A Global Product and Pipeline Analysis of Antiretroviral Drug Development for the Treatment of HIV/AIDS
Human Immunodeficiency Virus (HIV) Antiretrovirals
The 2006 launch of Atripla, the first single-tablet regimen (STR) for the treatment of HIV infection, marked an important advancement in antiretroviral therapy (ART), significantly enhancing efficacy and reducing pill burden. Research has continued to build on this innovation, and patients now have at their disposal a number of STRs that are highly effective and have good tolerability. Researchers are seeking to develop novel antiretroviral combinations that have a high barrier to resistance and a low cross-resistance with existing drugs, and that are easy to administer (ideally once-daily dosing).
Given the advancements in treatment, viral breakthrough is not uncommon. Keys to maintaining viral suppression are patient adherence, strategically guided treatment choices, and novel drug development.
Promising candidates in late trials include Tobira Therapeutics’ cenicriviroc with novel anti-inflammatory effects, and Gilead’s tenofovir alafenamide (TAF), which could overcome the safety concerns associated with tenofovir.
About this report
This research service focuses on antiviral/antiretroviral therapeutics for the treatment of HIV/AIDS. A product and pipeline assessment is provided for marketed and investigational products and combination regimens for the treatment of HIV infection. Segmentation by drug class is provided along with additional supporting information such as clinical trial timelines and results, historical and projected launch timelines, and global prevalence by region and country. Key market developments since Q1 2013 and key companies to watch are also included. This research service is an update of the 2013 research service titled Strategic Analysis of Antiviral Drug Development for Viral Hepatitis and HIV/AIDS.
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