjunctive Therapies in Anesthesia
    • RESEARCH AND DEVELOPMENT
      • Table Adjunctive Therapies in Anesthesia in Development
    • MARKET SIZE AND GROWTH
      • Total Market
        • Table The Market for Adjunctive Therapies in Anesthesia 2007-2014
      • Market by Geographical Region
        • Table The Market for Adjunctive Therapies in Anesthesia Estimated Products Sales by Geographic Region, 2009
    • COMPETITIVE ANALYSIS
      • Table The Market for Adjunctive Therapies in Anesthesia Estimated Revenues and Market Share of Leading Suppliers 2009
  • Anesthesia Drugs: Total Market Size and Forecast
    • TOTAL MARKET SIZE AND FORECAST
      • Table The Total World Market for Anesthesia Drugs 2007-2014
    • ANESTHESIA MARKET BY PRODUCT TYPE
      • Table Anesthesia Drug Market by Type 2007-2014
    • ANESTHESIA MARKET BY GEOGRAPHICAL REGION
      • Table Anesthesia Drug Market Estimated Products Sales by Geographic Region, 2009
    • COMPETITOR ANALYSIS
      • Table Leading Suppliers Anesthesia Revenues and Significant Segments of Participation, 2009
  • Issues and Trends Affecting the Anesthesia Drug Market
    • INTRODUCTION
    • REGULATION OF ANESTHESIA DRUGS
    • DENTISTRY AND ANESTHESIA
    • ANESTHESIA AND COMPLICATIONS IN PEDIATRIC APPLICATIONS
    • ALLERGIC REACTIONS IN ANESTHESIA
      • Recent Propofol Recall
    • ANESTHESIA AND THE BENEFITS TO DEPRESSION PATIENTS
    • ANESTHESIA AND SLEEP
    • GENDER DIFFERENCES IN ANESTHESIA REACTION
    • TRENDS IN CONSCIOUS SEDATION
    • LONG-TERM EFFECTS OF ANESTHESIA
  • Corporate Profiles
    • INTRODUCTION
    • ABBOTT LABORATORIES
    • ASTRAZENECA
    • BAXTER INTERNATIONAL
    • EISAI CO.
    • ENDO PHARMACEUTICALS HOLDINGS, INC.
    • HOSPIRA, INC.
    • MERCK/SCHERING-PLOUGH
    • ROCHE
  • List of Companies

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