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Pulmonary Arterial Hypertension (PAH) Market By Drug Class (Prostacyclin And Prostacyclin Analogs, Soluble Guanylate Cyclase (SGC) Stimulators, Endothelin Receptor Antagonists (ERA), Phosphodiesterase 5 (PDE-5)) And Segment Forecasts To 2025

Pulmonary Arterial Hypertension (PAH) Market By Drug Class (Prostacyclin And Prostacyclin Analogs, Soluble Guanylate Cyclase (SGC) Stimulators, Endothelin Receptor Antagonists (ERA), Phosphodiesterase 5 (PDE-5)) And Segment Forecasts To 2025

The Pulmonary Arterial Hypertension (PAH) market is expected to reach USD 8.7 billion by 2025, according to the new report by Grand View Research, Inc. Incidents of PAH, increasing geriatric population, and government support to develop orphan drugs are key driving factors. Cumulatively, the cases of PAH are in the range of 100,000 to 200,000 per year. However, in the past few years, the prevalence of this disorder is rising due to risk factors like sedentary lifestyle, HIV, smoking, alcohol/tobacco consumption, and other idiopathic conditions.

The presence of a large population over 60 years globally, which has lower immunity levels and is prone to PAH and associated diseases, which is a high impact-rendering driver for the growth of the market over the forecast period.

Supportive government initiatives for the development of drugs for rare diseases or orphan drugs are anticipated to facilitate the market growth over the forecast period. For instance, the Orphan Drug Act (ODA) 1983, and Rare Disease Act 2002 in the U.S. offer incentives such as tax credits for the development of orphan drugs.

Patent expiry of key PAH molecules is projected to have a deep impact on market dynamics. In coming two to four years the exclusivity of key brands such as Tracleer, Remodulin, Adcirca, Ventavis, Tyvaso, and Letairis will be lost. This will foster the entry of generic product at prices much lower than branded drugs.

Further Key Findings From the Study Suggest:

ERA dominated PAH market with a substantial share of around 40.0% in 2015. Tracleer and Opsumit target both the ETA and ETB receptors, whereas Letairis/Volibris targets only the ETA receptor. The cumulative sales from these drugs are expected to marginally decline over the next few years.

Prostacyclin and prostacyclin analogues are anticipated to exhibit lucrative growth over the forecast period. The sales of these drugs are expected to grow sharply over the forecast period, primarily due to the growth expected in oral prostacyclin agents (Uptravi and Orenitram). Adempas, a SGC stimulator launched in 2013, is expected to grow at a healthy rate during forecast period.

North America with its supportive infrastructure for development and distribution of high quality therapies dominated global pulmonary arterial hypertension market with more than 50.0% share in 2015. High awareness and well planned reimbursement structure resulted in superlative diagnosis rate ultimately impacting treatment rate.

On the other hand, Asia Pacific with its rapid economic developments, huge population base and improving healthcare systems is anticipated to grow at a lucrative growth rate. Economic developments in countries such as India and China are complimenting the growth of this region.

Some of the key players in this vertical are Actelion Pharmaceuticals, Ltd., Gilead Sciences, Inc., Gilead Sciences, Inc., United Therapeutics Corporation, GlaxoSmithKline Plc. and Pfizer, Inc..The firms are involved in adopting many mergers, acquisition, strategic collaboration and geographical expansion in order to maximize its revenue.

For instance, in January 2016, Actelion Pharmaceuticals, Ltd. announced commercial availability of Uptravi (Slelximab) in the U.S., which was previously approved in December 2015. This initiative helped company to strengthen its leadership in PAH portfolio.


Chapter 1 Research Methodology
1.1 Research Methodology
1.2 Research Scope & Assumptions
1.3 List of Data Sources
Chapter 2 Executive Summary
Chapter 3 Market Variables, Trends & Scope
3.1 Market Segmentation & Scope
3.2 Market Driver Analysis
3.3 Market Restraint Analysis
3.4 Penetration & Growth Prospect Mapping
3.5 SWOT Analysis, By Factor
3.5.1 Political
3.5.2 Economic
3.5.3 Technology
Chapter 4 Market Categorization 1: Drug Class Estimates & Trend Analysis
4.1 Drug Class Movement Analysis & Market Share, 2014 & 2024
4.2 Market Size & Forecasts and Trend Analyses, 2014 to 2024 For the Following Drug Class:
4.2.1 Prostacyclin and Prostacyclin Analogs
4.2.2 SGC Stimulators
4.2.3 ERA
4.2.4 PDE-5
Chapter 5 Market Categorization 2: Regional Estimates & Trend Analysis
5.1 Regional Movement Analysis & Market Share, 2015 & 2025
5.2 Market Size & Forecasts and Trend Analyses, 2014 to 2025 for the following regions:
5.2.1 North America
5.2.1.1 U.S.
5.2.1.2 Canada
5.2.2 Europe
5.2.2.1 UK
5.2.2.2 Germany
5.2.3 Asia Pacific
5.2.3.1 Japan
5.2.3.2 China
5.2.4 Latin America
5.2.4.1 Brazil
5.2.4.2 Mexico
5.2.5 MEA
5.2.5.1 South Africa
Chapter 6 Competitive Landscape
6.1 Strategy Framework
6.2 Company Profiles
6.2.1 Actelion Pharmaceuticals, Ltd
6.2.1.1 Company overview
6.2.1.2 Financial performance
6.2.1.3 Product benchmarking
6.2.1.4 Strategic initiatives
6.2.2 Gilead Sciences, Inc
6.2.2.1 Company overview
6.2.2.2 Financial performance
6.2.2.3 Product benchmarking
6.2.2.4 Strategic initiatives
6.2.3 United Therapeutics Corporation
6.2.3.1 Company overview
6.2.3.2 Financial performance
6.2.3.3 Product benchmarking
6.2.3.4 Strategic initiatives
6.2.4 Novartis International AG
6.2.4.1 Company overview
6.2.4.2 Financial performance
6.2.4.3 Product benchmarking
6.2.4.4 Strategic initiatives
6.2.5 GlaxoSmithKline Plc. (GSK)
6.2.5.1 Company overview
6.2.5.2 Financial performance
6.2.5.3 Product benchmarking
6.2.5.4 Strategic initiatives
6.2.6 Pfizer, Inc
6.2.6.1 Company overview
6.2.6.2 Financial performance
6.2.6.3 Product benchmarking
6.2.6.4 Strategic initiatives
6.2.7 Dong-A ST Co., Ltd.
6.2.7.1 Company overview
6.2.7.2 Financial performance
6.2.7.3 Product benchmarking
6.2.7.4 Strategic initiatives
6.2.8 Merck Sharp & Dohme Corp
6.2.8.1 Company overview
6.2.8.2 Financial performance
6.2.8.3 Product benchmarking
6.2.8.4 Strategic initiatives
6.2.9 Bayer HealthCare
6.2.9.1 Company overview
6.2.9.2 Financial performance
6.2.9.3 Product benchmarking
6.2.9.4 Strategic initiatives
6.2.10 Arena Pharmaceuticals
6.2.10.1 Company overview
6.2.10.2 Financial performance
6.2.10.3 Product benchmarking
6.2.10.4 Strategic initiatives
List of Tables
TABLE 1 North America PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 2 U.S. PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 3 Canada PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 4 Europe PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 5 UK PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 6 Germany PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 7 Asia Pacific PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 8 Japan PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 9 ChinaPAH market, by drug class 2014 - 2025 (USD Million)
TABLE 10 Latin America PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 11 Brazil PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 12 Mexico PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 13 MEA PAH market, by drug class 2014 - 2025 (USD Million)
TABLE 14 South Africa PAH market, by drug class 2014 - 2025 (USD Million)
List of Figures
FIG. 1 Market summary
FIG. 2 Market trends &outlook
FIG. 3 Market segmentation & scope
FIG. 4 Market driver relevance analysis (Current & future impact)
FIG. 5 Market restraint relevance analysis (Current & future impact)
FIG. 6 Penetration & growth prospect mapping
FIG. 7 SWOT Analysis, by factor (Political & legal, economic and technological)
FIG. 8 Porter’s Five Forces Analysis
FIG. 9 PAH market drug class outlook: Key takeaways
FIG. 10 PAH : Drug class movement analysis
FIG. 11 Prostacyclin and prostacyclin analogss market, 2014 - 2025 (USD Million)
FIG. 12 Padded medical lifting slings market, 2014 - 2025 (USD Million)
FIG. 13 SGC stimulatorsmarket, 2014 - 2025 (USD Million)
FIG. 14 ERA market, 2014 - 2025 (USD Million)
FIG. 15 PDE-5market, 2014 - 2025 (USD Million)
FIG. 16 PAH market regional outlook: Key takeaways
FIG. 17 North America PAH market, 2014 - 2025 (USD Million)
FIG. 18 U.S. PAH market, 2014 - 2025 (USD Million)
FIG. 19 Canada PAH market, 2014 - 2025 (USD Million)
FIG. 20 Europe PAH market, 2014 - 2025 (USD Million)
FIG. 21 UK PAH market, 2014 - 2025 (USD Million)
FIG. 22 Germany PAH market, 2014 - 2025 (USD Million)
FIG. 23 Asia Pacific PAH market, 2014 - 2025 (USD Million)
FIG. 24 Japan PAH market, 2014 - 2025 (USD Million)
FIG. 25 China PAH market, 2014 - 2025 (USD Million)
FIG. 26 Latin America PAH market, 2014 - 2025 (USD Million)
FIG. 27 Brazil PAH market, 2014 - 2025 (USD Million)
FIG. 28 Mexico PAH market, 2014 - 2025 (USD Million)
FIG. 29 MEA PAH market, 2014 - 2025 (USD Million)
FIG. 30 South Africa PAH market, 2014 - 2025 (USD Million)

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