Stem Cell Research Products – Opportunities, Tools, & Technologies (2020)

EXECUTIVE SUMMARY

Stem cells are primitive cells found in all multi-cellular organisms that are characterized by self-renewal and the capacity to differentiate into mature cell types. Several broad categories of stem cells exist, including:

  • Embryonic stem cells, derived from blastocysts
  • Perinatal stem cells, obtained during the period immediately before and after birth
  • Adult stem cells, found in adult tissues
  • Induced pluripotent stem cells, produced by genetically reprogramming adults cells
  • Cancer stem cells, which give rise to clonal populations of cells that form tumors or disperse in the body
Stem cell research and experimentation have been in process for well over five decades, as stem cells have the unique ability to divide and replicate repeatedly. In addition, their “unspecialized” nature allows them to differentiate into a wide variety of specialized cell types. In a developing embryo, stem cells can differentiate into all of the specialized embryonic tissues. In adult organisms, stem and progenitor cells act as a repair system for the body, replenishing specialized cells.

The possibilities arising from these characteristics have resulted in great commercial interest, with potential applications ranging from the use of stem cells in reversal and treatment of disease, to cell therapy, tissue regeneration, bioprinting, drug discovery, toxicology testing, and more. Of interest to clinical researchers is the potential to use stem cells within regenerative medicine, and the pharmaceutical industry is integrating stem cells to conduct pharmacological testing on cell-specific tissues. There is also demand for extracellular vesicles (EVs) derived from stem cells, because they can act as intercellular messengers and may be able to exert some types of therapeutic effects.

Traditionally, scientists have worked with both embryonic and adult stem cells as research tools. While the appeal of embryonic cells has been their ability to differentiate into any type of cell, there has been significant ethical, moral, and spiritual controversy surrounding their use for research purposes. Although some adult stem cells do have differentiation capacity, it is often limited in nature, which results in fewer options for use. Thus, when induced pluripotent stem cells (iPSCs) were discovered in 2006 by Shinya Yamanaka of Kyoto University in Japan, they represented a promising combination of adult and embryonic stem cell characteristics.

iPSCs are adult cells which are isolated and then transformed into embryonic-like stem cells through the manipulation of gene expression and other methods. The first successful generation of iPSCs was via research and experimentation using mouse cells at Kyoto University in Japan. In 2007, a series of follow-up experiments were done at Kyoto University in which human adult cells were transformed into iPSC cells. Nearly simultaneously, a research group led by James Thomson at the University of Wisconsin-Madison accomplished the same feat of deriving iPSC lines from human somatic cells.

To facilitate research resulting from interest in these far-ranging applications, a large and rapidly growing market for stem cells research products has emerged. Today, well over one-hundred companies produce products to support the activities of stem cell scientists worldwide. The tools commercialized by these companies include ones to isolate, expand, culture, differentiate, and characterize stem cells, as well as technologies to enable their production at any scale.

Broad categories of stem cell research products include, but are not limited to:
  • Stem cell lines (such as iPSCs, MSCs, HSCs, NSCs, and ESCs)
  • Stem cell culture media with supplements
  • Consumables (such as antibodies, consumables in assays, cryoprotective agents and microcarriers)
  • Instruments (such as freezers, bioreactors, cytometry devices, and assay systems)
  • Stem cell services
Specifically, the following compose the majority of stem cell product sales:
  • Primary antibodies to stem cell antigens
  • Bead-based stem cell separation systems
  • Fluorescent-based labeling and detection
  • Stem cell protein purification and analysis tools
  • Tools for DNA and RNA-based characterization of stem cells
  • Isolation/characterization services
  • Stem cell culture media and reagents
  • Stem cell specific growth factors and cytokines
  • Tools for stem cell gene regulation
  • Mechanisms for in vivo and in vitro stem cell tracking
  • Expansion/differentiation services for stem cell media and RNAi
  • Stem cell lines
  • Done-for-you or done-with-you services
With market competition growing increasingly fierce, ten of the largest companies selling stem cell research products are:
  • Thermo Fisher Scientific
  • BD Biosciences, a Division of Becton Dickinson (BD)
  • Merck KGaA
  • Miltenyi Biotec
  • STEMCELL Technologies
  • Lonza Group
  • Takara Bio
  • GE Healthcare Life Sciences
  • FUJIFILM CDI
  • Sigma Aldrich
Furthermore there are many specialty vendors of stem cell research products, such as FUJIFILM CDI, ReproCELL and Ncardia (who specialize in iPSC-related products), RoosterBio (who specializes in human MSC-specific products), and Corning (who specializes in Matrigel® products to support pluripotent stem cell culture and cultureware), for example.

Key report findings include:
  • Stem cell research applications, including priorities by segment
  • Relative demand for stem cell products, by stem cell type
  • Analysis of stem cell manufacturing technologies, including costs, risks, and the rise of contact manufacturing organizations (CMOs)
  • Analysis of market trends, including opportunities and threats
  • Competitive analysis for 128 market participants composing the global market
  • Market size determination, including detailed segmentation and 5-year projections (2019-2024)
Input Sources

The content and statistics contained in this report were compiled using a broad range of sources. These input sources include:
  • Interviews with Stem Cell Executives, completed by BioInformant’s Founder and Analysts
  • Stem Cell Grant Funding Database (RePORT Database, CIRM, MRC, Wellcome Trust – UK)
  • Stem Cell Patent Database (United States Patent and Trade Office, World Intellectual Property Organization)
  • Stem Cell Clinical Trial Database (ClinicalTrials.gov, International Clinical Trials Registry Platform, European Union Clinical Trials Register)
  • Stem Cell Scientific Publication Database (PubMed, Highwire Press, Google Scholar)
  • Stem Cell Product Launch Announcements (Trade Journals, Google News)
  • Stem Cell Industry Events (Google News, Google Alerts)
  • Stem Cell Company News (SEC Filings, Investor Publications, Historic Performance)
  • Social Analytics Platforms (Google Trends, Google Adwords, BuzzSumo, Hashtagify.me)
  • And More
The possibilities arising from stem cells have resulted in great commercial interest. The purpose of this report is to reveal market dynamics affecting basic and translational research, clinical and commercial applications, and the rising demand for stem cell research products on a global basis. Importantly, it unveils the identities of leading market competitors and presents a market size breakdown, including detailed segmentation with 5-year projections. Use it to identify emerging market opportunities, spot new product development opportunities before your competition, and make smarter decisions, faster.

As the first and only market research firm to specialize in the stem cell industry, BioInformant research has been cited by the Wall Street Journal, Xconomy, and Vogue Magazine. Headquartered in Washington, DC, BioInformant is strategically positioned near industry lawmakers, the National Institutes of Health (NIH), the U.S. FDA, and the Maryland Biotech Corridor. Serving Fortune 500 leaders that include GE Healthcare, Pfizer, and Goldman Sachs, BioInformant is your global leader in stem cell industry data.


  • REPORT OVERVIEW
    • Statement of the Report
    • Executive Summary
  • STEM CELL RESEARCH: AN INTRODUCTION
    • Identification of Stem Cells
    • Species Sources of Stem Cells for Research
    • Culturing Stem Cell Lines
    • Differentiation of Stem Cells
    • Benefits of Stem Cell Research
      • Basic Research
      • Stem Cells in Drug Discovery
      • Disease Modeling
      • Stem Cells in Toxicity Screening
  • STEM CELLS MARKERS
    • Embryonic Stem Cell (ESC) Markers
      • Table Examples of Embryonic Stem Cell Markers and Antibody Suppliers
    • Hematopoietic Stem Cell Markers
      • Table Examples of Hematopoietic Stem Cell (HSC) Markers and Antibody Suppliers
    • Cancer Stem Cell Markers
      • Table Examples of Cancer Stem Cell Markers and Antibody Suppliers
    • Osteoprogenitor Cell Markers
      • Table Examples of Osteoprogenitor Cell Markers and Antibody Suppliers
    • Neural Stem Cell Markers
      • Table Examples of Neural Stem Cell Markers and Antibody Suppliers
    • Mesenchymal Stem Cell (MSC) Markers
      • Table Examples of Mesenchymal Stem Cell Markers and Suppliers of Antibodies
    • Skin Stem Cell Markers
      • Table Examples of Skin Stem Cell Markers and Antibody Suppliers
  • STEM CELL ISOLATION PRODUCTS
    • Table Commercially Available Stem Cell Isolation Kits and Suppliers
    • Flow Cytometry in Stem Cell Isolation
    • Flow Cyometry Systems
      • Table Commercially Available Flow Cytometry Systems
  • ANTIBODIES
    • Primary Antibodies
      • Table Commercially Available Primary Antibodies
    • Secondary Antibodies
      • Table Commercially Available Secondary Antibodies
    • Recombinant Antibodies
      • Table Commercially Available Recombinant Antibodies
    • Trial Size Antibodies
      • Table Commercially Available Trial Size Antibodies
    • Apoptosis Antibodies
      • Table Commercially Available Apoptosis Antibodies
    • Epitope Tag and Fusion Protein Antibodies
      • Table Commercially Available Epitope Tag Antibodies
    • Isotype Control Antibodies
      • Table Commercially Available Isotype Control Antibodies
    • Stem Cell Marker Antibodies
    • Pluripotent Stem Cell Markers
      • Table Pluripotent Stem Cell Antibody Products
    • Mesenchymal Stem Cell Markers
      • Table Mesenchymal Stem Cell (MSC) Antibody Products
    • Hematopoietic Stem Cell (HSC) Antibody Products
      • Table Hematopoietic Stem Cell (HSC) Antibody Products
    • Neural Stem Cell (NSC) Marker Antibodies
      • Table Neural Stem Cell Marker Antibodies
    • Cancer Stem Cell Marker Antibodies
      • Table Cancer Stem Cell Marker Antibodies
    • Antibody Production
      • Antibody Production and Development Services
        • Table Companies Providing Antibody Production and Development Services
      • Monoclonal Antibody Production Services
        • Table Companies Providing Monoclonal Antibody Production Services
      • Polyclonal Antibody Production Services
        • Table Companies Offering Polyclonal Antibody Production Services
      • Antibody Purification Services
        • Table Companies Offering Antibody Purification Services
      • Antibody Conjugation and Labeling Services
        • Table Companies Offering Antibody Conjugation and Labeling Services
      • Hybridoma Services
        • Table Companies Providing Hybridoma Services
      • Recombinant Antibody Production Services
        • Table Companies Offering Recombinant Antibody Production Services
    • Stem Cell Factor ELISA Kits
      • Table Commercially Available Stem Cell Factor ELISA Kits and Suppliers
  • STEM CELL CULTURE MEDIA
    • Types of Culture Media
      • Table Types of Natural and Artificial Media
    • Choice of Cell Culture Media
      • Table Cell Lines and Choice of Culture Media
      • Recommended Media for Primary Cell Culture
        • Table Recommended Media for Primary Cell Culture
    • Stem Cell Culture Media
      • Table Leading Companies Offering Stem Cell Culture Media
      • Methylcellulose Media
        • Table Examples of Methylcellulose Media
      • Differentiation Media
        • Table Commercially Available Stem Cell Differentiation Media
      • Expansion Media
        • Table Commercially Available Stem Cell Expansion Media
    • Embryonic Stem Cell (ESC) Media
      • Table Commercially Available Embryonic Stem Cell Media
    • Hematopoietic Stem Cell (HSC) Media
      • Table Commercially Available Hematopoietic Stem Cell Media
    • Mesenchymal Stem Cell (MSC) Media
      • Table Commercially Available Mesenchymal Stem Cell Media
    • Neural Stem Cell Media
      • Table Commercially Available Neural Stem Cell Media
    • Media Supplements for Stem Cell Culture
      • Table Components of Media Supplements
      • Table Commercially Available Cell Culture Supplements and Vendors
    • Cell Storage Media
      • Table Examples of Cell Freezing Media
  • BIOREACTORS
    • Table Bioreactors used for Stem Cell Expansion
    • Stainless Steel Fixed Bioreactors
      • Table Pros and Cons of Fixed Bioreactors
    • Single-Use Bioreactors
      • Table Pros and Cons of Single Use Bioreactors
      • Single-Use System Types
        • Table Commercially Available Liter- and Cubic Meter-Scale SUBs
      • Main Features of Commercial Bioreactors
        • Table Main Features of Commercial Bioreactors
      • Main Differences between Single-Use and Multi-Use Bioreactors
        • Table Main Differences between Single-Use and Multi-Use Bioreactors
      • Microcarriers used in Bioreactors
        • Table Microcarriers Used in Bioreactors
  • STEM CELL LINES
    • Use of Stem Cell Lines
    • Types of Stem Cell Lines
      • Embryonic Stem Cell Lines (ESC Line)
      • Adult Stem Cell Lines
      • Induced Pluripotent Stem Cell Lines (iPSC Lines)
    • Commercially Available Stem Cell Lines
      • Table Examples of Commercially Available Stem Cell Lines
  • STEM CELL MANUFACTURING
    • Institutional Manufacturing of Stem Cells
      • Table Select Institutional Manufacturing Facilities for Stem Cell Manufacture
    • Transition to Commercial Manufacturing of Stem Cells
    • CMOs Involved with Stem Cell Manufacturing
      • Table Select CMOs and Their Services in Stem Cell Manufacturing
    • Stem Cell Manufacturing Process
      • Scale-Up Methods
        • Table Select Cell Manufacturing Solutions
      • Closed Automated Systems
        • Table Select Closed Manufacturing Systems
  • COST OF STEM CELL MANUFACTURING
    • Table Categories of Expenditures in Stem Cell Manufacturing
    • Labor Cost in Manufacturing Stem Cells
      • Table The Impact of Head Count on Labor Cost
    • Cost of Stem Cell Manufacture in a Partially-Automated Facility
      • Table Cost of Stem Cell Manufacture in a Partially-Automated Facility
    • Cost of Stem Cell Manufacture in a Fully-Automatic Facility
      • Table Cost of Stem Cell Manufacture in a Fully-Automatic Facility
  • STEM CELL RESEARCH PRODUCTS: MARKET ANALYSIS
    • Global Market for Flow Cytometry Systems used in Cell Culture Studies
      • Table Global Market for Flow Cytometry Systems used in Stem Cell Culture, 2019- 2026
      • Flow Cytometry Market Share by Company
    • Global Market for Stem Cell Research Antibodies
      • Table Global Market for Stem Cell Research Antibodies, 2019-2026
      • Stem Cell Research Antibodies Market Share by Company
    • Market for Stem Cell Assay Products
      • Table Global Market for Stem Cell Assays by Geography, 2019-2026
      • Global Market for Stem Cell Assays by Product Segments
    • Global Market for Stem Cell Culture Media
      • Table Global Market for Stem Cell Media by Geography, 2019-2026
      • Stem Cell Culture Media Market Share by Company
    • Global Market for Recombinant Cell Culture Supplements
      • Table Global Market for Recombinant Cell Culture Supplements, 2019-2026
    • Global Market for Stem Cell Cryopreservation Products
      • Table Market for Stem Cell Cryopreservation Products by Geography, 2019-2026
      • Market Share of Stem Cell Cryopreservation Products by Type
    • Market for Single-Use Bioreactors in Stem Cell Culture
      • Table Global Market for SUBs in Stem Cell Culture by Geography, 2019-2026
      • Market for Single-Use Bioreactors in Stem Cell Culture by Product Segment
      • Single-Use Bioreactor Market Share by Company
      • Massive Investments in Single-Use Bioreactors
    • Global Market for Microcarriers Used in Stem Cell Culture
      • Table Global Market for Stem Cell Microcarriers by Geography, 2019-2026
    • Market for Induced Pluripotent Stem Cells (iPSCs)
      • Table Companies Offering iPSC Research Products
      • Table Global Market for iPSC Research Products by Geography, 2019-2026
      • Toxicology Assays using iPSCs
    • Market for Human Mesenchymal Stem Cells (hMSCs)
      • Table Global Market for Mesenchymal Stem Cells by Geography, 2019-2026
    • Global Market for Embryonic Stem Cell (ESC) Research Products
      • Table Global Market for Embryonic Stem Cell (ESC) Research Products by Geography, 2019-2026
    • Global Market for Stem Cells and Their Differentiated Cell Types
      • Table Global Market for Stem Cells by Cell Type, 2019-2026
    • Global Market for Stem Cell Research Products
      • Table Global Market for Stem Cell Research Products, 2019-2026
      • Leaders in Consumables and Instruments used in Stem Cell Research
        • Table Major Suppliers of Consumables and Instruments in Stem Cell Research
  • COMPANY PROFILES
    • 3D Biotek LLC
      • Products
    • Abbexa Ltd.
      • Products
    • ABclonal
      • Products
    • Abeomics Inc.
      • Products
      • Services
    • Abnova
      • Products
    • Absolute Antibody Ltd.
      • Products
    • Agilent Technologies Inc.
      • Products
    • Alomone Labs Ltd.
      • Products
    • AmProtein - China Inc.
      • Products
    • Antigenix America Inc.
      • Products
    • Apceth Biopharma GmbH
      • Cell Types Offered
      • Cell Banking & Formulation
    • Applikon Biotechnology BV
      • Products
    • AS ONE INTERNATIONAL, INC.
    • Assaypro
      • Products
    • ATCC
      • Products
    • Athersys, Inc.
      • Multistem
    • Atlas Antibodies AB
      • Products
    • ATVIO Biotech, Ltd.
      • Services
    • Aviva Systems Biology Corp.
      • Products
    • Becton, Dickinson and Company (BD)
      • Offerings
    • Bio Basic
      • Products & Services
    • BioIVT
      • Products
      • Services
    • BioLegend
      • Products
    • BioLife Solutions Inc.
      • Products
    • Bio-Rad Laboratories, Inc.
      • Products
    • Biorbyt Ltd.
      • Products
    • BioSperix Ltd.
      • Products
    • Bioss Antibodies Inc.
      • Products
    • BioVendor - Laboratorni Medicina A.S.
      • Products & Services
    • BioVision Inc.
      • Products
    • Bio X Cell
      • Products
    • Bon Opus Biosciences
      • Products
    • BosterBio
      • Products
      • Services
    • CEDARLANE
      • Products
    • Cell Culture Technologies LLC
      • Products
      • Platforms
    • Cellexus Ltd.
      • CellMaker Bioreactors
    • Cell Microsystems Inc.
      • Products
    • Cell Signaling Technology Inc.
      • Products
    • Celltainer Biotech
      • Products
    • ChromoTek GmbH
      • Products
    • Cognate BioServices Inc.
      • Services
    • Corning Life Sciences
      • Products
    • CUSABIO Technology LLC
      • Products
    • Cygnus Technologies
      • Products
    • Diagenode SA
      • Products
    • DWK Life Sciences
      • Cell Culture Products
    • EMD Millipore Corp.
      • Services
    • enQuire BioReagents
      • Products
    • Enzo Lifesciences Inc.
      • Products
    • EpiGentek Group Inc.
      • Products
    • Eppendorf AG
      • Products
    • Eurogentec, S.A.
      • Products
    • EXBIO Praha a.s
      • Products
    • FabGennix International Inc.
      • Products
    • Fitzgerald Industries International
      • Products
    • GE Healthcare Bio-Sciences
      • Products
    • GeneTex Inc.
      • Products
    • GenScript
      • Products
    • Greiner Bio-One International GmbH
      • Products
    • HemaCare Corporation
      • Products
    • HiMedia Laboratories
      • Products
    • HuaBio
      • Products
      • Services
    • Hycult Biotech
      • Products
    • HyTest Ltd.
      • Products
    • ImmuQuest Ltd.
      • Products
    • InSphero AG
      • Product
    • Invent Biotechnologies Inc.
      • Products
    • InvivoGen
      • Products
    • Irvine Scientific, Inc. (FUJIFILM Irvine Scientific, Inc.)
      • Products
    • iXCells Biotechnologies
      • Products
    • Kerafast, Inc.
      • Products
    • LifeSpan BioSciences Inc.
      • Antibodies
    • Lonza AG
      • Products & Services
    • Maine Biotechnology Services (BBI Group)
      • Services
    • MaSTherCell S.A.
      • Services
    • MBL International
      • Products
    • MD Biosciences (Bioproducts Division)
      • Products
    • Miltenyi Biotec GmbH
      • Products
    • Minerva Biotechnologies Corporation
    • Monash Antibody Technologies Facility (MATF)
      • Services
    • MP Biomedicals LLC
      • Products
    • MyBioSource Inc.
      • Products
    • Ncardia AG
      • Manufacturing and Drug Discovery Solutions
    • New England Biolabs
      • Products
    • Novasep Holding SAS
      • Services
    • NovaTeinBio
      • Products
    • Novus Biologicals
      • Products
    • NSJ Bioreagents
      • Products
    • Octane
      • Cocoon
    • PBS Biotech Inc.
      • Products
    • PROGEN
      • Products
    • PromoCell GmbH
      • Products & Services
    • ProSci Inc.
      • Products
      • Services
    • Proteintech Group Inc.
      • Products
    • ProteoGenix
      • Products & Services
    • QED Bioscience Inc.
      • Products
    • Ray Biotech
      • Products
    • Rev MAb Biosciences
      • Products
    • Reddot Biotech Inc.
      • Products
    • R & D Systems
      • Products
    • REPROCELL Inc.
      • Products
      • Services
    • RoosterBio, Inc.
      • Products
    • RoslinCT
      • Products
    • SAFC Biosciences Inc.
      • Products
    • Santa Cruz Biotechnology Inc.
      • Products
    • Sartorius AG
      • Products
    • ScienCell Research Laboratories
      • Products
    • Sigma-Aldrich Corp.
      • Products
    • Signalway Antibody LLC
      • Products
    • Sino Biological Inc.
      • Antibodies
    • Shanghai Korain Biotech Co., Ltd.
      • Products
    • SouthernBiotech
      • Products
    • StemBioSys, Inc.
      • CELLvo™ Matrix and Media Kits
      • CELLvo™ Cells
    • STEMCELL Technologies
      • Products
    • Synaptic Systems GmbH
      • Products
    • Synthecon Inc.
      • Products
    • Takara Bio Inc.
      • Products
    • Terumo BCT Inc.
      • Products & Services
    • Thermo Fisher Scientific Inc
      • Products
    • United States Biological
      • Products
    • Vitrolife AB
      • Products
    • VWR International LLC
      • Products
    • Wuxi Donglin Sci & Tech Development Co. Ltd.
      • Products
    • Xcellerex (GE Healthcare)
      • Products
    • YposKesi, SAS (Genethon)
      • Products
    • Zen-Bio, Inc.
      • Products
    • Zellwerk GmbH
      • Zellwerk's Z(R) RP Cell- and Tissue Culturing Systems

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