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Cell-Based Assays (Basic Research, ADME Testing, Drug Discovery, Instruments, Consumables, Software, Services)

Cell-Based Assays (Basic Research, ADME Testing, Drug Discovery, Instruments, Consumables, Software, Services)

This report analyzes the worldwide markets for Cell-Based Assays in US$ Million by the following Applications: Drug Discovery, ADME Testing, and Basic Research. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2016 through 2024. Also, a five-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 57 companies including many key and niche players such as -

BD Biosciences
Beckman Coulter, Inc.
BioVision, Inc.
Cisbio Bioassays
Eurofins DiscoverX Corporation
Merck KgaA

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1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
2. INDUSTRY OVERVIEW
Global Cell-based Assays Market Witnesses Rapid Growth
Drug Discovery Leads the Cell-based Assays Application
Table 1: Cell-based Assays Market by Application (2018): Percentage Share Breakdown of Value Sales for Drug Discovery, ADME Testing, and Basic Research (includes corresponding Graph/Chart)
Major Types of Cell-Based HTS Assays for Drug Screening
Table 2: Global Cell-based Assays Market by Segment (2018): Percentage Share Breakdown of Value Sales for Consumables, Instruments, Software, and Services(includes corresponding Graph/Chart)
Table 3: Global Market for Cell-based Assays by End-User (2018): Percentage Share Breakdown of Value Sales for Pharma & Biotech Companies, Government & Academic Institutes, CROs, and Others (includes corresponding Graph/Chart)
A Glance at Growth Drivers and Market Challenges
Growth Drivers
Market Challenges
Developed Regions Lead the Market, Developing Regions to Witness Fastest Growth
Increased Spending on Pharma R&D Spurs the Cell-based Assays Market
Table 4: Global Pharmaceutical R&D Spending (US$ Billion) for the Years 2010 through 2017 (includes corresponding Graph/Chart)
Table 5: Percentage Breakdown of Total Number of Compounds in Pipeline by Phase for Pre-Clinical, Phase I, Phase II and Phase III: 2017E (includes corresponding Graph/Chart)
Table 6: New FDA Approvals (2010-2016): Breakdown of Number of Approvals by Type for New Molecular Entity (NME) and Biologic License Application (BLA) Approvals (includes corresponding Graph/Chart)
China and India: Hot Spots for R&D Investment
Table 7: World R&D Market by Geographic Region (2015 & 2016): Percentage Breakdown of R&D Spending for Asia, Europe, Middle East & Africa, North America and South America (includes corresponding Graph/Chart)
Growing Prominence of Cell-based Assays in Drug Discovery
Table 8: Increasing Clinical Trial Failure Rate: 1990 and 2010 (includes corresponding Graph/Chart)
Table 9: Factors Leading to Failure of Drugs in Phase II Clinical Trials: Percentage Breakdown of Number of Cases for Efficacy, Pharmacokinetics, Toxicity and Others (includes corresponding Graph/Chart)
Table 10: Factors Leading to Failure of Drugs in Phase III Clinical Trials: Percentage Breakdown of Number of Cases for Efficacy, Pharmacokinetics, Toxicity and Others (includes corresponding Graph/Chart)
Cell-based Assays in HTS and UHTS
Resolving Technical Limitations: Cornerstone for Future Success of Cell-based HTS
High-Content Screening (HCS) - An Expanding Technology in Cell-Based Assays
High Content Screening - Key Application Areas
HCS Market Ripe with Growth Opportunity
HCS vs. HTS
Use of Cell-based Assays in ADME-Toxicity Testing Gains Traction
Table 11: Phase-I Clinical Trial Failures Before and After the Advent of Preclinical ADME/Pharmacokinetics (includes corresponding Graph/Chart)
Table 12: Drug Withdrawals Due to Toxicity Issues (1990-2010): Percentage Share Breakdown of Number of Drugs Withdrawn Due to Cardiotoxicity, Hepatotoxicity and Others (includes corresponding Graph/Chart)
Growing Inclination towards In-vitro Assays for Toxicology Studies
Hepatotoxicity Testing Occupies Largest Market Share
Cell-Based Assays Emerge as a Popular Tool in Basic Research
3. GROWTH DRIVERS AND MARKET TRENDS
Pharmaceutical Industry Leads the Way
Rising Number of Drug Targets Surge Demand for Cell-Based Assays
Rising Investment in Proteomics R&D Drive Cell-based Assays Market
Growing Focus on the Development of Reproducible and Robust Cell-based Assays
Shift towards High Throughput Research Builds Momentum for HTS
Stem Cells Exude Great Potential in Drug Toxicity Testing
Global Market for Stem Cell-Assays
Functional Assays: An Effective Way of Predicting Specific Toxic Effects
GPCR Targets to Drive Growth in Functional Cell Assay Market
Innovation in Screening Guarantees Success for Drug Discovery Programs
3D Cell Culture Technology to Put a New Spin on In Vitro Cell Analyses
Automated Multiplexing Platforms Present Growth Opportunities
Miniaturized Cell-based Assays on the Horizon
Automation of Cell-based Assays: A Growing Trend
Technology Advances in Drug Discovery Processes Spurs Cell-Based Assay Market
Development of Label-free Cell-based Assays: A Recent Trend in Biological Assays
Microfluidics Systems in Cell-based Assays
Cell-Based Assays Likely to Gain from Microfluidic Devices
Other Trends
Raman Spectroscopy: An Attractive Analytical Tool for Pharmaceutical Industry
Fluorescence Spectroscopy for Cellular Imaging Analyses
Cell-based Immunoassays: Novel Assay Technology for Autoantibodies Detection
Shift Away from Established Cell Lines to Primary Cells
Role of Cell-based Assays in Personalized Medicine: A Research Focus
Select Innovations in Cell-based Assays Market
Cell-based Assays Featuring hPBMCs for Drug Discovery and Cell Therapy Applications
Thermo Fisher Develops Innovative Tools for Aiding Cell-based Assays in Cancer Research Studies
CROs – The Targeted Customers for Cell-based Assays
Table 13: Leading CROs Worldwide by Revenue: 2016 (includes corresponding Graph/Chart)
Outsourcing of R&D Projects to Propel CRO Market, Driving CTMS Demand
Noteworthy Contracts of Major CROs
4. CELL-BASED ASSAYS - APPLICATION AREAS
Cell-Based Assays in Drug Discovery
Drug Target Validation
Lead Identification
Lead Optimization
Sources and Types of Cells Available for Drug Screening
Cell-Based Assays in ADME Testing
Table 14: Leading Causes of Failure During New Drug Development: Percentage Share Breakdown by ADME/Tox Issues, Insufficient Efficacy, Adverse Side Effects, and Commercial Viability (includes corresponding Graph/Chart)
Need for Better Models: A Major Factor Driving Innovation in the Market
5. CELL-BASED ASSAYS: AN OVERVIEW
What Drives Advances in Cell-based Assays?
Cell Culture Fundamentals
An Insight into Cell Biology
Cell-based Assays: Basic Facts
Defining Cell-based Assays
Assays
Biological Assays
Quantification of Biological Activity
Cell-based Assays
Cell Based Assays: Prerequisites for Proof of Concept
List of Factors to be considered in Cell-Based Assays
Contamination with Mycoplasma: A Critical Factor
Modes of Contamination
Prevention
Uses of Cell-Based Assays
Challenges
Transient Transfection Cells
Limitations
Cell-based Assays: Product Segmentation
Assay Kits
Cell Function-Associated Assays
Cell Growth-Associated Assays
Select Methods of Evaluating Cell-Growth
Various Types of Cell Growth Associated Assays
Cell Death-Associated Assays
Lab Automation
MIACA
6. COMPETITIVE LANDSCAPE
6.1 Focus on Select Global Players
BD Biosciences (USA)
Beckman Coulter, Inc. (USA)
BioVision, Inc. (USA)
Cisbio Bioassays (USA)
Eurofins DiscoverX Corporation (USA)
Merck KgaA, (Germany)
Enzo Life Sciences, Inc. (USA)
Evotec AG (Germany)
GE Healthcare Life Sciences (UK)
New England Biolabs, Inc. (USA)
PerkinElmer, Inc. (USA)
Promega Corporation (USA)
ProQinase GmbH (Germany)
Qiagen NV (The Netherlands)
Thermo Fisher Scientific, Inc. (USA)
Xenometrix AG (Switzerland)
6.2 Recent Industry Activity
BioIVT Takes Over Ascendance Biotechnology
Agilent Acquires Luxcel Biosciences
Eurofins Acquires DiscoverX
IntelliCyt Introduces Cy-Clone Plus Assay System
7. GLOBAL MARKET PERSPECTIVE
Table 15: World Recent Past, Current and Future Analysis for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 16: World Historic Review for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 17: World 14-Year Perspective for Cell-Based Assays by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
Cell-Based Assays Market by Application
Table 18: World Recent Past, Current and Future Analysis for Cell-Based Assays for Basic Research by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 19: World Historic Review for Cell-Based Assays for Basic Research by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 20: World 14-Year Perspective for Cell-Based Assays for Basic Research by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024(includes corresponding Graph/Chart)
Table 21: World Recent Past, Current and Future Analysis for Cell-Based Assays for ADME Testing by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 22: World Historic Review for Cell-Based Assays for ADME Testing by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 23: World 14-Year Perspective for Cell-Based Assays for ADME Testing by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
Table 24: World Recent Past, Current and Future Analysis for Cell-Based Assays for Drug Discovery by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 25: World Historic Review for Cell-Based Assays for Drug Discovery by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 26: World 14-Year Perspective for Cell-Based Assays for Drug Discovery by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
Table 27: World Recent Past, Current and Future Analysis for Cell-Based Assays Segment by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 28: World Historic Review for Cell-Based Assays Segment by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 29: World 14-Year Perspective for Cell-Based Assays Segment by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
8. REGIONAL MARKET PERSPECTIVE
8.1 The United States
A. Market Analysis
Cell-Based Assay Market to Witness Significant Growth
Functional Cell Assays – A Key Segment
Increased Usage Drives Growth of Cell-based Assays
Impact of Automation & High-Throughput Screening on CBA Market
HTS Assumes Critical Importance in Drug Discovery Projects
Spending on HTS Soars in Pharmaceutical Sector
HTS Outsourcing Gathers Steam
Custom Designed Assays to Drive the US Cell-based Assay Market
Clinical Trials Market in the US
Competitive Scenario
Increased Reliance on CROs by Drug Developers Drive the Cell-based Assays Market
B. Market Analytics
Table 30: The US Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 31: The US Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 32: The US 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
8.2 Japan
A. Market Analysis
Demographics Drive Market Growth
Table 33: Japanese Population by Age Group 2017E): Percentage Breakdown for 0-14 Years, 15-24 Years, 25-54 Years, 55-64 Years, 64 Years and Above (includes corresponding Graph/Chart)
B. Market Analytics
Table 34: Japanese Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 35: Japanese Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 36: Japanese 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
8.3 Europe
A. Market Analysis
Current and Future Analysis
HTS in European Pharmaceutical Sector
Innovations in Cell Culture Drive Adoption of Cell-based Assay HTS
Cell-based Assays Represent the Primary Drug Discovery Tool in HTS Laboratories
Pharmaceutical Companies Opt for Cell-Based Assays in Drug Discovery
Rising Number of Drug Targets Surge Demand for Cell-Based Assays
GPCR Targets to Drive Growth in Functional Cell Assay Market
Cell Growth-Based Assay Kits Market Makes Progress
Cell Death-Based Assays: Efficiency Improvements in Development Programs Favor Growth
Rising Cancer Incidence Propels the Need for Increased Research
Table 37: Number of New Cancer Cases in Europe (2012-2030) (in Million) (includes corresponding Graph/Chart)
Advances in Technology, Identification Methods, and Lab Disciplines in CBA Market
Regulatory Requirements in Cell-Based Assays Market
Validation Assays for Compliance with ICH Guidelines
Growth of European Drug Discovery CRO Market: Opportunities for CBA Market
Clinical Trials Market in Europe
Competitive Landscape
Clinical Trials Market in Select Regions
Spain
Garnering Investments from Multinational Pharma Companies
Table 38: Apportion of R & D Expenditure by Study Phase in Spain: 2015 (includes corresponding Graph/Chart)
Russia
Table 39: Russian Clinical Trials Market by Trial Type (2015): Percentage Breakdown of Number of Trials for Bioequivalence Studies (Foreign Sponsors), Bioequivalence Studies (Local Sponsors), Global Multi-Center Clinical Trials, Local Clinical Trials (Foreign Sponsors), and Local Clinical Trials (Local Sponsors) (includes corresponding Graph/Chart)
Table 40: Russian Clinical Trials Market Volume (2015): Percentage Breakdown of Trials by Hosting Country (includes corresponding Graph/Chart)
B. Market Analytics
Table 41: European Recent Past, Current and Future Analysis for Cell-Based Assays by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 42: European Historic Review for Cell-Based Assays by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 43: European 14-Year Perspective for Cell-Based Assays by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, Spain and Rest of Europe Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
Table 44: European Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 45: European Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 46: European 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
8.4 Asia-Pacific
A. Market Analysis
Current and Future Analysis
Asia-Pacific Emerges as Fastest Growing Market for HTS
Asia: The Most Preferred Destination for Clinical Trials
An Overview of Clinical Trials Market in Select Countries in the Region
China
Opportunities in Expanding in the Chinese Life Sciences Sector
Growing Drug Discovery Outsourcing Market Bodes Well for Market
Pharmaceutical Outsourcing Sector in China- An Overview .
Going Ahead....
India
A Thriving Clinical Trials Market
Table 47: Cost of Conducting Clinical Trials: India Vs. US (in US$ Thousand) (includes corresponding Graph/Chart)
Australia
Australia Makes Strong Pitch for Clinical Trials
Major Challenges Facing Australian Clinical Trials Market
B. Market Analytics
Table 48: Asia-Pacific Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 49: Asia-Pacific Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 50: Asia-Pacific 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
8.5 Rest of World
A. Market Analysis
Current and Future Analysis
Latin America: An Emerging Market for Clinical Trials
The Middle East – Brimming with Potential for Clinical Trials
Table 51: The Middle East Clinical Trial Market (2015): Percentage Breakdown of Registered Clinical Trials in Iran, Israel, Turkey and Rest of Middle East (includes corresponding Graph/Chart)
Emerging Nations Capitalize on the Outsourcing Trend
B. Market Analytics
Table 52: Rest of World Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
Table 53: Rest of World Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
Table 54: Rest of World 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
9. COMPANY PROFILES Total Companies Profiled: 57 (including Divisions/Subsidiaries - 61)
The United States (36)
Japan (1)
Europe (22)
- France (3)
- Germany (5)
- The United Kingdom (7)
- Italy (1)
- Rest of Europe (6)
Asia-Pacific (Excluding Japan) (1)
Latin America (1)

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