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Synthetic Biology: Global Markets

Synthetic Biology: Global Markets

The global synthetic-biology market reached nearly $3.9 billion in 2016 and should reach $11.4 billion by 2021, growing at a compound annual growth rate (CAGR) of 24.0% through 2021.

Report Includes
An overview of the global markets for synthetic biology.
Analyses of global market trends, with data from 2015, estimates for 2016, and projections of compound annual growth rates (CAGRs) through 2021.
Coverage of core synthetic biology products: synthetic genes, other DNA parts, chassis organisms, synthetic cells
Coverage of enabling technologies: DNA sequencing, oligonucleotides, specialty media, bioinformatics
Coverage of enabled technologies: biofuels, specialty chemicals, diagnostics, pharmaceuticals, agriculture 
Analysis of the synthetic biology industry structure, competitors and intellectual property landscape
An assessment of the products and technologies most commercially viable in the immediate and near-future time frame.
Profiles of major players in the industry


Report Scope

The study scope includes core synthetic-biology products (synthetic genes, biobrick parts, delivery plasmids, chassis organisms, synthetic cells, production systems), enabling technologies (DNA sequencing, DNA synthesis and assembly, genome editing, bioinformatics and specialty media) and enabled technologies (biofuels, chemicals, pharmaceuticals, agriculture) that are already commercialized or are forecast to be commercialized within the next five years.

We analyze key synthetic-biology technologies and products to determine present and future market status, and forecasted growth from 2016 through 2021. We also discuss strategic alliances, industry structures, competitive dynamics, patents and market driving forces.

BCC Research examines the synthetic-biology industry by market segment, including the following segments: DNA sequencing; DNA synthesis; genome editing; synthetic-biology foundries; industrial biotechnology; pharmaceuticals; and agriculture. The role of key strategic alliances and acquisitions from 2014 through 2016 is discussed. Emerging markets including synthetic genes, synthetic-biology-enabled drugs and vaccines, genome-edited crops, chassis organisms, as well as metabolically engineered factories for producing synthetic fuels and specialty chemicals are analyzed, and more than 135 companies in these fields are highlighted.

CHAPTER 1 INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
CONTRIBUTION OF THE STUDY AND FOR WHOM
SCOPE AND FORMAT
METHODOLOGY
INFORMATION SOURCES
RELATED BCC RESEARCH REPORTS
ANALYST'S CREDENTIALS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 SUMMARY
SUMMARY TABLE GLOBAL VALUE OF SYNTHETIC-BIOLOGY MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
SUMMARY FIGURE GLOBAL VALUE OF SYNTHETIC-BIOLOGY MARKET, BY PRODUCT TYPE, 2015-2021 ($ MILLIONS)
CHAPTER 3 OVERVIEW
SYNTHETIC-BIOLOGY TECHNOLOGIES COVERED IN THIS REPORT
TABLE 1 SCOPE
FIGURE 1 SYNTHETIC-BIOLOGY VALUE-ADDED CHAIN
WHAT IS SYNTHETIC BIOLOGY?
DEVELOPMENT STAGE OF SYNTHETIC BIOLOGY
FIGURE 2 FROM THE NATURAL TO THE ARTIFICIAL
TABLE 2 SYNTHETIC-BIOLOGY PARADIGM
FORCES DRIVING SYNTHETIC-BIOLOGY MARKET GROWTH
TABLE 3 SYNTHETIC-BIOLOGY GROWTH: DRIVING FORCES
GLOBAL MARKETS FOR SYNTHETIC-BIOLOGY PRODUCTS
TABLE 4 GLOBAL VALUE OF SYNTHETIC-BIOLOGY MARKET, BY END-USER INDUSTRY, THROUGH 2021 ($ MILLIONS)
LIFE-CYCLE STATUS OF PRODUCTS AND TECHNOLOGIES
TABLE 5 SYNTHETIC-BIOLOGY PRODUCTS AND TECHNOLOGY LIFE-CYCLE
STAGE
SYNTHETIC-BIOLOGY INDUSTRY
TABLE 6 SYNTHETIC-BIOLOGY COMPETITORS BY MARKET FOCUS
CHAPTER 4 SYNTHETIC-BIOLOGY TECHNOLOGIES
INTRODUCTION
SYNTHETIC BIOLOGY DEFINED
TABLE 7 SYNTHETIC BIOLOGY DEFINITIONS
HISTORY OF SYNTHETIC BIOLOGY
TABLE 8 SYNTHETIC-BIOLOGY HISTORY
PARADIGM SHIFT IN BIOLOGY
TABLE 9 PARADIGM SHIFT CAUSED BY SYNTHETIC BIOLOGY
TABLE 10 GENETIC ENGINEERING AND SYNTHETIC BIOLOGY COMPARED
FIGURE 3 SCALE OF SYNTHETIC BIOLOGY
SYNTHETIC-BIOLOGY TECHNOLOGY OVERVIEW
TABLE 11 SYNTHETIC-BIOLOGY APPLICATIONS BY TECHNOLOGY
ENABLING TECHNOLOGIES
TABLE 12 IMPORTANCE OF ENABLING TECHNOLOGIES
DNA-SYNTHESIS AND DNA-SEQUENCING COST TRENDS
TABLE 13 COST TO SEQUENCE A SINGLE HUMAN GENOME, 2001-2015 ($)
TABLE 14 DNA-SYNTHESIS COSTS, 2006 AND 2016 ($/bp)
DNA-SYNTHESIS TECHNOLOGIES
FIGURE 4 SCHEMATIC OF DNA-SYNTHESIS TECHNOLOGIES
TABLE 15 COMPARISONS OF GENE-SYNTHESIS TECHNOLOGIES
PCR-Based Approaches
Solid-Phase-Based Approaches
MICROFLUIDIC TECHNOLOGIES
TABLE 16 IMPORTANCE OF MICROFLUIDICS TECHNOLOGIES IN SYNTHETIC BIOLOGY
DNA Microarrays
FIGURE 5 MICROARRAYS IN DNA SYNTHESIS
NEXT-GENERATION SEQUENCING TECHNOLOGIES
TABLE 17 NEXT-GENERATION SEQUENCING TECHNOLOGIES, BY COMPANY
GENOME-EDITING TOOLS
TABLE 18 COMPARISON OF GENENOME-EDITING PLATFORMS
TABLE 19 GENOME-EDITING TECHNOLOGIES: ADVANTAGES AND LIMITATIONS
GENE DRIVES
TABLE 20 POTENTIAL MARKET APPLICATIONS FOR GENE-DRIVE-
MODIFIED ORGANISMS
BIOINFORMATICS TECHNOLOGIES
TABLE 21 SYNTHETIC-BIOLOGY BIOINFORMATICS TECHNOLOGIES
BIOLOGIC COMPONENTS AND INTEGRATED SYSTEMS TECHNOLOGIES
TABLE 22 NUCLEIC ACIDS, GENES AND GENOMES
SYNTHETIC DNA
TABLE 23 SYNTHETIC DNA
TABLE 24 SYNTHETIC GENES AS MOLECULAR-BIOLOGY TOOL
TABLE 25 SYNTHETIC GENES VERSUS PCR CLONING
BIOBRICK PARTS
TABLE 26 DNA CONSTRUCTS
FIGURE 6 ROLE OF PROMOTERS AND REPORTERS IN SYNTHETIC-BIOLOGY SYSTEMS
MINIMAL GENOMES AND CHASSIS ORGANISMS
TABLE 27 ATTRIBUTES OF A MINIMAL GENOME
Case Study: Minimal E. coli Genome
Role of Directed Evolution in Designing Biologic Parts
ENABLED TECHNOLOGIES
TABLE 28 ENABLED TECHNOLOGIES: KEY APPLICATION FIELDS
PATHWAY ENGINEERING
FIGURE 7 HOW SYNTHETIC BIOLOGY CREATES ENABLED PRODUCTS
TABLE 29 METABOLIC ENGINEERING FOR ARTEMISINIC ACID
RESEARCH AND DEVELOPMENT APPLICATIONS
TABLE 30 RESEARCH AND DEVELOPMENT APPLICATIONS FOR SYNTHETIC-BIOLOGY PRODUCTS
BIOFUELS TECHNOLOGIES
OVERVIEW
TABLE 31 ADVANCED BIOFUELS TYPES
FIRST- AND SECOND-GENERATION BIOFUEL TECHNOLOGIES
TABLE 32 FIRST--AND SECOND-GENERATION BIOFUELS COMPARED
CROP FEEDSTOCKS
TABLE 33 ENERGY BALANCE OF SELECTED FIRST-GENERATION BIOFUEL
FEEDSTOCKS
CELLULOSIC FEEDSTOCKS
TABLE 34 APPROXIMATE COMPOSITION OF CELLULOSIC BIOMASS (%)
TABLE 35 SYNTHETIC-BIOLOGY STRATEGIES FOR CONVERTING
CELLULOSIC BIOMASS INTO ETHANOL
ALGAE FEEDSTOCKS
TABLE 36 BIODIESEL YIELD OF SELECTED CROPS (GALLONS/ACRE/YEAR)
CARBON DIOXIDE FEEDSTOCKS
BIOFUEL END PRODUCTS
TABLE 37 EFFICIENCY OF VARIOUS FUELS (%)
Cellulosic Ethanol
FIGURE 8 CELLULOSIC ETHANOL PRODUCTION SCHEMATIC
Biodiesel
TABLE 38 IODINE NUMBER OF VARIOUS OILS
Other Biofuels
Role of Genetic Engineering and Synthetic Biology in Biofuels
TABLE 39 CONTRIBUTION OF SYNTHETIC BIOLOGY TO BIOFUELS
SYNTHETIC-BIOLOGY INITIATIVES
TABLE 40 SYNTHETIC-BIOLOGY INITIATIVES
CHAPTER 5 SYNTHETIC-BIOLOGY APPLICATIONS
ENABLING TECHNOLOGIES APPLICATIONS
TABLE 41 SYNTHETIC-BIOLOGY PRODUCTS IMPACTED BY ENABLING
TECHNOLOGIES
BIOLOGIC COMPONENTS AND INTEGRATED SYSTEMS APPLICATIONS
TABLE 42 BIOLOGIC COMPONENTS AND INTEGRATED SYSTEMS NEAR-TERM
APPLICATIONS
SYNTHETIC GENES
TABLE 43 SYNTHETIC GENES NEAR-TERM APPLICATIONS
BIOBRICK PARTS
INTEGRATED SYSTEMS
TABLE 44 E. COLI AS A CHASSIS ORGANISM
ENABLED PRODUCTS APPLICATIONS
PHARMACEUTICALS
Drug Discovery and Development
TABLE 45 DRUG-DISCOVERY AND DEVELOPMENT APPLICATIONS FOR SYNTHETIC-BIOLOGY PRODUCTS
Genome-Edited Pharmaceuticals
TABLE 46 GENOME-EDITING NEAR-TERM CLINICAL APPLICATIONS
Immuno-Oncology
TABLE 47 CAR-T CELL ALLIANCES AND SYNTHETIC-BIOLOGY
PLATFORMS
Other Pharmaceuticals Applications
TABLE 48 SYNTHETIC-BIOLOGY-ENABLED PHARMACEUTICAL
APPLICATIONS
INDUSTRIAL BIOTECHNOLOGY APPLICATIONS
Biofuels
TABLE 49 SYNTHETIC-BIOLOGY-ENABLED BIOFUELS APPLICATIONS
TABLE 50 GROWTH STATUS OF SPECIALTY VERSUS DROP-IN BIOFUELS, 2000-2020
Chemicals
TABLE 51 SYNTHETIC-BIOLOGY-ENABLED CHEMICALS APPLICATIONS
AGRICULTURE AND ANIMALS APPLICATIONS
TABLE 52 SYNTHETIC-BIOLOGY-ENABLED AGRICULTURE AND ANIMALS
APPLICATIONS
TABLE 53 REGULATORY STATUS OF GENOME-EDITIED CROPS
DNA STORAGE APPLICATIONS
CHAPTER 6 SYNTHETIC-BIOLOGY INDUSTRY
INDUSTRIAL BIOTECHNOLOGY VALUE CHAIN
FIGURE 9 INDUSTRIAL BIOTECHNOLOGY VALUE CHAIN WITH SYNTHETIC
BIOLOGY LEVERAGE POINTS
INDUSTRY STRUCTURAL FORCES
TABLE 54 SYNTHETIC-BIOLOGY INDUSTRY STRUCTURAL FORCES
PRODUCTS AND TECHNOLOGY LIFE CYCLE
TABLE 55 SYNTHETIC--BIOLOGY PRODUCTS AND TECHNOLOGY LIFE-CYCLE
STAGE
DNA-SEQUENCING INSTRUMENT INDUSTRY
TABLE 56 NEXT-GENERATION SEQUENCING INSTRUMENT COMPANIES
SUMMARY
THIRD-GENERATION SEQUENCING INDUSTRY
TABLE 57 THIRD-GENERATION SEQUENCING INDUSTRY
OLIGONUCLEOTIDE SYNTHESIS INDUSTRY
TABLE 58 GLOBAL MARKET SHARES OF OLIGONUCLEOTIDE SYNTHESIS INDUSTRY, BY COMPANY, 2016 ($ MILLIONS/%)
GENE-SYNTHESIS INDUSTRY
WORKFLOW
TABLE 59 GENE-SYNTHESIS WORKFLOW
COMPETITORS
TABLE 60 GLOBAL MARKET SHARES OF GENE-SYNTHESIS INDUSTRY, BY COMPANY, 2016 ($ MILLIONS/%)
TABLE 61 GENE-SYNTHESIS KEY COMPETITOR STRATEGIES
VALUE CHAIN
GENE-SYNTHESIS MARKET SEGMENTS
Standardized Segment
Value-Added Segment
TABLE 62 GENE-SYNTHESIS MARKET FACTORS OF DIFFERENTIATION
GENOME-EDITING TOOLS INDUSTRY
TABLE 63 GENOME-EDITING TOOLS INDUSTRY
SYNTHETIC-BIOLOGY FOUNDRIES INDUSTRY
TABLE 64 SYNTHETIC-BIOLOGY FOUNDRIES INDUSTRY
PHARMACEUTICALS INDUSTRY
TABLE 65 PHARMACEUTICALS INDUSTRY SYNTHETIC-BIOLOGY STRATEGIES
TABLE 66 MICROBIOME THERAPEUTICS INDUSTRY
AGRICULTURE INDUSTRY
TABLE 67 SYNTHETIC-BIOLOGY AGRICULTURE INDUSTRY
ACQUISITIONS AND STRATEGIC ALLIANCES
TABLE 68 SYNTHETIC-BIOLOGY INDUSTRY ACQUISITIONS, 2014-2016
TABLE 69 STRATEGIC ALLIANCES, 2014-2016
CHAPTER 7 SYNTHETIC-BIOLOGY MARKETS
INDUSTRY GROWTH-DRIVING FORCES
TABLE 70 SYNTHETIC-BIOLOGY GROWTH-DRIVING FORCES
SYNTHETIC-BIOLOGY MARKETS BY END-USER INDUSTRY
RESEARCH MARKET
TABLE 71 GLOBAL VALUE OF RESEARCH MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
PHARMACEUTICALS MARKET
TABLE 72 GLOBAL VALUE OF PHARMACEUTIALS MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
CHEMICALS MARKET
TABLE 73 GLOBAL VALUE OF CHEMICALS MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
ENERGY MARKET
TABLE 74 GLOBAL VALUE OF ENERGY MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
AGRICULTURE MARKET
TABLE 75 GLOBAL VALUE OF AGRICULTURE MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
SYNTHETIC-BIOLOGY MARKET BY PRODUCT TYPE
TABLE 76 GLOBAL VALUE OF SYNTHETIC--BIOLOGY MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
ENABLING PRODUCTS MARKETS
TABLE 77 GLOBAL VALUE OF ENABLING PRODUCTS, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
TABLE 78 GLOBAL VALUE OF ENABLING PRODUCTS, BY END-USE INDUSTRY, THROUGH 2021 ($ MILLIONS)
BIOLOGIC COMPONENTS MARKET
TABLE 79 GLOBAL VALUE OF BIOLOGIC COMPONENTS MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
Synthetic-Gene Standardized Market Segment
Synthetic-Gene Value-Added Market Segment
TABLE 80 GLOBAL VALUE OF BIOLOGIC COMPONENTS MARKET, BY END-USER INDUSTRY, THROUGH 2021 ($ MILLIONS)
INTEGRATED SYSTEMS MARKET
TABLE 81 GLOBAL VALUE OF INTEGRATED SYSTEMS MARKET, BY TYPE, THROUGH 2021 ($ MILLIONS)
TABLE 82 GLOBAL VALUE OF INTEGRATED SYSTEMS, BY END-USER INDUSTRY, THROUGH 2021 ($ MILLIONS)
ENABLED PRODUCTS MARKET
SOURCES OF COMPETITIVE ADVANTAGE
TABLE 83 BIODIESEL FUEL PERFORMANCE COMPARISON
TABLE 84 ARTEMISININ DRUG PRODUCTION COMPARISON
TABLE 85 SWEETENER PRODUCT COMPARISON
TABLE 86 GLOBAL VALUE OF ENABLED PRODUCTS MARKET, BY END-USER INDUSTRY, THROUGH 2021 ($ MILLIONS)
PHARMACEUTICALS MARKET
TABLE 87 GLOBAL VALUE OF ENABLED PHARMACEUTICALS MARKET, BY DRUG CLASS, THROUGH 2021 ($ MILLIONS)
CHEMICALS MARKET
TABLE 88 FACTORS FOR SYNTHETIC-BIOLOGY-BASED CHEMICAL
PROCESSES
TABLE 89 GLOBAL VALUE OF ENABLED CHEMICALS MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
ENERGY MARKET
TABLE 90 ADVANCED BIOFUEL GROWTH FACTORS
TABLE 91 CRUDE OIL PRICES, 2011-2016
TABLE 92 STRATEGIC SHIFTS IN BIOFUELS
TABLE 93 GLOBAL VALUE OF THE ENERGY MARKET, BY FUEL TYPE, THROUGH 2021 ($ MILLIONS)
AGRICULTURE MARKET
TABLE 94 GLOBAL VALUE OF AGRICULTURE MARKET, BY END USE, THROUGH 2021 ($ MILLIONS)
Animals Market
TABLE 95 GLOBAL VALUE OF ANIMAL MARKET, BY APPLICATION, THROUGH 2021 ($ MILLIONS)
Pest-Control Market
TABLE 96 MOSQUITO-CONTROL METHODS
TABLE 97 AEDES AEGYPTI INITIAL MARKETS
Seeds Market
TABLE 98 GLOBAL VALUE OF SEED MARKETS, BY END-USE APPLICATION, THROUGH 2021 ($ MILLIONS)
TABLE 99 ADVANTAGES OF GENOME EDITING FOR CROP
MODIFICATION
TABLE 100 GENOME-EDITED CROPS MARKET LANDSCAPE (MILLION TONNES)
TABLE 101 GENOME-EDITED CROPS COMMERCIALIZATION PATHWAY
REGIONAL MARKETS
SYNTHETIC-BIOLOGY PRODUCTS BY REGION
TABLE 102 GLOBAL VALUE OF SYNTHETIC-BIOLOGY MARKET, BY REGION, THROUGH 2021 ($ MILLIONS)
ENABLING PRODUCTS MARKET BY REGION
TABLE 103 GLOBAL VALUE OF ENABLING PRODUCTS MARKET, BY REGION, THROUGH 2021 ($ MILLIONS)
CORE PRODUCTS BY REGION
TABLE 104 GLOBAL VALUE OF CORE PRODUCTS MARKET, BY REGION, THROUGH 2021 ($ MILLIONS)
ENABLED PRODUCTS BY REGION
TABLE 105 GLOBAL VALUE OF ENABLED PRODUCTS MARKET, BY REGION, THROUGH 2021 ($ MILLIONS)
TABLE 106 BIOFUELS BLEND MANDATES IN KEY COUNTRIES (%)
CHAPTER 8 PATENTS
INTRODUCTION
TABLE 107 SYNTHETIC-BIOLOGY PATENT SCOPE
FOUNDATIONAL PATENTS
TABLE 108 SYNTHETIC-BIOLOGY FOUNDATIONAL PATENTS
SYNTHETIC-BIOLOGY INDUSTRY PATENT ANALYSIS
TABLE 109 SYNTHETIC-BIOLOGY PATENT LANDSCAPE, BY COMPANY
TABLE 110 PATENT DESCRIPTION BY COMPANY
GENOME EDITING - CRISPR/CAS9 PATENT LANDSCAPE
TABLE 111 GENOME-EDITING PATENT LEADERS
TABLE 112 CRISPR-CAS9 IP LANDSCAPE
CHAPTER 9 COMPANY PROFILES
20N LABS INC.
ABEONA THERAPEUTICS INC.
ACTIVE MOTIF
AGILIS BIOTHERAPEUTICS LLC
AGRIVIDA
TABLE 113 AGRIVIDA TECHNICAL APPROACH
ALGENUITY
AMBRX INC.
AMYRIS INC.
ARAKNITEK
ARZEDA CORP.
ASTRAZENECA PLC
ATG BIOSYNTHETICS GMBH
ATUM
AVIDBIOTICS CORP.
BASF AG
BAYER AG
BETA RENEWABLES
BIOAMBER INC.
BIO BASIC CANADA INC.
BIOMAX INFORMATICS AG
BIONEER CORP.
BIO S&T INC.
BLUEBIRD BIO
BLUE MARBLE BIOMATERIALS
BOLT THREADS
BRITISH PETROLEUM
BRISTOL-MYERS SQUIBB
CALYSTA INC.
CARGILL INC.
CARIBOU BIOSCIENCES INC.
CELL DESIGN LABS
CELLECTIS SA
CHAIN BIOTECHNOLOGY LTD
CIBUS INC.
CODEXIS INC.
DEMURIS LIMITED
DESKTOP GENETICS LTD.
DOW CHEMICAL COMPANY
E.I. DU PONT DE NEMOURS AND COMPANY
DYADIC INTERNATIONAL INC.
EDITAS MEDICINE INC.
ENBIOTIX INC.
ENEVOLV INC.
EPOCH LIFE SCIENCE INC.
EUROFINS MWG OPERON
EVOLVA SA
TABLE 114 EVOLVA'S GENETIC CHEMISTRY PLATFORM
EVONETIX
EXXONMOBIL CORP.
GEN9 INC.
TABLE 115 LINEAR GENE-SYNTHESIS PRODUCTS
GENEMED SYNTHESIS INC.
GENE ORACLE INC.
GENEWORKS PTY. LTD.
GENOMATICA
GENSCRIPT
GEVO INC.
GINKGO BIOWORKS
TABLE 116 ENGINEERED-ORGANISM WORKFLOW
GLAXOSMITHKLINE PLC
GLOBAL BIOENERGIES
GLYCOS BIOTECHNOLOGIES INC.
GOODYEAR TIRE & RUBBER CO.
GREEN BIOLOGICS LTD.
HELIX NANOTECHNOLOGIES INC.
ILLUMINA INC.
TABLE 117 RECENT PLATFORMS INTRODUCED BY ILLUMINA
INDUSTRIAL MICROBES INC.
INGENZA LTD.
INOVIO PHARMACEUTICALS INC.
INTEGRATED DNA TECHNOLOGIES INC.
INTELLIA THERAPEUTICS
INTERNATIONAL BUSINESS MACHINES
INTREXON CORP.
JOULE UNLIMITED
JUNO THERAPEUTICS INC.
LABGENIUS LTD.
LANZATECH
LATTICE AUTOMATION INC.
LC SCIENCES
LYGOS INC.
MERCK & CO.
METABOLIX INC.
MICHELIN SA
MICROSOFT CORP.
MODULAR GENETICS INC.
MORPHOSYS AG
MYRIANT TECHNOLOGIES LLC
NEW ENGLAND BIOLABS
NOVARTIS PHARMA AG
NOVOZYMES A/S
OMEGA BIO-TEK INC.
ORAGENICS INC.
ORIGENE TECHNOLOGIES INC.
PACIFIC BIOSCIENCES OF CALIFORNIA INC.
PFIZER INC.
PHYLOGICA LIMITED
PHYTOWELT GREEN TECHNOLOGIES GMBH
PRECISION BIOSCIENCES
PROKARIUM HOLDINGS LTD.
QTEROS INC.
RADIANT GENOMICS INC.
RENNOVIA INC.
ROOSTERBIO INC.
ROYAL DSM NV
SAMPLE6 TECHNOLOGIES
SANGAMO THERAPEUTICS INC.
SANOFI-AVENTIS
SCARAB GENOMICS LLC
SEA6 ENERGY PVT LTD.
SGI-DNA INC.
SHANGHAI GENERAY BIOTECH CO. LTD.
SHANGHAI SHINEGENE MOLECULAR BIO-TECHNOLOGIES INC.
SIGMA ALDRICH CORP.
SILICOLIFE LDA.
SOLIGENIX INC.
SPIBER INC.
SYNLOGIC
SYNPROMICS LTD.
SYNTHACE LTD.
SYNTHETIC BIOLOGICS INC.
SYNTHETIC GENOMICS INC.
SYNTHORX INC.
SYNVITROBIO INC.
TAXA BIO-ENGINEERING
TEEWINOT LIFE SCIENCES CORP.
TERRAVIA HOLDINGS INC.
TESELAGEN BIOTECHNOLOGY INC.
THERMO FISHER SCIENTIFIC INC.
TOUCHLIGHT GENETICS LTD
TRANSCRIPTIC INC.
TRITON ALGAE INNOVATIONS LTD.
TWIST BIOSCIENCE
VERDEZYNE INC.
ZIOPHARM ONCOLOGY INC.
ZYMERGEN

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