Soluble Guanylate Cyclase (sGC or EC 184.108.40.206) - Pipeline Review, H2 2018
According to the recently published report 'Soluble Guanylate Cyclase (sGC or EC 220.127.116.11) - Pipeline Review, H2 2018'; Soluble Guanylate Cyclase (sGC or EC 18.104.22.168) pipeline Target constitutes close to 30 molecules. Out of which approximately 27 molecules are developed by companies and remaining by the universities/institutes.
Soluble Guanylate Cyclase (sGC or EC 22.214.171.124) - Soluble guanylyl cyclase (sGC) is the known receptor for nitric oxide. Binding of nitric oxide to the heme moiety of the cyclase induces its capacity to synthesize the second messenger cGMP. Although the changes in the state of the heme moiety upon exposure of enzyme to NO and its correlation to the stimulation of sGC catalytic activity.
The report 'Soluble Guanylate Cyclase (sGC or EC 126.96.36.199) - Pipeline Review, H2 2018' outlays comprehensive information on the Soluble Guanylate Cyclase (sGC or EC 188.8.131.52) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Soluble Guanylate Cyclase (sGC or EC 184.108.40.206) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I and Preclinical stages are 3, 6, 3 and 15 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 2 and 1 molecules, respectively.
Report covers products from therapy areas Ophthalmology, Cardiovascular, Metabolic Disorders, Respiratory, Central Nervous System, Gastrointestinal, Hematological Disorders, Immunology, Infectious Disease, Oncology, Dermatology, Genetic Disorders, Genito Urinary System And Sex Hormones and Toxicology which include indications Glaucoma, Ocular Hypertension, Diabetic Nephropathy, Open-Angle Glaucoma, Pulmonary Hypertension, Sickle Cell Disease, Tinea Pedis (Athlete Foot), Acute Respiratory Distress Syndrome, Alzheimer's Disease, Carotid Artery Stenosis, Chemotherapy Induced Peripheral Neuropathy, Chronic Kidney Disease (Chronic Renal Failure), Cystic Fibrosis, Diabetic Foot Ulcers, Diabetic Neuropathic Pain, Diastolic Heart Failure, Duchenne Muscular Dystrophy, Esophageal Achalasia, Inflammation, Ischemic Stroke, Liver Diseases, Lung Disease, Mycobacterium Infections, Onychomycosis (Tinea Unguium), Optic Neuropathy, Osteoporosis, Pancreatic Cancer, Prostate Cancer, Pulmonary Arterial Hypertension, Stroke, Systemic Sclerosis (Scleroderma), Systolic Heart Failure, Vascular Dementias and Wounds.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
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