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Women's Health Cluster Drug Development Pipeline Review, 2017

Women's Health Cluster Drug Development Pipeline Review, 2017

Summary

This report provides an overview of the women’s health pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for female infertility, polycystic ovarian syndrome and endometriosis, and also features dormant and discontinued projects.

Infertility is defined as the inability to get pregnant after a year of unprotected intercourse. Female infertility can be also be caused by a number of factors, which include damage to fallopian tubes, hormonal causes, cervical causes, uterine causes, unexplained infertility. There are a total of 87 products in development for this indication, by 47 companies and 11 academic institutions. Key companies operating in this pipeline space include Bayer, Evotec, AlphaMab, Zydus Cadila Healthcare and Ferring.

Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women of reproductive age. Symptoms include menstrual abnormality, acne, thinning hair on the scalp, weight gain, excess androgen and polycystic ovaries. There are a total of 12 products in development for this indication, by eight companies and three academic institutions. A number of companies are operating in this space, with EffRx alone developing multiple programs within the area.

Finally, endometriosis is an often painful disorder in which tissue that normally lines the inside of uterus (the endometrium) grows outside the uterus (endometrial implant). Symptoms include pelvic pain, menstrual cramps, inflammation, infertility and abnormal bleeding. There are a total of 53 products in development for this indication, by 29 companies and eight academic institutions. Key companies operating in this pipeline space include Bayer and Evotec, which are each developing five distinct programs in this disease area.

Generally the main types of therapy being developed act on hormone receptors, reflecting the hormone-driven pathophysiology of this disease area. However, particularly in polycystic ovarian syndrome, a broader range of molecular targets, such as intracellular protein kinases, chemokine receptors and other cell signaling components are also targeted.

Scope

  • Which companies are the most active within the pipeline for women’s health therapeutics?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in the field of women’s health therapeutics?
Reasons to buy
  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration


Executive Summary
Introduction
Women's Health Cluster Report Coverage
Women Infertility – Overview
Polycystic Ovarian Syndrome – Overview
Endometriosis – Overview
Therapeutics Development
Women Infertility
Polycystic Ovarian Syndrome
Endometriosis
Therapeutics Assessment
Women Infertility
Polycystic Ovarian Syndrome
Endometriosis
Companies Involved in Therapeutics Development
Women Infertility
Polycystic Ovarian Syndrome
Endometriosis
Dormant Projects
Women Infertility
Polycystic Ovarian Syndrome
Endometriosis
Discontinued Products
Women Infertility
Polycystic Ovarian Syndrome
Endometriosis
Product Development Milestones
Women Infertility
Polycystic Ovarian Syndrome
Endometriosis
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
List of Tables
Number of Products under Development for Women Infertility
Number of Products under Development by Companies, Women Infertility
Number of Products under Development by Universities/Institutes, Women Infertility
Products under Development by Companies, Women Infertility
Products under Development by Universities/Institutes, Women Infertility
Number of Products under Development for Polycystic Ovarian Syndrome
Number of Products under Development by Companies, Polycystic Ovarian Syndrome
Number of Products under Development by Universities/Institutes, Polycystic Ovarian Syndrome
Products under Development by Companies, Polycystic Ovarian Syndrome
Products under Development by Universities/Institutes, Polycystic Ovarian Syndrome
Number of Products under Development for Endometriosis
Number of Products under Development by Companies, Endometriosis
Number of Products under Development by Universities/Institutes, Endometriosis
Products under Development by Companies, Endometriosis
Products under Development by Universities/Institutes, Endometriosis
Number of Products by Stage and Target, Women Infertility
Number of Products by Stage and Mechanism of Action, Women Infertility
Number of Products by Stage and Route of Administration, Women Infertility
Number of Products by Stage and Molecule Type, Women Infertility
Number of Products by Stage and Target, Polycystic Ovarian Syndrome
Number of Products by Stage and Mechanism of Action, Polycystic Ovarian Syndrome
Number of Products by Stage and Route of Administration, Polycystic Ovarian Syndrome
Number of Products by Stage and Molecule Type, Polycystic Ovarian Syndrome
Number of Products by Stage and Target, Endometriosis
Number of Products by Stage and Mechanism of Action, Endometriosis
Number of Products by Stage and Route of Administration, Endometriosis
Number of Products by Stage and Molecule Type, Endometriosis
Women Infertility – Pipeline by 4P Therapeutics LLC
Women Infertility – Pipeline by AbbVie Inc
Women Infertility – Pipeline by Addex Therapeutics Ltd
Women Infertility – Pipeline by AlphaMab Co Ltd
Women Infertility – Pipeline by APAvadis Biotechnologies Srl
Women Infertility – Pipeline by ASKA Pharmaceutical Co Ltd
Women Infertility – Pipeline by Astellas Pharma Inc
Women Infertility – Pipeline by Bayer AG
Women Infertility – Pipeline by Dong-A Socio Holdings Co Ltd
Women Infertility – Pipeline by Dongkook Pharmaceutical Co Ltd
Women Infertility – Pipeline by ElexoPharm GmbH
Women Infertility – Pipeline by EndoCeutics Inc
Women Infertility – Pipeline by Enteris BioPharma Inc
Women Infertility – Pipeline by Evotec AG
Women Infertility – Pipeline by Ferring International Center SA
Women Infertility – Pipeline by Forendo Pharma Ltd
Women Infertility – Pipeline by Glycotope GmbH
Women Infertility – Pipeline by Isifer AB
Women Infertility – Pipeline by Kissei Pharmaceutical Co Ltd
Women Infertility – Pipeline by Lipicard Technologies Ltd
Women Infertility – Pipeline by Livzon Pharmaceutical Group Inc
Women Infertility – Pipeline by Luye Pharma Group Ltd
Women Infertility – Pipeline by Merck & Co Inc
Women Infertility – Pipeline by Navya Biologicals Pvt Ltd
Women Infertility – Pipeline by Nippon Shinyaku Co Ltd
Women Infertility – Pipeline by Nora Therapeutics Inc
Women Infertility – Pipeline by ObsEva SA
Women Infertility – Pipeline by Ogeda SA
Women Infertility – Pipeline by Orphagen Pharmaceuticals Inc
Women Infertility – Pipeline by Pangen Biotech Inc.
Women Infertility – Pipeline by Pantec Biosolutions AG
Women Infertility – Pipeline by PharmaEssentia Corp
Women Infertility – Pipeline by Philogen SpA
Women Infertility – Pipeline by Repros Therapeutics Inc
Women Infertility – Pipeline by Richter Gedeon Nyrt
Women Infertility – Pipeline by SK Chemicals Co Ltd
Women Infertility – Pipeline by Takeda Pharmaceutical Company Ltd
Women Infertility – Pipeline by TocopheRx Inc
Women Infertility – Pipeline by ValiRx Plc
Women Infertility – Pipeline by Viramal Ltd
Women Infertility – Pipeline by Zydus Cadila Healthcare Ltd
Polycystic Ovarian Syndrome – Pipeline by Addex Therapeutics Ltd
Polycystic Ovarian Syndrome – Pipeline by Crinetics Pharmaceuticals Inc
Polycystic Ovarian Syndrome – Pipeline by EffRx Pharmaceuticals SA
Polycystic Ovarian Syndrome – Pipeline by Millendo Therapeutics Inc
Polycystic Ovarian Syndrome – Pipeline by Ogeda SA
Polycystic Ovarian Syndrome – Pipeline by Vicore Pharma AB
Endometriosis – Pipeline by AbbVie Inc
Endometriosis – Pipeline by Addex Therapeutics Ltd
Endometriosis – Pipeline by APAvadis Biotechnologies Srl
Endometriosis – Pipeline by Astellas Pharma Inc
Endometriosis – Pipeline by Bayer AG
Endometriosis – Pipeline by Dongkook Pharmaceutical Co Ltd
Endometriosis – Pipeline by ElexoPharm GmbH
Endometriosis – Pipeline by EndoCeutics Inc
Endometriosis – Pipeline by Enteris BioPharma Inc
Endometriosis – Pipeline by Evotec AG
Endometriosis – Pipeline by Forendo Pharma Ltd
Endometriosis – Pipeline by Kissei Pharmaceutical Co Ltd
Endometriosis – Pipeline by Lipicard Technologies Ltd
Endometriosis – Pipeline by Luye Pharma Group Ltd
Endometriosis – Pipeline by Nippon Shinyaku Co Ltd
Endometriosis – Pipeline by Ogeda SA
Endometriosis – Pipeline by Orphagen Pharmaceuticals Inc
Endometriosis – Pipeline by Philogen SpA
Endometriosis – Pipeline by Repros Therapeutics Inc
Endometriosis – Pipeline by SK Chemicals Co Ltd
Endometriosis – Pipeline by Takeda Pharmaceutical Company Ltd
Endometriosis – Pipeline by ValiRx Plc
Endometriosis – Pipeline by Viramal Ltd
Women Infertility – Dormant Projects
Polycystic Ovarian Syndrome – Dormant Projects
Endometriosis – Dormant Projects
Women Infertility – Discontinued Products
Polycystic Ovarian Syndrome – Discontinued Products
Endometriosis – Discontinued Products
List of Figures
Number of Products under Development for Women Infertility
Number of Products under Development by Companies, Women Infertility
Number of Products under Development by Universities/Institutes, Women Infertility
Number of Products under Development for Polycystic Ovarian Syndrome
Number of Products under Development by Companies, Polycystic Ovarian Syndrome
Number of Products under Development for Endometriosis
Number of Products under Development by Companies, Endometriosis
Number of Products under Development by Universities/Institutes, Endometriosis
Number of Products by Top 10 Targets, Women Infertility
Number of Products by Stage and Top 10 Targets, Women Infertility
Number of Products by Top 10 Mechanism of Actions, Women Infertility
Number of Products by Stage and Top 10 Mechanism of Actions, Women Infertility
Number of Products by Routes of Administration, Women Infertility
Number of Products by Stage and Routes of Administration, Women Infertility
Number of Products by Molecule Types, Women Infertility
Number of Products by Stage and Molecule Types, Women Infertility
Number of Products by Top 10 Targets, Polycystic Ovarian Syndrome
Number of Products by Stage and Top 10 Targets, Polycystic Ovarian Syndrome
Number of Products by Top 10 Mechanism of Actions, Polycystic Ovarian Syndrome
Number of Products by Stage and Top 10 Mechanism of Actions, Polycystic Ovarian Syndrome
Number of Products by Routes of Administration, Polycystic Ovarian Syndrome
Number of Products by Stage and Routes of Administration, Polycystic Ovarian Syndrome
Number of Products by Molecule Types, Polycystic Ovarian Syndrome
Number of Products by Stage and Molecule Types, Polycystic Ovarian Syndrome
Number of Products by Top 10 Targets, Endometriosis
Number of Products by Stage and Top 10 Targets, Endometriosis
Number of Products by Top 10 Mechanism of Actions, Endometriosis
Number of Products by Stage and Top 10 Mechanism of Actions, Endometriosis
Number of Products by Routes of Administration, Endometriosis
Number of Products by Stage and Routes of Administration, Endometriosis
Number of Products by Molecule Types, Endometriosis
Number of Products by Stage and Molecule Types, Endometriosis

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