Non-cystic Fibrosis Bronchiectasis (NCFB) – Pipeline Insight, 2020

DelveInsight’s, “Non-cystic Fibrosis Bronchiectasis (NCFB) – Pipeline Insight, 2020,” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Non-cystic Fibrosis Bronchiectasis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
• Global coverage
Non-cystic Fibrosis Bronchiectasis Understanding
Non-cystic Fibrosis Bronchiectasis (NCFB): Overview
Non‐cystic fibrosis bronchiectasis (NCFB) is a chronic, progressive respiratory disorder characterized by irreversibly and abnormally dilated airways, persistent cough, excessive sputum production and recurrent pulmonary infections. The changes in the bronchial walls may be due to chronic inflammation secondary to recurrent or chronic infections in the lung, but often the exact cause is not identified.1 Symptoms vary from intermittent episodes of respiratory infections with excessive mucus production to chronic symptoms with persistent daily expectoration of purulent sputum. Non‐cystic fibrosis bronchiectasis is associated with comorbidities such as anxiety, depression, fatigue, and has a significant impact on quality of life.
Symptoms
Symptoms include chronic (lasting more than four weeks) wet or productive cough, shortness of breath, abnormal chest sounds, weakness, weight loss and fatigue. Recurrent chest infections may produce coloured mucus. A chronic wet cough is often the only symptom present for some children with bronchiectasis.
Diagnosis
Bronchiectasis is diagnosed via a chest computed tomography (CT) scan. A chest X-ray, bronchoscopy, lung function, blood tests, sputum culture, and other tests (e.g. immune function, sweat test and genetics) for associated diseases may also be performed.
Treatment
Treatment requires a multi-disciplinary approach with regular reviews. The aim is to control symptoms, improve quality of life and prevent disease progression. Treatment includes:
• Early use of antibiotics for acute flare-ups or epsiodes
• Daily airway clearance techniques (chest physiotherapy – see below)
• Appropriate vaccinations
• Avoiding irritants such as cigarette smoke
• Bronchodilators (only if asthma is also present)
Non-cystic Fibrosis Bronchiectasis Emerging Drugs Chapters
This segment of the Non-cystic Fibrosis Bronchiectasis report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Non-cystic Fibrosis Bronchiectasis Emerging Drugs
• CHF 6333: Chiesi Farmaceutici
CHF 6333 is a medicinal product on development for the treatment of cystic fibrosis and non-CF bronchiectasis and undergoing clinical testing. It has not yet been approved by the authorities for the treatment of these diseases. CHF6333 is an inhaled anti-inflammatory which mechanism of action is based on the inhibition of Human Neutrofil Elastase.
Further product details are provided in the report……..
Non-cystic Fibrosis Bronchiectasis: Therapeutic Assessment
This segment of the report provides insights about the different Non-cystic Fibrosis Bronchiectasis drugs segregated based on following parameters that define the scope of the report, such as:
• Major Players in Non-cystic Fibrosis Bronchiectasis
There are approx. 5+ key companies which are developing the therapies for Non-cystic Fibrosis Bronchiectasis. The companies which have their Non-cystic Fibrosis Bronchiectasis drug candidates in mid to early stage, i.e. Phase II and I include, Chiesi Farmaceutici, Insmed etc.
Phases
DelveInsight’s report covers around 5+ products under different phases of clinical development like
• Mid-stage products (Phase II and Phase I/II)
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

• Route of Administration
Non-cystic Fibrosis Bronchiectasis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
• Oral
• Intravenous
• Molecule Type

Products have been categorized under various Molecule types such as
• Small molecules

• Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Non-cystic Fibrosis Bronchiectasis: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Non-cystic Fibrosis Bronchiectasis therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Non-cystic Fibrosis Bronchiectasis drugs.

Report Highlights
• The companies and academics are working to assess challenges and seek opportunities that could influence Non-cystic Fibrosis Bronchiectasis R&D. The therapies under development are focused on novel approaches to treat/improve Non-cystic Fibrosis Bronchiectasis.
• September 2020: US biotech Insmed has trumpeted updated phase 2 data from its brensocatib, at this week’s virtual European Respiratory Society conference, showing the drug prolonged time to exacerbations caused by the rare lung disease known as non-cystic fibrosis bronchiectasis (NCFBE).
The results, also published in the New England Journal of Medicine, showed that brensocatib significantly prolonged time to first pulmonary exacerbation, the primary endpoint, over the 24-week treatment period for both treatment doses versus placebo.
Non-cystic Fibrosis Bronchiectasis Report Insights
• Non-cystic Fibrosis Bronchiectasis Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs
Non-cystic Fibrosis Bronchiectasis Report Assessment
• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions
Current Treatment Scenario and Emerging Therapies:
• How many companies are developing Non-cystic Fibrosis Bronchiectasis drugs?
• How many Non-cystic Fibrosis Bronchiectasis drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Non-cystic Fibrosis Bronchiectasis?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Non-cystic Fibrosis Bronchiectasis therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Non-cystic Fibrosis Bronchiectasis and their status?
• What are the key designations that have been granted to the emerging drugs?
Key Players
• Chiesi Farmaceutici
• AstraZeneca/Insmed
Key Products
• CHF 6333
• Brensocatib

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Introduction
Executive Summary
Non-cystic Fibrosis Bronchiectasis: Overview
• Causes
• Mechanism of Action
• Signs and Symptoms
• Diagnosis
• Disease Management
Pipeline Therapeutics
• Comparative Analysis
Therapeutic Assessment
• Assessment by Product Type
• Assessment by Stage and Product Type
• Assessment by Route of Administration
• Assessment by Stage and Route of Administration
• Assessment by Molecule Type
• Assessment by Stage and Molecule Type
Non-cystic Fibrosis Bronchiectasis – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
• Non-cystic Fibrosis Bronchiectasis companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Non-cystic Fibrosis Bronchiectasis Collaboration Deals
• Company-Company Collaborations (Licensing / Partnering) Analysis
• Company-University Collaborations (Licensing / Partnering) Analysis
Mid Stage Products (Phase II)
• Comparative Analysis
Brensocatib: Insmed
• Product Description
• Research and Development
• Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
• Comparative Analysis
CHF-6333: Chiesi Farmaceutici
• Product Description
• Research and Development
• Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
• Comparative Analysis
• Product Description
• Research and Development
• Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
• Comparative Analysis
Non-cystic Fibrosis Bronchiectasis Key Companies
Non-cystic Fibrosis Bronchiectasis Key Products
Non-cystic Fibrosis Bronchiectasis- Unmet Needs
Non-cystic Fibrosis Bronchiectasis- Market Drivers and Barriers
Non-cystic Fibrosis Bronchiectasis- Future Perspectives and Conclusion
Non-cystic Fibrosis Bronchiectasis Analyst Views
Non-cystic Fibrosis Bronchiectasis Key Companies
Appendix
Table 1 Total Products for Non-cystic Fibrosis Bronchiectasis
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
Figure 1 Total Products for Non-cystic Fibrosis Bronchiectasis
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products

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