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Toxicology Cluster Chemotherapy Related Toxicity Drug Development Pipeline Review, 2017

Toxicology Cluster Chemotherapy Related Toxicity Drug Development Pipeline Review, 2017

Summary

This report provides an overview of the toxicology pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for Chemotherapy Induced Nausea and Vomiting, Chemotherapy Induced Neutropenia, Chemotherapy Induced Anemia, Chemotherapy Induced Peripheral Neuropathy and features dormant and discontinued projects.

Chemotherapy induced nausea and vomiting or CINV is nausea and vomiting that results specifically from treatment with chemotherapy drugs. There are a total of 28 products in development for this indication, by 20 companies. Key companies operating in this pipeline space include Helsinn, Luxena Pharmaceuticals, Aphios, Nemus Bioscience and Tesaro.

Chemotherapy-induced neutropenia is a very common side effect of cancer treatment. Symptoms include severe fatigue, weakness, anxiety, lack of energy, shortness of breath, headaches, pale appearance, rapid heart rate or palpitations, chest pain dizziness and abdominal pain. There are a total of 41 products in development for this indication, by 31 companies and one academic institution. Key companies operating in this pipeline space include Bolder Biotechnology, USV, Apotex, Biocon, Biogenomics, Generon and Pfizer.

Chemotherapy-induced anemia is a very common side effect of cancer treatment. Symptoms include severe fatigue, weakness, anxiety, lack of energy, shortness of breath, headaches, pale appearance, rapid heart rate or palpitations, chest pain dizziness, cognitive impairment, loss of sexual desire, inability to perform daily functions and/or depression associated with anemia. There are a total of 16 products in development for this indication, by 14 companies. Key companies operating in this pipeline space include Chong Kun Dang and Tolero Pharmaceuticals.

Finally, chemotherapy-induced peripheral neuropathy (CIPN) is a further potential side effect of cancer treatment. Symptoms include pain, burning, tingling, constipation, muscle weakness, blood pressure changes and balance problems. There are a total of 41 products in development for this indication, by 34 companies and four academic institutions. Key companies operating in this pipeline space include Apexian Pharmaceuticals, Celgene and Metys Pharmaceuticals.

The dominant molecular targets vary across each of the four pipelines. In CINV and CIPN, there is a relatively diverse range of targets which are being studied. The 5-hydroxytryptamine receptor 3 and substance P receptors are most commonly being studied in CINV, as are the cannabinoid receptors 1 and 2. There is some overlap between this and the CIPN pipeline, with cannabinoid receptors being present amongst the relatively diverse range of targets in development, although with the glutamate ionotropic receptor NMDA-type being the most-frequently selected target.

In chemotherapy-induced neutropenia, on the other hand, the granulocyte colony stimulating factor receptor is overwhelmingly the target of choice, accounting for virtually the entire pipeline. Similarly, the erythropoietin receptor makes up the majority of the chemotherapy-induced anemia pipeline. This reflects the relatively focused nature of R&D within these two indications.

Scope

  • Which companies are the most active within the pipeline for toxicology therapeutics?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in the field of toxicology therapeutics?
Reasons to buy
  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration


Executive Summary
Introduction
Toxicology Cluster Chemotherapy Related Toxicity Report Coverage
Chemotherapy Induced Nausea and Vomiting – Overview
Chemotherapy Induced Neutropenia – Overview
Chemotherapy Induced Anemia – Overview
Chemotherapy Induced Peripheral Neuropathy – Overview
Therapeutics Development
Chemotherapy Induced Nausea and Vomiting
Chemotherapy Induced Neutropenia
Chemotherapy Induced Anemia
Chemotherapy Induced Peripheral Neuropathy
Therapeutics Assessment
Chemotherapy Induced Nausea and Vomiting
Chemotherapy Induced Neutropenia
Chemotherapy Induced Anemia
Chemotherapy Induced Peripheral Neuropathy
Companies Involved in Therapeutics Development
Chemotherapy Induced Nausea and Vomiting
Chemotherapy Induced Neutropenia
Chemotherapy Induced Anemia
Chemotherapy Induced Peripheral Neuropathy
Dormant Projects
Chemotherapy Induced Nausea and Vomiting
Chemotherapy Induced Neutropenia
Chemotherapy Induced Anemia
Chemotherapy Induced Peripheral Neuropathy
Discontinued Products
Chemotherapy Induced Nausea and Vomiting
Chemotherapy Induced Neutropenia
Chemotherapy Induced Anemia
Chemotherapy Induced Peripheral Neuropathy
Product Development Milestones
Chemotherapy Induced Nausea and Vomiting
Chemotherapy Induced Neutropenia
Chemotherapy Induced Anemia
Chemotherapy Induced Peripheral Neuropathy
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
List of Tables
Number of Products under Development for Chemotherapy Induced Nausea and Vomiting
Number of Products under Development by Companies, Chemotherapy Induced Nausea and Vomiting
Products under Development by Companies, Chemotherapy Induced Nausea and Vomiting
Number of Products under Development for Chemotherapy Induced Neutropenia
Number of Products under Development by Companies, Chemotherapy Induced Neutropenia
Number of Products under Development by Universities/Institutes, Chemotherapy Induced Neutropenia
Products under Development by Companies, Chemotherapy Induced Neutropenia
Products under Development by Universities/Institutes, Chemotherapy Induced Neutropenia
Number of Products under Development for Chemotherapy Induced Anemia
Number of Products under Development by Companies, Chemotherapy Induced Anemia
Products under Development by Companies, Chemotherapy Induced Anemia
Number of Products under Development for Chemotherapy Induced Peripheral Neuropathy
Number of Products under Development by Companies, Chemotherapy Induced Peripheral Neuropathy
Number of Products under Development by Universities/Institutes, Chemotherapy Induced Peripheral Neuropathy
Products under Development by Companies, Chemotherapy Induced Peripheral Neuropathy
Products under Development by Universities/Institutes, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Stage and Target, Chemotherapy Induced Nausea and Vomiting
Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Nausea and Vomiting
Number of Products by Stage and Route of Administration, Chemotherapy Induced Nausea and Vomiting
Number of Products by Stage and Molecule Type, Chemotherapy Induced Nausea and Vomiting
Number of Products by Stage and Target, Chemotherapy Induced Neutropenia
Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Neutropenia
Number of Products by Stage and Route of Administration, Chemotherapy Induced Neutropenia
Number of Products by Stage and Molecule Type, Chemotherapy Induced Neutropenia
Number of Products by Stage and Target, Chemotherapy Induced Anemia
Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Anemia
Number of Products by Stage and Route of Administration, Chemotherapy Induced Anemia
Number of Products by Stage and Molecule Type, Chemotherapy Induced Anemia
Number of Products by Stage and Target, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Stage and Mechanism of Action, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Stage and Route of Administration, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Stage and Molecule Type, Chemotherapy Induced Peripheral Neuropathy
Chemotherapy Induced Nausea and Vomiting – Pipeline by Acacia Pharma Ltd
Chemotherapy Induced Nausea and Vomiting – Pipeline by Aphios Corp
Chemotherapy Induced Nausea and Vomiting – Pipeline by Astellas Pharma Inc
Chemotherapy Induced Nausea and Vomiting – Pipeline by Camurus AB
Chemotherapy Induced Nausea and Vomiting – Pipeline by Daewoong Pharmaceutical Co Ltd
Chemotherapy Induced Nausea and Vomiting – Pipeline by Heron Therapeutics Inc
Chemotherapy Induced Nausea and Vomiting – Pipeline by INSYS Therapeutics Inc
Chemotherapy Induced Nausea and Vomiting – Pipeline by Kyowa Hakko Kirin Co Ltd
Chemotherapy Induced Nausea and Vomiting – Pipeline by MannKind Corp
Chemotherapy Induced Nausea and Vomiting – Pipeline by Medlab Clinical Ltd
Chemotherapy Induced Nausea and Vomiting – Pipeline by Nemus Bioscience Inc
Chemotherapy Induced Nausea and Vomiting – Pipeline by RedHill Biopharma Ltd
Chemotherapy Induced Nausea and Vomiting – Pipeline by Serina Therapeutics Inc
Chemotherapy Induced Nausea and Vomiting – Pipeline by SoluBest Ltd
Chemotherapy Induced Nausea and Vomiting – Pipeline by Suda Ltd
Chemotherapy Induced Nausea and Vomiting – Pipeline by Tesaro Inc
Chemotherapy Induced Nausea and Vomiting – Pipeline by Therapix Biosciences Ltd
Chemotherapy Induced Neutropenia – Pipeline by Apotex Inc
Chemotherapy Induced Neutropenia – Pipeline by Biocon Ltd
Chemotherapy Induced Neutropenia – Pipeline by Biogenomics Ltd
Chemotherapy Induced Neutropenia – Pipeline by Bolder Biotechnology Inc
Chemotherapy Induced Neutropenia – Pipeline by Cellerant Therapeutics Inc
Chemotherapy Induced Neutropenia – Pipeline by Chong Kun Dang Pharmaceutical Corp
Chemotherapy Induced Neutropenia – Pipeline by Cinfa Biotech SL
Chemotherapy Induced Neutropenia – Pipeline by Dr. Reddy's Laboratories Ltd
Chemotherapy Induced Neutropenia – Pipeline by Gene Techno Science Co Ltd
Chemotherapy Induced Neutropenia – Pipeline by Generon (Shanghai) Corp Ltd
Chemotherapy Induced Neutropenia – Pipeline by Genexine Inc
Chemotherapy Induced Neutropenia – Pipeline by GlycoMimetics Inc
Chemotherapy Induced Neutropenia – Pipeline by Hanmi Pharmaceuticals Co Ltd
Chemotherapy Induced Neutropenia – Pipeline by Mycenax Biotech Inc
Chemotherapy Induced Neutropenia – Pipeline by Myelo Therapeutics GmbH
Chemotherapy Induced Neutropenia – Pipeline by Nohla Therapeutics Inc
Chemotherapy Induced Neutropenia – Pipeline by Octapharma AG
Chemotherapy Induced Neutropenia – Pipeline by Pfenex Inc
Chemotherapy Induced Neutropenia – Pipeline by Pfizer Inc
Chemotherapy Induced Neutropenia – Pipeline by Reliance Life Sciences Pvt Ltd
Chemotherapy Induced Neutropenia – Pipeline by Richter Gedeon Nyrt
Chemotherapy Induced Neutropenia – Pipeline by Sandoz International GmbH
Chemotherapy Induced Neutropenia – Pipeline by USV Pvt Ltd
Chemotherapy Induced Anemia – Pipeline by 3SBio Inc
Chemotherapy Induced Anemia – Pipeline by Chong Kun Dang Pharmaceutical Corp
Chemotherapy Induced Anemia – Pipeline by Dr. Reddy's Laboratories Ltd
Chemotherapy Induced Anemia – Pipeline by Galenica Ltd
Chemotherapy Induced Anemia – Pipeline by Novartis AG
Chemotherapy Induced Anemia – Pipeline by Panacea Biotec Ltd
Chemotherapy Induced Anemia – Pipeline by Pfizer Inc
Chemotherapy Induced Anemia – Pipeline by PharmaEssentia Corp
Chemotherapy Induced Anemia – Pipeline by PhytoHealth Corp
Chemotherapy Induced Anemia – Pipeline by Pieris Pharmaceuticals Inc
Chemotherapy Induced Anemia – Pipeline by SBI Pharmaceuticals Co Ltd
Chemotherapy Induced Anemia – Pipeline by Therapure Biopharma Inc
Chemotherapy Induced Anemia – Pipeline by Tolero Pharmaceuticals Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Achelios Therapeutics Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Advinus Therapeutics Ltd
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Apollo Endosurgery Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Aptinyx Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Asahi Kasei Pharma Corp
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Can-Fite BioPharma Ltd
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Celgene Corp
Chemotherapy Induced Peripheral Neuropathy – Pipeline by DermaXon LLC
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Eisai Co Ltd
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Immune Pharmaceuticals Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by INSYS Therapeutics Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Kineta Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by KPI Therapeutics Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Krenitsky Pharmaceuticals Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by MAKScientific LLC
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Metys Pharmaceuticals AG
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Midatech Pharma US Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Mundipharma International Ltd
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Nemus Bioscience Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Neurocentrx Pharma Ltd
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Panacea Pharmaceuticals Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by PeriphaGen Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by PharmatrophiX Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by PledPharma AB
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Sova Pharmaceuticals Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by Virobay Inc
Chemotherapy Induced Peripheral Neuropathy – Pipeline by WEX Pharmaceuticals Inc
Chemotherapy Induced Nausea and Vomiting – Dormant Projects
Chemotherapy Induced Neutropenia – Dormant Projects
Chemotherapy Induced Anemia – Dormant Projects
Chemotherapy Induced Peripheral Neuropathy – Dormant Projects
Chemotherapy Induced Nausea and Vomiting – Discontinued Products
Chemotherapy Induced Neutropenia – Discontinued Products
Chemotherapy Induced Anemia – Discontinued Products
Chemotherapy Induced Peripheral Neuropathy – Discontinued Products
List of Figures
Number of Products under Development for Chemotherapy Induced Nausea and Vomiting
Number of Products under Development by Companies, Chemotherapy Induced Nausea and Vomiting
Number of Products under Development for Chemotherapy Induced Neutropenia
Number of Products under Development by Companies, Chemotherapy Induced Neutropenia
Number of Products under Development for Chemotherapy Induced Anemia
Number of Products under Development by Companies, Chemotherapy Induced Anemia
Number of Products under Development for Chemotherapy Induced Peripheral Neuropathy
Number of Products under Development by Companies, Chemotherapy Induced Peripheral Neuropathy
Number of Products under Development by Universities/Institutes, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Targets, Chemotherapy Induced Nausea and Vomiting
Number of Products by Stage and Targets, Chemotherapy Induced Nausea and Vomiting
Number of Products by Mechanism of Actions, Chemotherapy Induced Nausea and Vomiting
Number of Products by Stage and Mechanism of Actions, Chemotherapy Induced Nausea and Vomiting
Number of Products by Top 10 Routes of Administration, Chemotherapy Induced Nausea and Vomiting
Number of Products by Stage and Top 10 Routes of Administration, Chemotherapy Induced Nausea and Vomiting
Number of Products by Stage and Molecule Types, Chemotherapy Induced Nausea and Vomiting
Number of Products by Targets, Chemotherapy Induced Neutropenia
Number of Products by Stage and Targets, Chemotherapy Induced Neutropenia
Number of Products by Mechanism of Actions, Chemotherapy Induced Neutropenia
Number of Products by Stage and Mechanism of Actions, Chemotherapy Induced Neutropenia
Number of Products by Routes of Administration, Chemotherapy Induced Neutropenia
Number of Products by Stage and Routes of Administration, Chemotherapy Induced Neutropenia
Number of Products by Molecule Types, Chemotherapy Induced Neutropenia
Number of Products by Stage and Molecule Types, Chemotherapy Induced Neutropenia
Number of Products by Targets, Chemotherapy Induced Anemia
Number of Products by Stage and Targets, Chemotherapy Induced Anemia
Number of Products by Mechanism of Actions, Chemotherapy Induced Anemia
Number of Products by Stage and Mechanism of Actions, Chemotherapy Induced Anemia
Number of Products by Routes of Administration, Chemotherapy Induced Anemia
Number of Products by Stage and Routes of Administration, Chemotherapy Induced Anemia
Number of Products by Molecule Types, Chemotherapy Induced Anemia
Number of Products by Stage and Molecule Types, Chemotherapy Induced Anemia
Number of Products by Top 10 Targets, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Stage and Top 10 Targets, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Top 10 Mechanism of Actions, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Stage and Top 10 Mechanism of Actions, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Routes of Administration, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Stage and Routes of Administration, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Molecule Types, Chemotherapy Induced Peripheral Neuropathy
Number of Products by Stage and Molecule Types, Chemotherapy Induced Peripheral Neuropathy

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