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Diarrhea and Constipation Drug Development Pipeline Review, 2018

Diarrhea and Constipation Drug Development Pipeline Review, 2018

Summary


Diarrhea is a contagious gastrointestinal infection occurring mostly due to unhygienic conditions. Diarrhea may be related to a viral or bacterial infection and is sometimes the result of food poisoning. Symptoms include nausea, abdominal pain, cramping, bloating, dehydration, fever, bloody stools, frequent urge to evacuate the bowels and incontinence. There are 54 products in development for this indication and molecular targets present in the pipeline landscape include cystic fibrosis transmembrane conductance regulator and glucagon like peptide 2 receptor.

Constipation refers to the infrequent or difficult passing of stool. Constipation occurs when bowel movements become difficult or less frequent. Symptoms of constipation include swollen abdomen or abdominal pain, pain and vomiting. The predisposing factors include eating disorders, irritable bowel syndrome, and hypothyroidism, overuse of laxatives (stool softeners) which, over time, weaken the bowel muscles, stress, inadequate water intake and inadequate fiber in the diet. There are 25 products in development for this indication and molecular targets present in the pipeline landscape include 5-hydroxytryptamine receptor 4 and heat stable enterotoxin receptor.

Companies operating in this pipeline space include Synthetic Biologics, Allergan and Ardelyx.

This report “Diarrhea and Constipation Drug Development Pipeline Review, 2018”provides an overview of the pipeline landscape for diarrhea and constipation. It provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for diarrhea and constipation, and features dormant and discontinued products.

Scope

  • Which companies are the most active within each pipeline?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in this disease area?
Reasons to buy
  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration


  • GBI Research Report Guidance
  • Executive Summary
  • Introduction
    • Diarrhea and Constipation Report Coverage
    • Constipation – Overview
    • Diarrhea – Overview
  • Therapeutics Development
    • Constipation
      • Pipeline Overview
        • Table Figure 1: Number of Products under Development for Constipation
        • Table Number of Products under Development for Constipation
      • Pipeline by Companies
        • Table Figure 2: Number of Products under Development by Companies, Constipation
        • Table Number of Products under Development by Companies, Constipation
      • Pipeline by Universities/Institutes
        • Table Number of Products under Development by Universities/Institutes, Constipation
      • Products under Development by Companies
        • Table Products under Development by Companies, Constipation
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Constipation
    • Diarrhea
      • Pipeline Overview
        • Table Figure 3: Number of Products under Development for Diarrhea
        • Table Number of Products under Development for Diarrhea
      • Pipeline by Companies
        • Table Figure 4: Number of Products under Development by Companies, Diarrhea
        • Table Number of Products under Development by Companies, Diarrhea
      • Pipeline by Universities/Institutes
        • Table Figure 5: Number of Products under Development by Universities/Institutes, Diarrhea
        • Table Number of Products under Development by Universities/Institutes, Diarrhea
      • Products under Development by Companies
        • Table Products under Development by Companies, Diarrhea
      • Products under Development by Universities/Institutes
        • Table Products under Development by Universities/Institutes, Diarrhea
  • Therapeutics Assessment
    • Constipation
      • Assessment by Target
        • Table Figure 6: Number of Products by Targets, Constipation
        • Table Figure 7: Number of Products by Stage and Targets, Constipation
        • Table Number of Products by Stage and Target, Constipation
      • Assessment by Mechanism of Action
        • Table Figure 8: Number of Products by Top 10 Mechanism of Actions, Constipation
        • Table Figure 9: Number of Products by Stage and Top 10 Mechanism of Actions, Constipation
        • Table Number of Products by Stage and Mechanism of Action, Constipation
      • Assessment by Route of Administration
        • Table Figure 10: Number of Products by Routes of Administration, Constipation
        • Table Figure 11: Number of Products by Stage and Routes of Administration, Constipation
        • Table Number of Products by Stage and Route of Administration, Constipation
      • Assessment by Molecule Type
        • Table Figure 12: Number of Products by Molecule Types, Constipation
        • Table Figure 13: Number of Products by Stage and Molecule Types, Constipation
        • Table Number of Products by Stage and Molecule Type, Constipation
    • Diarrhea
      • Assessment by Target
        • Table Figure 14: Number of Products by Top 10 Targets, Diarrhea
        • Table Figure 15: Number of Products by Stage and Top 10 Targets, Diarrhea
        • Table Number of Products by Stage and Target, Diarrhea
      • Assessment by Mechanism of Action
        • Table Figure 16: Number of Products by Top 10 Mechanism of Actions, Diarrhea
        • Table Figure 17: Number of Products by Stage and Top 10 Mechanism of Actions, Diarrhea
        • Table Number of Products by Stage and Mechanism of Action, Diarrhea
      • Assessment by Route of Administration
        • Table Figure 18: Number of Products by Routes of Administration, Diarrhea
        • Table Figure 19: Number of Products by Stage and Routes of Administration, Diarrhea
        • Table Number of Products by Stage and Route of Administration, Diarrhea
      • Assessment by Molecule Type
        • Table Figure 20: Number of Products by Top 10 Molecule Types, Diarrhea
        • Table Figure 21: Number of Products by Stage and Top 10 Molecule Types, Diarrhea
        • Table Number of Products by Stage and Molecule Type, Diarrhea
  • Companies Involved in Therapeutics Development
    • Constipation
      • Allergan Plc
        • Table Constipation – Pipeline by Allergan Plc
      • Ardelyx Inc
        • Table Constipation – Pipeline by Ardelyx Inc
      • Braintree Laboratories Inc
        • Table Constipation – Pipeline by Braintree Laboratories Inc
      • Dong-A ST Co Ltd
        • Table Constipation – Pipeline by Dong-A ST Co Ltd
      • EA Pharma Co Ltd
        • Table Constipation – Pipeline by EA Pharma Co Ltd
      • Ironwood Pharmaceuticals Inc
        • Table Constipation – Pipeline by Ironwood Pharmaceuticals Inc
      • Johnson & Johnson
        • Table Constipation – Pipeline by Johnson & Johnson
      • MallInckrodt Plc
        • Table Constipation – Pipeline by MallInckrodt Plc
      • NGM Biopharmaceuticals Inc
        • Table Constipation – Pipeline by NGM Biopharmaceuticals Inc
      • RaQualia Pharma Inc
        • Table Constipation – Pipeline by RaQualia Pharma Inc
      • Sanwa Kagaku Kenkyusho Co Ltd
        • Table Constipation – Pipeline by Sanwa Kagaku Kenkyusho Co Ltd
      • SK Biopharmaceuticals Co Ltd
        • Table Constipation – Pipeline by SK Biopharmaceuticals Co Ltd
      • Sumitomo Dainippon Pharma Co Ltd
        • Table Constipation – Pipeline by Sumitomo Dainippon Pharma Co Ltd
      • Synthetic Biologics Inc
        • Table Constipation – Pipeline by Synthetic Biologics Inc
      • Vanda Pharmaceuticals Inc
        • Table Constipation – Pipeline by Vanda Pharmaceuticals Inc
      • Yuhan Corp
        • Table Constipation – Pipeline by Yuhan Corp
      • Zensun (Shanghai) Sci & Tech Co Ltd
        • Table Constipation – Pipeline by Zensun (Shanghai) Sci & Tech Co Ltd
    • Diarrhea
      • Aegis Therapeutics LLC
        • Table Diarrhea – Pipeline by Aegis Therapeutics LLC
      • Akthelia Pharmaceuticals Ltd
        • Table Diarrhea – Pipeline by Akthelia Pharmaceuticals Ltd
      • Albireo Pharma Inc
        • Table Diarrhea – Pipeline by Albireo Pharma Inc
      • Allergan Plc
        • Table Diarrhea – Pipeline by Allergan Plc
      • Ardelyx Inc
        • Table Diarrhea – Pipeline by Ardelyx Inc
      • AzurRx BioPharma Inc
        • Table Diarrhea – Pipeline by AzurRx BioPharma Inc
      • Bharat Biotech Ltd
        • Table Diarrhea – Pipeline by Bharat Biotech Ltd
      • Chongqing Zhifei Biological Products Co Ltd
        • Table Diarrhea – Pipeline by Chongqing Zhifei Biological Products Co Ltd
      • Cosmo Pharmaceuticals NV
        • Table Diarrhea – Pipeline by Cosmo Pharmaceuticals NV
      • DiscoveryBiomed Inc
        • Table Diarrhea – Pipeline by DiscoveryBiomed Inc
      • Ferring International Center SA
        • Table Diarrhea – Pipeline by Ferring International Center SA
      • GP Pharm SA
        • Table Diarrhea – Pipeline by GP Pharm SA
      • Kuhnil Pharmaceutical Co Ltd
        • Table Diarrhea – Pipeline by Kuhnil Pharmaceutical Co Ltd
      • Metacrine Inc
        • Table Diarrhea – Pipeline by Metacrine Inc
      • Miyarisan Pharmaceutical Company Ltd
        • Table Diarrhea – Pipeline by Miyarisan Pharmaceutical Company Ltd
      • Napo Pharmaceuticals Inc
        • Table Diarrhea – Pipeline by Napo Pharmaceuticals Inc
      • Nippon Shinyaku Co Ltd
        • Table Diarrhea – Pipeline by Nippon Shinyaku Co Ltd
      • Novartis AG
        • Table Diarrhea – Pipeline by Novartis AG
      • Pfizer Inc
        • Table Diarrhea – Pipeline by Pfizer Inc
      • Prokarium Ltd
        • Table Diarrhea – Pipeline by Prokarium Ltd
      • Protagonist Therapeutics Inc
        • Table Diarrhea – Pipeline by Protagonist Therapeutics Inc
      • RaQualia Pharma Inc
        • Table Diarrhea – Pipeline by RaQualia Pharma Inc
      • RedHill Biopharma Ltd
        • Table Diarrhea – Pipeline by RedHill Biopharma Ltd
      • RxBio Inc
        • Table Diarrhea – Pipeline by RxBio Inc
      • Scandinavian Biopharma Holding AB
        • Table Diarrhea – Pipeline by Scandinavian Biopharma Holding AB
      • Sublimity Therapeutics Ltd
        • Table Diarrhea – Pipeline by Sublimity Therapeutics Ltd
      • Summit Therapeutics Plc
        • Table Diarrhea – Pipeline by Summit Therapeutics Plc
      • Synthetic Biologics Inc
        • Table Diarrhea – Pipeline by Synthetic Biologics Inc
      • Syntiron LLC
        • Table Diarrhea – Pipeline by Syntiron LLC
      • Tasly Pharmaceutical Group Co Ltd
        • Table Diarrhea – Pipeline by Tasly Pharmaceutical Group Co Ltd
      • Wuhan Institute of Biological Products Co Ltd
        • Table Diarrhea – Pipeline by Wuhan Institute of Biological Products Co Ltd
      • Zealand Pharma AS
        • Table Diarrhea – Pipeline by Zealand Pharma AS
  • Dormant Projects
    • Constipation
      • Table Constipation – Dormant Projects
    • Diarrhea
      • Table Diarrhea – Dormant Projects
  • Discontinued Products
    • Constipation
      • Table Constipation – Discontinued Products
    • Diarrhea
      • Table Diarrhea – Discontinued Products
  • Product Development Milestones
    • Constipation
      • Featured News & Press Releases
    • Diarrhea
      • Featured News & Press Releases
  • Appendix
    • Methodology
    • Coverage
    • Secondary Research
    • Primary Research
    • Expert Panel Validation
    • Contact Us
    • Disclaimer

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