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Renal Cluster Drug Development Pipeline Review, 2017

Renal Cluster Drug Development Pipeline Review, 2017

Summary

This report provides an overview of the renal cluster pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for Kidney Fibrosis, Chronic Kidney Disease (Chronic Renal Failure), Acute Renal Failure (ARF), Kidney Transplant Rejection, and also features dormant and discontinued projects.

Accumulation of extracellular matrix in the kidney causes kidney fibrosis. It is a progressive disorder characterized by glomerulosclerosis and tubulointerstitial fibrosis and may lead to detrimental effects on the kidney functioning. There are a total of 39 products in development for this indication, by 28 companies and five academic institutions. Key companies operating in this pipeline space include Angion Biomedica, Pharmaxis, Cellmid and Vascular Biogenics.

Chronic kidney disease is the slow loss of kidney function over time. Signs and symptoms of kidney disease include nausea, vomiting, loss of appetite, fatigue and weakness, sleep problems, hiccups and swelling of feet and ankles. There are a total of 59 products in development for this indication, by 48 companies and two academic institutions. Key companies operating in this pipeline space include Angion Biomedica, Apceth Biopharma, AstraZeneca, Bayer, Evotec, Novartis, Sarfez Pharmaceuticals and Vidasym.

Acute kidney failure occurs when kidneys suddenly become unable to filter waste products from blood. Symptoms include drowsiness, shortness of breath, fatigue, seizures or coma in severe cases and chest pain. There are a total of 36 products in development for this indication, by 34 companies and one academic institution. A number of companies are operating in this space, with A1M Pharma alone developing multiple programs within the area.

Finally, kidney transplantation is a therapy performed to replace a diseased kidney with a healthy kidney from another person. Due to differences between the two patients, an autoimmune reaction against the donor kidney may occur in the recipient. There are a total of 39 products in development for this indication, by 33 companies and two academic institutions. Key companies operating in this pipeline space include Astellas Pharma, GlaxoSmithKline, Hillhurst Biopharmaceuticals and Kyowa Hakko Kirin.

While kidney transplant rejection treatments are largely focused on immune system molecular targets such as tumor necrosis factor alpha and complement factors, a range of cellular signaling components are being pursued in the other three key indications, including the activin receptors, cyclin dependent kinases, and growth factor receptors.

Scope

  • Which companies are the most active within the pipeline for renal cluster therapeutics?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in the field of renal cluster therapeutics?
Reasons to buy
  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration


Executive Summary
Introduction
GBI Research Report Coverage
Kidney Fibrosis – Overview
Chronic Kidney Disease (Chronic Renal Failure) – Overview
Acute Renal Failure (ARF) (Acute Kidney Injury) – Overview
Kidney Transplant Rejection – Overview
Therapeutics Development
Kidney Fibrosis
Chronic Kidney Disease (Chronic Renal Failure)
Acute Renal Failure (ARF) (Acute Kidney Injury)
Kidney Transplant Rejection
Therapeutics Assessment
Kidney Fibrosis
Chronic Kidney Disease (Chronic Renal Failure)
Acute Renal Failure (ARF) (Acute Kidney Injury)
Kidney Transplant Rejection
Companies Involved in Therapeutics Development
Kidney Fibrosis
Chronic Kidney Disease (Chronic Renal Failure)
Acute Renal Failure (ARF) (Acute Kidney Injury)
Kidney Transplant Rejection
Dormant Projects
Kidney Fibrosis
Chronic Kidney Disease (Chronic Renal Failure)
Acute Renal Failure (ARF) (Acute Kidney Injury)
Kidney Transplant Rejection
Discontinued Products
Chronic Kidney Disease (Chronic Renal Failure)
Acute Renal Failure (ARF) (Acute Kidney Injury)
Kidney Transplant Rejection
Product Development Milestones
Kidney Fibrosis
Chronic Kidney Disease (Chronic Renal Failure)
Acute Renal Failure (ARF) (Acute Kidney Injury)
Kidney Transplant Rejection
Appendix
Methodology
Coverage
Secondary Research
Primary Research
Expert Panel Validation
Contact Us
Disclaimer
List of Tables
Number of Products under Development for Kidney Fibrosis
Number of Products under Development by Companies, Kidney Fibrosis
Number of Products under Development by Universities/Institutes, Kidney Fibrosis
Products under Development by Companies, Kidney Fibrosis
Products under Development by Universities/Institutes, Kidney Fibrosis
Number of Products under Development for Chronic Kidney Disease (Chronic Renal Failure)
Number of Products under Development by Companies, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products under Development by Universities/Institutes, Chronic Kidney Disease (Chronic Renal Failure)
Products under Development by Companies, Chronic Kidney Disease (Chronic Renal Failure)
Products under Development by Universities/Institutes, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products under Development for Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products under Development by Companies, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products under Development by Universities/Institutes, Acute Renal Failure (ARF) (Acute Kidney Injury)
Products under Development by Companies, Acute Renal Failure (ARF) (Acute Kidney Injury)
Products under Development by Universities/Institutes, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products under Development for Kidney Transplant Rejection
Number of Products under Development by Companies, Kidney Transplant Rejection
Number of Products under Development by Universities/Institutes, Kidney Transplant Rejection
Products under Development by Companies, Kidney Transplant Rejection
Products under Development by Universities/Institutes, Kidney Transplant Rejection
Number of Products by Stage and Target, Kidney Fibrosis
Number of Products by Stage and Mechanism of Action, Kidney Fibrosis
Number of Products by Stage and Route of Administration, Kidney Fibrosis
Number of Products by Stage and Molecule Type, Kidney Fibrosis
Number of Products by Stage and Target, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Stage and Mechanism of Action, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Stage and Route of Administration, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Stage and Molecule Type, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Stage and Target, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Stage and Mechanism of Action, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Stage and Route of Administration, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Stage and Molecule Type, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Stage and Target, Kidney Transplant Rejection
Number of Products by Stage and Mechanism of Action, Kidney Transplant Rejection
Number of Products by Stage and Route of Administration, Kidney Transplant Rejection
Number of Products by Stage and Molecule Type, Kidney Transplant Rejection
Kidney Fibrosis – Pipeline by AbbVie Inc
Kidney Fibrosis – Pipeline by Allergan Plc
Kidney Fibrosis – Pipeline by Angion Biomedica Corp
Kidney Fibrosis – Pipeline by Apollo Endosurgery Inc
Kidney Fibrosis – Pipeline by BiOrion Technologies BV
Kidney Fibrosis – Pipeline by Cellmid Ltd
Kidney Fibrosis – Pipeline by Epigen Biosciences Inc
Kidney Fibrosis – Pipeline by Evotec AG
Kidney Fibrosis – Pipeline by Galectin Therapeutics Inc
Kidney Fibrosis – Pipeline by GenKyoTex SA
Kidney Fibrosis – Pipeline by Horizon Pharma Plc
Kidney Fibrosis – Pipeline by Intercept Pharmaceuticals Inc
Kidney Fibrosis – Pipeline by Isarna Therapeutics GmbH
Kidney Fibrosis – Pipeline by MorphoSys AG
Kidney Fibrosis – Pipeline by Pharmaxis Ltd
Kidney Fibrosis – Pipeline by ProMetic Life Sciences Inc
Kidney Fibrosis – Pipeline by Regulus Therapeutics Inc
Kidney Fibrosis – Pipeline by Sirnaomics Inc
Kidney Fibrosis – Pipeline by Symic Biomedical Inc
Kidney Fibrosis – Pipeline by Vascular Biogenics Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Angion Biomedica Corp
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by apceth Biopharma GmbH
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Astellas Pharma Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by AstraZeneca Plc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Bayer AG
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by BLR Bio LLC
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Boehringer Ingelheim GmbH
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Boryung Pharmaceutical Co Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Cellmid Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Chugai Pharmaceutical Co Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Complexa Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Corvidia Corp
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by CTI BioPharma Corp
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Evotec AG
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by F. Hoffmann-La Roche Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Gilead Sciences Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by GNI Group Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Lupin Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Navya Biologicals Pvt Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Nippon Zoki Pharmaceutical Co Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Novartis AG
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Otsuka Holdings Co Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Prismic Pharmaceuticals Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Prolong Pharmaceuticals LLC
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by ProMetic Life Sciences Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Reata Pharmaceuticals Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Regulus Therapeutics Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Relypsa Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Resverlogix Corp
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Spotlight Innovation Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Taisho Pharmaceutical Co Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Toray Industries Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Tricida Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Unity Biotechnology Inc
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Vascular BioSciences
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by VESSL Therapeutics Ltd
Chronic Kidney Disease (Chronic Renal Failure) – Pipeline by Vicore Pharma AB
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by A1M Pharma AB
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Alloksys Life Sciences BV
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Am-Pharma BV
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Angion Biomedica Corp
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Atox Bio Ltd
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Cellmid Ltd
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Complexa Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by DiaMedica Therapeutics Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by DURECT Corp
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Evotec AG
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Exponential Biotherapies Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by F. Hoffmann-La Roche Ltd
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by G1 Therapeutics Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Kringle Pharma Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Mitotech SA
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by NephroGenex Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by NeuroVive Pharmaceutical AB
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Nyken BV
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by ProMetic Life Sciences Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Quark Pharmaceuticals Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Rediscovery Life Sciences
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Regulus Therapeutics Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by SBI Pharmaceuticals Co Ltd
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Spherium Biomed SL
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by STATegics Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Stealth BioTherapeutics Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Thrasos Therapeutics Inc
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Torrent Pharmaceuticals Ltd
Acute Renal Failure (ARF) (Acute Kidney Injury) – Pipeline by Xigen SA
Kidney Transplant Rejection – Pipeline by Amgen Inc
Kidney Transplant Rejection – Pipeline by Angion Biomedica Corp
Kidney Transplant Rejection – Pipeline by Apellis Pharmaceuticals Inc
Kidney Transplant Rejection – Pipeline by Astellas Pharma Inc
Kidney Transplant Rejection – Pipeline by Biogen Inc
Kidney Transplant Rejection – Pipeline by Catalyst Biosciences Inc
Kidney Transplant Rejection – Pipeline by Corline Biomedical AB
Kidney Transplant Rejection – Pipeline by CSL Ltd
Kidney Transplant Rejection – Pipeline by GlaxoSmithKline Plc
Kidney Transplant Rejection – Pipeline by Grifols SA
Kidney Transplant Rejection – Pipeline by Hansa Medical AB
Kidney Transplant Rejection – Pipeline by Kyowa Hakko Kirin Co Ltd
Kidney Transplant Rejection – Pipeline by Magnus Life Ltd
Kidney Transplant Rejection – Pipeline by Noorik Biopharmaceuticals AG
Kidney Transplant Rejection – Pipeline by Novartis AG
Kidney Transplant Rejection – Pipeline by Opsona Therapeutics Ltd
Kidney Transplant Rejection – Pipeline by OSE Immunotherapeutics
Kidney Transplant Rejection – Pipeline by Pharmicell Co Ltd
Kidney Transplant Rejection – Pipeline by Pharming Group NV
Kidney Transplant Rejection – Pipeline by Prolong Pharmaceuticals LLC
Kidney Transplant Rejection – Pipeline by Quark Pharmaceuticals Inc
Kidney Transplant Rejection – Pipeline by Shire Plc
Kidney Transplant Rejection – Pipeline by Tiziana Life Sciences Plc
Kidney Fibrosis – Dormant Projects
Chronic Kidney Disease (Chronic Renal Failure) – Dormant Projects
Acute Renal Failure (ARF) (Acute Kidney Injury) – Dormant Projects
Kidney Transplant Rejection – Dormant Projects
Chronic Kidney Disease (Chronic Renal Failure) – Discontinued Products
Acute Renal Failure (ARF) (Acute Kidney Injury) – Discontinued Products
Kidney Transplant Rejection – Discontinued Products
List of Figures
Number of Products under Development for Kidney Fibrosis
Number of Products under Development by Companies, Kidney Fibrosis
Number of Products under Development for Chronic Kidney Disease (Chronic Renal Failure)
Number of Products under Development by Companies, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products under Development by Universities/Institutes, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products under Development for Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products under Development by Companies, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products under Development for Kidney Transplant Rejection
Number of Products under Development by Companies, Kidney Transplant Rejection
Number of Products under Development by Universities/Institutes, Kidney Transplant Rejection
Number of Products by Top 10 Targets, Kidney Fibrosis
Number of Products by Stage and Top 10 Targets, Kidney Fibrosis
Number of Products by Top 10 Mechanism of Actions, Kidney Fibrosis
Number of Products by Stage and Top 10 Mechanism of Actions, Kidney Fibrosis
Number of Products by Routes of Administration, Kidney Fibrosis
Number of Products by Stage and Routes of Administration, Kidney Fibrosis
Number of Products by Molecule Types, Kidney Fibrosis
Number of Products by Stage and Molecule Types, Kidney Fibrosis
Number of Products by Top 10 Targets, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Stage and Top 10 Targets, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Top 10 Mechanism of Actions, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Stage and Top 10 Mechanism of Actions, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Top 10 Routes of Administration, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Stage and Top 10 Routes of Administration, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Top 10 Molecule Types, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Stage and Top 10 Molecule Types, Chronic Kidney Disease (Chronic Renal Failure)
Number of Products by Top 10 Targets, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Stage and Top 10 Targets, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Top 10 Mechanism of Actions, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Stage and Top 10 Mechanism of Actions, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Routes of Administration, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Stage and Routes of Administration, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Molecule Types, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Stage and Molecule Types, Acute Renal Failure (ARF) (Acute Kidney Injury)
Number of Products by Top 10 Targets, Kidney Transplant Rejection
Number of Products by Stage and Top 10 Targets, Kidney Transplant Rejection
Number of Products by Top 10 Mechanism of Actions, Kidney Transplant Rejection
Number of Products by Stage and Top 10 Mechanism of Actions, Kidney Transplant Rejection
Number of Products by Routes of Administration, Kidney Transplant Rejection
Number of Products by Stage and Routes of Administration, Kidney Transplant Rejection
Number of Products by Top 10 Molecule Types, Kidney Transplant Rejection
Number of Products by Stage and Top 10 Molecule Types, Kidney Transplant Rejection

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