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Botulinum Toxin (Botox, Cosmetic Applications, Therapeutic Applications)

Botulinum Toxin (Botox, Cosmetic Applications, Therapeutic Applications)

This report analyzes the worldwide markets for Botulinum Toxin in US$ Million by the following Segments: Cosmetic Applications, and Therapeutic Applications. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2015 through 2022. Also, a six-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 15 companies including many key and niche players such as -

Allergan Plc
Ipsen Group
Medy-Tox Inc.
Merz Pharma GmbH & Co. KGaA
Metabiologics, Inc.

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I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations
Disclaimers
Data Interpretation & Reporting Level
Quantitative Techniques & Analytics
Product Definitions and Scope of Study
Cosmetic Applications
Therapeutic Applications
II. EXECUTIVE SUMMARY
1. INDUSTRY OVERVIEW
Botulinum Toxin: Expanding Cosmetic & Therapeutic Applications to Propel Growth
Developed Regions Dominate Botulinum Toxin Market
Developing Markets to Drive Future Growth
Table 1: Healthcare Spending as % of GDP by Geographic Region (2016E) (includes corresponding Graph/Chart)
Table 2: Top Countries with the Highest Per Capita Healthcare Spending (2014) (includes corresponding Graph/Chart)
Cosmetic BTX – A Promising Application Market
Factors Propelling the Cosmetic BT Market – In a Nut Shell
Rise in the Number of Musculoskeletal Indications – An Opportunity Indicator
Pharma Companies Keenly Eye Lucrative BT Market
2. COMPETITIVE LANDSCAPE
Allergan Leads the Global BTX Market
Table 3: Leading Brands in the Global Botulinum Toxin Market (2015): Percentage Breakdown of Sales for Botox, BTX-A, Dysport, Meditoxin and Xeomin (includes corresponding Graph/Chart)
Botulinum Toxin Products Worldwide
Botox – The Leading Brand in Cosmetic BTX Market
Biosimilar BTX Variants Challenge Botox’s Leadership
Discontinuation of PurTox Averts Competition to Botox®
Lack of Differentiation among Approved BTX Products
Comparison of Leading Neurotoxins - Botox, Dysport and Xeomin by Safety and Efficacy
Revance Therapeutics: All Hopes on Topical Botox Formulation
Daewoong Pharmaceutical All Set to Make a Mark on the International Scenario
A Review of Major BTX Products
Comparison of Botox®, Dysport® and Xeomin® by Indications and Year of Approval
BOTOX®
Approvals and Indications of Botox in Select Regions
Key Characteristics of Botox® and Botox® Cosmetic
Common Adverse Reactions with Botox
Therapeutics to Offer Higher Prospects for Botox
Botox Therapeutic Approvals in the US by Indication
Migraine Indication Bolsters Allergan’s Botox Sales
Dysport®
Key Characteristics of Dysport®
Ipsen Counts on New Indications for Future Growth of Dysport
Dysport Therapeutic Development Pipeline by Region
Dysport Cosmetic Development Pipeline by Region
Next Generation Dysport – A Breakthrough in BTX Market on the Cards
Xeomin®
Key Characteristics of Xeomin®
Xeomin® FDA Approval and Indications
Global Expansion Helps Merz Gain in the BTX Market
Myobloc®/NeuroBloc®
Key Characteristics of Myobloc®
Meditoxin®
PurTox®
Key Characteristics of PurTox®
RT001
Revance’s RT001 – Potential Revolution in BTX Market under Development
How Does RT001 Work?
RT001 – A Potential Convenient Treatment Option for Hyperhydrosis Patients
RT002
RT002 – Opportunities in the Therapeutics Arena
3. MARKET TRENDS & ISSUES
Rising Demand for Non-Invasive Cosmetic Treatments Bodes Well for BTX Market
Table 4: Non-Surgical Cosmetic Procedures Worldwide (2015): Percentage Breakdown of Procedure Volume for Injectables (Botulinum Toxin, Calcium Hydroxylapatite, Hyaluronic Acid and Poly-L-Lactic Acid), Facial Rejuvenation and Others (includes corresponding Graph/Chart)
Botulinum Toxin – The Preferred Solution in Facial Injectables Market
Table 5: Cosmetic Botulinum Toxin Procedures Performed Worldwide (2015): Percentage Breakdown of Procedure Volume by Age Group (includes corresponding Graph/Chart)
Table 6: Cosmetic Botulinum Toxin Procedures Performed Worldwide (2015): Percentage Breakdown of Procedure Volume by Gender (includes corresponding Graph/Chart)
Growing Acceptance of Cosmetic BTX Treatments Favors Market Growth
Rising Disposable Incomes Propel Sales
Table 7: Annual Disposable Incomes in US$ ‘000 for Select Countries (2012) (includes corresponding Graph/Chart)
Longer Life Expectancy Bolsters Market Growth
Table 8: Life Expectancy at Birth in Years of People in Select Countries (2015E) (includes corresponding Graph/Chart)
Unmet Medical Needs Encourage Off-Label Use: A Cause for Concern or Jubilation?
Urgent Need for Physician Education about Off-Label Usage
High Voltage Ad Campaigns Boost Patient Awareness
Digital Revolution to Impact Consumer Choices
Financing of Non-Reimbursed Healthcare: Need of the Hour
Combination Therapies: A Double Whammy Success
Botulinum Toxin – Potential Applications in Treatment of Dental Diseases
Short-lived Aesthetic Effects: A Strong Business Case for Revision Treatments
Undesirable Side Effects: A Challenge to Reckon With
Immunogenicity Undermines Patient Compliance
Reduction of Protein Load in BTX Products – The Probable Answer for Immunogenicity
Antigenicity: A Problematic Issue in Drug Development
Stringent Regulations Delay Market Approvals & Put Reimbursements in Limbo
Non-Injectable Alternatives to Turn On the Heat
Alternative Methods of Botulinum Application under Development – A Review
Higher Product Costs to Challenge Market Growth
Consumer Skepticism: The Biggest Challenge to Beat
Animal Cruelty – A Part & Parcel of Botox Testing
Botulinum Toxins – A Wonder Drug or Bio-terror Threat?
Fears of Terrorism & Biological Warfare Thwart International Trade
4. PRODUCT OVERVIEW
Botulinum Toxin: A Poison That Cures
Structure & Mechanism of Action
Disadvantages
Classification of Botulinum Toxin
Botulinum Toxin Type A
Historical Timeline of Botulinum Toxin: 1885-2002
Botulinum Toxin Type B
Procedure
Anaesthesia
Injection Procedure
Applications of Botulinum Toxin
Cosmetic Applications
Glabellar Lines
Facial Wrinkles
Key Cosmetic Indications for Botulinum Toxin
Crow's Feet
Forehead Rhytids
Temporal Brow Lift
Lower Eyelid Rhytids
Downturned Lips
Pebbly Chin
Therapeutic Applications
Movement Disorders/Pain
Cervical Dystonia
Hemifacial Spasm
Blepharospasm
Strabismus
Site of Injection and Doses of Neurotoxins used in the Treatment of Dystonias
Chronic Pain
Botox in Migraine Treatment
List of Countries where Botox has been Approved for Prophylaxis of Headache in Adults Suffering from Chronic Migraine
Table 9: Modes of Injection of Onabotulinum ToxinA for Chronic Migraine by Dose and Muscle Injected
Hyperhidrosis
Bladder Dysfunctions
Spasticity
Other Applications
Side Effects
An Overview of Side Effects of BTX Treatment
Table 10: Side-Effects of BOTOX Treatment for Urinary Incontinence Associated with Neuromuscular Disorders: Percentage Breakdown of Major Conditions Reported Within 12 weeks of Injections during Phase III Clinical Trials (includes corresponding Graph/Chart)
Table 11: Side-Effects of BOTOX Treatment for Urinary Incontinence Associated with Neuromuscular Disorders: Percentage Breakdown of Major Conditions Reported Within 44 weeks of Injections during Phase III Clinical Trials (includes corresponding Graph/Chart)
5. RESEARCH BREAKTHROUGHS IN THE RECENT PAST
University of Kansas Researchers Study Botulinum ToxinA Role in Minimally Invasive Treatment of Neurogenic Bladder
Researchers at Baylor College of Medicine Revealed Use of Botox Injections for Treatment of Filamentary Keratitis
Researchers at Medical School of Hannover and Sanford-Burnham Medical Research Institute Study Effect of the Hostile Human Stomach Environment on BT
Investigators Prove Role of BTX A for Treatment of Achalasia
Researchers at University of Freiburg Conduct New Studies on Salmonella
Researchers at Monash University Use Botox to Resolve Asthma Wrinkles
6. PRODUCT INTRODUCTIONS/APPROVALS
Galderma Initiates Phase II Clinical Trial on Botulinum Toxin
Daewoong Unveils Nabota Botulinum Toxin-Type Formula
Medy-TOX Submits Patent Application for Lyophilized Botulinum Toxin
Botox Receives Approval for Treatment of Ankle Disability in the UK
Anterios Develops
Next-Generation Injectable Botulinum Product
Ipsen Receives Health Canada Approval for Dysport®
Eisai Announces Plans to Launch Nerbloc® in Japan
Cangene Receives FDA Approval for Botulism Antitoxin
Allergan Receives FDA Approval for BOTOX® for the Treatment of Crow's Feet Lines in Adults
7. RECENT INDUSTRY ACTIVITY
Allergan Gains Marketing Approval for BOTOX Vista® in Japan
Allergan Takes Over Anterios
FDA Approves BOTOX® for Treatment of Adult Lower Limb Spasticity
Revance Releases Phase 2 Trial Results of RT001 Topical Botulinum Toxin Type A Drug Candidate
Ipsen Collaborates with EpiVax for Developed Next-Gen Botulinum Toxins
Revance Begins Phase 3 Clinical Trial for Botulinum Toxin Type A Topical Gel
Revance Commences Phase 2 Study for RT002 Botulinum Toxin Type A
Revance Begins Phase 2 Trial for Botulinum toxin Type A Topical Gel
Bloomage BioTechnology and Medytox to Establish JV in China
Ipsen Gains FDA’s sBLA Approval for Dysport®
Actavis Bags FDA Approval for Expanding BOTOX® Label
Actavis Acquires Allergan
Ipsen and Galderma Expand Partnership
Allergan Completes Licensing Agreement with Medytox
Ipsen Acquires Syntaxin
Ipsen Enters into R&D Collaboration with Harvard Medical School
Galderma Commences Clinical Trials on BT-based Muscle Relaxant
Anterios Conducts Phase 2b Clinical Trials on
Botulinum Toxin
Medytox Inks Technology Transfer Agreement with Allergan
8. FOCUS ON SELECT GLOBAL PLAYERS
Allergan Plc (Ireland)
Ipsen Group (France)
Medy-Tox Inc. (South Korea)
Merz Pharma GmbH & Co. KGaA (Germany)
Metabiologics, Inc. (US)
Revance Therapeutics, Inc. (US)
US WorldMeds (US)
9. GLOBAL MARKET PERSPECTIVE
Table 12: World Recent Past, Current & Future Analysis for Botulinum Toxin by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 13: World Historic Review for Botulinum Toxin by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 14: World 14-Year Perspective for Botulinum Toxin by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for the Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)
Table 15: World Recent Past, Current & Future Analysis for Botulinum Toxin in Cosmetic Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 16: World Historic Review for Botulinum Toxin in Cosmetic Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 17: World 14-Year Perspective for Botulinum Toxin in Cosmetic Applications by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for the Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)
Table 18: World Recent Past, Current & Future Analysis for Botulinum Toxin in Therapeutic Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 19: World Historic Review for Botulinum Toxin in Therapeutic Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 20: World 14-Year Perspective for Botulinum Toxin in Therapeutic Applications by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for the Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)
III. MARKET
1. THE UNITED STATES
A. Market Analysis
Current and Future Analysis
Therapeutic BTX Market – New Entrants Slow in Gaining Market Share
Approved Therapeutic Indications of Botulinum Toxin in the US by Year of Approval
Neurogenic OAB – A Relatively Smaller Market Opportunity
Idiopathic OAB Bodes Healthy Prospects for Botox
Cosmetic BTX Market: Rapid Growth in Store
Table 21: Age-wise Distribution for Botulinum Toxin Procedures Performed in the US for the Year 2015 (includes corresponding Graph/Chart)
Table 22: Gender Distribution for Botulinum Toxin Procedures Performed in the US (2015) (includes corresponding Graph/Chart)
Increasing Demand for Cosmetic Treatments Bodes Well for BTX Market
Some Interesting Facts on Cosmetic Procedures
Table 23: Number of Surgical & Non-Surgical Cosmetic Procedures ('000s) in the US for the Years 1997, 2014 & 2015 (includes corresponding Graph/Chart)
Table 24: Top 5 Surgical Cosmetic Procedures in the US - Ranked by the Number of Procedures Performed (In ‘000s) for 2015 (includes corresponding Graph/Chart)
Table 25: Top 5 Non-Surgical Cosmetic Procedures in the US - Ranked by the Number of Procedures Performed (‘000s) for 2015 (includes corresponding Graph/Chart)
Table 26: Total Number of Cosmetic Procedures Performed by Category in the US (2015)
Table 27: Number of Botulinum Toxin Procedures Performed in the US (1997, 2014 & 2015) (includes corresponding Graph/Chart)
Table 28: Average Cost of Botulinum Toxin Per Procedure in the US (2007- 2015) (includes corresponding Graph/Chart)
Demand for Professional Help On Rise
Aging Baby Boomers Drive Aesthetic Business
Table 29: US Population by Age Group (2015 & 2030): Percentage Share Breakdown for 0-14, 15-64, and 65+ Age Groups (includes corresponding Graph/Chart)
Table 30: North American Aging Population by Age Group: 1975-2050 (includes corresponding Graph/Chart)
Expanding Physician Base Extends Impetus to Growth
Table 31: Average Physician/Surgeon Fees per Procedure in the US (2015)
Competitive Landscape
Allergan’s Botox Leads Cosmetic BTX Market
Major BTX Products and Associated Fillers in the Cosmetic Botulinum Toxin Market
Table 32: Leading Brands in the US Cosmetic Neurotoxin Treatment Market (2015): Percentage Breakdown of Value Sales for Botox, Dysport and Others (includes corresponding Graph/Chart)
Dysport Takes on Botox in the Therapeutic Space
Table 33: Leading Brands in the US Therapeutic Botulinum Toxin Market (2013): Percentage Breakdown of Value Sales for Botox and Dysport (includes corresponding Graph/Chart)
AAN Releases New Guidelines on BTX for Identified Disorders
Rise in Botulinum Toxin Lawsuits – A Concern for Physicians?
Product Launches/Approvals
Strategic Corporate Developments
Key Players
B. Market Analytics
Table 34: US Recent Past, Current & Future Analysis for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 35: US Historic Review for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 36: US 14-Year Perspective for Botulinum Toxin by Application - Percentage Breakdown of Dollar Sales for Cosmetic and Therapeutic Markets for the Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)
2. CANADA
Market Analysis
Table 37: Canadian Recent Past, Current & Future Analysis for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 38: Canadian Historic Review for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 39: Canadian 14-Year Perspective for Botulinum Toxin by Application - Percentage Breakdown of Dollar Sales for Cosmetic and Therapeutic Markets for the Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)
3. JAPAN
A. Market Analysis
Current and Future Analysis
Strategic Corporate Development
B. Market Analytics
Table 40: Japanese Recent Past, Current & Future Analysis for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 41: Japanese Historic Review for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 42: Japanese 14-Year Perspective for Botulinum Toxin by Application - Percentage Breakdown of Dollar Sales for Cosmetic and Therapeutic Markets for the Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)
4. EUROPE
A. Market Analysis
Current and Future Analysis
BTX Cosmetic Market Positioned for Growth
Botox Approvals and Indications in Select European Countries
Anti-Aging Treatment on the Rise among Young Mothers
Regulations for Botulinum Toxin Usage in the EU
The United Kingdom
Cosmetic Treatment Procedures in the UK
Snapshots
Russia
Mandates Registration of BTX Drugs
Product Approvals/Trials
Strategic Corporate Developments
Key Players
B. Market Analytics
Table 43: European Recent Past, Current & Future Analysis for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 44: European Historic Review for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 45: European 14-Year Perspective for Botulinum Toxin by Application - Percentage Breakdown of Dollar Sales for Cosmetic and Therapeutic Markets for the Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)
5. ASIA-PACIFIC
A. Market Analysis
Current and Future Analysis
Botox Approvals and Indications in Select Asian Countries
A Peek into Select Markets
Australia
China
Rising Demand for Cosmetic Treatments – Opportunity for BTX
Botulinum Toxin Injections Approved by China Food and Drug Administration (CFDA)
India – An Emerging Market for Botox
South Korea
Botulinum Toxin Market – Cosmetic Sector to Fuel Growth
Table 46: South Korean Botulinum Toxin Use by Application for the Years 2005, 2010 and 2015 (includes corresponding Graph/Chart)
Strong Demand for Cosmetic Procedures – Potential for BTX Market
Table 47: Working Women as % of Total Female Population and Monthly Income of Working Women (in KRW Million) for 2005, 2010 & 2015 (includes corresponding Graph/Chart)
Table 48: Aging Population in Korea (2015 & 2025): Percentage Breakdown of Population by Age Group (includes corresponding Graph/Chart)
Table 49: Foreign Patients Visiting Korea for Plastic Surgery & Dermatology Procedures as a % of Total Visits of Foreign Patients (includes corresponding Graph/Chart)
Meditoxin Dominates Domestic BTX Market
Table 50: Leading Brands in the South Korean Botulinum Toxin Market (2015): Percentage Breakdown of Sales for Botox, Botulax, Meditoxin, Nabota and Others (includes corresponding Graph/Chart)
Table 51: Average Price of Botulinum Toxin Products by Brand in South Korea (2015) (In KRW per Unit) (includes corresponding Graph/Chart)
List of Domestic Botox Products in Korea
Product Launches/Approvals
Strategic Corporate Developments
Key Players
B. Market Analytics
Table 52: Asia-Pacific Recent Past, Current & Future Analysis for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 53: Asia-Pacific Historic Review for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 54: Asia-Pacific 14-Year Perspective for Botulinum Toxin by Application - Percentage Breakdown of Dollar Sales for Cosmetic and Therapeutic Markets for the Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)
6. REST OF WORLD
A. Market Analysis
Current and Future Analysis
Latin America: Facial Injectables Market Set for Strong Growth
Israel: Health Ministry Bans Cosmetic Botox Treatment by Dentists
Botox Approvals and Indications in RoW
Botox Approvals and Indications in Select Latin American Regions
Botox Approvals and Indications in Other Select Global Regions
B. Market Analytics
Table 55: Rest of World Recent Past, Current & Future Analysis for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2015 through 2022 (includes corresponding Graph/Chart)
Table 56: Rest of World Historic Review for Botulinum Toxin by Application - Cosmetic and Therapeutic Markets Independently Analyzed by Annual Sales Figures in US$ Million for the Years 2009 through 2014 (includes corresponding Graph/Chart)
Table 57: Rest of World 14-Year Perspective for Botulinum Toxin by Application - Percentage Breakdown of Dollar Sales for Cosmetic and Therapeutic Markets for the Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)
IV. COMPETITIVE LANDSCAPE
Total Companies Profiled: 15 (including Divisions/Subsidiaries - 18)
The United States (6)
Japan (1)
Europe (5)
- France (1)
- Germany (1)
- The United Kingdom (1)
- Rest of Europe (2)
Asia-Pacific (Excluding Japan) (6

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