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CNS Cluster Addiction Drug Development Pipeline Review, 2017

CNS Cluster Addiction Drug Development Pipeline Review, 2017

Summary


This report provides an overview of the CNS Clusters pipeline landscape. The report provides comprehensive information on the therapeutics under development, and key players involved in therapeutic development for Alcohol Addiction, Drug Addiction, Nicotine Addiction, Opium (Opioid) Addiction and features dormant and discontinued projects.

Alcohol addiction refers to a psychological and physical dependency on alcohol. Symptoms include decreased involvement in extracurricular activities, depression, restlessness, inability to control drinking and violent behavior. There are a total of 38 products in development for this indication, by 29 companies and five academic institutions. Key companies operating in this pipeline space include Abbvie, Astraea Therapeutics, Lochola Research and SK Biopharmaceuticals.

Drug addiction, also called substance dependence or chemical dependency, is a disease that is characterized by a destructive pattern of drug abuse that leads to significant problems involving tolerance to or withdrawal from the substance. There are a total of 67 products in development for this indication, by 38 companies and 16 academic institutions. Key companies operating in this pipeline space include Astraea Therapeutics, Addex therapeutics, The University of Kansas, Embera NeuroTherapeutics, InterveXion Therapeutics, Omeros, Opiant Pharmaceuticals and Orexigen Therapeutics.

Nicotine addiction also called tobacco dependence is an addiction to tobacco products caused by the drug nicotine. There are a total of 19 products in development for this indication, by 13 companies and 5 academic institutions. The majority of companies are developing single pipeline program in this space, while Omeros are developing two.

Finally, opioid addiction develops after using opioids regularly for a period of time. Prolonged use of opiates can lead to nerve damage within the brain that causes cells to stop producing endogenous opiates (natural painkillers known as endorphins). There are a total of 33 products in development for this indication, by 23 companies and three academic institutions. Key companies operating in this pipeline space include Indivior, INSYS Therapeutics, Omeros, Pfizer and Zynerba Pharmaceuticals.

There is a substantial degree of overlap between these indications in terms of the types of molecular target which are being studied. The mu and kappa-opioid receptors are the dominant molecular target across alcohol, drug and opioid addiction, and other neurotransmitter receptors such as the cannabinoid and dopamine receptors are common molecular targets across the three. In contrast, while such neurotransmitter receptors are present in the nicotine addiction pipeline, the opioid receptors are not, and the dominant molecular target is the orexin receptor type 1.

Scope

  • Which companies are the most active within the pipeline for addiction therapeutics?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have happened in the field of addiction therapeutics?
Reasons to buy
  • Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
  • Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
  • Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
  • Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration


  • GBI Research Report Guidance
  • Executive Summary
  • Introduction
    • CNS Cluster Addiction Report Coverage
    • Alcohol Addiction - Overview
    • Drug Addiction - Overview
    • Nicotine Addiction - Overview
    • Opium (Opioid) Addiction - Overview
  • Therapeutics Development
    • Alcohol Addiction
      • Table Figure 1: Number of Products under Development for Alcohol Addiction
      • Table Number of Products under Development for Alcohol Addiction
      • Table Figure 2: Number of Products under Development by Companies, Alcohol Addiction
      • Table Number of Products under Development by Companies, Alcohol Addiction
      • Table Figure 3: Number of Products under Development by Universities/Institutes, Alcohol Addiction
      • Table Number of Products under Development by Universities/Institutes, Alcohol Addiction
      • Table Products under Development by Companies, Alcohol Addiction
      • Table Products under Development by Universities/Institutes, Alcohol Addiction
    • Drug Addiction
      • Table Figure 4: Number of Products under Development for Drug Addiction
      • Table Number of Products under Development for Drug Addiction
      • Table Figure 5: Number of Products under Development by Companies, Drug Addiction
      • Table Number of Products under Development by Companies, Drug Addiction
      • Table Figure 6: Number of Products under Development by Universities/Institutes, Drug Addiction
      • Table Number of Products under Development by Universities/Institutes, Drug Addiction
      • Table Products under Development by Companies, Drug Addiction
      • Table Products under Development by Universities/Institutes, Drug Addiction
    • Nicotine Addiction
      • Table Figure 7: Number of Products under Development for Nicotine Addiction
      • Table Number of Products under Development for Nicotine Addiction
      • Table Figure 8: Number of Products under Development by Companies, Nicotine Addiction
      • Table Number of Products under Development by Companies, Nicotine Addiction
      • Table Number of Products under Development by Universities/Institutes, Nicotine Addiction
      • Table Products under Development by Companies, Nicotine Addiction
      • Table Products under Development by Universities/Institutes, Nicotine Addiction
    • Opium (Opioid) Addiction
      • Table Figure 9: Number of Products under Development for Opium (Opioid) Addiction
      • Table Number of Products under Development for Opium (Opioid) Addiction
      • Table Figure 10: Number of Products under Development by Companies, Opium (Opioid) Addiction
      • Table Number of Products under Development by Companies, Opium (Opioid) Addiction
      • Table Figure 11: Number of Products under Development by Universities/Institutes, Opium (Opioid) Addiction
      • Table Number of Products under Development by Universities/Institutes, Opium (Opioid) Addiction
      • Table Products under Development by Companies, Opium (Opioid) Addiction
      • Table Products under Development by Universities/Institutes, Opium (Opioid) Addiction
  • Therapeutics Assessment
    • Alcohol Addiction
      • Table Figure 12: Number of Products by Top 10 Targets, Alcohol Addiction
      • Table Figure 13: Number of Products by Stage and Top 10 Targets, Alcohol Addiction
      • Table Number of Products by Stage and Target, Alcohol Addiction
      • Table Figure 14: Number of Products by Top 10 Mechanism of Actions, Alcohol Addiction
      • Table Figure 15: Number of Products by Stage and Top 10 Mechanism of Actions, Alcohol Addiction
      • Table Number of Products by Stage and Mechanism of Action, Alcohol Addiction
      • Table Figure 16: Number of Products by Routes of Administration, Alcohol Addiction
      • Table Figure 17: Number of Products by Stage and Routes of Administration, Alcohol Addiction
      • Table Number of Products by Stage and Route of Administration, Alcohol Addiction
      • Table Figure 18: Number of Products by Molecule Types, Alcohol Addiction
      • Table Figure 19: Number of Products by Stage and Molecule Types, Alcohol Addiction
      • Table Number of Products by Stage and Molecule Type, Alcohol Addiction
    • Drug Addiction
      • Table Figure 20: Number of Products by Top 10 Targets, Drug Addiction
      • Table Figure 21: Number of Products by Stage and Top 10 Targets, Drug Addiction
      • Table Number of Products by Stage and Target, Drug Addiction
      • Table Figure 22: Number of Products by Top 10 Mechanism of Actions, Drug Addiction
      • Table Figure 23: Number of Products by Stage and Top 10 Mechanism of Actions, Drug Addiction
      • Table Number of Products by Stage and Mechanism of Action, Drug Addiction
      • Table Figure 24: Number of Products by Routes of Administration, Drug Addiction
      • Table Figure 25: Number of Products by Stage and Routes of Administration, Drug Addiction
      • Table Number of Products by Stage and Route of Administration, Drug Addiction
      • Table Figure 26: Number of Products by Molecule Types, Drug Addiction
      • Table Figure 27: Number of Products by Stage and Molecule Types, Drug Addiction
      • Table Number of Products by Stage and Molecule Type, Drug Addiction
    • Nicotine Addiction
      • Table Figure 28: Number of Products by Top 10 Targets, Nicotine Addiction
      • Table Figure 29: Number of Products by Stage and Top 10 Targets, Nicotine Addiction
      • Table Number of Products by Stage and Target, Nicotine Addiction
      • Table Figure 30: Number of Products by Top 10 Mechanism of Actions, Nicotine Addiction
      • Table Figure 31: Number of Products by Stage and Top 10 Mechanism of Actions, Nicotine Addiction
      • Table Number of Products by Stage and Mechanism of Action, Nicotine Addiction
      • Table Figure 32: Number of Products by Stage and Routes of Administration, Nicotine Addiction
      • Table Number of Products by Stage and Route of Administration, Nicotine Addiction
      • Table Figure 33: Number of Products by Molecule Types, Nicotine Addiction
      • Table Figure 34: Number of Products by Stage and Molecule Types, Nicotine Addiction
      • Table Number of Products by Stage and Molecule Type, Nicotine Addiction
    • Opium (Opioid) Addiction
      • Table Figure 35: Number of Products by Top 10 Targets, Opium (Opioid) Addiction
      • Table Figure 36: Number of Products by Stage and Top 10 Targets, Opium (Opioid) Addiction
      • Table Number of Products by Stage and Target, Opium (Opioid) Addiction
      • Table Figure 37: Number of Products by Top 10 Mechanism of Actions, Opium (Opioid) Addiction
      • Table Figure 38: Number of Products by Stage and Top 10 Mechanism of Actions, Opium (Opioid) Addiction
      • Table Number of Products by Stage and Mechanism of Action, Opium (Opioid) Addiction
      • Table Figure 39: Number of Products by Routes of Administration, Opium (Opioid) Addiction
      • Table Figure 40: Number of Products by Stage and Routes of Administration, Opium (Opioid) Addiction
      • Table Number of Products by Stage and Route of Administration, Opium (Opioid) Addiction
      • Table Figure 41: Number of Products by Molecule Types, Opium (Opioid) Addiction
      • Table Figure 42: Number of Products by Stage and Molecule Types, Opium (Opioid) Addiction
      • Table Number of Products by Stage and Molecule Type, Opium (Opioid) Addiction
  • Companies Involved in Therapeutics Development
    • Alcohol Addiction
      • Table Alcohol Addiction - Pipeline by AbbVie Inc
      • Table Alcohol Addiction - Pipeline by Addex Therapeutics Ltd
      • Table Alcohol Addiction - Pipeline by Adial Pharmaceuticals LLC
      • Table Alcohol Addiction - Pipeline by Astraea Therapeutics LLC
      • Table Alcohol Addiction - Pipeline by BioCorRx Inc
      • Table Alcohol Addiction - Pipeline by Bionex Pharmaceuticals LLC
      • Table Alcohol Addiction - Pipeline by Bioprojet SCR
      • Table Alcohol Addiction - Pipeline by Cerecor Inc
      • Table Alcohol Addiction - Pipeline by Chronos Therapeutics Ltd
      • Table Alcohol Addiction - Pipeline by Corcept Therapeutics Inc
      • Table Alcohol Addiction - Pipeline by Curemark LLC
      • Table Alcohol Addiction - Pipeline by Eli Lilly and Company
      • Table Alcohol Addiction - Pipeline by Ethypharm SA
      • Table Alcohol Addiction - Pipeline by Euthymics Bioscience Inc
      • Table Alcohol Addiction - Pipeline by H. Lundbeck A/S
      • Table Alcohol Addiction - Pipeline by Heptares Therapeutics Ltd
      • Table Alcohol Addiction - Pipeline by Indivior Plc
      • Table Alcohol Addiction - Pipeline by Kinnov Therapeutics SAS
      • Table Alcohol Addiction - Pipeline by Kyorin Pharmaceutical Co Ltd
      • Table Alcohol Addiction - Pipeline by Lohocla Research Corp
      • Table Alcohol Addiction - Pipeline by Omeros Corp
      • Table Alcohol Addiction - Pipeline by Pfizer Inc
      • Table Alcohol Addiction - Pipeline by Savant HWP Inc
      • Table Alcohol Addiction - Pipeline by SK Biopharmaceuticals Co Ltd
      • Table Alcohol Addiction - Pipeline by Tonix Pharmaceuticals Holding Corp
      • Table Alcohol Addiction - Pipeline by VM Discovery Inc
      • Table Alcohol Addiction - Pipeline by XenoPort Inc
      • Table Alcohol Addiction - Pipeline by Zynerba Pharmaceuticals Inc
    • Drug Addiction
      • Table Drug Addiction - Pipeline by Addex Therapeutics Ltd
      • Table Drug Addiction - Pipeline by Aelis Farma SAS
      • Table Drug Addiction - Pipeline by Aphios Corp
      • Table Drug Addiction - Pipeline by Astraea Therapeutics LLC
      • Table Drug Addiction - Pipeline by BioCorRx Inc
      • Table Drug Addiction - Pipeline by Cerecor Inc
      • Table Drug Addiction - Pipeline by Chiesi Farmaceutici SpA
      • Table Drug Addiction - Pipeline by Curemark LLC
      • Table Drug Addiction - Pipeline by Embera NeuroTherapeutics Inc
      • Table Drug Addiction - Pipeline by F. Hoffmann-La Roche Ltd
      • Table Drug Addiction - Pipeline by Foresee Pharmaceuticals LLC
      • Table Drug Addiction - Pipeline by Heptares Therapeutics Ltd
      • Table Drug Addiction - Pipeline by Immunovaccine Inc
      • Table Drug Addiction - Pipeline by Indivior Plc
      • Table Drug Addiction - Pipeline by InterveXion Therapeutics LLC
      • Table Drug Addiction - Pipeline by Intra-Cellular Therapies Inc
      • Table Drug Addiction - Pipeline by Kyorin Pharmaceutical Co Ltd
      • Table Drug Addiction - Pipeline by Kyowa Hakko Kirin Co Ltd
      • Table Drug Addiction - Pipeline by MedRev Pharma
      • Table Drug Addiction - Pipeline by NLS Pharma Group
      • Table Drug Addiction - Pipeline by Omeros Corp
      • Table Drug Addiction - Pipeline by Opiant Pharmaceuticals Inc
      • Table Drug Addiction - Pipeline by Orexigen Therapeutics Inc
      • Table Drug Addiction - Pipeline by P2D Bioscience
      • Table Drug Addiction - Pipeline by Saniona AB
      • Table Drug Addiction - Pipeline by Savant HWP Inc
      • Table Drug Addiction - Pipeline by Stada Arzneimittel AG
      • Table Drug Addiction - Pipeline by Teva Pharmaceutical Industries Ltd
      • Table Drug Addiction - Pipeline by Zynerba Pharmaceuticals Inc
    • Nicotine Addiction
      • Table Nicotine Addiction - Pipeline by Addex Therapeutics Ltd
      • Table Nicotine Addiction - Pipeline by Astraea Therapeutics LLC
      • Table Nicotine Addiction - Pipeline by C4X Discovery Holdings PLC
      • Table Nicotine Addiction - Pipeline by Chronos Therapeutics Ltd
      • Table Nicotine Addiction - Pipeline by CV Sciences Inc
      • Table Nicotine Addiction - Pipeline by Hager Biosciences LLC
      • Table Nicotine Addiction - Pipeline by Heptares Therapeutics Ltd
      • Table Nicotine Addiction - Pipeline by Omeros Corp
      • Table Nicotine Addiction - Pipeline by Savant HWP Inc
    • Opium (Opioid) Addiction
      • Table Opium (Opioid) Addiction - Pipeline by Alkermes Plc
      • Table Opium (Opioid) Addiction - Pipeline by Aoxing Pharmaceutical Company Inc
      • Table Opium (Opioid) Addiction - Pipeline by Aquilus Pharmaceuticals Inc
      • Table Opium (Opioid) Addiction - Pipeline by BioCorRx Inc
      • Table Opium (Opioid) Addiction - Pipeline by BioDelivery Sciences International Inc
      • Table Opium (Opioid) Addiction - Pipeline by Camurus AB
      • Table Opium (Opioid) Addiction - Pipeline by Foresee Pharmaceuticals LLC
      • Table Opium (Opioid) Addiction - Pipeline by Heron Therapeutics Inc
      • Table Opium (Opioid) Addiction - Pipeline by Indivior Plc
      • Table Opium (Opioid) Addiction - Pipeline by INSYS Therapeutics Inc
      • Table Opium (Opioid) Addiction - Pipeline by Omeros Corp
      • Table Opium (Opioid) Addiction - Pipeline by Opiant Pharmaceuticals Inc
      • Table Opium (Opioid) Addiction - Pipeline by Orexigen Therapeutics Inc
      • Table Opium (Opioid) Addiction - Pipeline by Orexo AB
      • Table Opium (Opioid) Addiction - Pipeline by Pfizer Inc
      • Table Opium (Opioid) Addiction - Pipeline by Relmada Therapeutics Inc
      • Table Opium (Opioid) Addiction - Pipeline by Savant HWP Inc
      • Table Opium (Opioid) Addiction - Pipeline by Teva Pharmaceutical Industries Ltd
      • Table Opium (Opioid) Addiction - Pipeline by Titan Pharmaceuticals Inc
      • Table Opium (Opioid) Addiction - Pipeline by Zynerba Pharmaceuticals Inc
  • Dormant Projects
    • Alcohol Addiction
      • Table Alcohol Addiction - Dormant Projects
    • Drug Addiction
      • Table Drug Addiction - Dormant Projects
    • Nicotine Addiction
      • Table Nicotine Addiction - Dormant Projects
    • Opium (Opioid) Addiction
      • Table Opium (Opioid) Addiction - Dormant Projects
  • Discontinued Products
    • Alcohol Addiction
      • Table Alcohol Addiction - Discontinued Products
    • Drug Addiction
      • Table Drug Addiction - Discontinued Products
    • Nicotine Addiction
      • Table Nicotine Addiction - Discontinued Products
    • Opium (Opioid) Addiction
      • Table Opium (Opioid) Addiction - Discontinued Products
  • Product Development Milestones
    • Alcohol Addiction
    • Drug Addiction
    • Nicotine Addiction
    • Opium (Opioid) Addiction
  • Appendix
    • Methodology
    • Coverage
    • Secondary Research
    • Primary Research
    • Expert Panel Validation
    • Contact Us
    • Disclaimer

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