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Regenerative Medicines: Bone and Joint Applications

Regenerative Medicines: Bone and Joint Applications

The U.S. market for regenerative medicine products used in bone and joint applications is expected to grow at a compound annual growth rate (CAGR) of 6.8% from $2.9 billion in 2015 to nearly $4.1 billion in 2020.

This report provides:

An overview of the market for regenerative medicines in bone and joint applications, whose key objectives are the utilization of living cells to repair or replace body tissue damaged by injury, disease, or the aging process.

Analyses of market trends, with data from 2014, estimates for 2015, and projections of CAGRs through 2020.

Coverage of other regenerative applications, such as dental, neurologic, organ regeneration, cardiovascular, urologic, diabetes, and wound care, as well as stem cell research.

Identification of market drivers, including an increase in diseases and disorders that will benefit from these products, primarily arthritis, osteoporosis, and various types of bone and joint trauma (e.g., hip fractures, knee injuries); increasing use of nonautograft products by physicians; and innovative devices that incorporate bone- and cartilage-growth-stimulating agents in a regenerative appliance.

Descriptions of products, such as bone and cartilage grafting and regenerative products derived from autologous, allogeneic, and synthetic sources, as well as electrical stimulators for bone growth and regenerative cartilage products.


STUDY SCOPE AND FORMAT

The U.S. has been the main regenerative medicine market in terms of R&D innovation, patents and product sales often accounting for as much as half of the market depending on the product niche; hence, the scope of the study is mainly the U.S., although worldwide developments are discussed and measurements provided where relevant. The Overview section provides a background of the demographics underlying the market for bone and joint products, a definition of regenerative medicine and the technologies involved, and a discussion of regenerative products in development for applications other than bones and joints. Various application sections describe the leading bone and joint diseases and disorders applicable to regenerative technologies, including incidence and current methods of treatment.

The section on Products provides extensive descriptions and analyses (e.g., comparative analysis) of regenerative products used to treat bone and joint disorders, as well as a discussion of products in development.

The section on FDA clinical trials and newly approved products provides a discussion of regulatory issues affecting regenerative medicine products.

An extensive Company Profiles section provides estimates for the revenues of the leading companies and a concise description of leading and emerging companies in the area of regenerative products for bones and joints, including product introductions, patents and overall business strategies.

CHAPTER 1 INTRODUCTION
OBJECTIVES AND GOALS OF STUDY
INTENDED AUDIENCE
STUDY SCOPE AND FORMAT
METHODOLOGY
INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 SUMMARY
SUMMARY TABLE U.S. MARKET FOR REGENERATIVE MEDICINE PRODUCTS USED IN BONE AND JOINT APPLICATIONS, THROUGH 2020 ($ MILLIONS)
SUMMARY FIGURE U.S. MARKET FOR REGENERATIVE MEDICINE PRODUCTS USED IN BONE AND JOINT APPLICATIONS, 2014-2020 ($ MILLIONS)
CHAPTER 3 OVERVIEW AND OVERALL STATUS OF THE INDUSTRY
SCOPE OF REGENERATIVE MEDICINE MARKET
ESTIMATED NUMBER OF COMPANIES IN REGENERATIVE SECTOR
TABLE 1 FUNCTIONAL ACTIVITIES WITH REGENERATIVE MEDICINE SECTOR
TABLE 2 MOST PROMINENT COMPANIES IN THE REGENERATIVE MEDICINE
BUSINESS
SIZE OF ORTHOPEDIC SECTOR AND LEADING SUPPLIERS
TABLE 3 REVENUES FOR TOP SUPPLIERS OF ORTHOPEDIC PRODUCTS AND MATERIALS, 2014 ($ BILLIONS)
HOW REGENERATIVE MEDICINE WORKS
TISSUES AND ORGANS ON DEMAND
ORGAN REPLACEMENT IS A $100 BILLION PER YEAR BUSINESS
EXAMPLES OF IMPACT ON EXISTING CONDITIONS AND DISEASES
BARRIERS TO REGENERATIVE MEDICINE
TABLE 4 NINE PRINCIPAL MARKET DRIVERS
CURRENT R&D PRIORITIES
TABLE 5 R &D FOCUSES FOR PRINCIPAL REGENERATIVE MEDICINE
TABLE 6 TWENTY-YEAR PLANNING HORIZON FOR REGENERATIVE MEDICINE
BUSINESS: LIKELY DEVELOPMENTS
NATIONAL SCIENCE FOUNDATION PRIORITIES
TABLE 7 NATIONAL SCIENCE FOUNDATION REGENERATIVE MEDICINE FUNDING PRIORITIES, APRIL 1, 2015 ($)
TOTAL OUTPUT OF THE SECTOR
REGENERATIVE MEDICINE AND HEALTHCARE ECONOMICS
POPULATION TRENDS
MARKET TIMING
OVERSEAS INITIATIVES
CHAPTER 4 PRINCIPLE APPROACHES TO REGENERATIVE MEDICINE
HUMAN SUBSTANCES
CELLS AND TISSUES
TISSUE ENGINEERING
Importance of Scaffolding in Tissue Engineering
Plastic Scaffolding
Blood Vessel Scaffolding
Center for Integration of Medicine and Innovative Technology (CIMIT)
TABLE 8 PRINCIPLE RESEARCH PROJECTS OF CIMIT IN THE
TISSUE-ENGINEERING AND BIOMATERIALS FIELDS,
2008-2012
Massachusetts General Hospital
Duke University Stem Cell and Regenerative Medicine Program
University of Iowa
EMBRYONIC STEM CELLS
Therapeutic Cloning
ADULT STEM CELLS: JUST AS GOOD AS EMBRYONIC STEM CELLS
Genzyme
University of Minnesota Stem Cell Institute
STEM CELL RESEARCH PATENTS AND EFFECT ON STEM CELL MARKETERS
Stem Cells via Indirect Lineage Conversion (ILC)
COMPANIES INVOLVED IN BONE AND JOINT STEM CELL–BASED
THERAPEUTICS
TABLE 9 COMPANIES INVOLVED IN BONE AND JOINT STEM CELL-BASED
THERAPEUTICS
SETTING THE STAGE FOR REGENERATIVE MEDICINE TO TREAT BONE AND JOINT DISORDERS
NOVEL MATERIALS
Nanoneedles
GENE THERAPY
Gene Therapy Trials Targeting Bone and Joint Diseases and Disorders
BIOREACTOR USE IN REGENERATIVE MEDICINE
TABLE 10 COMMERCIAL SUPPLIERS OF BIOREACTORS FOR USE IN REGENERATIVE MEDICINE
THE IMPACT OF GENOMICS
CHAPTER 5 PRODUCTS AND TECHNOLOGIES: CATEGORIES OF REGENERATIVE MEDICINE
GENE- AND PROTEIN-BASED APPROACHES
ANTIBODIES
The Importance of Antibody Drugs
Advantages of Monoclonal Antibody Drugs
Antibodies and Osteoarthritis
Denosumab
GROWTH FACTORS
HOW BMPS FUNCTION
TABLE 11 BONE MORPHOGENETIC PROTEINS
Clinical Uses
Companies
CELLS AND TISSUES
TISSUE ENGINEERING
ARTIFICIAL SKIN
CARTILAGE
Other Approaches to Cartilage
haMPC Therapy for Knee Osteoarthritis
Biosynthetic Composites for Cartilage Repair
3D Tissue Printing of Cartilage
3D Tissue Printing of Bone
Histogenics
Columbia University Work
The Market for Tissue-Engineered Cartilage Products
TABLE 12 U.S. MARKET FOR TISSUE-ENGINEERED AND CELL THERAPY-BASED CARTILAGE PRODUCTS, THROUGH 2020 ($ MILLIONS)
OTHER PRODUCTS
CREATION OF ENTIRE ORGANS
EMBRYONIC STEM CELLS
NOVEL MATERIALS AND BIOMATERIALS
TABLE 13 WORLD'S LARGEST IMPLANTABLE BIOMATERIALS COMPANIES
CHAPTER 6 STEM CELL THERAPIES AND REGENERATIVE MEDICINE
STEM CELLS AS POTENTIAL REPLACEMENT CELLS
OVERALL MARKET AND PARTICIPANTS
STEM CELL MARKET RISKS
TECHNICAL IMPEDIMENTS
OVERVIEW OF FUNDING
TABLE 14 FEDERAL FUNDING FOR STEM CELL RESEARCH, THROUGH 2013 ($ MILLIONS)
STATE-LEVEL INITIATIVES FOR STEM CELL RESEARCH
TABLE 15 STATE LEVEL PROGRAMS FOCUSED ON STEM CELL RESEARCH
POTENTIAL APPLICATIONS: CURRENT STATUS
IN VIVO REPROGRAMMING
UMBILICAL CORD BLOOD STEM CELLS
Recent Research Developments
INDUCED PLURIPOTENT STEM CELLS
Recent Research Developments
Adult Multipotent Stem Cells
Embryonic Stem Cells
Adipose Stem Cells for Bone and Joint Applications
GERON AND THE FIRST HUMAN TRIALS
OTHER STEM CELL RESEARCH
STATUS OF OTHER CLINICAL TRIALS
STEM CELL THERAPY FOR ALS
STEM CELL THERAPY FOR DUCHENNE MUSCULAR DYSTROPHY
STEM CELL THERAPY AND BONE MARROW TRANSPLANTS
CHAPTER 7 REGENERATIVE PRODUCTS TO TREAT BONE DISEASES
REGENERATIVE PRODUCTS TO TREAT BONE DISEASES
OSTEOBIOLOGICS
BONE GRAFTS
PRINCIPAL USES OF BONE GRAFTS
TABLE 16 CHARACTERISTICS OF IDEAL BONE GRAFT MATERIAL
TABLE 17 U.S. BONE GRAFT PROCEDURE VOLUMES BY APPLICATION, THROUGH 2020 (NUMBER)
TABLE 18 U.S. BONE GRAFT PROCEDURE VOLUMES BY TYPE OF GRAFT, THROUGH 2020 (NUMBER)
TABLE 19 BONE GRAFT MATERIALS
TABLE 20 SUBSTITUTE BONE GRAFTS
AUTOGRAFTS
BIOSEED GRAFTS
ALLOGRAFTS
Demineralized Bone Matrix Products
TABLE 21 SELECTED DBM PRODUCTS AND PERCENTAGE OF DEMINERALIZED BONE MATRIX
Allograft Suppliers
Accell
AlphaGRAFT
Allomatrix
Bioset, BioReady
Mozaik
Grafton DBM
DBX
DynaBlast and DynaGraft-D
Graftech
Grafton
Opteform
OrthoBlast II
AlphaGRAFT
Xenografts
Market for Allografts
TABLE 22 U.S. MARKET FOR PRECISION-MACHINED ALLOGRAFTS, THROUGH 2020 ($ MILLIONS)
BONE REPLACEMENT AND REPAIR PRODUCTS
CELL-BASED BONE GRAFT SUBSTITUTES
Factor-based Bone Graft Substitutes
BONE MORPHOGENIC PROTEINS
InductOs
InFUSE Bone Graft
OP-1 Implant
CERAMIC-BASED BONE GRAFT SUBSTITUTES
Bioactive Glasses
Types of Ceramics
Alpha-BSM
BioActys
BioGran
Bio-Oss
BoneSource
Calcigen S
Collagraft Strip Bone Graft Matrix
Conduit TCP Granules
Exabone
Gamma-bsm
IsoTis Products
Mimix Bone Substitute Material
Norian SRS
OsteoGraf
OsteoMatrix
Osteoset
Osteostim Resorbable Bone Graft Substitute
PerioGlas
Pro Osteon Implant
Vitoss
POLYMER-BASED BONE GRAFT SUBSTITUTES
Cortoss
Healos
Immix Extenders and Immix CB
MARKET FOR BONE GRAFT PRODUCTS
TABLE 23 GLOBAL MARKET FOR BONE REPLACEMENT PRODUCTS, THROUGH 2020 ($ MILLIONS)
TABLE 24 U.S. MARKET FOR BONE-REPLACEMENT AND GRAFTING PRODUCTS, THROUGH 2020 ($ MILLIONS)
RESEARCH AND DEVELOPMENT OF OTHER REGENERATIVE MEDICINE PRODUCTS FOR BONE APPLICATIONS
BIOLOGIC/SYNTHETIC GRAFTS
CHRYSALIN
NEW SCAFFOLDING TECHNIQUES
Honeycomb Implants
Electrospun Fiber Multiwell Plates
BIOCELLULAR GRAFTS
CHAPTER 8 REGENERATIVE APPLICATIONS FOR BONES AND JOINTS
MATERIALS FOR BONE TISSUE REPAIR
TABLE 25 EXAMPLES OF NANOSTRUCTURED BIOMATERIALS USEFUL IN BONE AND JOINT REGENERATION
VANADIUM COMPOUNDS TO ACCELERATE BONE HEALING
BIONANOPARTICLES IN BONE HEALING
BIODEGRADABLE NANOSCALE FILAMENTS
SILK PROTEIN MICROFIBERS
INHERENT REGENERATION OF BONE
OVERALL SIZE OF BONE GRAFT BUSINESS
BONE GRAFT SUBSTITUTES
ALLOGRAFT TISSUE
OTHER OSTEOCONDUCTIVE BONE GRAFT SUBSTITUTES
HYDROGELS AND REGENERATION
UNIVERSITY OF ROCHESTER RESEARCH ON HYDROGELS
HYDROGEL SCAFFOLDING
HYDROGEL PATENTS
Bone Implant Materials Comprising Cross-Linked Bioactive Hydrogel
Matrices
Abstract
Hydrogel Bone Void Filler
Abstract
Amphiphilic Peptides and Hydrogel Matrices Thereof for Bone Repair
Abstract
Hydrogel Bioscaffold and Coating for Bone and Tooth Repair
Abstract
Antimicrobial Nanostructured Hydrogel Web Containing Silver
Abstract
Injectable Peptide Hydrogel That Kills Methicillin–Resistant
Staphylococcus Aureus
Abstract
Method to Repair a Damaged Intervertebral Disc Through the Use of a Bioadhesive, Thermogelling Hydrogel
Abstract
Hydrogel Compositions
Abstract
Self–Assembling Protein Hydrogel With Bio-Active Protein
Abstract
Superporous Hydrogel with Cells Encapsulated Therein and Method for Producing the Same
Abstract
Hydrogel Particles
Abstract
Composition and Method for Self-Assembly and Mineralization of Peptide Amphiphiles
Abstract
Chondroitinase ABC I Polynucleotides
Abstract
Transdiscal Administration of Cycline Compounds
Abstract
Composition and Method for Preparing Biocompatible Surfaces
Abstract
Spinal Mobility Preservation Apparatus Having an Expandable
Membrane
Abstract
MAJOR DISEASES AND CONDITIONS AFFECTING BONES
OSTEOPOROSIS
Currently Available Products to Treat Osteoporosis
Bisphosphonates
Fosamax
Boniva
New Approaches
Sclerostin Antibody
Romosozumab
Probiotics
Stem Cell Treatments
TABLE 26 DRUGS USED TO TREAT OSTEOPOROSIS
Hormones
Evista
Forteo
Miacalcin
STEROIDS AND OSTEOPOROSIS
Glucocorticoids
MARKET FOR PRODUCTS TO TREAT OSTEOPOROSIS
TABLE 27 GLOBAL MARKET FOR DRUGS TO TREAT OSTEOPOROSIS BY CATEGORY, THROUGH 2020 ($ MILLIONS)
PAGET'S DISEASE
DRUGS CURRENTLY AVAILABLE TO TREAT PAGET'S DISEASE
Actonel
Aredia
Skelid
Zometa
MARKET FOR PRODUCTS TO TREAT PAGET'S DISEASE
TABLE 28 GLOBAL MARKET FOR DRUGS TO TREAT PAGET'S DISEASE, THROUGH 2020 ($ MILLIONS)
INJURIES AND DEGENERATIVE CONDITIONS
HIP FRACTURES
TABLE 29 GLOBAL HIP FRACTURE VOLUMES, THROUGH 2020 (NUMBER)
TABLE 30 U.S. HIP FRACTURE VOLUMES, THROUGH 2020 (NUMBER/%)
TRADITIONAL TREATMENTS FOR BONE AND JOINT DISORDERS
TABLE 31 U.S. MARKET SHARES FOR MUSCULOSKELETAL PRODUCTS BY CATEGORY, 2014 (%)
TABLE 32 U.S. MARKET SHARES FOR RECONSTRUCTIVE DEVICES BY CATEGORY, 2014 (%)
MARKET LEADERS
JOINT-REPLACEMENT SURGERY
TABLE 33 NUMBER OF U.S. HIP REPLACEMENT PROCEDURE VOLUMES, THROUGH 2020
TABLE 34 NUMBER OF HIP REPLACEMENT PROCEDURES IN SIX MAJOR STATES, 2001
TABLE 35 GLOBAL MARKET FOR HIP REPLACEMENTS, THROUGH 2020 ($ MILLIONS)
TABLE 36 U.S. MARKET FOR HIP REPLACEMENTS, THROUGH 2020 ($ MILLIONS)
KNEE REPLACEMENTS
VENDORS
TABLE 37 GLOBAL KNEE-REPLACEMENT PROCEDURE VOLUMES, THROUGH 2020 (NUMBER)
TABLE 38 U.S. KNEE REPLACEMENT PROCEDURES, THROUGH 2020 (NUMBER)
TABLE 39 GLOBAL MARKET FOR KNEE REPLACEMENTS, THROUGH 2020 ($ MILLIONS)
TABLE 40 U.S. MARKET FOR KNEE REPLACEMENTS, THROUGH 2020 ($ MILLIONS)
TABLE 41 U.S. MARKET FOR UNICONDYLAR KNEE REPLACEMENTS, THROUGH 2020 ($ MILLIONS)
NATURAL THERAPEUTIC TREATMENTS FOR ARTHRITIS
IMAGING MARKETS AND REGENERATIVE THERAPIES
CHAPTER 9 ELECTRICAL BONE GROWTH STIMULATOR MARKET
OVERVIEW
SCIENTIFIC BASIS
ULTRASONIC OSTEOGENESIS STIMULATORS FOR BONE HEALING
MARKETERS OF INVASIVE AND NONINVASIVE ELECTRICAL BONE GROWTH
STIMULATORS
BIOMET
ORTHOFIX
DJO INC.
SMITH & NEPHEW (BIOVENTUS)
MARKET SIZE
TABLE 42 GLOBAL MARKET FOR NONINVASIVE BONE GROWTH STIMULATORS BY APPLICATION, THROUGH 2020 ($ MILLIONS)
TABLE 43 U.S. MARKET FOR NONINVASIVE BONE GROWTH STIMULATORS BY APPLICATION, THROUGH 2020 ($ MILLIONS)
R&D - FUTURE PRODUCT POSSIBILITIES
CHAPTER 10 ORTHOPEDICS – FDA CLEARANCES AND NEW PRODUCT
DEVELOPMENT
SUPPLIERS OF REGENERATIVE BONE AND JOINT PRODUCTS
TABLE 44 RECENTLY APPROVED ORTHOPEDIC BONE AND JOINT DEVICES BY PRODUCT, 2008-2015
CHAPTER 11 MARKET FOR TISSUE ENGINEERING PRODUCTS
COMPANY INVOLVEMENT
TISSUE ENGINEERING AND CELL THERAPY
RESEARCH INITIATIVES
NATIONAL INSTITUTES OF HEALTH (NIH)
DREXEL UNIVERSITY
BIO2 TECHNOLOGIES INC.
YESHIVA UNIVERSITY
CHAPTER 12 REGENERATIVE CONCEPTS AND PRODUCTS IN DENTISTRY
OVERVIEW
INDICATIONS AND HISTORY
CHARACTERISTICS AND MATERIALS
BARRIER MEMBRANES
Nonresorbable
Resorbable
COLLAGEN RESORBABLE MEMBRANES
SYNTHETIC RESORBABLE MEMBRANES
BIOENGINEERED HYBRID TEETH FROM AUTOLOGOUS GUM CELLS
STEM CELL STUDY RAISES HOPE FOR BONE REPAIR PASTES
DENTAL REGENERATIVE PRODUCT VENDORS
GEISTLICH PHARMA NORTH AMERICA INC.
ZIMMER
ORGANOGENESIS INC.
MATRICEL GMBH
COLLAGEN MATRIX INC.
CURASAN AG
CHAPTER 13 SKIN TECHNOLOGIES
TABLE 45 EXAMPLES OF FDA APPROVED HUMAN SKIN SUBSTITUTES
TABLE 46 GLOBAL MARKET FOR ENGINEERED SKIN GRAFTS AND REPLACEMENTS, THROUGH 2020 ($ MILLIONS)
SKIN-LIKE TISSUE DEVELOPED FROM HUMAN EMBRYONIC STEM CELLS
SOLUBLE SYSTEMS
INVESTIGATIONAL SKIN AND SOFT TISSUE SUBSTITUTES
TABLE 47 INVESTIGATIONAL SKIN AND SOFT TISSUE SUBSTITUTES, MARCH 2015
CHAPTER 14 NEUROLOGICAL APPLICATIONS IN REGENERATIVE
MEDICINE
OVERVIEW
NEURODEGENERATIVE DISEASES
BEST PROSPECTS FOR STEM CELLS IN THIS MARKET
STROKE
MULTIPLE SCLEROSIS
ALZHEIMER'S
CURRENT CONVENTIONAL THERAPIES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASE SYMPTOMS
SPINAL CORD INJURY, NEURODEGENERATIVE DISEASES AND REGENERATIVE
POTENTIAL
UNIVERSITY OF SOUTHERN CALIFORNIA (USC)
CHAPTER 15 REGENERATIVE MEDICINE AND APPLICATIONS IN CARDIAC
CARE
OVERVIEW
ACTIVE COMPANIES
Aastrom
Amorcyte
Athersys Inc.
Capricor
Cytomedix
Cytori Therapeutics
Juventas Therapeutics
Mesoblast
VentriNova
GENETIC BASIS FOR REGENERATING CELLS AFTER HEART ATTACK
STEM CELLS FOR THE FUTURE TREATMENT OF HEART DISEASE
PARTICULAR R&D PRIORITIES
STEM CELLS AND BIOLOGICAL PACEMAKERS
HEART PROGENITOR CELLS DEVELOPED FROM EMBRYONIC STEM CELLS
OTHER CURRENT REGENERATIVE MEDICINE AS IT RELATES TO THE HEART
CHAPTER 16 REGENERATIVE MEDICINE AND DIABETES
BACKGROUND
POSSIBLE APPLICATIONS FOR REGENERATIVE MEDICINE
CLINICAL TRIALS
SERNOVA CORP
ATHERSYS INC.
MESOBLAST
VIACYTE
CHAPTER 17 FDA-APPROVED CLINICAL TRIALS INVOLVING
REGENERATIVE MEDICINE
CURRENT STATUS OF THE REGENERATIVE MEDICINE BUSINESS
REGULATORY AND LEGAL ENVIRONMENT
STATUS OF RESEARCH AND CLINICAL TRIALS
ANALYSIS OF CLINICAL TRIALS
TABLE 48 REGENERATIVE MEDICINE CLINICAL TRIALS BY CATEGORY (NUMBER/%)
TABLE 49 CURRENT CLINICAL TRIALS IN THE FIELD OF REGENERATIVE MEDICINE, STATUS, CONDITIONS AND SPONSOR, MARCH 30, 2015
CHAPTER 18 OVERSEAS ACTIVITIES
DOMESTIC VERSUS OVERSEAS REGENERATIVE MEDICINE COMPANIES
JAPAN
Japan's Regenerative Therapies Market Prospects
TABLE 50 JAPAN’S MARKET FOR REGENERATIVE AND TISSUE ENGINEERING, 2009 AND 2020
EUROPE
REMEDIC
Nanobiocom
Regenerating Bone Defects using New Biomedical Engineering
Approaches – (REBORNE)
Gene Activated Matrices for Bone and Cartilage Regeneration in Arthritis – (GAMBA)
BIRAX
AUSTRALIA AND CHINA
CHAPTER 19 PATENT ANALYSIS
ANALYSIS
TISSUE ENGINEERING PATENTS
TABLE 51 TOP PATENT ASSIGNEES IN THE TISSUE ENGINEERING FIELD
GEOGRAPHIC DISTRIBUTION
TABLE 52 GLOBAL DISTRIBUTION OF REGENERATIVE MEDICINE PATENTS ISSUED BY COUNTRY, 1985-2012 (%)
RECENT PATENTS
METHOD FOR OBTAINING PANCREATIC PROGENITOR CELL USING NEPH3
Abstract
SPONTANEOUSLY IMMORTALIZED MULTIPONENT MESENCHYMAL CELL-LINE
DERIVED FROM MOUSE SUBCUTANEOUS ADIPOSE TISSUE: TOOL FOR
REGENERATIVE MEDICINE AND BIOACTIVE MOLECULES AND/OR DRUGS
SCREENING
Abstract
METHODS OF MANUFACTURING BIOACTIVE GELS FROM EXTRACELLULAR
MATRIX MATERIAL
Abstract
ALIMENTARY PROTEIN-BASED SCAFFOLDS (APS) FOR WOUND HEALING, REGENERATIVE MEDICINE AND DRUG DISCOVERY
Abstract
POLYMER CARRIER
Abstract
HERBAL COMPOSITION FOR THE TREATMENT OF WOUND HEALING, A REGENERATIVE MEDICINE
Abstract
MAGNETIC CELL AND METHOD OF USING THE SAME
Abstract
THREE-DIMENSIONAL BIOPRINTING OF BIOSYNTHETIC CELLULOSE (BC)
IMPLANTS AND SCAFFOLDS FOR TISSUE ENGINEERING
Abstract
BIOMATERIAL BASED ON WHARTON'S JELLY FROM THE HUMAN UMBILICAL
CORD
Abstract
NONWOVEN FABRIC AND PROCESS FOR PRODUCING THE SAME
Abstract
THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE
MEDICINE, AGING AND CANCER
Abstract
DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC USES OF LONG
NON-CODING RNAS FOR CANCER AND REGENERATIVE
MEDICINE
Abstract
NANO/MACROPOROUS BONE TISSUE SCAFFOLDS FOR REGENERATIVE
MEDICINE
Abstract
GUIDED DELIVERY OF CELL-, PARTICLE- AND DRUG-BASED THERAPIES
Abstract
TRANSGENIC NONHUMAN ANIMAL AND METHODS FOR STEM CELL
ENGRAFTMENT
Abstract
METHODS FOR MODULATING THE PROLIFERATION AND DIFFERENTIATION
POTENTIAL OF STEM CELLS AND PROGENITOR CELLS
Abstract
BIOPOLYMER PRODUCED BY FERMENTING THE EXTRACT OF SOYBEAN WITH FOLIC ACID AND A COMPOSITION CONTAINING THEREOF
Abstract
SUBPOPULATIONS OF BONE MARROW-DERIVED ADHERENT STEM CELLS
AND METHODS OF USE THEREFOR
Abstract
METHOD FOR PREPARING BIOLOGICAL SCAFFOLD MATERIAL
Abstract
COMPOSITION FOR REGENERATIVE TREATMENT OF CARTILAGE DISEASE
Abstract
REGULATION OF STEM CELL GENE PRODUCTION WITH SPECIFIC AND SELECTIVE ELECTRIC AND ELECTROMAGNETIC FIELDS
Abstract
COMPOSITIONS AND METHODS FOR BONE FORMATION AND REMODELING
Abstract
NEURAL CELL POPULATIONS FROM PRIMATE PLURIPOTENT STEM CELLS
Abstract
OSTEOINDUCTIVE BONE MATERIAL
Abstract
GENES WITH ES CELL-SPECIFIC EXPRESSION
Abstract
USE OF TGF BETA SUPERFAMILY ANTAGONISTS AND NEUROTROPHINS TO MAKE NEURONS FROM EMBRYONIC STEM CELLS
Abstract
HYDROXYPHENYL CROSS-LINKED MACROMOLECULAR NETWORK AND APPLICATIONS THEREOF
Abstract
MAGNETIC CELL AND METHOD OF USING THE SAME
Abstract
DIRECT DIFFERENTIATION METHOD FOR MAKING CARDIOMYOCYTES FROM HUMAN EMBRYONIC STEM CELLS
Abstract
ISOLATION AND PRESERVATION OF FETAL HEMATOPOIETIC AND MESENCYMAL SYSTEM CELLS FROM NONCONTROVERSIAL
MATERIALS AND/OR TISSUES RESULTING FROM MISCARRIAGES
AND METHODS OF THERAPEUTIC USE
Abstract
USE OF TGF BETA SUPERFAMILY ANTAGONISTS TO MAKE DOPAMINERGIC
NEURONS FROM EMBRYONIC STEM CELLS
Abstract
DIRECT DIFFERENTIATION METHOD FOR MAKING CARDIOMYOCYTES FROM HUMAN EMBRYONIC STEM CELLS
Abstract
METHOD FOR PREPARING NOVEL TRANSCRIPTION FACTORS AND USE
Abstract
ENDODERM CELLS FROM HUMAN EMBRYONIC STEM CELLS
Abstract
GENES WITH ES CELL–SPECIFIC EXPRESSION
Abstract
MARKER SYSTEM FOR PREPARING AND CHARACTERIZING HIGH-QUALITY
HUMAN EMBRYONIC STEM CELLS
Abstract
CHAPTER 20 COMPANY PROFILES
TABLE 53 PUBLICLY TRADED COMPANIES IN THE REGENERATIVE MEDICINE INDUSTRY, MARCH 6, 2015 ($/$ MILLIONS)
TABLE 54 COMPANIES ESTIMATED SALES ATTRIBUTABLE TO REGENERATIVE THERAPIES (BONE AND JOINT), 2012 ($ MILLIONS)
ACELITY
AESCULAP INC.
ALPHATEC SPINE INC.
ANIKA THERAPEUTICS INC.
APERION BIOLOGICS INC.
ARTERIOCYTE MEDICAL SYSTEMS INC.
ARTHREX INC.
ARTHROCARE CORP.
AUDAX MEDICAL INC.
BAXTER
BERKELEY ADVANCED BIOMATERIALS INC.
BIOMATLANTE
BIOMET INC.
BIOMIMETIC THERAPEUTICS INC.
BIOSURFACE ENGINEERING TECHNOLOGIES (BIOSET)
BIOTIME INC.
BIOTISSUE TECHNOLOGIES GMBH
BONALIVE BIOMATERIALS LTD
BONE SOLUTIONS INC.
CAM BIOCERAMICS B.V.
CAPSTONE THERAPEUTICS
CELLING BIOSCIENCES LLC
CERAPEDICS INC.
CESCA THERAPEUTICS
CITAGENIX INC.
CO.DON AG
COLLPLANT LTD.
CONMED CORP.
CRYOLIFE INC.
CURASAN AG
CURIS
CYTORI THERAPEUTICS INC.
DELENEX THERAPEUTICS AG
DEPUY ORTHOPAEDICS INC. (UNIT OF THE DEPUY COMPANIES)
DISCGENICS
DJO SURGICAL
ETEX CORP.
EXABONE GMBH
EXACTECH INC.
FATE THERAPEUTICS INC.
GARNET BIOTHERAPEUTICS
GEISTLICH PHARMA AG
GERON CORP.
GRAFTYS
HARVARD BIOSCIENCE
HISTOGEN
INTEGRA LIFESCIENCES HOLDING CORP.
INTELLICELL BIOSCIENCES INC.
INTERNATIONAL STEM CELL CORP.
INTERPORE CROSS INTERNATIONAL
ISTO TECHNOLOGIES INC.
K2M INC.
KENSEY NASH CORP.
KUROS BIOSURGERY AG
MCEWEN CENTRE FOR REGENERATIVE MEDICINE
MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE
MEDTRONIC INC.
MESOBLAST LTD
MIMEDX GROUP INC.
NATIONAL CENTER FOR REGENERATIVE MEDICINE
NATIONAL TISSUE ENGINEERING CENTER (NTEC)
NEURALSTEM INC.
NOVABONE PRODUCTS LLC
NOVARTIS CORP.
NUO THERAPEUTICS
NUVASIVE
OCATA THERAPEUTICS INC.
OLYMPUS BIOTECH CORP.
OPEXA THERAPEUTICS INC.
ORGANOGENESIS INC.
ORTHOFIX INTERNATIONAL N.V.
ORTHOPEUTICS L.P.
OSIRIS THERAPEUTICS INC.
OSTEOGENICS BIOMEDICAL INC.
PARCELL LABORATORIES
PFIZER INC.
PLURISTEM THERAPEUTICS
PROMOCELL GMBH
REGENECURE LTD.
REGENTIS BIOMATERIALS LTD.
RENEURON
REPLACEMENT THERAPY MATERIALS (R.T. MAT)
REPLIGEN CORP.
ROSLIN CELLAB
RTI SURGICAL INC.
SANOFI BIOSURGERY
SCIL TECHNOLOGY GMBH
SHIRE REGENERATIVE MEDICINE
SIGMA-ALDRICH CORP.
SMITH & NEPHEW
STEMCELLS INC.
STRAUMANN USA LLC
STRYKER CORP.
SURGICAL SPECIALTIES, INC.
SYNTHES INC.
TEKNIMED
TEPHA INC.
TETEC TISSUE ENGINEERING TECHNOLOGIES AG
TIGENIX N.V.
UCB S.A. (HEADQUARTERS)
VERICEL CORP.
VIACYTE INC.
WAKE FOREST INSTITUTE FOR REGENERATIVE MEDICINE
WRIGHT MEDICAL GROUP INC.
ZIMMER HOLDINGS INC.
OTHER ORGANIZATIONS INVOLVED IN REGENERATIVE MEDICINE R&D
ACADEMIC INSTITUTIONS
U.S. GOVERNMENT
OTHER SOCIETIES AND ORGANIZATIONS
CHAPTER 21 GLOSSARY OF KEY TERMS IN REGENERATIVE MEDICINE
BUSINESS

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