Parkinson’s Disease - Heat Map and Analysis
Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive loss of muscular control, leading to resting tremor, rigidity, akinesia and postural reflex impairment. PD is an age-related disorder; symptoms typically begin to first appear in patients in their mid-sixties, and progress in varying stages.
There is currently no cure for PD, with inadequate symptomatic treatments on the market that are suboptimal in terms of efficacy. The most urgent unmet need is the lack of disease-modifying therapies that demonstrate neuroprotective properties to prevent or at least significantly slow neuronal cell death. Significant efforts have been made to develop new treatments to address this need.
The differences between many of these products lie in their mechanisms of action, which must be fully understood by companies looking to position a novel drug in this market. This tabular heat map framework, designed to provide an easily digestible summary of these clinical characteristics, provides detailed readouts of all late-stage clinical trial results for products in the PD market and Phase III pipeline. These are split by classes of therapy.
All safety and efficacy endpoints reported in these trials are displayed, for both the drug and placebo groups. In addition, key study characteristics such as the size, composition and patient segment of the study population, are provided. These results are presented in a visually accessible, color-coded manner in order to maximize ease of use.
The accompanying text provides a detailed analysis of the clinical benchmarks set by the current market landscape, and the anticipated changes to these benchmarks, and to the treatment algorithm, as a result of the late-stage pipeline.