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Global Royalty Rate Trends in Pharma and Biotech Dealmaking 2014-2019

Global Royalty Rate Trends in Pharma and Biotech Dealmaking 2014-2019

The Global Royalty Rate Trends in Pharma and Biotech Dealmaking 2014- 2019 report is your one-stop source for providing real-deal information on hundreds of transactions, including the technology licensed, royalty rates, license fees, upfront and milestone payments.

This report provides details of the latest partnering deals which disclose a royalty rate, announced in the pharmaceutical, biotechnology and diagnostic sectors. The report provides details of partnering deals disclosing royalty rates from 2014 to 2019.

The report provides an overview of how and why companies enter partnering deals where a royalty is payable upon commercialization of the compound or technology.

Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases and databases do not.

This report contains a comprehensive listing of all partnering deals announced since 2014 where a quantitative royalty rate has been disclosed, as recorded in the Current Agreements deals and alliances database. Each deal record and royalty disclosure is available in further detail via a link to online copy of the deal including actual contract document, where available, as submitted to the Securities Exchange Commission by companies and their partners.

The initial chapters of this report provide an orientation of royalty rate trends in pharma and biotech since 2014. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an overview of the trends in royalty rates in the pharma and biotech sectors since 2014, including a summary of the recent literature on the subject.

Chapter 3 provides an average benchmark royalty rates. The chapter includes numerous tables and figures summarizing the benchmark royalty rates by stage of development, therapy area and technology area.

Chapter 4 provides a more detailed insight into the structure of a royalty rate clause and how it fits with the other financial terms of the partnering deal. The chapter includes numerous case studies for actual deals where royalty rates have been disclosed.

Chapter 5 provides an insight into companies active in disclosing royalty rates as well as those deals attracting the highest royalty rates, and why.

Chapter 6 provides comprehensive and detailed access to deals which disclose a royalty rate since 2014 where a contract document is available. Contract documents provide an in-depth insight into the actual deal terms agreed between the parties with respect to the royalty rate.

In addition the report includes a comprehensive appendix listing of all deals where a royalty rate has been disclosed announced since 2014. Each listing is organized as an appendix by company A-Z, stage of development at signing, therapeutic area, and technology type. Each deal title links via hyperlink to an online version of the deal record including, where available, the actual contract document.

The report includes deals announced by hundreds of life science companies including big pharma such as Abbott, Abbvie, Actavis, Amgen, Astellas, AstraZeneca, Baxter, Bayer, Biogen Idec, BMS, Celgene, Eisai, Eli Lilly, Gilead, GSK, J&J, Kyowa Hakko, Merck, Mitsubishi, Mylan, Novartis, Pfizer, Roche, Sanofi, Shire, Takeda, Teva, and Valeant, amongst many others.

The report also includes numerous table and figures that illustrate the trends in royalty rates in pharma and biotech deal making since 2014.

In conclusion, this report provides everything a prospective dealmaker needs to know about royalty rates in the pharma and biotech sector.

Key benefits

Global Royalty Rate Trends in Pharma and Biotech Dealmaking 2014- 2019 provides the reader with the following key benefits:

In-depth understanding of royalty rate partnering deal trends since 2014
Analysis of the structure of royalty clauses with numerous real life case studies
Comprehensive listing of all partnering deals since 2014 where a royalty rate is disclosed, together with deal terms, value and press release
Comprehensive access to actual partnering deal contracts entered into by the world’s life science companies where a royalty rate is disclosed
Insight into the royalty terms included in a licensing agreement, together with real world clause examples
Understand the key deal terms companies have agreed in previous deals
Undertake due diligence to assess suitability of your proposed deal terms for partner companies

Report scope

Global Royalty Rate Trends in Pharma and Biotech Dealmaking 2014- 2019 is intended to provide the reader with an in-depth understanding of the royalty rate trends and structure of deals entered into by leading life science companies worldwide.

Global Royalty Rate Trends in Pharma and Biotech Dealmaking 2014- 2019 includes:

Trends in royalty rates in the biopharma industry since 2014
Analysis of royalty rate clause structure
Case studies of real-life licensing deals which disclose royalty rates
Comprehensive listing of licensing deals which disclose royalty rates since 2014
Access to licensing contract documents which disclose royalty rates
The leading licensing deals by royalty rate value since 2014
Most active royalty rate disclosures since 2014

In Global Royalty Rate Trends in Pharma and Biotech Dealmaking 2014- 2019 available deals and contracts are listed by:

Company A-Z
Headline value
Therapeutic area
Technology type

Each deal title links via Weblink to an online version of the actual deal record and where available, contract document, providing easy access to each contract document on demand.

The Global Royalty Rate Trends in Pharma and Biotech Dealmaking 2014-2019 report provides comprehensive access to available contract documents for licensing deals. Analyzing actual contract agreements allows assessment of the following:

What are the precise royalty rates granted?
What is actually granted by the agreement to the partner company?
What exclusivity is granted?
What is the payment structure for the deal?
How are sales and payments audited?
What is the deal term?
How are the key terms of the agreement defined?
How are IPRs handled and owned?
Who is responsible for commercialization?
Who is responsible for development, supply, and manufacture?
How is confidentiality and publication managed?
How are disputes to be resolved?
Under what conditions can the deal be terminated?
What happens when there is a change of ownership?
What sublicensing and subcontracting provisions have been agreed?
Which boilerplate clauses does the company insist upon?
Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
Which jurisdiction does the company insist upon for agreement law?


  • Executive Summary
  • Introduction
    • What are royalties?
    • History of royalty rates
    • Royalties in pharma and biotech
    • Royalties versus revenue share
    • Overview of the report
  • An overview of pharma and biotech royalty rates
    • Trends in royalty rates 2014- 2019
    • How do revenue shares figure?
    • A review of recent literature
    • Royalty rates in the future
  • Average royalty rates for pharma and biotech partnering
    • Royalty rates in early stage deals
    • Royalty rates by stage of development
    • Royalty rates by therapy area
  • The royalty clause in pharma and biotech deals
    • Partnering agreement structure
    • Structure of a typical royalty clause
    • Example royalty clauses
      • Case study 1: Merck Serono-Opexa Therapeutics
      • Case study 2: Aradigm - Grifols
      • Case study 3: Forect Laboratories - Trevena
      • Case study 4: Sage Therapeutics - University of California
  • Companies actively disclosing royalty rates
    • Most active companies in disclosing royalty rates
      • AstraZeneca
      • FSD Pharma
      • Ligand Pharmaceuticals
      • Novartis
      • OptiBiotix
      • Abbvie
      • Celgene
      • GlaxoSmithKline
      • Incyte
      • Janssen Biotech
      • Merck and Co
      • Oramed Pharmaceuticals
      • Sanofi
      • Takeda Pharmaceutical
      • Athenex
      • Axovant Sciences
      • BioNTech
      • Can-Fite BioPharma
      • Canntab Therapeutics
      • Denali Therapeutics
      • Genentech
      • Genmab
      • Genzyme
      • Gilead Sciences
      • Hefei Tianhui Incubation of Technologies
    • Top partnering deals by royalty rate
      • Table Top deals by royalty rate 2014- 2019
    • Top revenue share partnering deals
      • Table Deals disclosing revenue share 2014- 2019
  • Royalty rate contract directory
    • Explore royalty rates within the deal contract document to gain greater insight
  • Appendices
    • Royalty rates in deals - by company A-Z
      • Abbvie
      • Acura Pharmaceuticals
      • Adlai Nortye
      • Aduro BioTech
      • Advanced Dosage Forms
      • Advaxis
      • Aegerion Pharmaceutical
      • AEterna Zentaris
      • Agenus Bio
      • Agios Pharmaceuticals
      • AIT Therapeutics
      • Akcea Therapeutics
      • Akebia Therapeutics
      • Alder Biopharmaceuticals
      • Alector
      • Almirall
      • Alnylam Pharmaceuticals
      • Amgen
      • Amherst Pharmaceuticals
      • AnaBios
      • AnGes MG
      • Antibe Therapeutics
      • Antigen Express
      • Aratana Therapeutics
      • Arch Pharmalabs
      • Ardelyx
      • Arena Pharmaceuticals
      • Astellas Pharma
      • AstraZeneca
      • Athenex
      • Atossa Genetics
      • Aurigene Discovery Technologies
      • Authentic Brands Group
      • Axovant Sciences
      • Azaya Therapeutics
      • Bellerophon Therapeutics
      • Benitec Biopharma
      • Besins Healthcare
      • BioInvent
      • BioMarin Pharmaceutical
      • BioNovion
      • BioNTech
      • Bioprocess Capital Ventures
      • Biostem US
      • Bluebird Bio
      • BMV Medica
      • Braeburn Pharmaceuticals
      • BrainStorm Cell Therapeutics
      • Breathtec BioMedical
      • Bristol-Myers Squibb
      • Calico
      • Can-Fite BioPharma
      • Cancer Prevention Pharmaceuticals
      • CanniMed Therapeutics
      • Canntab Therapeutics
      • Cannus Partners
      • Celdara Medical
      • Celgene
      • Celyad
      • Cereal Ingredients
      • Cerus
      • Chi-Med
      • Chiesi Farmaceutici
      • Chongqing Jingdong Pharmaceutical
      • Chong Kun Dang
      • Cimtech
      • Cipher Pharmaceuticals
      • Circassia
      • Clal Biotech
      • Cleveland BioLabs
      • Cocrystal Pharma
      • Common Sense
      • ContraFect
      • CRISPR Therapeutics
      • CTT Pharmaceutical
      • Cumberland Pharmaceuticals
      • Cures Within Reach
      • CureTech
      • Curis
      • Cytori Therapeutics
      • Denali Therapeutics
      • Duke University
      • Easton Pharmaceuticals
      • Eisai
      • Elencee
      • Emergent BioSolutions
      • Emory University
      • Evolva
      • Exact Sciences
      • Exelixis
      • Eyevance
      • Fosun Pharmaceutical
      • Fresenius Kabi Pharmaceuticals
      • FSD Pharma
      • Galapagos
      • Galmed Pharmaceuticals
      • Genentech
      • Generex Biotechnology
      • Genevant Sciences
      • Genmab
      • Genzyme
      • Gilead Sciences
      • GlaxoSmithKline
      • Gravocore
      • Grifols
      • Halo Labs
      • Health Canada
      • Hefei Life Science
      • Hefei Tianhui Incubation of Technologies
      • Hemogenyx
      • Hoffmann La Roche
      • Ice + Jam
      • Idera Pharmaceuticals
      • Idorsia
      • IMetabolic Biopharma
      • Immugenyx
      • Immunomic
      • Imprimis Pharmaceuticals
      • Incuron
      • Incyte
      • Innate Pharma
      • Innovus Pharmaceuticals
      • INO Therapeutics
      • Intrexon
      • Invekra
      • Ionis Pharmaceuticals
      • Ipsen
      • Israeli National Authority for Technological Innovation
      • Janssen Biotech
      • Janssen Pharmaceuticals
      • Jiangsu NHWA Pharmaceutical
      • John Morley Foods
      • Kadmon Pharmaceuticals
      • KemPharm
      • Klaria
      • Knighton Foods
      • Knight Therapeutics
      • KVK-Tech
      • Kwang Dong Pharmaceutical
      • Laboratories Acbel
      • Legend Biotech
      • Level Brands
      • LFB Biotechnologies
      • Lifestyle Delivery Systems
      • Ligand Pharmaceuticals
      • Lubrizol
      • Macrogenics
      • MainPointe
      • Mallinckrodt Pharmaceuticals
      • Medicines Patent Pool Foundation
      • MedImmune
      • Medivation
      • Medivir
      • Merck and Co
      • Merck KGaA
      • Merus
      • Moderna Therapeutics
      • Mologen
      • MultiCell Immunotherapeutics
      • NantCell
      • Nantong Jinghua Pharmaceutical
      • NantWorks
      • National Green Biomed
      • Nektar Therapeutics
      • Neurocrine Biosciences
      • New York University
      • Nexvet
      • NGM Biopharmaceuticals
      • Nicox
      • Notable Labs
      • NovaDel Pharma
      • Novartis
      • Novocure
      • Nucorion
      • Oculus Innovative Sciences
      • Ocumension Therapeutics
      • Omeros
      • Oncologie
      • Oncolytics Biotech
      • One Way Liver Genomics (OWL)
      • OptiBiotix
      • Oramed Pharmaceuticals
      • Orexigen Therapeutics
      • Orgenesis
      • Otsuka
      • Oxford BioMedica
      • Oxis Biotech
      • Parnell Pharmaceutical Holdings
      • Par Pharmaceutical
      • PDL BioPharma
      • Pernix Therapeutics
      • Pfizer
      • Pharmastrip
      • Pieris
      • Pluristem Therapeutics
      • ProQR Therapeutics
      • Protalix BioTherapeutics
      • ProtoKinetix
      • Recordati
      • Regeneron Pharmaceuticals
      • Relmada Therapeutics
      • Resarci Therapeutics
      • Revolution Medicines
      • REVO Biologics
      • Rigel Pharmaceuticals
      • Roche
      • Roivant Sciences
      • SACCO
      • Sage Therapeutics
      • Sanofi
      • Sarepta Therapeutics
      • Seattle Genetics
      • Seelos Therapeutics
      • Sermonix Pharmaceutical
      • Shenzhen BioScien Pharmaceuticals
      • Shionogi
      • Sinopharm
      • Solarvest BioEnergy
      • Soligenix
      • Sorrento Therapeutics
      • STADA Arzneimittel
      • Strongbridge Biopharma
      • Sucampo AG
      • Swedish Orphan Biovitrum
      • Synergy Strips
      • Takeda Pharmaceutical
      • Tango Therapeutics
      • Tauriga Sciences
      • Technion Research and Development Foundation
      • TetraLogic Pharmaceuticals
      • Teva Pharmaceutical Industries
      • Theravance
      • Theravance Biopharma
      • TiGenix
      • Tilray
      • Tiziana Life Sciences
      • Tramorgan
      • Transgene
      • Trellis Bioscience
      • Trevena
      • TTFactor
      • University of Alberta
      • Uppsalagruppen Medical
      • Valeant Pharmaceuticals
      • Vasomune Therapeutics
      • Vertex Pharmaceuticals
      • Virbac
      • Vividion Therapeutics
      • Voyager Therapeutics
      • WAVE Life Sciences
      • World Class Extractions
      • Xbrane Bioscience
      • Xynomic Pharmaceuticals
      • Yeda Research and Development Company
      • ZAI Laboratory
      • Zalicus
    • Appendix 2 - Royalty rates in deals - by therapy area
      • Breast
      • Cardiovascular
      • Cardiomyopathy (heart muscle disease)
      • Congestive heart failure
      • Hypercholesterolemia
      • Hypertension
      • Central Nervous System
      • Migraine
      • Motor Neurone Disease (Amyotrophic Lateral Sclerosis/Lou Gehrig's Disease)
      • Multiple sclerosis
      • Pain
      • Parkinson's disease
      • Dermatology
      • Actinic keratosis
      • Cosmetics
      • Dermatitis
      • Psoriasis
      • Inflammatory bowel disease
      • Crohn's disease
      • Ulcerative colitis
      • Irritable bowel syndrome
      • Gastric ulcer
      • Genetic disorders
      • Huntington's disease
      • Rare genetic disorders
      • Sickle cell disease
      • Amyloidosis
      • Chronic kidney disease (CKD)
      • Gynaecology
      • Human papillomavirus (HPV)
      • Hematology
      • Anemia
      • Hemophilia
      • Thalassemia
      • Thrombocytopenia
      • Accident and emergency
      • Surgery
      • Transplantation
      • Immunology
      • Allergy
      • Anaphylactic shock
      • Other autoimmune
      • Inflammation
      • Infectives
      • Bacterial
      • Viral
      • Common cold
      • HIV
      • Influenza
      • Diabetes
      • Growth hormone disorders
      • Nonalcoholic steatohepatitis (NASH)
      • Lysosomal storage disorders
      • Nutrition and vitamins
      • Musculoskeletal
      • Ankylosing spondylitis
      • Osteoarthritis
      • Psoriatic arthritis
      • Rheumatoid arthritis
      • Knee
      • Muscular dystrophy
      • Osteoporosis
      • Oncology
      • Bladder cancer
      • Bone cancer
      • Breast cancer
      • Colorectal cancer
      • Endometrial
      • Gastric cancer
      • Head and neck cancer
      • Kidney cancer
      • Leukemia
      • Liver cancer
      • Lung cancer
      • Non small cell lung cancer
      • Lymphoma
      • Non Hodgkin's lymphoma
      • Melanoma
      • Multiple myeloma
      • Prostate cancer
      • Renal cell carcinoma
      • Solid tumors
      • Cancer pain
      • Chemotherapy
      • Thyroid cancer
      • Ophthalmics
      • Age-related macular degeneration
      • Cataracts
      • Conjunctivitis
      • Diabetic macular edema
      • Glaucoma
      • Ocular hypertension
      • Retinopathy
      • Uveitis
      • Orphan disease
      • Pediatrics
      • Psychiatry
      • Dementia
      • Alzheimers
      • Depression
      • Insomnia
      • Narcolepsy
      • Alcohol
      • Obesity
      • Respiratory
      • Asthma
      • Emphysema
      • Pulmonary arterial hypertension
      • Sexual Health
    • Royalty rates in deals - by stage of development at signing
      • Discovery
      • Preclinical
      • Phase I
      • Phase II
      • Phase III
      • Regulatory
      • Marketed
      • Formulation
    • Royalty rates in deals - by technology type
      • Adjuvant
      • Analysis
      • Animal models
      • Antibiotics
      • Antibodies
      • Antibody-drug conjugate
      • Bispecific antibodies
      • Monoclonal antibodies
      • Humanized mAb
      • Human mAb
      • Biological compounds
      • Biomarkers
      • Biosimilars/Bio-betters
      • Blood products
      • Cell culture
      • Clinical testing
      • CRISPR
      • Devices
      • Diagnostics
      • Companion
      • In vitro diagnostics
      • Prognostics
      • Discovery tools
      • Drug delivery
      • Bioavailability
      • Oral delivery
      • Delayed release
      • Injectable
      • Pro-drug
      • Targeted
      • Topical
      • Transdermal
      • Transmucosal
      • Inhaled
      • Ocular
      • Sublingual
      • Enabling technology
      • Equipment
      • Facilities
      • Gene therapy
      • Genomics
      • Microarray
      • Nanotechnology
      • Natural product
      • Oligonucleotide
      • Peptides
      • Personalised medicine
      • Precision medicine
      • Recombinant DNA
      • Anti-aging
      • Cell therapy
      • Stem cells
      • Research services
      • RNA therapeutics
      • Screening
      • Small molecules
      • Software tools
      • Vaccines
    • Royalty rate references
    • Resources
    • Deal type definitions
    • Example royalty rate deal contract document
  • About Wildwood Ventures
    • Current Partnering
    • Current Agreements
    • Recent report titles from CurrentPartnering

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