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Organ and Tissue Transplantation and Alternatives

Organ and Tissue Transplantation and Alternatives

The global market for organ and tissue transplantation products and devices reached $55.6 billion in 2014. This market is estimated to grow at a compound annual growth rate (CAGR) of 6.8% to reach $62.9 billion by 2015 and $88.1 billion by 2020.

This report provides:

An overview of the global markets for organ and tissue transplantation and alternatives.

Analyses of global market trends, with data from 2014, estimates for 2015 and projections of CAGR through 2020.

Detailed examination of procurement and preservation, solid organ transplantation, tissue transplantation, immunosuppressives and other pharmaceuticals, post-transplantation concerns, as well as alternatives to transplantation.

Coverage of post-transplant immunosuppression and monitoring methods and post-transplant drug regimens and patient and graft survival rates.

In-depth analysis of the market's dynamics, specifically growth drivers, inhibitors, and opportunities

Comprehensive profiles of major players in the industry.


This report offers forecasts, by product segment, from 2015 through 2020, including supporting analyses for projections. Product segments covered consist of the solid organ (e.g., kidneys, liver, heart-lung, pancreas, intestines) and the tissue transplantation (e.g., bone, skin, cornea, heart valve) markets, along with the pharmaceuticals that accompany each market. Also included are experimental xenografts and artificial organs; tissue transplants; and cell transplants (e.g., bone marrow, cord blood, peripheral blood, islet cell). The report touches on the use of fetal cells, stem cells and altered cancer cells. The arrangement of this report offers an overview of the key elements in the transplantation process: tissue typing, procurement and preservation, immunosuppressants for solid organ and tissue transplants and postoperative monitoring. International markets are discussed, and information is provided on industry structure and the regulatory environment. Within each section are discussions of commercialization opportunities for each segment of the market. New or emerging devices, techniques and pharmaceuticals are highlighted. Profiles of more than 50 leading companies involved with solid organ transplantation, tissue transplantation, and alternative technologies are included. The report provides information on company placement within the market and strategic analyses of the companies’ available and emerging products. An appendix featuring various terms and processes used in transplantation is provided at the end of the report. This report cites autologous products only in relation to their impact on the market for allografts. It does not include blood products, with the exception of peripheral and umbilical cord blood as a source of stem cells.

CHAPTER 1 Introduction
REASONS FOR DOING THE STUDY
STUDY GOALS AND OBJECTIVES
SCOPE OF REPORT
METHODOLOGIES AND INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 SUMMARY
COST OF CARE
GLOBAL MARKET
SOLID ORGAN PRESERVATION
IMMUNOSUPPRESSION
DONATION
SOFT TISSUE MARKET
ORGAN ALTERNATIVES
GLOBAL MARKET PROJECTIONS
SUMMARY TABLE PROJECTED GLOBAL MARKET FOR TRANSPLANTATION PRODUCTS AND DEVICES, THROUGH 2020 ($ MILLIONS)
SUMMARY FIGURE PROJECTED GLOBAL MARKET SHARE OF TRANSPLANTATION PRODUCTS AND DEVICES, 2015 AND 2020 (%)
CHAPTER 3 INDUSTRY OVERVIEW
HISTORY OF TRANSPLANTATION
TABLE 1 TIMELINE OF ORGAN TRANSPLANTATION HISTORY, 1900-2012
INDUSTRY ACQUISITIONS
TABLE 2 SELECTED TRANSPLANT INDUSTRY ACQUISITIONS, 2010-EARLY 2015 ($ MILLIONS)
NECESSARY COMPONENTS TO ORGAN AND TISSUE TRANSPLANTATION
TISSUE TYPING
PRESERVATION
Tissue Preservation
IMMUNOSUPPRESSION
Newer Immunosuppressive Drugs
POSTOPERATIVE INFECTION CONTROL
OVERVIEW OF THE DONATION PROCESS
BLACK MARKET DONORS
THE TRANSPLANTATION PROCESS
PREPARATION
The Role of the Organ Procurement Organization
SURGERY
RECUPERATION
MAINTENANCE
SOLID ORGANS
COST OF SOLID ORGAN TRANSPLANTATION IN THE U.S.
TABLE 3 U.S. ORGAN/TISSUE TRANSPLANTS: AVERAGE FIRST YEAR COST,
ESTIMATED NUMBER OF PROCEDURES, AND VALUE BY TYPE OF ORGAN TRANSPLANT, 2011
KIDNEY TRANSPLANTS IN THE U.S.
Living Donor Efforts
Necessary Inputs for Successful Kidney Transplantation
LIVER TRANSPLANTATION IN THE U.S.
Promising Treatments
Necessary Inputs for Successful Liver Transplantation
HEART TRANSPLANTS IN THE U.S.
Necessary Inputs for Successful Heart Transplantation
INTESTINE TRANSPLANTATION IN THE U.S.
Necessary Inputs for Successful Intestine Transplantation
PANCREAS TRANSPLANTATION IN THE U.S.
Necessary Inputs for Successful Pancreas Transplantation
TISSUE TRANSPLANTATION IN THE U.S.
TRANSPLANTATION TRENDS OUTSIDE THE U.S.
ORGAN DONATION IN EUROPE
TABLE 4 ORGAN DONATIONS IN EUROPE, BY TYPE, 2012-2013
Standards in Europe
Transplant Organizations in the EU
JAPANESE ORGAN TRANSPLANT CRITERIA
Tradition and Beliefs
Brain Death in Japan
Three Key Elements of Conventional Death in Japan
TRENDS IN LIVING AND CADAVERIC DONATIONS OUTSIDE THE U.S.
GLOBAL SOLID ORGAN TRANSPLANTATION
TABLE 5 GLOBAL ACTIVITY IN ORGAN TRANSPLANTATION, 2012
KIDNEY DONATIONS
LIVER DONATIONS
LIMITED ORGAN SUPPLY CURTAILS TRANSPLANTATIONS
LIVING DONOR PROGRAMS
KEY FACTORS IN INDUSTRY GROWTH
REDUCING DEMAND
INCREASING PATIENT SURVIVAL RATES
TABLE 6 U.S. GRAFT SURVIVAL RATES, BY ORGAN AND YEARS (%)
DEVELOPING ORGAN SUBSTITUTES
Organs from Animals: Xenotransplantation
Emotional/Ethical Implications of Xenotransplantation
Organ Primordia
ARTIFICIAL ORGANS
KEY FACTORS INHIBITING GROWTH
LACK OF DONORS
ALTERNATIVE THERAPIES
PHARMACEUTICAL TREATMENTS
CULTURAL STIGMAS
Opt-in Consent and Presumed Consent
Anatomical Intent and Payment for Organs in the U.S.
REGULATIONS AND REIMBURSEMENT
REGULATIONS IN THE U.S.
U.S. FEDERAL REGULATION OF HUMAN TISSUE
HISTORY OF REGULATION IN THE U.S.
REGULATIONS OUTSIDE THE U.S.
TRANSPLANT "TOURISM"
REIMBURSEMENT IN THE U.S.
ORGAN ACQUISITION COSTS
REIMBURSEMENT FOR HOSPITAL COSTS
REIMBURSEMENT FOR PHYSICIAN SERVICES
REIMBURSEMENT FOR IMMUNOSUPPRESSANTS IN THE U.S.
TABLE 7 IMMUNOSUPPRESSIVE DRUGS CURRENTLY COVERED BY MEDICARE*
TABLE 8 OVERVIEW OF MEDICARE IMMUNOSUPPRESSIVE DRUG
COVERAGE
REIMBURSEMENT OUTSIDE THE U.S.
TREATMENT IN EU COUNTRIES
CHAPTER 4 TISSUE TYPING TECHNOLOGIES
ROLE OF TISSUE TYPING IN TRANSPLANTATION
TISSUE TYPING TECHNOLOGIES
TABLE 9 TISSUE TYPING TECHNOLOGIES
HLA ANALYSIS METHODS
SEQUENCE-SPECIFIC TYPING
Panel Reactive Antibodies (PRA)
Sequence-Specific Primer (SSP)
Sequence-Specific Oligonucleotide Probes (SSOP)
REFERENCE STRAND-BASED MEDIATED CONFORMATION ANALYSIS (RSCA)
GLOBAL TISSUE TYPING MARKET
TABLE 10 PROJECTED GLOBAL MARKET FOR TISSUE TYPING, THROUGH 2020 ($ MILLIONS)
COMMERCIALIZATION OPPORTUNITIES IN TISSUE TYPING
MARKET LEADERS
FIGURE 1 GLOBAL MARKET SHARES IN TISSUE TYPING TECHNOLOGIES BY MARKET LEADER, 2014 (%)
REGIONAL ANALYSIS
TABLE 11 PROJECTED GLOBAL TISSUE TYPING MARKET, BY REGION, THROUGH 2020 ($ MILLIONS)
CHAPTER 5 SOLID ORGAN PROCUREMENT AND PRESERVATION
DEFINITION OF BRAIN DEATH
ORGANS OBTAINED FOR TRANSPLANT
INCREASING SUPPLY IN THE U.S.
THE TRANSPLANT GROWTH AND MANAGEMENT COLLABORATIVE
SUPPLY MANAGEMENT
REDUCING WASTE AND REJECTION
FIGHTING REJECTION
TABLE 12 U.S. ORGAN RECIPIENTS WHO PREVIOUSLY HAD A TRANSPLANT: ALL ORGANS, 2007-2013
INCREASING THE HARVEST
TABLE 13 PERCENT OF U.S. ORGAN DISCARDS, BY TYPE, 2012 (%)
NON-BEATING HEART DONORS
LESS WASTE
ORGAN PROCUREMENT OUTSIDE THE U.S.
MANAGEMENT OF DONATED ORGANS IN THE EU
CHINA
JAPAN
ALLOCATION CRITERIA IN THE U.S.
TABLE 14 MEDIAN U.S. WAITLIST TIME FOR POTENTIAL RECIPIENTS, BY ORGAN AND NUMBER OF MONTHS, 2008 (NO. OF MONTHS)
MELD/PELD SYSTEM
ALLOCATION CRITERIA IN THE EU
MELD/PELD IN THE U.K.
SOLID ORGAN PRESERVATION
TABLE 15 COLD ISCHEMIA TIME FOR TRANSPLANTED ORGANS (HOURS)
GLOBAL MARKET FOR ORGAN PRESERVATION METHODS
TABLE 16 PROJECTED GLOBAL MARKET FOR ORGAN PRESERVATION METHODS, THROUGH 2020 ($ MILLIONS)
SIMPLE STATIC COLD STORAGE
TABLE 17 OPTIMAL PRESERVATION SOLUTION DESIGN
Rinse and Preservation Solutions
TABLE 18 MAJOR ORGAN PRESERVATION SOLUTIONS
KIDNEY COLD-STORAGE METHODS STUDY
TYPES OF COLD STORAGE SOLUTIONS
Celsior
Euro Collins Solution
Custodiol
Hypothermosol FRS
Perfadex
UW Solution
KPS-1 Kidney Perfusion Solution
Lifor
MARKET FOR PRESERVATION SOLUTIONS
TABLE 19 PROJECTED GLOBAL MARKET FOR SOLID ORGAN PRESERVATION SOLUTIONS (NOT INCLUDING THE PAPWORTH COCKTAIL) BY GEOGRAPHIC REGION, THROUGH 2020 ($ MILLIONS)
GLOBAL MARKET SHARE OF ORGAN PRESERVATION SOLUTIONS
FIGURE 2 GLOBAL MARKET SHARE OF ORGAN PRESERVATION SOLUTIONS 2013 (%)
MACHINE PERFUSION
EARLY MACHINE PERFUSION
CURRENT MACHINE PERFUSION
TABLE 20 ADVANTAGES AND DISADVANTAGES OF MACHINE PERFUSION
MARKET FOR MACHINE PERFUSION/ORGAN TRANSPORT SYSTEMS
TABLE 21 PROJECTED GLOBAL MARKET FOR MACHINE PERFUSION /ORGAN TRANSPORT SYSTEMS, THROUGH 2020 ($ MILLIONS)
ORGAN TRANSPORT AND PERFUSION SYSTEMS
Sherpa Perfusion Systems
Waves Renal Perfusion
LifePort
KidneyAssist
LifeCradle
Organ Care System
PRESERVATION SOLUTIONS IN DEVELOPMENT
KYOTO UNIVERSITY SOLUTION
IGL-1 SOLUTION
SOMAH SOLUTION
VASOWAVE
CHAPTER 6 TISSUE PRODUCTS
TABLE 22 PROJECTED GLOBAL TISSUE GRAFTING MARKET, BY TISSUE TYPE THROUGH 2020 ($ MILLIONS)
GLOBAL TISSUE MARKET, BY REGION
TABLE 23 PROJECTED GROWTH IN TISSUE MARKET REVENUES, BY REGION, THROUGH 2020 ($ MILLIONS)
FIGURE 3 GLOBAL TISSUE MARKET SHARES BY REGION, 2015 AND 2020 (%)
SOFT TISSUE REPAIR AND REPLACEMENT
CARTILAGE REPAIR AND REPLACEMENT
OTHER SOFT TISSUE REPAIR AND REPLACEMENT
TABLE 24 CARTILAGE AND SOFT TISSUE BIOLOGICS AND BIOMATERIALS
PROJECTED GLOBAL SOFT TISSUE MARKET
TABLE 25 PROJECTED GLOBAL MARKET FOR SOFT TISSUE REPAIR AND REPLACEMENT, THROUGH 2020 ($ MILLIONS)
PROJECTED GLOBAL SOFT TISSUE MARKET, BY REGION
TABLE 26 PROJECTED GLOBAL MARKET FOR SOFT TISSUE REPAIR AND REPLACEMENT, BY REGION, THROUGH 2020 ($ MILLIONS)
FIGURE 4 GLOBAL SOFT TISSUE MARKET, BY REGION, IN 2015 AND 2020
(%)
HEART VALVES
MECHANICAL
BIOLOGICAL/TISSUE
HOMOGRAFT
TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR)
GROWTH IN THE HEART VALVE MARKET
TABLE 27 GLOBAL HEART VALVE MARKET, THROUGH 2020 ($ MILLIONS)
HEART VALVE MARKET LEADERS
FIGURE 5 LEADING HEART VALVE SUPPLIERS, 2014 (%)
GLOBAL HEART VALVE MARKET, BY REGION
TABLE 28 PROJECTED GLOBAL MARKET FOR HEART VALVES, BY REGION, THROUGH 2020 ($ MILLIONS)
HEART VALVE MARKET IN THE FUTURE
CORNEA
CORNEAL TRANSPLANTS IN THE U.S.
GLOBAL CORNEAL TRANSPLANT MARKET
TABLE 29 PROJECTED GLOBAL GROWTH OF CORNEAL TRANSPLANT MARKET, THROUGH 2020* ($ MILLIONS)
BLOOD STEM CELLS
HISTORY
First Successful Transplant
Donor Registries
GLOBAL STEM CELL TRANSPLANT ACTIVITY
INDICATIONS FOR STEM CELL TRANSPLANTS
REJECTION
TYPES OF STEM CELLS
Bone Marrow
Peripheral Blood
Umbilical Cord Blood
GLOBAL MARKET FOR BLOOD STEM CELL TRANSPLANTATION
TABLE 30 PROJECTED GLOBAL MARKET FOR BLOOD STEM CELL TRANSPLANTATION, THROUGH 2020 ($ MILLIONS)
WORLDWIDE INCIDENCE OF PROCEDURES
THE ORTHOBIOLOGICS MARKET
TABLE 31 PROJECTED GLOBAL MARKET FOR ORTHOBIOLOGICAL PRODUCTS, THROUGH 2020* ($ MILLIONS)
BASE TISSUE
BONE PUTTY/DEMINERALIZED BONE MATRIX (DBM) PRODUCTS
MACHINED IMPLANTS
TABLE 32 HUMAN BONE PRODUCTS AND MARKETERS
SYNTHETIC BONE REPLACEMENTS
TABLE 33 SYNTHETIC BONE-REPLACEMENT PRODUCTS AND MARKETERS
SKIN GRAFTS
APPLICATIONS
MARKET FOR SKIN GRAFTS
TABLE 34 PROJECTED GLOBAL GROWTH OF SKIN GRAFTS, THROUGH 2020 ($ MILLIONS)
VASCULAR TISSUE TRANSPLANTATION
PRODUCTS
GLOBAL MARKET FOR VASCULAR TISSUE
TABLE 35 PROJECTED GLOBAL VASCULAR TISSUE TRANSPLANTATION MARKET, THROUGH 2020 ($ MILLIONS)
CHAPTER 7 IMMUNOSUPPRESSANTS, ANTI-INFECTIVES AND POST-TRANSPLANT MONITORING
TOLERANCE OF TRANSPLANTED ORGANS
ANTISENSE THERAPY
COSTIMULATION
CHIMERISM
COMMON ANTI-REJECTION DRUG PROTOCOLS
TYPES OF IMMUNOSUPPRESSANTS
TABLE 36 PROJECTED GLOBAL MARKET FOR IMMUNOSUPPRESSANTS USED IN TRANSPLANTS, BY TYPE, THROUGH 2020 ($ MILLIONS)
FIGURE 6 PROJECTED GLOBAL MARKET SHARES OF IMMUNOSUPPRESSIVES BY TYPE, THROUGH 2020 (%)
TABLE 37 IMMUNOSUPPRESSANT DRUGS APPROVED IN THE U.S., THE EU, AND JAPAN, THROUGH 2014
TABLE 38 IMMUNOSUPPRESSANTS BY DRUG CLASS, GENERIC NAME, BRAND NAME, AND MANUFACTURER
CALCINEURIN INHIBITORS
CYCLOSPORINE
Generic Cyclosporine
TACROLIMUS
TABLE 39 GLOBAL MARKET FOR CALCINEURIN INHIBITORS TO TREAT ORGAN TRANSPLANT REJECTION, THROUGH 2020 ($ MILLIONS)
ANTI-PROLIFERATIVE AGENTS
AZATHIOPRINE
MYCOPHENOLATE MOFETIL
MYCOPHENOLATE SODIUM
TABLE 40 GLOBAL MARKET FOR ANTI-PROLIFERATIVE AGENTS TO TREAT ORGAN TRANSPLANT REJECTION, THROUGH 2020 ($ MILLIONS)
M-TOR INHIBITORS
SIROLIMUS
TEMSIROLIMUS
EVEROLIMUS (CERTICAN/ZORTRESS)
TABLE 41 PROJECTED GLOBAL MARKET FOR M-TOR INHIBITORS TO TREAT ORGAN TRANSPLANT REJECTION, THROUGH 2020 ($ MILLIONS)
MONOCLONAL AND POLYCLONAL ANTIBODY PRODUCTS
TABLE 42 ANTIBODY PRODUCTS FOR TREATMENT OF ORGAN
TRANSPLANT REJECTION
POLYCLONAL ANTIBODY PRODUCTS
Thymoglobulin
Atgam
TABLE 43 PROJECTED GLOBAL MARKET FOR POLYCLONAL ANTIBODY PRODUCTS, THROUGH 2020 ($ MILLIONS)
MONOCLONAL ANTIBODY PRODUCTS
Off-label Medications
Rituximab
T-CELL COSTIMULATION BLOCKER
TABLE 44 PROJECTED GLOBAL MARKET FOR T-CELL COSTIMULATION BLOCKERS, THROUGH 2020 ($ MILLIONS)
TREATMENTS BY STAGE OF PROCEDURE
INDUCTION THERAPY
Disadvantages of Induction Therapy
Standard Treatments
TABLE 45 IMMUNOSUPPRESSANT USE FOR INDUCTION BY ORGAN IN U.S., 2012* (%)
MAINTENANCE THERAPY
TABLE 46 IMMUNOSUPPRESSANT USE FOR MAINTENANCE (UP TO 2 YEARS POST-TRANSPLANT) BY ORGAN, 2010* (%)
IMMUNOSUPPRESSANT USE IN PEDIATRIC TRANSPLANTATION
ADVANCES IN POST-OPERATIVE DESENSITIZATION
GLOBAL IMMUNOSUPPRESSANT MARKET
TABLE 47 PROJECTED GLOBAL MARKET FOR IMMUNOSUPPRESSANTS, BY REGION, THROUGH 2020 ($ MILLIONS)
FIGURE 7 PROJECTED GLOBAL MARKET FOR IMMUNOSUPPRESSANTS, BY REGION, 2015 AND 2020 (%)
ANTI-INFECTIVES AND POST-TRANSPLANT MONITORING IN ORGAN AND TISSUE TRANSPLANTATION
ANTI-INFECTIVES AND IMMUNOSUPPRESSANTS
TABLE 48 COMMON ANTI-INFECTIVE AND IMMUNOSUPPRESSANT
AGENTS AND INTERACTIONS, 2012*
Market for Anti-infectives in transplantation
TABLE 49 POST-TRANSPLANT INFECTIONS BY TYPE OF TRANSPLANT, WITH COMMON TIME FRAMES FOR INFECTION
POST-TRANSPLANT MONITORING
TABLE 50 RECOMMENDED POST-TRANSPLANT CARE, 2012
CHAPTER 8 ALTERNATIVE DEVICES AND TECHNOLOGIES
TABLE 51 PROJECTED GLOBAL MARKET FOR TRANSPLANTATION ALTERNATIVE DEVICES, THROUGH 2020 ($ MILLIONS)
ALTERNATIVES TO HEART TRANSPLANTATION
MEDICAL
SURGICAL
Cardiac Support Devices
MECHANICAL
Total Artificial Heart
Ventricular Assist Devices
Generations of Designs
TABLE 52 GLOBAL MARKET FOR ARTIFICIAL HEART DEVICES, THROUGH 2020 ($ MILLIONS)
TOTAL ARTIFICIAL HEARTS
TABLE 53 GLOBAL MARKET FOR TOTAL ARTIFICIAL HEARTS, THROUGH 2020 ($ MILLIONS)
VENTRICULAR ASSIST DEVICES
Regeneration Instead of Replacement
TABLE 54 GLOBAL MARKET FOR VADS, THROUGH 2020 ($ MILLIONS)
VAD as Destination Therapy
VAD Development Outside the U.S.
OPPORTUNITIES IN THE ORTHOPEDIC DEVICE MARKET
TABLE 55 SELECTED GLOBAL COMMERCIAL OPPORTUNITIES FOR NEW DEVICES IN THE FUTURE
TABLE 56 PROJECTED GLOBAL MARKET FOR ORTHOPEDIC DEVICES USED IN TRANSPLANTATION, THROUGH 2020 ($ MILLIONS)
FIGURE 8 GLOBAL MARKET FOR ORTHOPEDIC DEVICES, BY TYPE, 2015 AND 2020 (%)
MARKET LEADERS IN ORTHOPEDIC REPLACEMENTS
FIGURE 9 ORTHOPEDIC REPLACEMENT DEVICE MARKET, BY COMPANY MARKET SHARE, 2014 (%)
HIP
COSTS OF HIP REPLACEMENT SURGERIES
ALTERNATIVES TO HIP REPLACEMENT/RECONSTRUCTION
TABLE 57 PROJECTED GLOBAL MARKET FOR HIP REPLACEMENTS, THROUGH 2020 ($ MILLIONS)
KNEE
TABLE 58 PROJECTED GLOBAL MARKET FOR KNEE REPLACEMENTS, THROUGH 2020 ($ MILLIONS)
SPINE
TABLE 59 PROJECTED GLOBAL MARKET FOR SPINAL RECONSTRUCTIVE PRODUCTS, THROUGH 2020 ($ MILLIONS)
FIGURE 10 GLOBAL MARKET SHARES OF THE SPINAL RECONSTRUCTION MARKET BY COMPANY, 2013 (%)
EXTREMITIES
MARKET DRIVERS
TABLE 60 PROJECTED GLOBAL MARKET FOR EXTREMITY REPAIR/REPLACEMENTS, THROUGH 2020 ($ MILLIONS)
ALTERNATIVES TO CORNEAL TRANSPLANTATION
SURGICAL
TABLE 61 THERAPEUTIC INDICATIONS FOR PTK
Cellular Retinal Transplants
Electronic Implants
ALTERNATIVES TO INTESTINAL TRANSPLANTATION
MEDICAL
ALTERNATIVES TO PANCREAS TRANSPLANTATION
SURGICAL
Islet Cell Transplantation
BIOARTIFICIAL PANCREAS
ALTERNATIVES TO LIVER TRANSPLANTATION
TABLE 62 INDICATIONS FOR BIOARTIFICIAL LIVER TRANSPLANTATION
ALTERNATIVES TO VASCULAR TRANSPLANTATION
TISSUE ENGINEERING OF VASCULAR GRAFTS
GENE THERAPY
REGIONAL ANALYSIS
TABLE 63 PROJECTED GLOBAL MARKET FOR ORTHOPEDIC AND CARDIAC ALTERNATIVE THERAPIES, BY REGION, THROUGH 2020 ($ MILLIONS)
FIGURE 11 PROJECTED GLOBAL MARKET FOR ORTHOPEDIC IMPLANT PRODUCTS, BY REGION, 2015 AND 2020 (%)
CHAPTER 9 EMERGING PROCEDURES AND PRODUCTS IN DEVELOPMENT
ORGAN PRESERVATION SOLUTIONS IN DEVELOPMENT
KYOTO UNIVERSITY SOLUTION
IGL-1 SOLUTION
SOMAH SOLUTION
VASOWAVE
ISOGARCINOL
REGENERATIVE MEDICINE
APPLICATIONS IN LIVER TRANSPLANTS
ISLET CELL TRANSPLANTATION
CELLULAR THERAPIES
TABLE 64 TYPES OF REGENERATIVE CELLULAR THERAPIES
KIDNEY TRANSPLANT
New Molecule for Stable Immunological Tolerance after Kidney
Transplantation
Veloxis Pharmaceuticals
Alexion
CYTOMEGALOVIRUS TREATMENTS
Astellas Pharmaceuticals
CORNEAL TRANSPLANTS
Stem Cells and Bioengineering
STEM CELL RESEARCH
STEM CELL RESEARCH FUNDING IN THE U.S, ADVANCES IN CARDIOVASCULAR TREATMENTS
FIBROBLAST GROWTH FACTORS
CARDIOVASCULAR BIOTHERAPEUTIC INC.
IMMUNOSUPPRESSIVE AGENTS IN DEVELOPMENT
TABLE 65 SELECTED IMMUNOSUPPRESSIVE AGENTS IN DEVELOPMENT, 2015
PHARMACEUTICAL PIPELINE DEVELOPMENT
TABLE 66 PHARMACEUTICAL PIPELINE/DEVICE BY MANUFACTURER, TYPE OF PRODUCT, INDICATIONS FOR USE, AND STAGE OF CLINICAL TESTING
EXTREMITY REPAIR/REPLACEMENT
WRIGHT MEDICAL TECHNOLOGY
Simpliciti
Augment Bone Graft
CHAPTER 10 COMPANY DIRECTORY
TISSUE TYPING/DIAGNOSTICS
ABBOTT LABORATORIES
Business Overview
Products
BIORAD LABORATORIES
Business Overview
Products
CELERA CORP. (QUEST DIAGNOSTICS)
Business Overview
Products
DIAGAST
Business Overview
Products
HOLOGIC (GEN-PROBE)
Business Overview
Products
LIFE TECHNOLOGIES (PART OF THERMO FISHER SCIENTIFIC)
Business Overview
Products
LUMINEX CORP.
Business Overview
Products
ONE LAMBDA INC. (THERMO FISHER SCIENTIFIC)
Business Overview
Products
PROTEOME SCIENCES, PLC
Business Overview
Products
PRESERVATION SOLUTIONS (SOLID ORGAN/CELL/TISSUE)/ TRANSPORT
SYSTEMS
BRIDGE TO LIFE LTD.
Business Overview
Products
CRYOLIFE INC.
Business Overview
Products
DR. F. KOHLER CHEMIE GMBH
Business Overview
Products
INSTITUT GEORGES LOPEZ (IGL)
Business Overview
Products
LIFEBLOOD MEDICAL INC./CELL PRESERVATION SOLUTIONS
Business Overview
Products
LIFELINE SCIENTIFIC
Business Overview
Products
ORGAN ASSIST
Business Overview
Products
ORGAN TRANSPORT SYSTEMS
Business Overview
Products
PARAGONIX TECHNOLOGIES
Business Overview
Products
PRESERVATION SOLUTIONS INC
Business Overview
Products
SANOFI (SEE GENZYME IN TRANSPLANT PHARMACEUTICALS)
TRANSMEDICS INC
Business Overview
Products
XVIVO PERFUSION AB
Business Overview
Products
TRANSPLANT PHARMACEUTICALS (IMMUNOSUPPRESSANTS, POST-TRANSPLANT PHARMACEUTICALS)
AMGEN INC.
Business Overview
Products
ASTELLAS PHARMA INC.
Business Overview
Products
BRISTOL-MYERS SQUIBB
Business Overview
Products
GENZYME (A SANOFI COMPANY)
Business Overview
Products
JANSSEN BIOTECH
Business Overview
Products
JANSSEN CILAG (SEE JANSSEN BIOTECH)
KIADIS PHARMA
Business Overview
Products
NOVARTIS INTERNATIONAL AG
Business Overview
Products
PFIZER INC.
Business Overview
Products
ROCHE PHARMACEUTICALS
Business Overview
Products
VELOXIS PHARMACEUTICALS (FORMERLY LIFECYCLE PHARMA A/S)
Business Overview
Products
MECHANICAL HEART IMPLANTS
ABIOMED
Business Overview
Products
BERLIN HEART GMBH
Business Overview
Products
HEARTWARE INTERNATIONAL INC.
Business Overview
Products
SYNCARDIA SYSTEMS INC.
Business Overview
Products
TERUMO HEART
Business Overview
Products
THORATEC CORP.
Business Overview
Products
HEART VALVES
BOSTON SCIENTIFIC
Business Overview
Products
EDWARDS LIFESCIENCES
Business Overview
Products
MEDTRONIC
Business Overview
Products
SORIN S.P.A.
Business Overview
Products
TERUMO CARDIOVASCULAR SYSTEMS CORP.
Business Overview
Products
JOINT/ORTHOPEDIC IMPLANTS
ALPHATEC SPINE
Business Overview
Products
ARTHREX INC.
Business Overview
Products
BIOMET, INC
Business Overview
Products
CONMED-LINVATEC CORP.
Business Overview
Products
DEPUY SYNTHES
Business Overview
Products
DJO SURGICAL
Business Overview
Products
EXACTECH
Business Overview
Products
INTEGRA LIFESCIENCE
Business Overview
Products
K2M GROUP HOLDINGS INC.
Business Overview
Products
LDR HOLDING CORP.
Business Overview
Products
NUVASIVE INC.
Business Overview
Products
ORTHOFIX INTERNATIONAL
Business Overview
Products
RTI BIOLOGICS
Business Overview
Products
SMITH & NEPHEW, PLC
Business Overview
Products
STRYKER
Business Overview
Products
TORNIER INC. (U.S.)
Business Overview
Products
W.L. GORE & ASSOCIATES
Business Overview
Products
WRIGHT MEDICAL TECHNOLOGY INC.
Business Overview
Products
ZIMMER HOLDINGS INC.
Business Overview
Products
TISSUE/BONE REGENERATIVE PRODUCTS
ACELITY (FORMERLY KINETIC CONCEPTS INC. AND LIFECELL)
Business Overview
Products
ALLOSOURCE
Business Overview
Products
BAXTER BIOSURGERY (BAXTER AND SYNOVIS SURGICAL INNOVATIONS)
Business Overview
Products
BIOMATLANTE
Business Overview
Products
BIOMIMETIC THERAPEUTICS INC. (SEE WRIGHT MEDICAL GROUP)
BIOTISSUE TECHNOLOGIES GMBH
Business Overview
Products
BONALIVE BIOMATERIALS LTD.
Business Overview
Products
CITAGENIX INC.
Business Overview
Products
COOK MEDICAL
Business Overview
Products
CURASAN AG
Business Overview
Products
DISCGENICS
Business Overview
Products
ETEX CORP.
Business Overview
Products
EXABONE GMBH
Business Overview
Products
FORTICELL BIOSCIENCE (FORMERLY ORTEC INTERNATIONAL, INC.)
Business Overview
Products
GLOBUS MEDICAL
Business Overview
Products
GRAFTYS
Business Overview
Products
DSM BIOMEDICAL (FORMERLY KENSEY NASH CORP.)
Business Overview
Products
MEDTRONIC INC.
Business Overview
Products
MOLNLYCKE HEALTH CARE
Business Overview
Products
MUSCULOSKELETAL TRANSPLANT FOUNDATION
Business Overview
Products
ORTHOVITA INC. (SEE STRYKER)
OSIRIS THERAPEUTICS INC.
Business Overview
Products
OSTEOGENICS BIOMEDICAL INC.
Business Overview
Products
TEI BIOSCIENCES
Business Overview
Products
TEKNIMED
Business Overview
Products
TETEC TISSUE ENGINEERING TECHNOLOGIES AG
Business Overview
Products
TIGENIX N.V.
Business Overview
Products
VIACYTE INC.
Business Overview
Products
CHAPTER 11 APPENDIX
TABLE 67 DEFINITIONS

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