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Global Immunology Drugs Market to 2022 - Increasing Prevalence, Repositioning Opportunities and Strong Uptake of Interleukin Receptor Inhibitors to Drive Growth

Global Immunology Drugs Market to 2022 - Increasing Prevalence, Repositioning Opportunities and Strong Uptake of Interleukin Receptor Inhibitors to Drive Growth

Summary

Immune-mediated inflammatory diseases are a common set of chronic disorders that affect 5-7% of people in Western populations. Although they are often disparate in terms of their symptoms and key patient demographics, they are pathophysiological linked, being characterized by dysregulation of immune pathways and an inappropriate immune response. Key examples are rheumatoid arthritis (RA), psoriasis, lupus and ankylosing spondylitis.

Immunology is a therapy area characterized by disorders of the immune system, specifically an aberrant autoimmune response against healthy tissues in the body, leading to chronic or acute inflammation. Depending on the specific site affected, this can lead to various types of chronic pain and mobility loss, and have a negative impact on quality of life.

Generally, disease-modifying anti-rheumatic drugs (DMARD) - a highly genericized class of systemic small molecule based agents - are used in the first-line treatment of these diseases. These are supplemented in many cases with shorter-term glucocorticoid therapy, another class of highly genericized systemic agents.

However, as these therapies often fail to elicit an adequate long-term response, a large second-line therapy segment has emerged in these markets, which began with the approval of Remicade (infliximab) and Enbrel (etanercept) in 1998. This segment consists largely of premium systemic monoclonal antibodies (mAb), which are highly commercially successful due to their widespread use and high cost.

Although the patents for many of these mAbs have either already expired or are due to expire during the forecast period, the market is expected to experience continued growth, from $57.7 billion in 2015 to $75.4 billion in 2022, at a compound annual growth rate (CAGR) of 3.88%. This is due to practical and regulatory barriers to entry for biosimilars that are not present for small molecule generics, and a moderately strong late-stage pipeline. There is a large pharmaceutical pipeline for immunology, consisting of 2,054 products in active development. The majority of pipeline products (73%) are in the early stages of development, at either the Preclinical or Discovery stages, but 96 (5%) are in Phase III.

The key market players, namely AbbVie, Johnson & Johnson, Roche, Amgen and Pfizer, are forecast to maintain their strong market shares throughout the forecast period, despite the fact that many of the approaching patent expiries - especially that of adalimumab, marketed by AbbVie, and Remicade, marketed by Johnson & Johnson - will affect these companies directly.

The report “Global Immunology Drugs Market to 2022 - Increasing Prevalence, Repositioning Opportunities and Strong Uptake of Interleukin Receptor Inhibitors to Drive Growth” focuses on four key indications within immunology: Rheumatoid arthritis, Systemic lupus erythematosus (SLE), Psoriasis and Inflammatory bowel disease.

In particular, this report provides the following analysis -

  • Provides an introduction to immunology therapeutics, including disease epidemiology, symptoms, etiology, pathophysiology, co-morbidities and complications and prognosis.
  • Provides an overview of the immunology therapeutics marketed products landscape, including product profiles of key marketed products and revenue projections for each of these drugs.
  • Analyzes the immunology therapeutics pipeline, detailing, among other parameters, drug distribution by stage of development, molecule type and molecular target, plus an analysis of the key indications in the pipeline. The clinical trial landscape is also examined, with an emphasis on trends in clinical trial failure rates, duration and size.
  • Provides forecast projections to 2022 on a global level, with forecasts provided for the US, plus aggregate revenue forecasts of the top five EU markets (the UK, France, Germany, Italy and Spain) and Japan. Additionally, revenue forecasts for the major product categories and key players are provided.
  • Assesses the company landscape in immunology therapeutics, with an analysis of the key players, the types of company involved in this therapy area and whether this therapy area comprises a large proportion of each company’s pipeline portfolio and total revenues.
  • Analyses trends in co-development and licensing deals relating to therapeutic products in immunology.
Companies mentioned in this report: AbbVie, Johnson & Johnson, Roche, Amgen, Pfizer, Celgene, Takeda, Novartis, Eli Lilly, Bristol-Myers Squibb, UCB, Merck & Co, Regeneron, GlaxoSmithKline, Mallinckrodt, Astellas, Sanofi, Shire, Mitsubishi Tanabe, AstraZeneca, Eisai, Ono, Allergan, Biogen, Swedish Orphan Biovitrum, Valeant, Daiichi Sankyo.

Scope
  • Global revenues for the immunology market are forecast to grow at a compound annual growth rate of 3.63%, from $57.7 billion in 2015 to $74.1 billion in 2022.
  • Which drugs will achieve blockbuster status and how will the key player companies perform during the forecast period?
  • The immunological disorders pipeline is large and diverse, and contains 2,054 products. How does the composition of the pipeline compare with that of the existing market?
  • What molecular targets and molecule types are most commonly being trialed in pipeline products in the key indications?
  • Which products will contribute to market growth most significantly, and which will achieve blockbuster status?
  • Will the current market leaders retain their dominance over the forecast period, and how is their revenue share of the immunology market set to change?
Reasons to buy
  • Understand the current clinical and commercial landscape by considering disease pathogenesis, diagnosis, prognosis, and the treatment options available at each stage of diagnosis
  • Visualize the composition of the immunology market across each indication, in terms of dominant molecule types and targets, highlighting the key commercial assets and players
  • Analyze the immunological disorders pipeline and stratify by stage of development, molecule type and molecular target, with a granular breakdown across key indications
  • Understand the growth in patient epidemiology and market revenues for the immunology market, globally and across the key players and product types
  • Stratify the market in terms of the split between generic and premium products, and assess the role of these product types in the treatment of the various immunological disorders.
  • Identify commercial opportunities in the immunology deals landscape by analyzing trends in licensing and co-development deals


1 Table of Contents
1.1 List of Tables
1.2 List of Figures
2 Introduction
2.1 Therapy Area Introduction
2.1.1 Rheumatoid Arthritis
2.1.2 Systemic Lupus Erythematosus
2.1.3 Psoriasis
2.1.4 Inflammatory Bowel Disease
2.2 Symptoms
2.3 Etiology and Pathophysiology
2.3.1 Pathophysiology
2.4 Epidemiology
2.4.1 Rheumatoid Arthritis
2.4.2 Systemic Lupus Erythematosus
2.4.3 Psoriasis
2.4.4 Inflammatory Bowel Disease
2.5 Co-morbidities and Complications
2.6 Treatment
2.6.1 Rheumatoid Arthritis
2.6.2 Systemic Lupus Erythematosus
2.6.3 Psoriasis
2.6.4 Inflammatory Bowel Disease
3 Key Marketed Products
3.1 Overview
3.2 Humira (adalimumab)
3.3 Enbrel (etanercept)
3.4 Remicade (infliximab)
3.5 Rituxan (rituximab)
3.6 Stelara (ustekinumab)
3.7 Simponi (golimumab)
3.8 Prograf (tacrolimus)
3.9 Cimzia (certolizumab pegol)
3.10 Entyvio (vedolizumab)
3.11 Cosentyx (Secukinumab)
4 Pipeline Landscape Assessment
4.1 Overview
4.2 Pipeline Development Landscape
4.3 Molecular Targets in the Pipeline
4.4 Clinical Trials
4.4.1 Failure Rate by Stage of Development, Indication, Molecule Type and Molecular Target
4.4.2 Clinical Trial Duration by Stage of Development, Indication, Molecule Type and Molecular Target
4.4.3 Clinical Trial Size
4.4.4 Aggregate Clinical Program Size
4.4.5 Assessment of Key Pipeline Products
4.5 Conclusion
5 Multi-scenario Market Forecast to 2022
5.1 Overall Market Size
5.2 Generic Penetration
5.3 Revenue Forecast by Molecular Target
5.3.1 Tumor Necrosis Factor-Alpha
5.3.2 Interleukin Receptor
5.3.3 B and T Lymphocyte Antigens
5.3.4 Janus Kinases
6 Company Analysis and Positioning
6.1 Revenue and Market Share Analysis by Company
6.1.1 AbbVie – Will the Patent Expiration of Humira Cause a Loss in Market Size?
6.1.2 Pfizer – Xeljanz to Overcome Enbrel Revenue Loss
6.1.3 Johnson & Johnson – Steady Market Leader over Forecast Period
6.1.4 Amgen – Will the Patent Expiration of Enbrel Have an Effect on Overall Immunology Revenue?
6.1.5 Roche – Moderate Revenue Loss Expected due to Biosimilar Competition
6.1.6 Eli Lilly – Approval of RA Drug to Drive Revenue
6.1.7 Bristol-Myers Squibb – Will Biosimilar Competition Affect Orencia Revenue?
6.1.8 Celgene – Otezla and Ozanimod Hydrochloride to Become Blockbuster Drugs
6.2 Company Landscape
6.3 Marketed and Pipeline Portfolio Analysis
7 Strategic Consolidations
7.1 Licensing Deals
7.1.1 Deals by Region, Year and Value
7.1.2 Deals by Stage of Development and Value
7.1.3 Deals by Molecule Type, Mechanism of Action and Value
7.1.4 Licensing Deals Valued over $100m
7.2 Co-development Deals
7.2.1 Deals by Region, Year and Value
7.2.2 Deals by Stage of Development and Value
7.2.3 Deals by Molecule Type, Mechanism of Action and Value
7.2.4 Co-development Deals Valued over $100m
8 Appendix
8.1 References
8.2 Table of All Clinical Stage Pipeline Products
8.3 Abbreviations
8.4 Disease List
8.5 Methodology
8.5.1 Coverage
8.5.2 Secondary Research
8.5.3 Market Size and Revenue Forecasts
8.5.4 Pipeline Analysis
8.5.5 Competitive Landscape
8.6 Contact Us
8.7 Disclaimer
1.1 List of Tables
Table 1: Immunology Therapeutics Market, Symptoms of RA, SLE, Psoriasis and IBD
Table 2: Immunology Therapeutics Market, Etiology of RA, SLE, Psoriasis and IBD
Table 3: Immunology, Global, Epidemiology of Inflammatory Immunological Disorders, 2017
Table 4: Immunology Therapeutics Market, Global, Approved Indications for Humira, 2017
Table 5: Immunology Therapeutics Market, Global, Approved Indications for Enbrel, 2017
Table 6: Immunology Therapeutics Market, Global, Approved Indications for Remicade, 2017
Table 7: Immunology Therapeutics Market, Global, Approved Indications for Rituxan, 2017
Table 8: Immunology Therapeutics Market, Global, Approved Indications for Stelara, 2017
Table 9: Immunology Therapeutics Market, Global, Approved Indications for Simponi, 2017
Table 10: Immunology Therapeutics Market, Global, Approved Indications for Prograf, 2017
Table 11: Immunology Therapeutics Market, Global, Approved Indications for Cimzia, 2017
Table 12: Immunology Therapeutics Market, Global, Approved Indications for Entyvio, 2017
Table 13: Immunology Therapeutics Market, Global, Approved Indications for Cosentyx, 2017
Table 14: Immunology, Global, Annual Revenue Forecast for Key Products ($m), 2015–2022
Table 15: Immunology, Global, Usage of Generics Across Key Indications, 2017
Table 16: Immunology Therapeutics Market, Global, Forecast Revenues by Company, 2015–2022
Table 17: Immunology Therapeutics Market, Global, Licensing Deals Valued over $100m, 2006–2016
Table 18: Immunology Therapeutics Market, Global, Co-development Deals Valued over $100m, 2006–2017
1.2 List of Figures
Figure 1: Immunology, Global, Epidemiology Patterns for Rheumatoid Arthritis (‘000), 2016–2023
Figure 2: Immunology, Global, Epidemiology Patterns for Systemic Lupus Erythematosus (‘000), 2016–2023
Figure 3: Immunology, Global, Epidemiology Patterns for Psoriasis (‘000), 2016–2023
Figure 4: Immunology, Global, Epidemiology Patterns for Inflammatory Bowel Disease (‘000), 2016–2023
Figure 5: Immunology, Global, Key Marketed Products and Approved Indications, 2016
Figure 6: Immunology Therapeutics Market, Global, Annual Revenues for Humira ($bn), 2006–2022
Figure 7: Immunology Therapeutics Market, Global, Annual Revenues for Enbrel ($bn), 2006–2022
Figure 8: Immunology Therapeutics Market, Global, Annual Revenues for Remicade ($bn), 2006–2022
Figure 9: Immunology Therapeutics Market, Global, Annual Revenues for Enbrel ($bn), 2006–2022
Figure 10: Immunology Therapeutics Market, Global, Annual Revenues for Stelara ($bn), 2006–2022
Figure 11: Immunology Therapeutics Market, Global, Annual Revenues for Simponi ($bn), 2006–2022
Figure 12: Immunology Therapeutics Market, Global, Annual Revenues for Prograf ($bn), 2006–2022
Figure 13: Immunology Therapeutics Market, Global, Annual Revenues for Cimzia ($bn), 2006–2022
Figure 14: Immunology Therapeutics Market, Global, Annual Revenues for Entyvio ($bn), 2006–2022
Figure 15: Immunology Therapeutics Market, Global, Annual Revenues for Cosentyx ($bn), 2006–2022
Figure 16: Antibacterial Drug Market, Global, Overall Pharmaceutical Industry Pipeline by Therapy Area, 2017
Figure 17: Immunology Therapeutics Market, Global, Pipeline for Immunology by Stage of Development, Molecule Type and Program Type, 2017
Figure 18: Immunology Therapeutics Market, Global, Pipeline for Key Immunology Indications by Stage of Development, 2017
Figure 19: Immunology Therapeutics Market, Global, Pipeline for Key Immunology Indications by Molecule Type, 2017
Figure 20: Immunology Therapeutics Market, Pipeline by Mechanism of Action (%), 2017
Figure 21: Immunology Therapeutics Market, Global, Pipeline for Key Immunology Indications by Molecular Target, 2017
Figure 22: Immunology Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development (%), 2006–2017
Figure 23: Immunology Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development and Indication (%), 2006–2017
Figure 24: Immunology Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development and Molecule Type (%), 2006–2017
Figure 25: Immunology Therapeutics Market, Global, Clinical Trial Attrition Rates by Stage of Development and Molecular Target (%), 2006–2017
Figure 26: Immunology Therapeutics Market, Global, Clinical Trial Duration by Stage of Development (months), 2006–2017
Figure 27: Immunology Therapeutics Market, Global, Clinical Trial Duration by Stage of Development and Indication (months), 2006–2017
Figure 28: Immunology Therapeutics Market, Global, Clinical Trial Duration by Stage of Development and Molecule Type (months), 2006–2017
Figure 29: Immunology Therapeutics Market, Global, Clinical Trial Duration by Stage of Development and Molecular Target (months), 2006–2017
Figure 30: Immunology Therapeutics Market, Global, Clinical Trial Size by Stage of Development (patients), 2006–2017
Figure 31: Immunology Therapeutics Market, Global, Clinical Trial Size by Stage of Development and Indication (participants), 2006–2017
Figure 32: Immunology Therapeutics Market, Global, Clinical Trial Size by Stage of Development and Molecule Type (participants), 2006–2017
Figure 33: Immunology Therapeutics Market, Global, Clinical Trial Size by Stage of Development and Molecular Target (participants), 2006–2017
Figure 34: Immunology Therapeutics Market, Global, Clinical Program Size by Stage of Development (months), 2006–2017
Figure 35: Immunology Therapeutics Market, Global, Clinical Program Size by Stage of Development and Indication (participants), 2006–2017
Figure 36: Immunology Therapeutics Market, Global, Clinical Program Size by Stage of Development and Molecule Type (participants), 2006–2017
Figure 37: Immunology Therapeutics Market, Global, Clinical Program Size by Stage of Development and Molecular Target (participants), 2006–2017
Figure 38: Immunology Therapeutics Market, Global, Revenue Forecast for sarilumab ($bn), 2016–2022
Figure 39: Immunology Therapeutics Market, Global, Revenue Forecast for sirukumab ($m), 2015–2022
Figure 40: Immunology, Global, Annual Revenue Forecast for baricitinib ($bn), 2015–2022
Figure 41: Immunology, Global, Annual Revenue Forecast for upadacitinib ($m), 2015–2022
Figure 42: Immunology, Global, Annual Revenue Forecast for ozanimod ($bn), 2019–2022
Figure 43: Immunology, Global, Market Size ($m), 2015–2022
Figure 44: Immunology, Global, Annual Revenue Forecast for Key Products ($m), 2015–2022
Figure 45: Immunology, Global, Annual Revenue Forecast for Tumor Necrosis Factor-Alpha Inhibitors ($bn), 2015–2022
Figure 46: Immunology, Global, Annual Revenue Forecast for Interleukin Inhibitors ($bn), 2015–2022
Figure 47: Immunology, Global, Annual Revenue Forecast for B and T Lymphocyte Antigens ($bn), 2015–2022
Figure 48: Immunology, Global, Annual Revenue Forecast for Janus Kinases ($bn), 2015–2022
Figure 49: Immunology Therapeutics Market, Global, Cluster by Growth and Market Share, 2015–2022
Figure 50: Immunology Therapeutics Market, Global, Forecast Market Share by Company (%), 2015–2022
Figure 51: Immunology, Global, Companies by Compound Annual Growth Rate (%), 2014–2022
Figure 52: Immunology, Global, Revenues by Product Type, 2015–2022
Figure 53: Immunology, Global, AbbVie Annual Revenue Forecast ($bn), 2015–2022
Figure 54: Immunology, Global, Pfizer Annual Revenue Forecast ($bn), 2015–2022
Figure 55: Immunology, Global, Johnson & Johnson Annual Revenue Forecast ($bn), 2015–2022
Figure 56: Immunology, Global, Amgen Annual Revenue Forecast ($bn), 2015–2022
Figure 57: Immunology, Global, Roche Annual Revenue Forecast ($bn), 2015–2022
Figure 58: Immunology, Global, Eli Lilly Annual Revenue Forecast ($bn), 2015–2022
Figure 59: Immunology, Global, Bristol-Myers Squib Annual Revenue Forecast ($bn), 2015–2022
Figure 60: Immunology, Global, Celgene Annual Revenue Forecast ($bn), 2015–2022
Figure 61: Immunology, Global, Companies by Type, 2017
Figure 62: Immunology, Global, High-Activity and Late-Stage Pipeline Developers by Level of immunology specialization, 2017
Figure 63: Immunology, Global, Proportion of Company Revenue Attributed to immunology, 2015–2022
Figure 64: Immunology, Global, Licensing Deals, 2006–2017
Figure 65: Immunology, Global, Licensing Deals by Indication and Value, 2006–2017
Figure 66: Immunology, Global, Licensing Deals, 2006–2017
Figure 67: Immunology, Global, Licensing Deals by Molecule Type and Mechanism of Action, 2006–2017
Figure 68: Immunology, Global, Co-development Deals, 2006–2017
Figure 69: Immunology, Global, Co-development Deals by Indication and Value, 2006–2017
Figure 70: Immunology, Global, Co-development Deals, 2006–2017
Figure 71: Immunology, Global, Co-development Deals by Molecule Type and Mechanism of Action, 2006–2017
Figure 72: Immunology, Global, Table of all Clinical Stage Pipeline Products, Part I, 2017
Figure 73: Immunology, Global, Table of all Clinical Stage Pipeline Products, Part II, 2017
Figure 74: Immunology, Global, Table of all Clinical Stage Pipeline Products, Part III, 2017
Figure 75: Immunology, Global, Table of all Clinical Stage Pipeline Products, Part IV, 2017

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