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p53 Signaling Pathway in Cancer Drug Pipeline Update

p53 Signaling Pathway in Cancer Drug Pipeline Update

p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
There are today 120 companies plus partners developing 108 p53 signaling pathway targeting drugs in 340 developmental projects in cancer. In addition, there is 1 suspended drug and the accumulated number of ceased drugs over the last years amount to another 67 drugs. P53 Signaling Pathway In Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 84 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 82 out of the 82 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 34 classifications of molecular function and with pathway referrals to BioCarta, KEGG, NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use?
* Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators
Includes more than 120 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.

Note: You are able to sort and find drugs according to companies and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms
Lists commercial, generic and code names for drugs.

Developmental stage
This Drug Pipeline Update contains 108 p53 signaling pathway targeting drugs in development, which have a total of 340 developmental projects in cancer. In addition there are suspended and ceased drugs.

Pipeline Breakdown According to Number of Drugs
Marketed# 3
Pre-registration# 1
Phase III# 7
Phase II# 31
Phase I# 48
Preclinical# 54
No Data# 4
Suspended# 1
Ceased# 67

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications
Included p53 signaling pathway targeting drugs are also in development for 110 other indications, where of 89 are different cancer indications.

Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets
Mutations
All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 82 out of the 82 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.

Biological Structures
The identity of available biological structures on 68 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 1416 structures available today among drug targets.

Identified drugs are linked to more than 84 different targets, divided into 34 classifications of molecular function:
Catalytic activity
Cell adhesion molecule activity
Cysteine-type peptidase activity
DNA binding
DNA topoisomerase activity
G-protein coupled receptor activity
Growth factor activity
Growth factor binding
GTPase activity
Hormone activity
Kinase activity
Kinase binding
Kinase regulator activity
Lipid phosphatase activity
Metallopeptidase activity
Molecular function unknown
Protease inhibitor activity
Protein binding
Protein serine/threonine kinase activity
Protein serine/threonine phosphatase activity
Protein threonine/tyrosine kinase activity
Protein tyrosine/serine/threonine phosphatase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor signaling complex scaffold activity
Receptor signaling protein serine/threonine kinase activity
RNA-directed DNA polymerase activity
Serine-type peptidase activity
T cell receptor activity
Transcription factor activity
Transcription regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Ubiquitin-specific protease activity

Sub-Cellular Localization
Identified targets are categorized into 17 different primary and alternate sub-cellular localizations:
Centrosome
Cytoplasm
Cytoskeleton
Cytosol
Endoplasmic reticulum
Endosome
Extracellular
Extracellular matrix
Golgi apparatus
Integral to membrane
Mitochondrial membrane
Mitochondrion
Nucleolus
Nucleus
Perinuclear region
Peroxisome
Plasma membrane

Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile
Direct links are provided from inside the application to 133 protein expression profiles of 78 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Pathway Referals
Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
BioCarta# 184 Pathways
KEGG# 139 Pathways
NCI-Nature# 209 Pathways
NetPath# 32 Pathways

Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism
In total there are different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound
Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile
Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms
Presentation of drug name and synonyms

Principal Company & Partners
Presentation of principal company and partners

Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol – Chromosome Location – Gene & Protein Name – Molecular Function

Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Mutation
All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.

Biological Structures
The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism
Drug mechanism of action

Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma – Phase II Clinical Trial – Active
Cancer, prostate – Phase III Clinical Trial – Ceased

Drug Description
Short introduction to drug

Compound Data
Compound type, Chemical name, CAS Number and molecular weight

Patent Data
Available patent information related to the drug is presented here.

Fillings and Approvals
Approvals and submissions
Analyst comments

Deals & Licensing
Collaborations and deals
Availability for licensing

Phase IV Data
Available Phase IV development data, developmental history and scientific data.

Phase III Data
Available Phase III development data, developmental history and scientific data.

Phase II Data
Available Phase II development data, developmental history and scientific data.

Phase I Data
Available Phase I development data, developmental history and scientific data.

Phase 0 Data
Available Phase 0 development data, developmental history and scientific data.

Preclinical Data
Available preclinical development data, developmental history and scientific data.

Discovery Data
Available discovery development data, developmental history and scientific data.

Application Features
Search, Find and Filter Panel with Initial Result Presentation
With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.


The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.

Direct linkage from inside the application to related internet resources
Drug data is linked to search engines like Google and PubMed
Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
Direct links to company web pages of companies

Dynamic Report Generator
Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.




System Requirements
Operating system: Windows (2000/XP/Vista/7/8) for Mac Users the service is only available online
Browser Application (Internet Explorer, Firefox, Chrome, Safari)
Internet access (to access related internet resources)


Please Note: For TOC please view description

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