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Spinal Intervention: Markets for Surgical, Replacement and Neurostimulation Technologies

Spinal Intervention: Markets for Surgical, Replacement and Neurostimulation Technologies

The global market for spinal and neurostimulation intervention products is expected to reach $15.8 billion by 2021 from $12.6 billion in 2016, rising at a compound annual growth rate (CAGR) of 4.5% from 2016 through 2021. 

This report provides:
An overview of the global markets for surgical, replacement, and neurostimulation technologies as they relate to spinal intervention.
Analyses of global market trends, with data from 2015, estimates for 2016, and projections of compound annual growth rates (CAGRs) through 2021.
Coverage of several types of surgical procedure currently available for the treatment of spinal diseases and injury, including spinal fusion, disc replacement, facet replacement and kyphoplasty, all of which use different products and technologies, and have different advantages and drawbacks.
Analyses of the market in terms of key product and technology areas, major manufacturers and factors influencing market growth and demand.
Key corporate activities, including such a mergers & acquisitions, strategic alliances and research & development.
Profiles of major players in the industry.


SCOPE OF REPORT

The report provides an analysis of the markets for spinal and neurostimulation products, including trends and sales to 2021. It analyzes the market in terms of key product and technology areas, major manufacturers and factors influencing market growth.

Manufacturers of neurostimulation and spinal technologies are discussed and analyzed based on product types, market share and key corporate activities, including a mergers and acquisitions, strategic alliances, and research and development. In addition to neurostimulation products used for the treatment of spinal conditions, the report looks at the wider neurostimulation industry in order to provide a more comprehensive analysis of the overall market and growth opportunities for companies operating in this field.

The report also includes an in-depth analysis of new products and technologies in development, as well as the development of new products that can address a growing number of therapeutic indications.

Excluded from the scope of the report are spinal soft goods, bracing products and externally worn neurostimulation devices.

CHAPTER 1 Introduction
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE OF REPORT
INTENDED AUDIENCE
INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 SUMMARY
SUMMARY TABLE GLOBAL MARKET FOR SPINAL AND NEUROSTIMULATION, BY CATEGORY, THROUGH 2021 ($ MILLIONS)
SUMMARY FIGURE GLOBAL MARKET FOR SPINAL AND NEUROSTIMULATION, BY MAJOR CATEGORY, 2015-2021 ($ MILLIONS)
CHAPTER 3 MARKET OVERVIEW
TABLE 1 NUMBER OF SPINAL SURGERIES PERFORMED IN THE U.S., 2010 AND 2015
FIGURE 1 NUMBER OF SPINAL SURGERIES PERFORMED IN THE U.S., 2010 AND 2015
APPLICATIONS FOR SPINAL SURGERIES
DEGENERATIVE DISC DISEASE
SPINAL DISC HERNIATION
SPINAL DEFORMITY
SPINAL TRAUMA
APPLICATIONS FOR NEUROSTIMULATION TECHNOLOGIES
TABLE 2 NEUROSTIMULATION: PREVALENCE OF ADDRESSABLE CONDITIONS IN THE U.S., 2015 (NO. OF CASES)
CHRONIC PAIN MANAGEMENT
FIGURE 2 LOCATION OF CHRONIC PAIN IN THE U.S.
NEUROLOGICAL DISORDERS
Essential Tremor
Parkinson's Disease
Dystonia
Epilepsy
Chronic Migraine and Headache
CARDIOVASCULAR DISEASE
Hypertension
FIGURE 3 GLOBAL RATE OF UNCONTROLLED HYPERTENSION, 1980 AND 2008 (MILLIONS)
Heart Failure
GASTROINTESTINAL DISORDERS
URINARY AND RECTAL DISORDERS
SLEEP APNEA
OBESITY
FIGURE 4 PERCENTAGE OF POPULATION WITH OBESITY IN THE U.S., 1999-2014 (%)
PSYCHIATRIC DISORDERS
CHAPTER 4 CURRENT MARKET ENVIRONMENT
TABLE 3 GLOBAL MARKET FOR SPINAL AND NEUROSTIMULATION, BY CATEGORY, THROUGH 2021 ($ MILLIONS)
FIGURE 5 GLOBAL MARKET SHARES OF SPINAL AND NEUROSTIMULATION, BY CATEGORY, 2015 (%)
MAJOR MARKETS BY PRODUCT TYPE
SPINAL PRODUCTS
TABLE 4 GLOBAL MARKET FOR SPINAL DEVICES, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
FIGURE 6 GLOBAL MARKET SHARES OF SPINAL DEVICES, BY PRODUCT, 2015 (%)
NEUROSTIMULATION
TABLE 5 GLOBAL MARKET FOR NEUROSTIMULATION, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
FIGURE 7 GLOBAL MARKET SHARE OF NEUROSTIMULATION, BY PRODUCT, 2015 (%)
MAJOR COMPANIES AND MARKET SHARE
SPINAL PRODUCTS COMPETITIVE LANDSCAPE
TABLE 6 GLOBAL MARKET FOR SPINAL PRODUCTS, BY MAJOR COMPANIES, THROUGH 2015 ($ MILLIONS)
FIGURE 8 GLOBAL COMPANY MARKET SHARES OF SPINAL DEVICES, 2015 (%)
TABLE 7 U.S. MARKET FOR MAJOR SPINAL DEVICES, BY COMPANY, THROUGH 2015 ($ MILLIONS)
FIGURE 9 U.S. COMPANY MARKET SHARES OF SPINAL DEVICES, 2015 (%)
TABLE 8 MARKET SHARES OUTSIDE THE U.S. FOR MAJOR SPINAL DEVICES, BY COMPANY, THROUGH 2015 ($ MILLION)
FIGURE 10 COMPANY MARKET SHARES OUTSIDE THE U.S. FOR MAJOR SPINAL DEVICES, 2015 (%)
NEUROSTIMULATION PRODUCTS COMPETITIVE LANDSCAPE
TABLE 9 GLOBAL MARKET FOR NEUROSTIMULATION, BY MAJOR COMPANIES, THROUGH 2015 ($ MILLIONS)
FIGURE 11 GLOBAL MARKET SHARES OF NEUROSTIMULATION, BY MAJOR COMPANIES, 2015 (%)
MAJOR MARKETS BY REGION
THE SPINAL PRODUCTS MARKET
TABLE 10 GLOBAL MARKET FOR SPINAL DEVICES, BY REGION, THROUGH 2021 ($ MILLIONS)
FIGURE 12 GLOBAL MARKET SHARES OF SPINAL DEVICES, BY REGION, 2015 (%)
NEUROSTIMULATION MARKET
TABLE 11 GLOBAL MARKET FOR NEUROSTIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
FIGURE 13 GLOBAL MARKET SHARES OF NEUROSTIMULATION, BY REGION, 2015 (%)
MARKET TRENDS AND GROWTH DRIVERS
CHAPTER 5 SPINAL IMPLANT PRODUCTS AND TECHNOLOGIES
SPINAL FUSION
THE FUSION MARKET
TABLE 12 GLOBAL MARKET FOR SPINAL FUSION, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
FIGURE 14 GLOBAL MARKET SHARES OF SPINAL FUSION, BY PRODUCT, 2015 (%)
TABLE 13 GLOBAL MARKET FOR SPINAL FUSION, BY REGION, THROUGH 2021 ($ MILLIONS)
FIGURE 15 GLOBAL MARKET SHARES OF SPINAL FUSION, BY REGION, 2015 (%)
MATERIALS TECHNOLOGY
Polyetheretherketone
K2M's Lamellar 3D Titanium Technology
Orthofix International's FORZA PTC (Peek Titanium Composite) Spacer
System
Spineart's Ti-LIFE Technology
Amedica's Silicon Nitride Technology
SeaSpine's NanoMetalene
B. Braun/Aesculap's PlasmaporeXP Coating
Zimmer Biomet's Trabecular Metal Technology
THORACOLUMBAR PRODUCTS
TABLE 14 KEY THORACOLUMBAR PRODUCTS AVAILABLE IN THE MARKET
New Products and Technologies
Alphatec Spine's Arsenal System
DePuy Synthes' Expedium Verse Spinal System
Globus Medical's Creo
K2M's MESA 2 Deformity Spinal System
K2M's Nile Alternative Fixation Spinal System
Medtronic's CD Horizon Fenestrated Screw Set
Medtronic's Vertex Reconstruction System
NuVasive's Integrated Global Alignment (iGA) Platform
INTERBODY SYSTEMS
TABLE 15 KEY INTERBODY PRODUCTS AVAILABLE IN THE MARKET
New Products and Technologies
Aesculap's TSpace PEEK Interbody System
Aesculap's ProSpaceXP Interbody System
Alphatec Spine's Battalion Universal Spacer System
Amedica's Valeo II Lateral Lumbar (LL) Interbody Fusion Device
Globus Medical's RISE-L
Globus Medical's Monument
Globus Medical's SILC Fixation System
K2M's Cascadia Products
Medtronic's Divergence Stand Alone Interbody Cage
Orthofix' Forza PTC (Peek Titanium Composite) Spacer System
SeaSpine's Hollywood VI NanoMetalene Interbody Device
Spineart's JULIETTi System
Spinal Elements' Expandable Interbody Fusion Devices
Spine Wave's Velocity L Expandable Interbody Device and XLR II
Lateral Access System
Vertebral Body Replacements
Aesculap's Modulift Vertebral Body Replacement
K2M's Capri Corpectomy Cage System
NuVasive's X-Core Mini Cervical Corpectomy System
CERVICAL SPINAL PRODUCTS
DePuy Synthes' Synapse Occipital-Cervical-Thoracic System
K2M's Mesa Mini Spinal System and Denali Mini Spinal System
K2M's Pyrenees Mono Cervical Plate
Medtronic's DIVERGENCE System
Medtronic's Zevo Anterior Cervical Plate System.
Zimmer Biomet's Optio-C Anterior Cervical Plate
RTI Surgical's Streamline OCT System
Zimmer Biomet's Virage OCT System
MINIMALLY INVASIVE SPINAL FUSION
THE MINIMALLY INVASIVE SURGERY MARKET
TABLE 16 GLOBAL MARKET FOR MINIMALLY INVASIVE VS. TRADITIONAL SPINAL FUSION, THROUGH 2021 (UNIT)
FIGURE 16 GLOBAL MARKET SHARES OF MINIMALLY INVASIVE VS. TRADITIONAL SPINAL FUSION, 2015 (%)
NEW PRODUCTS AND TECHNOLOGIES
TABLE 17 KEY MINIMALLY INVASIVE SPINAL SURGERY PRODUCTS
Aesculap's S4 Element MIS System
LDR Holding's ROI-C Titanium-Coated Cervical Cage
K2M's Everest Minimally Invasive (MI) XT Spinal System
Medtronic's CD Horizon Solera Voyager Spinal System
Medtronic's Oblique Lateral Interbody Fusion Platform
NuVasive's Maximum Access Surgery Products
Orthofix International's Phoenix Minimally Invasive Spinal Fixation
System
TOTAL DISC REPLACEMENT
THE TOTAL DISC REPLACEMENT MARKET
TABLE 18 GLOBAL MARKET FOR TOTAL DISC REPLACEMENT, BY PRODUCT, THROUGH 2021 (UNIT)
FIGURE 17 GLOBAL MARKET SHARES OF TOTAL DISC REPLACEMENT, BY PRODUCT, 2015 (%)
TABLE 19 GLOBAL MARKET FOR TOTAL DISC REPLACEMENT, BY REGION, THROUGH 2021 (UNIT)
FIGURE 18 GLOBAL MARKET SHARES OF TOTAL DISC REPLACEMENT, BY REGION, 2015 (%)
LUMBAR DISCS
Currently Available Products
Aesculap's activL Artificial Disc
DePuy Synthes' ProDisc-L
CERVICAL DISCS
TABLE 20 CURRENTLY AVAILABLE CERVICAL DISC REPLACEMENTS
Currently Available Products
Aesculap's Activ-C
DePuy Synthes' ProDisc-C
Clinical Data
Globus Medical's Secure-C
K2M's Rhine Cervical Disc System
LDR Holding's (Zimmer Biomet) Mobi-C Cervical Disc Replacement
Device
Clinical Data
Medtronic's Prestige LP Cervical Disc System
Clinical Data
Spinal Kinetics' M6-C
DYNAMIC STABILIZATION
CURRENTLY AVAILABLE PRODUCTS
Medtronic's X-STOPPK
Zimmer Biomet's Dynesys Dynamic Stabilization System
BIOLOGICS
BONE GRAFT SUBSTITUTES
MEDTRONIC'S INFUSE BONE GRAFT
EUROPEAN MARKETING SUSPENSION OF MEDTRONIC'S INDUCTOS
DEPUY SYNTHES' VIVIGEN CELLULAR BONE MATRIX
SYNTHETIC BONE GRAFTS
Alphatec's Neocore Osteoconductive Matrix
NuVasive's AttraX Putty
Orthofix International's Trinity Evolution
FRACTURE REPAIR
THE FRACTURE REPAIR MARKET
TABLE 21 GLOBAL MARKET FOR SPINAL TRAUMA, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
FIGURE 19 GLOBAL MARKET SHARES OF SPINAL TRAUMA, BY PRODUCT, 2015 (%)
CURRENTLY AVAILABLE PRODUCTS
TABLE 22 CURRENTLY AVAILABLE TREATMENTS FOR VERTEBRAL
COMPRESSION FRACTURES
Medtronic and Kyphon Balloon Kyphoplasty
Cement and Cement Delivery Systems
DePuy Synthes' Confidence Spinal Cement System
Biomet's VCF Products
Styker's Cortoss Bone Augmentation Material
Spineology's OptiMesh
CHAPTER 6 NEUROSTIMULATION PRODUCTS AND TECHNOLOGIES
TECHNOLOGICAL DEVELOPMENTS
MRI COMPATIBILITY
TABLE 23 NUMBER OF MRI SCANS PERFORMED IN THE U.S., 1995-2015 (PER 1,000 OF THE POPULATION)
FIGURE 20 NUMBER OF MRI SCANS PERFORMED IN THE U.S., 1995-2015 (PER 1,000 OF THE POPULATION)
RECHARGEABLE AND NONRECHARGEABLE DEVICES
SPINAL CORD STIMULATION PRODUCTS
CURRENT MARKET LANDSCAPE
TABLE 24 GLOBAL MARKET FOR SPINAL CORD STIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
FIGURE 21 GLOBAL MARKET SHARES OF SPINAL CORD STIMULATION, BY REGION, 2015 (%)
USES OF SPINAL CORD STIMULATION AND COMPLEMENTARY THERAPIES
IMPROVED THERAPY OPTIONS
SPINAL CORD STIMULATION PRODUCTS ON THE MARKET
TABLE 25 CURRENTLY AVAILABLE SPINAL CORD STIMULATION
PRODUCTS
RECENT SPINAL CORD STIMULATION PRODUCT LAUNCHES AND
HIGHLIGHTS
Boston Scientific's Precision Spectra System and Illumina 3D
Technology
Clinical Data
Boston Scientific's Precision Novi and MultiWave Technology
Boston Scientific's Precision Montage MRI System
Medtronic's Spinal Cord Stimulation Products
Nevro's Senza System and HF10 Therapy
Clinical Data
Nuvectra's Algovita System
St. Jude Medical's Proclaim Elite and Burst Stimulation
Burst Stimulation Clinical Data
Invisible Trial System
St. Jude Medical's MRI-Safe Systems
Stimwave Technologies' Freedom Systems
Freedom-8A SCS System
ALTERNATIVES TO TRADITIONAL SPINAL CORD STIMULATION
St. Jude Medical's Axium System for Dorsal Root Ganglion Stimulation
ACCURATE Clinical Study
Peripheral Nerve Stimulation
Stimwave's StimQ Peripheral Nerve Stimulator System
DEEP BRAIN STIMULATION
RECENT THERAPY IMPROVEMENTS AND NEW INDICATIONS FOR USE THE DEEP BRAIN STIMULATION MARKET
TABLE 26 GLOBAL MARKET FOR DEEP BRAIN STIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
FIGURE 22 GLOBAL MARKET SHARES OF DEEP BRAIN STIMULATION, BY REGION, 2015 (%)
COMPETITIVE LANDSCAPE
TABLE 27 CURRENTLY AVAILABLE DEEP BRAIN STIMULATION PRODUCTS RECENT DEEP BRAIN STIMULATION PRODUCT LAUNCHES AND HIGHLIGHTS
Boston Scientific's Vercise Deep Brain Stimulation System
Boston Scientific's Vercise Primary Cell (PC) Deep Brain Stimulation
System
Medtronic's Activa Systems
FIGURE 23 PATIENTS RECEIVING MEDTRONIC DBS THERAPY IN THE U.S. AND EUROPE, 2015, (NUMBER OF PATIENTS)
Expanded Approval for Parkinson's Disease Patients
Medtronic DBS Therapy for Refractory Epilepsy
Expanded Approval for Use With MRI
SureTune2 Software
TYRX Absorbable Antibacterial Envelope
NeuroPace's RNS System
Clinical Data
St. Jude Medical's Infinity Deep Brain Stimulation System
VAGUS NERVE STIMULATION
TABLE 28 GLOBAL MARKET FOR VAGUS NERVE STIMULATION, BY COMPANY, 2010-2015 ($ MILLIONS)
VAGUS NERVE STIMULATION MARKET
TABLE 29 GLOBAL MARKET FOR VAGUS NERVE STIMULATION, BY REGION, THROUGH 2021 ($ MILLIONS)
FIGURE 24 GLOBAL MARKET SHARES OF VAGUS NERVE STIMULATION, BY REGION, 2015 (%)
LIVANOVA'S VNS THERAPY
TABLE 30 CYBERONICS: VNS THERAPY UNIT SALES, YEAR ENDED APRIL 2010-2015
FIGURE 25 CYBERONICS: VNS THERAPY UNIT SALES, YEAR ENDED APRIL 2010-2015
FIGURE 26 CYBERONICS: SHARE OF VNS THERAPY UNIT SALES, BY REGION, YEAR ENDED APRIL 2015 (%)
VNS for the Treatment of Epilepsy
AspireSR Generator
VNS for the Treatment of Depression
Vitaria System for the Treatment of Heart Failure
EntroMedics' Maestro Rechargeable System and vBloc Therapy
Clinical Data
GASTRIC STIMULATION
MEDTRONIC'S ENTERRA THERAPY
INTRAPACE'S ABILITI SYSTEM
METACURE'S DIAMOND
OTHER FORMS OF NEUROSTIMULATION
SACRAL NERVE STIMULATION
Medtronic's InterStim System
Both products have FDA-approved labeling for 1.5 Tesla MRI head
scans.
AORTIC BARORECEPTOR STIMULATION
CVRx's Barostim
CARDIAC CONTRACTILITY MODULATION
Impulse Dynamics’ Optimizer IVs
HYPERGLOSSAL NEUROSTIMULATION
Inspire Medical Systems
LOWER ESOPHAGEAL SPHINCTER STIMULATION THERAPY
EndoStim's EndoStim Therapy
AUTONOMIC TECHNOLOGIES AND SPHENOPALATINE GANGLION
STIMULATION
CHAPTER 7 PRODUCT AND TECHNOLOGY PIPELINE
SPINAL PRODUCT PIPELINE DEVICES
TABLE 31 SPINAL PRODUCT PIPELINE HIGHLIGHTS
KEY SPINAL RESEARCH AND DEVELOPMENT PROJECTS
LDR Holdings' InterBRIDGE
LDR's New Minimal Implant Volume (MIVo) Spinal Implants
Amedica's 3D Printed Silicon Nitride Implants
RTI Surgical and Oxford Performance Materials
Axiomed's Freedom Lumbar Disc and Freedom Cervical Disc
Spinal Biologics Pipeline
B. Braun's TETEC Biologics Products
Mesoblast's MPC-06-ID
ISTO Technologies' NuQu Cell-Based Therapy
SpineOvations' DiscSeal
Amedica's Biologically Enhanced Implants
NEUROSTIMULATION PRODUCT PIPELINE
TABLE 32 NEUROSTIMULATION PRODUCT PIPELINE HIGHLIGHTS CURRENT INDICATIONS FOR USE
Spinal Cord and Peripheral Nerve Stimulation
Neuros Medical's Altius System High Frequency Nerve Block
Boston Scientific and Chronic Migraine
Deep Brain Stimulation
Aleva Neurotherapeutics' Directional Deep Brain Stimulation
Deep Brain Innovations' Temporally Optimized Patterned Stimulation
(TOPS)
Medtronic and Sapiens Steering Brain Stimulation
Vagus Nerve Stimulation
LivaNova's Development Pipeline
Enopace Biomedical's Harmony System
Aortic Baroreceptor Stimulation
CVRx's Barostim for Heart Failure
Hypoglossal Neurostimulation
ImThera Medical's THN Sleep Therapy
Nyxoah's Nyxoah System
NEW INDICATIONS AND NEUROSTIMULATION THERAPIES
TABLE 33 NEW INDICATIONS AND NEUROSTIMULATION THERAPIES
Vagus Nerve Stimulation for New Indications
LivaNova - Vagus Nerve Stimulation for Heart failure
Entromedics' Development Pipeline
Respicardia's remede System for Central Sleep Apnea
MicroTransponder's VNS Therapy for Stroke and Tinnitus
Vivistim System
Serenity System for Tinnitus
Neurosigma's Trigeminal Nerve Stimulation Technology
CHAPTER 8 INDUSTRY DEVELOPMENTS
MERGERS AND ACQUISITIONS
MERGERS AND ACQUISITIONS IN THE SPINAL PRODUCTS MARKET
Recent Transactions in the Spinal Products Industry
TABLE 34 RECENT MERGERS AND ACQUISITIONS IN THE SPINAL
PRODUCTS MARKET
SeaSpine and NLT Spine
Global Medical and Alphatec Holdings’ International Operations
Zimmer Bioment and LDR Holding
Stryker and CareFusion Vertebral Compression Fracture Portfolio
Zimmer and Biomet
Globus Medical and Transplant Technologies of Texas Ltd.
MERGERS AND ACQUISITIONS IN THE NEUROSTIMULATION MARKET
Recent Transactions in the Neurostimulation Products Industry
TABLE 35 RECENT MERGERS AND ACQUISITIONS IN THE NEUROSTIMULATION MARKET
Abbott and St. Jude Medical
Sorin and Cyberonics
St. Jude Medical and Spinal Modulation
Medtronic and Sapiens Steering Brain Stimulation
Medtronic and TYRX
STRATEGIC ALLIANCES
TABLE 36 RECENT ALLIANCES IN THE MARKET
MAJOR AND RECENT ALLIANCES
Amedica and Celling Biosciences
RTI Surgical and Oxford Performance Materials
LDR Holding and Poly-Shape
Medtronic and Samsung Electronics America
DePuy Synthes and AO Foundation
Boston Scientific and Brainlab
Stimwave Technologies and Epimed International
LDR Holding and Sentio
DePuy Synthes and LifeNet Health
DePuy Synthes and Brainlab
Orthofix International and Musculoskeletal Transplant Foundation
Nevro, Venturi Group and the Mayo Foundation for Medical Education and Research
K2M and Spinal LLC
CHAPTER 9 COMPANY PROFILES
SPINAL PRODUCT MANUFACTURERS
ALPHATEC HOLDINGS
B. BRAUN/AESCULAP
DEPUY SYNTHES
GLOBUS MEDICAL
K2M
MEDTRONIC
NUVASIVE
ORTHOFIX INTERNATIONAL
STRYKER
ZIMMER BIOMET
NEUROSTIMULATION PRODUCT MANUFACTURERS
BOSTON SCIENTIFIC
CVRX
LIVANOVA
MEDTRONIC
NEUROPACE
NEVRO
ST. JUDE MEDICAL

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