Global Paraganglioma Treatment Market - 2020-2027
The Global Paraganglioma Treatment Market size was worth US$ XX billion in 2018 and is estimated to reach US$ XX billion by 2027, growing at a CAGR of XX % during the forecast period (2020-2027).
Paraganglioma is a neuroendocrine tumor that forms near certain blood vessels and nerves outside of the adrenal glands. The adrenal glands are essential for making hormones that control many functions in the body and are located on top of the kidneys, and the nerve cells involved in paraganglioma are part of the peripheral nervous system. These tumors can also be called Extra-adrenal pheochromocytomas. Approximately 35-50% of paragangliomas may spread to other parts of the body. It is most often found in people aged 30 to 50 years old. Some signs and symptoms of paraganglioma occur when too much adrenaline or noradrenaline is released into the blood are High blood pressure, Headache, Heavy sweating for no known reason, A strong, fast, or irregular heartbeat, being shaky, Being extremely pale. The treatment includes Surgery, Radiation therapy, Chemotherapy, Ablation therapy, Embolization therapy, Targeted therapy. The market is expected to drive in the future due to the increasing prevalence rate of rare cancers.
The global Paraganglioma Treatment market growth is driven by the growing prevalance of paraganglioma cases, rapidly changing life style, growing number of clinical trials of drugs and continuous advancements in novel treatments, Rising healthcare expenditure are the major factors driving the market.
Increase Prevalence of Paraganglioma Cancers, is expected to drive the market during the forecast period.
As per the National Library of Medicine, it is estimated that the prevalence of pheochromocytoma is 1 in 500,000 people, and the prevalence of other paragangliomas is 1 in 1 million people. These statistics include syndromic and non-syndromic paraganglioma and pheochromocytoma.
Increased Drug approvals, is expected to drive the market during the forecast period.
Enterome is a clinical-stage company conducting a Phase 1/2 Trial of a Novel Therapeutic Vaccine (EO2401) in Combination with Immune Check Point Blockade (nivolumab) Treatment of Patients with Locally Advanced or Metastatic Malignant Pheochromocytoma/Paraganglioma.
Molecular Insight Pharmaceuticals, Inc got approval for marketing by conducting a study on expanded access of AZEDRA (Ultratrace Iobenguane I 131) and to evaluate the safety and tolerability of AZEDRA in subjects with iobenguane-avid malignant and recurrent pheochromocytoma/paraganglioma (PPGL).
Lack of awareness about the disease is likely to hinder the market growth.
Government and private organisations should initiate and implement awareness programs about the paraganglioma cancer as it is a rare type of cancer it may lead to advanced stage under no proper guidence and awareness. This may hamper the market growth majorly.
Based on Treatment Type, the global Paraganglioma Treatment market is segmented into Surgery, Peptide Receptor Radionuclide Therapy (PRRT) Chemotherapy, Radiation therapy.
Peptide Receptor Radionuclide Therapy (PRRT) segment is expected to grow at the fastest CAGR during the forecast period (2020-2027)
Radionuclide therapy implicates the usage of radiolabeled peptides with high affinity to the involved receptor. In addition to surgery and chemotherapy, 131I-MIBG (Azedra) treatment has been effectively used to manage malignant and metastatic Paraganglioma cancers. In August 2018, Progenics Pharmaceuticals, Inc received approval from the FDA for Azedra (iobenguane I131), a radioactive therapeutic agent for locally advanced or metastatic treatment pheochromocytoma or paraganglioma in adult and pediatric patients 12 years and older. It has also received Breakthrough Therapy designation, an Orphan Drug designation, Fast Track designations and Priority Review from the FDA to treat iobenguane-avid metastatic paraganglioma and pheochromocytoma. The approval of Azedra represents significant advances in non-surgical treatment for ultra-rare cancer paraganglioma.
Additionally, Advanced Accelerator Applications has recently been used in metastatic Paraganglioma cancers, 177Lu-DOTATATE (Lutathera®) therapy.
Based on Site of Origin, the global Paraganglioma Treatment market is segmented into Carotid paragangliomas, Vagal paragangliomas, Cervical paragangliomas.
Carotid paragangliomas appear with an expanding and pulsing mass. When this paraganglioma appears as a superficial, isolated lesion, you may experience relatively few symptoms. These tumors usually appear in the neck but can extend into the space between the head and the neck.
Cervical paragangliomas are slow-growing tumors that can cause palsy and spread into the skull base. It can be challenging to distinguish between tumors that affect the vagus and those that involve the carotid artery.
Vagal paragangliomas can cause paralysis to the lower cranial nerves (including the 10th cranial nerve, which can cause paralysis of the diaphragm), 12th cranial nerve paralysis (with paralysis of the tongue), problems in swallowing, and problems with raising your shoulder.
COVID-19 Impact Analysis
The COVID-19 pandemic has negatively impacted healthcare systems globally and on the vulvar Cancer market. According to the Centres for Disease Control and Prevention (CDC) and many medical professional organizations recommended that cancer screening and other health prevention services, along with elective surgeries, be postponed unless the risks outweighed the benefits and secure the hospital infrastructure for the treatment of COVID-19 patients. Thus, the COVID-19 pandemic has impacted the On-going clinical trials too. However, the situation is expected to improve gradually.
Based on End-User, the global Paraganglioma Treatment market is segmented into Hospitals, Cancer Research centers, Speciality Clinics, others.
Due to the growing patient population, the hospitals segment held the largest market share. This is mainly owing to increasing number of patients suffering from conditions which are treated in hospitals equipped with advanced infrastructure and adequate facilities. Moreover, growing number of hospitals along with adequate reimbursement policies is also contributing to the growth of this segment. Also the medications can only be administrated by intravenously and surgery is done under supervision of medical practioners at these locations.
North America served the largest share of the market due to the presence of major market players developing oncology products. The existence of a highly developed healthcare system, the high degree of acceptance by medical practitioners of novel radionuclide therapy and Radiation therapy methods, the total availability of advanced diagnostic tools. For instance, Clinical Study of the Use of Yttrium-90 (90Y) and/or Lutecium-177 (177Lu) DOTATATE (DOTA-0-Tyr3-Octreotate) in the Treatment of Disseminated and / or Symptomatic Tumors With Somatostatin Receptor Overexpression is under phase 2 clinical trials by University of Warmy and Mazury.
The Asia Pacific is expected to be the fastest-growing market over the forecast period owing to increasing prevalence rate, increasing focus on preventive care, and government initiatives promoting technological innovations. For instance, Ono Pharmaceuticals, Yervoy injection (Ipilimumab) Anti-CTLA-4 antibody is under Phase 3 clinical trials to treat patients with Head and Neck cancers.
The global Paraganglioma Treatment market is quite competitive with some key competitors like Progenics Pharmaceuticals, Inc, AstraZeneca, Advanced Accelerator Applications, Jubilant Life Sciences Ltd, Pfizer Inc, Teva Pharmaceutical Industries Ltd, Cipla Inc, Amneal Pharmaceuticals LLC, Apotex Inc, Ono Pharmaceuticals. The key players are adopting various growth strategies such as product launch, acquisitions and investments in multiple sectors.
For instance, according to clinicaltrials.gov; A Phase II Study to Evaluate the Effects of Cabozantinib in Patients with Unresectable Metastatic Pheochromocytomas and Paragangliomas by M.D. Anderson Cancer Center in Collaboration with National Cancer Institute (NCI).
Advanced Accelerator Applications
Company Overview: Advanced Accelerator Applications (AAA) was founded in 2002 by Stefano Buono, who was inspired to pursue medical applications for certain research conducted during his tenure at the European Organization for Nuclear Research, or CERN, with Nobel laureate Carlo Rubbia. Built first radiopharmaceutical laboratory in the Technoparc of Saint-Genis-Pouilly (France). In 2004, Achieved first Marketing Authorization to commercialize GLUSCAN® in Switzerland. In 2009, Completed the acquisition of Gipharma, an Italian pharmaceutical contract manufacturer for injectable and freeze-dried products. In 2010, Acquired BioSynthema Inc., a U.S. molecular nuclear medicine discovery company based in St. Louis, Missouri, to obtain the rights to develop and commercialize LUTATHERA® (lutetium Lu 177 dotatate). In 2018, AAA, acquired by Novartis, got FDA approval of LUTATHERA® (lutetium 177Lu oxodotreotide).
Product Portfolio: The Company’s portfolio comprised of include targeted radioligand therapy in oncology and several precision imaging products mainly used in clinical oncology, cardiology, neurology and infectious/inflammatory diseases.
Advanced Accelerator Applications are undergoing Phase I Trial of Peptide Receptor Radiotherapy (PRRT) With 177Lu-DOTA-tyr3-Octreotate (177Lu-DOTATATE) in Children and Adolescents with Neuroendocrine Tumor or Pheochromocytoma/Paraganglioma.
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