Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 22.214.171.124) - Pipeline Review, H1 2018
According to the recently published report 'Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 126.96.36.199) - Pipeline Review, H1 2018'; Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 188.8.131.52) pipeline Target constitutes close to 26 molecules. Out of which approximately 25 molecules are developed by companies and remaining by the universities/institutes.
Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 184.108.40.206) - Fibroblast growth factor receptor 4 is a protein encoded by the FGFR4 gene. It plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. It is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. It phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades.
The report 'Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 220.127.116.11) - Pipeline Review, H1 2018' outlays comprehensive information on the Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 18.104.22.168) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 22.214.171.124) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 1, 3, 6, 5, 1, 7 and 2 respectively. Similarly, the universities portfolio in Preclinical stages comprises 1 molecules, respectively. Report covers products from therapy areas Oncology, Metabolic Disorders, Central Nervous System, Gastrointestinal and Musculoskeletal Disorders which include indications Hepatocellular Carcinoma, Solid Tumor, Bile Duct Cancer (Cholangiocarcinoma), Breast Cancer, Type 2 Diabetes, Lung Adenocarcinoma, Ovarian Cancer, Bladder Cancer, Endometrial Cancer, Esophageal Cancer, Gastric Cancer, Head And Neck Cancer Squamous Cell Carcinoma, Melanoma, Metastatic Transitional (Urothelial) Tract Cancer, Non-Small Cell Lung Cancer, Obesity, Recurrent Glioblastoma Multiforme (GBM), Squamous Non-Small Cell Lung Cancer, Transitional Cell Carcinoma (Urothelial Cell Carcinoma), Achondroplasia, Adenoid Cystic Carcinoma (ACC), Adrenocortical Carcinoma (Adrenal Cortex Cancer), Constipation, Epithelial Ovarian Cancer, Ewing Sarcoma, Fallopian Tube Cancer, Glioblastoma Multiforme (GBM), Head And Neck Cancer, Hematological Tumor, High-Grade Glioma, Kidney Cancer (Renal Cell Cancer), Liver Cancer, Lung Cancer, Lymphoma, Metastatic Biliary Tract Cancer, Nasopharyngeal Cancer, Non-Alcoholic Steatohepatitis (NASH), Osteosarcoma, Peritoneal Cancer, Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, Primitive Neuroectodermal Tumor (PNET), Prostate Cancer, Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Renal Cell Carcinoma, Rhabdomyosarcoma, Small-Cell Lung Cancer, Spinal Cord Injury, Thymic Carcinoma, Thyroid Cancer and Transitional Cell Cancer (Urothelial Cell Cancer).
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.